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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name MYL12AP1
Plot displaying the genomic locations of a retrocopy (in chr8) and its respective parental gene (in chr18). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr8:93849494-93850283  UCSC
Coordinates (T2T) chr8:94974532-94975321  UCSC
Coordinates (hg19) chr8:94861722-94862511  UCSC
Strand +
Parental Sequence NM_006471.4
Parental seq. overlap 720 bp
Parental seq. overlap (%) 74.7%
Genomic Region Intergenic
Retrocopy Summary MYL12AP1, located on chr8:93849494-93850283, is a retrocopy of the parental gene MYL12A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MYL12A
Full Name myosin light chain 12A
Also known as HEL-S-24|MLC-2B|MLCB|MRCL3|MRLC3|MYL2B
Coordinate chr18:3247482-3256237
Strand +
Gene summary This gene encodes a nonsarcomeric myosin regulatory light chain. This protein is activated by phosphorylation and regulates smooth muscle and non-muscle cell contraction. This protein may also be involved in DNA damage repair by sequestering the transcriptional regulator apoptosis-antagonizing transcription factor (AATF)/Che-1 which functions as a repressor of p53-driven apoptosis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8.[provided by RefSeq, Dec 2014]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes MYL12AP1
Bonobo Pan paniscus LOC100978696P1
Gorilla Gorilla gorilla LOC101127500P1
Orangutan Pongo abelii MYL12AP1
Gibbon Nomascus leucogenys MYL12AP1
Green monkey Chlorocebus sabaeus MYL12AP1
Golden snub-nosed monkey Rhinopithecus roxellana MYL12AP1
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>MYL12AP1
cGGCAGCGAGGGGCTCGCTGACGTGCTTGGATTCTCGTAGCTGTGCTGGGATTTAACCACCATGTCAAGCAAAAGAGCAAACACCAAGACCACCAAGAAGTGCCCTCAGCACACGACATCCAATATGTTTGCTGTGTTTGATCAGTCACAGATTCAGGAGTTCAAAGAGGCCTTCAACATGATTGATCAGAACAGAGATGGTTTCATCGACAAGGAAGATTTGCAGGATATGCTTGCTTCATCCGGGAAGAGTCCAACTGATTGGTATCTGGATGCCATGATGAATGAGGCTCCAGGCCCAATCAGTTTCACCGTGTTCCTCACCATGTTTGGTGAGAAGTTAAATGGCACAGATCCTGAAGATGTCATCAGACATGCTTTTGCTTGCTTTGATGAAGAAGCAACTGGCACCATTCAGGAAGATTACCTGTGAGAGCTGCTGACAACCATGGGGGGATGGGTTCATGGATGAGGAAGTGGATGAGCTGTATAGAGAAGATCCTATTGACAAAAAGGGAAATTTCAATTATATTGAGTTCACATGCATCCTAAAACATGGAGCAAAAGACGAAGATGACTGAAAGAACTTCAAGTTCCAGCCAAACATTCCTTGTTGCCACTTGGGGTATTTCTGAGATTTTTCTCTTGCATGCCCTTAGCTTTACAGCTTTTGCATTTCCTGTTGTATTTATTCTCAGCCATTTGGGGCACCTGTATCTTTATACTCAGACTGGAAATGGGACTTTCTATTAATATCATTTTCAGAATAGAAAATAGGGTAATT
>NM_006471.4
AAGCAGAGGCCGGAAGCGGTGGTTTTTAGCGGCTCTCTGGGTAGCAGGGTGGTGTGATAGCGGCAGCGAGGGGCTCGGAGAGGTGCTCGGATTCTCGTAGCTGTGCCGGGACTTAACCACCACCATGTCGAGCAAAAGAACAAAGACCAAGACCAAGAAGCGCCCTCAGCGTGCAACATCCAATGTGTTTGCTATGTTTGACCAGTCACAGATTCAGGAGTTCAAAGAGGCCTTCAACATGATTGATCAGAACAGAGATGGTTTCATCGACAAGGAAGATTTGCATGATATGCTTGCTTCATTGGGGAAGAATCCAACTGATGAGTATCTAGATGCCATGATGAATGAGGCTCCAGGCCCCATCAATTTCACCATGTTCCTCACCATGTTTGGTGAGAAGTTAAATGGCACAGATCCTGAAGATGTCATCAGAAATGCCTTTGCTTGCTTTGATGAAGAAGCAACTGGCACCATACAGGAAGATTACTTGAGAGAGCTGCTGACAACCATGGGGGATCGGTTTACAGATGAGGAAGTGGATGAGCTGTACAGAGAAGCACCTATTGATAAAAAGGGGAATTTCAATTACATCGAGTTCACACGCATCCTGAAACATGGAGCCAAAGACAAAGATGACTGAAATAACTTCAAATTCCAGCCAAACGTTCCTTGTTGCCACTTTGGGTATTCTGAGATTTTCTCTTGCATGCCCTTAGCTTTACAGCTTTTGCATTTCCTGTTGTATTTATTCTCAGCCATTTTGGGCATATGTATCTTTATAATCAGACTGGAAACGGGACTTTCTATTAATATCATTTTCAGAATAAAAAATAGGATAATTTAACCTACCAGCCCTTCTCCCCCAATAACTGTGGTCTATACAGAGTCAATATATTTTTTCAGAGAAAGTTATTCGCTCGATTTTTTCTGAATCATAATTAAACTTTATGATAAAATA

Publications

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