Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name UBE2V1P20
Plot displaying the genomic locations of a retrocopy (in chr8) and its respective parental gene (in chr20). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr8:99002025-99003851  UCSC
Coordinates (T2T) chr8:100126762-100128588  UCSC
Coordinates (hg19) chr8:100014253-100016079  UCSC
Strand -
Parental Sequence NM_001032288.3
Parental seq. overlap 1705 bp
Parental seq. overlap (%) 80.6%
Genomic Region Intergenic
Retrocopy Summary UBE2V1P20, located on chr8:99002025-99003851, is a retrocopy of the parental gene UBE2V1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name UBE2V1
Full Name ubiquitin conjugating enzyme E2 V1
Also known as CIR1|CROC-1|CROC1|UBE2V|UEV-1|UEV1|UEV1A
Coordinate chr20:50081124-50115957
Strand -
Gene summary Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Alternatively spliced transcript variants encoding multiple isoforms have been described for this gene, and multiple pseudogenes of this gene have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Apr 2012]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes UBE2V1P11
Bonobo Pan paniscus UBE2V1P10
Gorilla Gorilla gorilla UBE2V1P10
Orangutan Pongo abelii UBE2V1P8
Gibbon Nomascus leucogenys UBE2V1P12
Green monkey Chlorocebus sabaeus UBE2V1P3
Baboon Papio anubis UBE2V1P8
Golden snub-nosed monkey Rhinopithecus roxellana LOC115892954P7
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>UBE2V1P20
GCCACCATGGGCTCGGGAGTAAAAGTCCCTCACAATTTCTGACTGTTGGAAGAACTCAGAGAAGGCCAGAAAGGAGTAGGAGATGGCACAGTTAGCTGAGGTCTAGAAGATGATGAAGACATGACAAAAGATGGACAGGGATGATAATTGGGCCTCCAAGAACAATTTATGAAAACCAAATATACAGCCTTAAAATAGAATGTGGACCTAAATACCCACTAGCACCCCCCTTTGTAAGATTTGTAACAAAAATTAATGTAAATGGAGTTAATAGTTCTAATGGAGTAGTGGACCCAAGAGCCATATCAGTGCTAGCAAAATGGCAGAATTCATATAGCATCAAAGTTGTCCTGCAAGAGCTTCAGTGCCTATTGATGTCTAAAGAAAATATGAAACTCCCTCAGCCACCGGCAGGACAGTGTTACAGCAATTAATCAAAAAGAAAAACCACAGGCCCTTCCGCTTCCCCCCGCCCGATTCGATTTAAGCAGTCTTCGTTTTCCACAGTAGTAAATTTTCTAGATACATCATGTAGACCTCAAAGTACTGGAAAGGAAGCTCCAATTCAAAGGAAATTTATCTTAAGATACTGTAAATGATACTAATTATCCATTTGAAATATATAAGTTTTGCTATAACAAATCATCCTATCAAGTGTAACCACTGTCCACGTAGTTGAACTTCTGGAATCGAGAAATTCTAATTAAATTGATTCCCATCATAACTAGTGGGGCATATCTAACTCAACTGTGAAAAGAAACATCACACAATCACCTTGCTGATTACATGGCCTGGGGGTCTCTGCCTTCTCCCCTTACCCTCCTGCCTCCCACCCTCCCTGCAACAGCCCTCTAGCTTGGCTTGTTAGAGTGGATGTGAAGGTTTCAGGTTGCAGCCTGTGGGACTACTGCTAGGTGTGTGGGGTGCTTCACCTGCACCCCTGGTTTCTTTAAGTCTTATGCACCTTCCAATCCGTCATCCTGTCCCCACACTCCTCCACTCCTGCCTTTGGCAGAAGCATAGGTTGTAACCCCTCCGCTCCCCTCTAAGATTGGCCTTTGGTAAGGAATTCAGGGCTTTCCCAGTATCTTCTCTCCCCCACCTTTATCGAGGGATGCTGTTTTTTCTTCCCTCCTCAAGTTGCTTTCTGCACCATCACCACTCAATACCTTCCATGACACTTCCTTGCTTTGGGCAGAAGCCATCAGGTAAGGTTAGAAAGTCTCTAACCTCCCTTGTTTAGTTTTGGAACCATACTTATTCATTCTCCATCAGCCTGGGAAATGAATATTGGGTTTTCAGCCCTGCCACCCTCTGCTGTCGTCAGCTGATGCGTTGTTTTTAGCTCAGGTTTTGATAAGGTGAAAAGGAAAGTCACCAGGGTTACTCAGACCTGCCAGCTCTCGGAGTCCTTGGTGGTTGAAATTGGAGAAAGACCACAAGAAGACACTTGTAAGCACACGTGATCCCTCTGAATTGTTTTACTTCCTGTAATTGCTTTTGCTTTTAAAAACTGAAGAAGTTTTAAACAGGGCTTTCATTTGGTCATCCTTGCAATCCATTGAGGTCTAGTTTGGAATCTGACAACTGGAACAAAAAGAACCTTGAATCCAGTGCGTGCCTTGGTTTTGGTGCTGCTGCTGCTTCTCAAGATCCTCAGCAGGGATTAAGAAAGAACCCAGTGTGCATAGCAGATCCCTGAAATTGGCGGGCTTGACCTCCTGGGAAATTGGTGCGTCTTTCCACTTTCTGTTCAGGACCATTAAATGCTGAAATGTGGATGCATACCGAAATAAAAGTAATTCATTGTGTAA
>NM_001032288.3
CTTCAAGCAAGAGCGACGCAAGATGGCAGCCACCACGGGCTCGGGAGTAAAAGTCCCTCGCAATTTCCGACTGTTGGAAGAACTCGAAGAAGGCCAGAAAGGAGTAGGAGATGGCACAGTTAGCTGGGGTCTAGAAGATGACGAAGACATGACACTTACAAGATGGACAGGGATGATAATTGGGCCTCCAAGAACAATTTATGAAAACCGAATATACAGCCTTAAAATAGAATGTGGACCTAAATACCCAGAAGCACCCCCCTTTGTAAGATTTGTAACAAAAATTAATATGAATGGAGTAAATAGTTCTAATGGAGTGGTGGACCCAAGAGCCATATCAGTGCTAGCAAAATGGCAGAATTCATATAGCATCAAAGTTGTCCTGCAAGAGCTTCGGCGCCTAATGATGTCTAAAGAAAATATGAAACTCCCTCAGCCGCCCGAAGGACAGTGTTACAGCAATTAATCAAAAAGAAAAACCACAGGCCCTTCCCCTTCCCCCCAATTCGATTTAATCAGTCTTCATTTTCCACAGTAGTAAATTTTCTAGATACGTCTTGTAGACCTCAAAGTACCGGAAAGGAAGCTCCCATTCAAAGGAAATTTATCTTAAGATACTGTAAATGATACTAATTTTTTGTCCATTTGAAATATATAAGTTGTGCTATAACAAATCATCCTGTCAAGTGTAACCACTGTCCACGTAGTTGAACTTCTGGGATCAAGAAAGTCTATTTAAATTGATTCCCATCATAACTGGTGGGGCACATCTAACTCAACTGTGAAAAGACACATCACACAATCACCTTGCTGCTGATTACACGGCCTGGGGTCTCTGCCTTCTCCCCTTACCCTCCCGCCTCCCACCCTCCCTGCAACAACAGCCCTCTAGCCTGGGGGGCTTGTTAGAGTAGATGTGAAGGTTTCAGGTCGCAGCCTGTGGGACTACTGCTAGGTGTGTGGGGTGTTTCGCCTGCACCCCTGGTTTCTTTAAGTCTTAAGTGATGCCCCTTCCAAACCATCATCCTGTCCCCACGCTCCTCCACTCCCGCCCTTGGCCGAAGCATAGATTGTAACCCCTCCACTCCCCTCTGAGATTGGCCTTCGGTGAGGAATTCAGGGCTTTCCCCATATCTTCTCTCCCCCACCTTTATCGAGGGGTGCTGCTTTTTCTCCCTCCTCCTCAAGTTCCTTTTTGCACCGTCACCACCCAACACCTTCCATGACACTTCCTTGCTTTGGCCAGAAGCCATCAGGTAAGGTTGGAAAGAGCCTCTGACCTCCCTTGTTTAGTTTTGGAACCATACTCACTCACTCTCCACCAGCCTGGGAAATGAATATTGGGTCCTCAGCCCTGCCACCCTCTGCTGTCATCAGCTGATGCATTGTTTTTAGCTCAGGTTTTGATAAGGTGAAAAGAATAGTCACCAGGGTTACTCAGACCTGCCAGCTCTCGGAGTCCTTGGTGGTTGAACTTGGAGAAAGACCGCATGAAGATACTTGTAAGCACACATGATCCCTCTGAATTGTTTTACTTTCCTGTAACTGCTTTTGCTTTTAAAAATTGAAGAAGTTTTAAACAGGGCTTTCATTTGGTCATCCTTGCAATCCATTGGGGTCTAGTTTGGAATCTGACAACTGGAAcaaaaagaaccttgaatccggtgcatgccttggttttggtgctgctgctgcttcccaagatcctcagcAGGGATTAAGAAGGAACCCGGTGTGCACAGCAGATCCCCGAAATTGGTGGGCTTGACCTCCTGGCAAATTGCTGCGTCTTTCCACTTGCTGTTCAGGACCACTAAATGCTGAAATGTGGATGCATACCGAAATAAAAGCAATTCATTGTGTACTAAAGGTTTTTTTTTTTTTTTTAATTTAGTATTTGTGTAAAACCACCTTTTGAAGCAGCAACTATCAAGTCTGAAAAGCAATTGATGTTTCCATTAATCTTTTTCTGGGGGGAAAACCTTAGTTCTAAGGATTTAACATCCTGTAAGTGAAGTTTAACATAACAGTATTCCATAAGCAGCCTTTTTATTGTCAGACCATTGCCTGATTTTAATATAATAAAAAAAAAGTGTGCGTTAATATTTAA

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