Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name UBE2HP1
Plot displaying the genomic locations of a retrocopy (in chr8) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr8:81254884-81257061  UCSC
Coordinates (T2T) chr8:81686480-81688657  UCSC
Coordinates (hg19) chr8:82167119-82169296  UCSC
Strand +
Parental Sequence NM_001202498.2
Parental seq. overlap 2011 bp
Parental seq. overlap (%) 41.9%
Genomic Region Intergenic
Retrocopy Summary UBE2HP1, located on chr8:81254884-81257061, is a retrocopy of the parental gene UBE2H. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name UBE2H
Full Name ubiquitin conjugating enzyme E2 H
Also known as E2-20K|GID3|UBC8|UBCH|UBCH2
Coordinate chr7:129830732-129952960
Strand -
Gene summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Three alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq, Feb 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes UBE2HP1
Bonobo Pan paniscus UBE2HP1
Gorilla Gorilla gorilla UBE2HP1
Orangutan Pongo abelii UBE2HP1
Gibbon Nomascus leucogenys UBE2HP1
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>UBE2HP1
GGGATTCATGCATAAAATTTTCCATCCCAACACTGACGACGCGTCAGGAACTGTGTGTCTAGATGTAATTAATCAAACTTGGACAGCTCTCTATGATCTTACCAATATATTTGAGTCCTTCCTGCCCCAGTTGTTGGCCTATCCTAACCCCATAGATCCTCTCAATGGTGAAGATGCAGCCATGTACCTCCAAAGACCAGAAGAATACAAGCAGAAAATTAAAGAGTACATCCAGAAATACACCACGGAGCAGGCGCTGAAAGAGCAGGAAGAGGGTACCAGGGACAGCTCATCGGAGAGCTCTATATCTGACTTTTCCAAAGATGAGGCCCAGGATATGGAGTTGTAGTAGAAAAAGCACCTGCTTTTCAGAAAGACTATTGTTTCCTAACCATGAGAAGCAGACTATAATATTCATATTTAAACACAGCAATTTTTTTATGACTAAACAAGGTTTTTATGAATAAAAGCATTGCACCCTTTAGATCTTGATTTCCTGGTCGTTTCTCAACCTGAGGTGCATAGCATATTCCCACATTCCATTTGGTAGCAATATGCGGTCCGAATGCATGCATTCATGAGTCCATGTGGCCAAGTCAGCCTGTGTGCTACTGAACTGTCAAAGGAAATAGCCGCTCTGATAGGTAGACGTAAGAAGAACGGGAAAAAAATCGCTTCTTTTATTGATGGTTCCAAAGAAACAAACCAAACCAACCAGCTCTTGGATGTGAAGATAAAATAGTGCTTTTCTGAAATGGAAAGGAAAAACTTGGGGAGGAAGGGGCCTGCTGTGGGGACATTAGAGCCAGCCACATAAGAATCAGAGCTACTACTTCCTGTGAATCCTAGGTGGCCCTATGTCTTCTGTGGAGTTACAGTATAAAACAGGGAGCTAATTAGAGTATTAAAACTTAAAACCGTTTTTTGACTCTGATTTTCAGTACGTTTTTACATGTCGGTTCCTGCCCTTCACACTACCAGGCCCTGCAGCCACAGTGTTCTGTTGGAGAAACTTGGAGAAGTGCTTTCTGAACCGGTTCTTTTTCTTGGGGTAGAGCTTGTAATCCAGACCTGTTTTTCAAAGGACAGCACAAGAGGAGAAAAGTGACTGGGACGATGCTTCCTCTCATCCAAAACACGTGCAGAGTCACATCCTCATCCTAGTGTTTGGCAGTTTGAGACTGCTACCCTGAACTTAAGAGCTTTAAATATGAGAGTTGTGTTTTCGCGGGGGTGGGGGGGGGGTATTTTTTTGgCTTAGAAAGGTTGCAGATTTCATCTTCACCTACCAAGAGGCAGCCGCCTCCTTGGACAAGCCGCTCATGGACCTTTAGACTTGAGAAGACCCGTGTGGTGACTGCAAAGCCCTGGGTACTTGCCTTCATGTTTTGGTTTGGTTTTCCCTTTTTCTGCTGCTCTTGGCAGCAGCCTGATCATCATCTGCTTGTGGGAGTGGGAAATGGGTATTTTAGACCCAACACAGGTTCTAAATTTAAAAAAATAATAATTGGAGCAAATAAAGGTTCTTGTACCCAGAGTGATTCTACATGGGAAAAACAAACCAGCTTTTTTTCAGAGAGTGACCGAATAGGAAGAAGGGATTCAGAAATATGATGTAGTAGAACATGCCCTGCAGGAAGAAAATGTGTTCTCTCCTGTGTATGTTAAGAGGAAATCAGTTTAAAATGCCTGCTAATCAAATGTTGTCTCAGCTAACCGTATGTCCAGGTTGCTGCAGAGTTTCTTTCAAATCTGAGTGTTGCCTGCTGAACTCAGATGGGAGTTTGAAGAAATTTTAGACAGCAGCTCTGTATTCTTTTTTTGCTGCAGCCAATAAGATAATAGCAGAATTTGCCAATCCTAAGACCTTCTGAAGACGATTTTTGAGCATCCCACTGGGATTATTTAATTTTTCTTTTTGACGTGTGTTTTTAGTTTGGAAATGCTGTATTCCACAAGGTTTAAGTCAGTGAGGTTGGAAGATGCCCTATCTTTTTTATTGAAAAAGCACAATCAATCTTTTGTTTGAAAATCTATATAAAGTACAACTTGCTTTTAGCATGATTATTTTCCTAAATAAAAAGACAAAGAATTTACTTACTTTATGT
>NM_001202498.2
AGAGCGAGGCTGGGGTAGGGAGGCCGACTGAGCAGGAGTCGTCCGCTTATAGTGGAGGCTGCTAGGAGCCGGTCAGAGGCATCGAGAGTAAACATGAGGTTACGATCCTGGGAGGACTTAATGAATTTGTAGTGAAGTTTTATGGACCACAAGGAACACCATATGAAGGCGGAGTATGGAAAGTTAGAGTGGACCTACCTGATAAATACCCTTTCAAATCTCCATCTATAGGATTCATGAATAAAATTTTCCATCCCAACATTGATGAAGCGTCAGGAACTGTGTGTCTAGATGTAATTAATCAAACTTGGACAGCTCTCTATGATCTTACCAATATATTTGAGTCCTTCCTGCCTCAGTTATTGGCCTATCCTAACCCCATAGATCCTCTCAATGGTGACGCTGCAGCCATGTACCTCCACCGACCAGAAGAATACAAGCAGAAAATTAAAGAGTACATCCAGAAATACGCCACGGAGGAGGCGCTGAAAGAACAGGAAGAGGGTACCGGGGACAGCTCATCGGAGAGCTCTATGTCTGACTTTTCCGAAGATGAGGCCCAGGATATGGAGTTGTAGTAGAAAAAGCACCTGCTTTTCAGAAAGACTATTATTTCCTAACCATGAGAAGCAGACTATAATATTCATATTTAAACAAAGCAATTTTTTTTATTACTAAACAAGGTTTTTATGAATAATAGCATTGatatatatatattatatatCACCCTTTAGATCTTGATTTCTTGGTCATTTCTCAACCTGAGGTGCATAGCATATTCCCACATTCCATTTGGTAGCAATATGCGGTCTGAATGCATGCATTCATGAGTCCATGTGGCCAAGTCAGCCTGTGTGCTACTGAACTGTCGAAGGAAATAGCCGCTCTGATAGGTAGATGTGAGTAAAAAGAACAGGAAAAAATTGCTTCTTTTATTGGTTTCCAAAGAAACAAACCAAACCAACCAGCTCTTGGATGTGAAGATAAAATAGTGCTTTTTTGAAATGGAGAGGAAAAACTTGGGGAGGAAGAGGCCTGCTGTGGGGGCATCGGAGCCAGCCATGTAAGAATCAGAGCTGCTCCTTCCTGTGAATCCTAGGTGGCCCTATGTCTTCTGTGGAGTTACAGTATAAAGCAGGGAGCTAATTAAGAGTATTAAAACTTAAAACCATTTTTTGACTCTGATTTTAAGTACATTTTTATATGTCAGTTGCTGCCCTTCACACTACCAGGCCCTGCAGCCACAGTGTTCTGTTGGAGAAACTTGGGGAAGTGTTTTCTGAACCAGTTCTTTTTCTTGGGGTAGAGCGTGAAATCCAGACCTGTTTTTGAAAGGACAGCACAGGAGGAGAAAAGTGACTGGGACGATGCTTCCTCTCATCCAAAACACATGCAGAGTCACATCCTCATCCTAGTGTTTGGCAGTTTGAGACCGCTACCCTGAACTTAAGAGCTTTAAATATGAGGGTTGTGTTTCTGGGGGGGTTATTTTTTTGgtgtgtgtgtgtgtgtattgtgCTTAGAAAGGTTGCAGATTTCATCTTCACCTACCAAGAGGCGGCCGCCTCCTTGGACAAGCCGCTCATGGACCATTAGACTTGAGAAGACGACCCACGTGGTGACTGCAAAGCCCTGGGTACTTGCCTTCATGTTCTGGTTTGGTTTTCCCTTTTTCTGCTGCTCTTGGCAGCAGCCTGGTCATCATCTGCTTGTGGGAGTGGGAAATGGGTATTTTAGACCCAACACAGGTTCTAAATTTAAAACAAATAATAATTGGAACAAATAAAGGTTCTTGTACCCAGAGTGATTCTACATGGGAAAAACAAACCAGCTTTTTTCAGAGAGTGACCGAATAGGAAGAAGGGATTCAGAAATATGATGTAGTAGAACATGCCCTGCAGGAAGAAAATGTTTTCTCTCCTGCGTATGTTAAGAGGAAATCAGTTTAAAATGCCTGCTAATCAAATGTCGACTCAGCTAACCATATGTCCAGGTTGCTGCAGAGTTTCTTTCAAATCTGAGTGTTGCCTGCTGAACTCGGAGGGGAGTTTGGAGAAATTTTAGACAGCAGCTCTGTGTTCTTTTTTTGCCGCAGCCAATAAGATAATAGCAGAATTAGCCAATCCTAAAACCTTCTAAAGACGATTTTTGAGCATCCCACTGGGATTATTTAATTTTTCTTTTTGACGTGTGTTTTTAGTTTAGAAGTGCTGTATTCCACAAGGTTTAAGTCAGTGAGGTTGGAAGATACCCTATCTTTTTTATTCAAAAAGCACAATCAATCTTTTGTTTGAAAATCTATATAAAGTACAACTTGCTTTTAGCATGATTATTTTCCTAAATAAAAAGACAAAGAATTTACTTACTTTATGTTAATTACGGGCATGAAGCAAAAGGTTTTCTTTAAAAAAAAAAAAAAGTGCAGTGATGTAGGGCTGTGGTTAGTTAACCGTACTGAGTTATCCATCTAGCATCTGTGGCTTGCTGGAAGGGTAGTATTAACTATTTAACATGTAATGGTGTACTTCACTCTTACCTAGCACGCTGTCTTCTCATTGCTTTGGGGGAGGGAGGGTCTCTCTGCTGGCACTGTCTAACTTGCTTACCTGCTGACTTTGCAGTTTGCTTGTGCTATGACATTTATTGTAGGTGCTATTTAGGGTAGGCTTAAAGTGCTGGGTGGTGATTTGAGTTCAAACAATAAAAAATTGTATTTTTTCAATATTGTATAAACAATAGTGTTCTAATTACCTTAAAAAAAAATAATGACCAGTTAAGAATTGCTTTTGATCTTGTCAAAAAACTGAATAGACCCCAGTTTCGGGAAGGTGTGTGAGCAGTGCCATGACTCTGCCCCTTACCTAATCCCACATCTCTCTAATGATAAGACATTGGCTCGCCTCTGACCAGAGCCCCAGCACCAGAGAGCGGAAGATGCAGAATTGTCAAATGACCTGCTGGGGGAGGTTGTAGGAGTTTAGCAGATTTGAGTGTGGCTGCAGAGAGAGAGAgtgtgtgtatgtgtgcacatgtgtgagagtgtgagcgagagtgtgtgtgtgtccatctaagtgtgtgtgATGAAGGTGGGATAAGGCTCCTCTGTTAGTGCTGGAAGCTCCTGTAATTGCCGCATGGATCCCACTGTGCCCTCTTGTTCTGTGCAAGTCTGTCCTGTCTGGGCACTAACCTTGGTCCCATGCATGTTTATGTTCTGGGTGGGGCTTTGCCTCTCCACTGGGAAACTGACTTTTGCTGGGTTGAACAGAGTCCCTTATGCTTTTTGTCCTCTCCCTGCGCCTGGGAGAGGTGGGAGTAGGAGCCCAAACACACAGGTACAGAAAGATCTGGAAGAAGGCCTGGCAGTGAATCCAAGGACTCTGGGCCCCCAACAATAGATGGTAGCGTAAGTCTGGAGCAGCGGTGTTTCACCACCAAATGCCTTTCCAGGCTGCCCTTCCAACACTCAGGAGAGCATCCAGATCCCTGGGCAGAGGCTCTACATTCTTGGCTTTAGAGGTGGTGGCAGCGGCAGCAGGTCAGAGCCACTTCTGGCGGTTTCCCTCCCCTTTTTAGTGCCCATAGTTTTTGGATCCTCCCTTGAGTTTTACCAGCACAAGCCATTCTTTGCCCCTGTTCACATAACTGAGCTCAAGCTCTTGCCAAACACCAACAAGCAAGATGGTTGCAACCTGGCAACATTGAATCCACCACCCTTGGGCTCCCTCTGGAAGCCCCAGCACCGGGGGGCTTTTGGGCACAGGGTCAGTGGTAGCCATCTTAGACACTGACATTTGGCTTTGTCGTCAATTTCATCACCCTCCTTGAGGTTACTGTGCAGTTTCAACCAGCATTTTATCCTAGTGAGGTCATTATCAGGAGTTGCCATATCATCTCTCCAGTACCTAACATTTCTCATCCACTTCAAAAGCTGTTCTGACTGCCAGCTGGCTGATCTAAGCTCCTGAGGAATGTCTCCTCTCAAAGGAATTTTTCCCTCCAAAGGCCCCCTGAAGTCCTAGTTGGCATTGGCCTGGCACATGCTTTATGTTAGGCCTCCCGTTGGGATGGCTGAGAATCATGAAAGACAGATCCTCCGCTAGCCTCTGTGGGTCAAGTTTCTGGACACCAAGTCTCTGGGAACTAGTGTTTGATTTTAAATGGCATGTGGCCCTTCCTTGTTTCAGTGACTTAGAAAAGTAAAAGCCATTTAAAAAAGTTAGCAAGATTTTTTATCGACTTCCCAACTGGGCTTCCAGCCTTGTTGAATGAAATCATCTATCTCTGATTGGGCGCAACGAACTGCATTTCTTTGGACTTCTGAATCCATGTTTGTGCTTTCTCTGGCCCGTGAACACCTCGGCGATTCTGTTAGGGATGGGATGAGTGGGAGGAAGCCCTTTGAGAAGGGGGAGCCGGCCCTGTCATGCGCAGGTTTTCCACTCATCTGAGGAAGAGCCAGGGCTCTGAATTTAGCCTAACACTCATCTTGGCTGTGGGCTTGGGAAGAAATGGCCATTATTTACAGATTGTATTTGGTACATATTGTGTGATACTTGAAAAGATAAAAGGGACTGCCAGCCCCTAACTGAAATCTGAAGCTTTTTATCGCTTATTTTTCCTCGCCCTGTCTCCTCCCTTCCACCTTTCTCCTTGCATTGTGATGATCTAGTAGGCACGTCTGTCAACAGGACACATGCCTCCTCTGACTATAACCTCTTAATAGTTGTGTATAATGAAAACTGTAAACTTTTTTAAATAAACGTGTATATACCTTGGCAAA

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