Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name HSPD1P3
Plot displaying the genomic locations of a retrocopy (in chr8) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr8:7418834-7421028  UCSC
Coordinates (T2T) chr8:7147824-7150018  UCSC
Coordinates (hg19) chr8:7276356-7278550  UCSC
Strand +
Parental Sequence NM_002156.5
Parental seq. overlap 2009 bp
Parental seq. overlap (%) 88.4%
Genomic Region Intergenic
Retrocopy Summary HSPD1P3, located on chr8:7418834-7421028, is a retrocopy of the parental gene HSPD1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name HSPD1
Full Name heat shock protein family D (Hsp60) member 1
Also known as CPN60|GROEL|HLD4|HSP-60|HSP60|HSP65|HuCHA60|SPG13
Coordinate chr2:197486584-197500274
Strand -
Gene summary This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13. [provided by RefSeq, Jun 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes HSPD1P9
Bonobo Pan paniscus HSPD1P9
Gibbon Nomascus leucogenys HSPD1P6
Crab-eating macaque Macaca fascicularis HSPD1P11
Rhesus Macaca mulatta HSPD1P12
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>HSPD1P3
ACCCCACAGAAATGCTTCCATTACCCACAGTCTTTCACCAGATGAGACCAGTGTCCAGGCTACTGGCTCCTCACCTCACTTGAAGTGATGGTAAAGATGTAAAATTTGGTGATGATGTCCGAGCCTTAATGCTTCAAAGTGTAGACTTTTTGTCGAGGCTGTAGCCATTACAATGGGGCCAAAGGGAAGAACAGTAATTATTGAACATAGCTGGGGAAGTCCCAAAGTAACAAAAGATGGTGTGACTGATGCAAAGTCAATTGACTTAAAGGATAAATATAAAAGCATTGGAGCTAAACTTGTCCAAGATGTTGCCAATAACACAGATGAAGAGACTGGGGGATGGCACTATCACTGCTGCTGTACTGGTATGCTCTATTTCCAAATAAGGCTTCCAGAAGGTTAGCAAAGGTGCTAATCCAGTGGAAATCAAGAGAGGTGTGATGTTAGCTGTTGATGCTGTAATTGCTGAACTTAAAAAGCAGTCTAAACCTGTGACCAAACCTGAAGAAATTGCACAGGTTGCTACAATTTCTGCAAATGGAGACAAAGAAATTGGTAACATCATCTCTGATGCAATGAAAAAGTTTGGAAGAAAGGGCATCATCACAGTAAAGGATGGAAAAACACTGACTGATGAATTAGAAATTATTGAAGGCATGAAAATTTGATCGAGGATATATTTCTCCATACTTTATTAATACATCAAAAGGTGAGAAATGTGAATTCCAGGATGCCTATGTTCTGTTGCATGAAAAGAAAATTTCTAGTGTCCAGTCCATTGTAACTGCTCTTGAAATTGCCAATGCTTACTGTAAGCCTTTGGTCATAATTGCTGGAGACATTGATGGAGAAGCTCTAACTACACTCATCCTGAATAGGCTAAAGGTTGGTCTTCAGGTTGTGGCAGTCAAAGCTCCAGGGTTTGGTGACAATAGAAAGAACCAGCTTAAAGATACGGTTATTGCTACTGGTGGTACAGTGTTTGGAGAAGAGGGCTGACACTAAATCTTGAAGACGTTCAGCCTCGTGACGTAGGAGAAGTTGGAGAGGTCACTGTGATCAAAGATTATGCCATGCTCTTAAAAGGAAAAGGTAACAAGTCTCAAATTGAAAAATGTGTTCAAGAAATCATTGACCAGTCAGATGTCACAACTAGTGAATACGAAAAGGAAAAAGTGAGTGGAGAAACTTTCAGATGGAGTAGCTGTGCTGAAGGTTGGTGGGACAAGTGATGTTGAAGTGAATGAAGAGAAAGACAGAGTTATAGGTGCACTTAATGCTACAAGAGCTGCTGTTGAAGAAGGCATTGTTTAGGGAGGGGGTTGTGCCCTGCTTCGATGCATTCCAGCCTTGGACTCATTCACTCCAGCTAATGAAGATAAAATAATTGGTATAGAAATTATTAAAAGAACACTCAAAATTCCAGCAATGACAATTGCTAAGAATGCAGGTGTTGATGGATTTTTGATAGTTGAGAAAATTATGTAAAGTTCCTCAGAAGTTGGTTATGATACTATGTTAGGAGATGTCGTGAATATGGTGGAAAAAGACATTATTGACCCAACAAAGGTTGTGAGAACTGCTTCATTGGATGCTGCTGGCATGGCCTCTCTATTAACTACAGCAGCTGTTGTAGTCACAGAAATTCCTAAAGAAGGGAACAGCCCTGGAATGGGTGCAATGTGTGGAATGGGAGGTGGCCTGTTCTAATTCCTAGAATAGTGCTTTACCTTTATTAATGAATTGTGATAGGAAGCCCAAGGCAGTGTTCCTCACCAATAACTTCAGAGAAGTCAGTTGGAGAAAATGAAGAAAAGGCTGGCTGATGTTTAAGAAACCACTATAACCATCAGTTACTGGTTTCAACTGACAAAATATATAATGGTTTACAGCTGTCATCCATGCCTACAGATAATTTAGTTTGTATTTTTGAATAGAAAGATCTTGTACATTCCTGACACTGGGTACAAGAGCCATGTACTGATGTACTGTTTTCAACTTAAATCACTGAGGCATTTTTTAGTAAAAATGAATAGTAGTCTATTCTGTTAAAATCAGGATTTTAGTGCTTGCAACCACCAAATGAGAAGTTAAGCAGCCTTTCTGTGCAGAGTGAGAATAATTGTGTACAAAGTAGAGAAACTTCCAATTATGTGACAACCTTTGTGTACTAAAAATGTGTTTAAAGTTAA
>NM_002156.5
CCCTCACTCGCCGCCGACGACCTGTCTCGCCGAGCGCACGCCTTGCCGCCGCCCCGCAGAAATGCTTCGGTTACCCACAGTCTTTCGCCAGATGAGACCGGTGTCCAGGGTACTGGCTCCTCATCTCACTCGGGCTTATGCCAAAGATGTAAAATTTGGTGCAGATGCCCGAGCCTTAATGCTTCAAGGTGTAGACCTTTTAGCCGATGCTGTGGCCGTTACAATGGGGCCAAAGGGAAGAACAGTGATTATTGAGCAGAGTTGGGGAAGTCCCAAAGTAACAAAAGATGGTGTGACTGTTGCAAAGTCAATTGACTTAAAAGATAAATACAAAAACATTGGAGCTAAACTTGTTCAAGATGTTGCCAATAACACAAATGAAGAAGCTGGGGATGGCACTACCACTGCTACTGTACTGGCACGCTCTATAGCCAAGGAAGGCTTCGAGAAGATTAGCAAAGGTGCTAATCCAGTGGAAATCAGGAGAGGTGTGATGTTAGCTGTTGATGCTGTAATTGCTGAACTTAAAAAGCAGTCTAAACCTGTGACCACCCCTGAAGAAATTGCACAGGTTGCTACGATTTCTGCAAACGGAGACAAAGAAATTGGCAATATCATCTCTGATGCAATGAAAAAAGTTGGAAGAAAGGGTGTCATCACAGTAAAGGATGGAAAAACACTGAATGATGAATTAGAAATTATTGAAGGCATGAAGTTTGATCGAGGCTATATTTCTCCATACTTTATTAATACATCAAAAGGTCAGAAATGTGAATTCCAGGATGCCTATGTTCTGTTGAGTGAAAAGAAAATTTCTAGTATCCAGTCCATTGTACCTGCTCTTGAAATTGCCAATGCTCACCGTAAGCCTTTGGTCATAATCGCTGAAGATGTTGATGGAGAAGCTCTAAGTACACTCGTCTTGAATAGGCTAAAGGTTGGTCTTCAGGTTGTGGCAGTCAAGGCTCCAGGGTTTGGTGACAATAGAAAGAACCAGCTTAAAGATATGGCTATTGCTACTGGTGGTGCAGTGTTTGGAGAAGAGGGATTGACCCTGAATCTTGAAGACGTTCAGCCTCATGACTTAGGAAAAGTTGGAGAGGTCATTGTGACCAAAGACGATGCCATGCTCTTAAAAGGAAAAGGTGACAAGGCTCAAATTGAAAAACGTATTCAAGAAATCATTGAGCAGTTAGATGTCACAACTAGTGAATATGAAAAGGAAAAACTGAATGAACGGCTTGCAAAACTTTCAGATGGAGTGGCTGTGCTGAAGGTTGGTGGGACAAGTGATGTTGAAGTGAATGAAAAGAAAGACAGAGTTACAGATGCCCTTAATGCTACAAGAGCTGCTGTTGAAGAAGGCATTGTTTTGGGAGGGGGTTGTGCCCTCCTTCGATGCATTCCAGCCTTGGACTCATTGACTCCAGCTAATGAAGATCAAAAAATTGGTATAGAAATTATTAAAAGAACACTCAAAATTCCAGCAATGACCATTGCTAAGAATGCAGGTGTTGAAGGATCTTTGATAGTTGAGAAAATTATGCAAAGTTCCTCAGAAGTTGGTTATGATGCTATGGCTGGAGATTTTGTGAATATGGTGGAAAAAGGAATCATTGACCCAACAAAGGTTGTGAGAACTGCTTTATTGGATGCTGCTGGTGTGGCCTCTCTGTTAACTACAGCAGAAGTTGTAGTCACAGAAATTCCTAAAGAAGAGAAGGACCCTGGAATGGGTGCAATGGGTGGAATGGGAGGTGGTATGGGAGGTGGCATGTTCTAACTCCTAGACTAGTGCTTTACCTTTATTAATGAACTGTGACAGGAAGCCCAAGGCAGTGTTCCTCACCAATAACTTCAGAGAAGTCAGTTGGAGAAAATGAAGAAAAAGGCTGGCTGAAAATCACTATAACCATCAGTTACTGGTTTCAGTTGACAAAATATATAATGGTTTACTGCTGTCATTGTCCATGCCTACAGATAATTTATTTTGTATTTTTGAATAAAAAACATTTGTACATTCCTGATACTGGGTACAAGAGCCATGTACCAGTGTACTGCTTTCAACTTAAATCACTGAGGCATTTTTACTACTATTCTGTTAAAATCAGGATTTTAGTGCTTGCCACCACCAGATGAGAAGTTAAGCAGCCTTTCTGTGGAGAGTGAGAATAATTGTGTACAAAGTAGAGAAGTATCCAATTATGTGACAACCTTTGTGTAATAAAAATTTGTTTAAAGTTAA

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