Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name LETM1P3
Plot displaying the genomic locations of a retrocopy (in chr8) and its respective parental gene (in chr4). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr8:99696004-99698520  UCSC
Coordinates (T2T) chr8:100820952-100823468  UCSC
Coordinates (hg19) chr8:100708232-100710748  UCSC
Strand +
Parental Sequence NM_012318.3
Parental seq. overlap 2189 bp
Parental seq. overlap (%) 40.6%
Genomic Region Intragenic (VPS13B)
Retrocopy Summary LETM1P3, located on chr8:99696004-99698520, is a retrocopy of the parental gene LETM1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name LETM1
Full Name leucine zipper and EF-hand containing transmembrane protein 1
Also known as CONDMIM|Mdm38|SLC55A1
Coordinate chr4:1811479-1856156
Strand -
Gene summary This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8, 15 and 19. [provided by RefSeq, Oct 2009]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes LETM1P1
Bonobo Pan paniscus LETM1P1
Gorilla Gorilla gorilla LETM1P1
Orangutan Pongo abelii LETM1P1
Gibbon Nomascus leucogenys LETM1P3
Green monkey Chlorocebus sabaeus LETM1P2
Crab-eating macaque Macaca fascicularis LETM1P2
Rhesus Macaca mulatta LETM1P2
Baboon Papio anubis LETM1P2
Golden snub-nosed monkey Rhinopithecus roxellana LETM1P2
Marmoset Callithrix jacchus LETM1P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>LETM1P3
AAATGTTCCATTTGGCTGTTGCACTCCGGTCCACCCCGTGTACCCTTCCTTCAGAGGCGATCGCCATGGCTGTTAGGCCTTGAGGCAGAAGTGCCCACGCACGGTGGCGAGAGTGCCATGGACCTCTGCCACAGTGGATTTTATGGTTGCGGGACCTCGGTGCCTTCCTGTGCACAGCTGGCACTCTTCACGCCGTGTCTCTGATGACTTGGTAGTAGAGAAGTCCCTCAAGTCCTTCAAGGACAAGAACAAGAAGCTTGAGGAAGGCGGCCAAGTGTACACCCCCACCCCACAGAGGTGGTGGTGAATAAGTCGCTCGGGCAGAGGGAGCTGGATGAGCTGAAGCGCTACTGCCTTGGCTTCTGCCTGCTGTGGATCCATGCCAAGATCGTGGTGCTCATGCTGTGGCACATCCTTGACAGCCACACCCTGACCAGGCAAAGCGCAGGCAGTTTCTCCGGATCCGCGCCGACCTCCTCCGCTTGGTGCCGTTCCTTGTGTTCGTGGTTGTCCAGTTCATGGAATTCCTGCCGCCCGTGACCATGAAGCTCTTCCCCAGCATGCCAGCATCCACGTTTGAGACCCAGTCCATCAAGGAGGAGAGCCTGAAGGAGCTTCGGGTCAACCTGGAGCTGGCAGAGTTCCTCCAGGACACCATCGAGGAGAGGACCTTGAAGAACATAGCAGCCAAGGGCAGTGCCACCAGACTTCTCCGTTTTCCCAGAAGATCCGGGGGATGGGGGAGAGACCCAGCAATGAGGAAATCATGCGTTTTTCCAAATTATTTGAGAATGAGCTGACCCTGGACAACCTGTCACGGCCGCAGCTGGTGGCGCCGTGCAAGCTGCTGGAGCTGCAGTCCATCGGCATCAACAACTTCTGCGGTTCCAGCTCACCATGTGACTGCGCTCCATAAAGGCCAATGATAAGCTGATTGCTGAGGAGGGGTGGACAACCTGAACGTCAAGGGGCTGCAGCCGGCGTGTGGGAAGTGAGGTATGTGGGCCCTCCGCCTCAGCTGAAGCAGTGTCTGGACCTGCACCTGCATCAGGAGATTCCCATATCGCTACTCATCCTGTCCCAGACGATGTACCTCCCAGAAACTCTTGCCAGCTGACCAGCTCAAGTCCATACTGCAGACTCTCCCAGAGATTGTGGCAAAGGAAGAGCAGGTGAAAGTGGCTGAGGTGGAGGGTGGGCAAGTGCACAAGGTAAAGCTGGAGGTCACGCTGCAGGAGGAGGCAGCCATCCAGCAGGAGCACCACAAGGAGCTGCAGAAGCGCTCGGAGTTGGAGAAGGATGTCGCGCCCGAAGGTGTGGAAGCCACCCCTCGAAGGCCAGGGGCCTAACCTCAGCCAGAAGTGCCTGAAGCAGTCCTGTGGTCAGAGACCCTGAAGGACACTGCCCCCTGCTAGAGAGCTTGAAGGAGAAGGAGATAACTAAGGAGGAAATCGACATCCTCAGCGATGCCTGCTCTAAGCTGAAGGAGCAGAAGTCGCTCACCAAAGAGAAGGAGGAGCTGGAGCTGCTGAAGGAGGACGTGCAGGACTACAGCGAGAACATGCAAGAGATCAAGAAGGAACTCTCAAAGACTGGTAGGTGAAGAAAAATATGTGAAAGCATCTAAAGCCACCAAGAGACTGACAGAGGGTGCAGCAGATGATCGGGCAGATCGAGGGCTTGATCTCACACCTGGAGATGGACCAGGGCCTGCAAGCTGGGCCTGGCCTAGGGCGCGCCCGTAGGGGAGAACATCATCAGTGTCACTGAGCTCATCAGCACCATGAAGCAAGTCAGGCACATTCCAGAAAGCAAGCTCACCAGCCTGGCCTCAGCACTGGATGAAGACAAGAATGGCAAGGTCAACATCAATGACCTCATCAATGTGATTGAGTTGGTGGACAAAGATGTTCATGCCTCCACCAGCCAGGTGGCCAAGATTGTAGCGACCTTGGAGAAAGAAGAGAAGATGGAGGAGAAGACTGAGAAGGAGGCCGCAGAGGTGAAGAGCTAGAGCTGCTGGCCTAGCCACCTGTCCTCCTGCTGCCCCACTGCCCTGGCGAGGGCCGTGAGAGCAATTGCTTTGAGGTGATTCTCAGTGGCTCATCTAATACATTGGCTGGAATGAATCAGAGACTTCCATAATCAAGTAAATTTTAATTTTCATCATTCCATGGATATTCACTTAGTCTGGAATCCCAGAACCCCTCCACAGAATTGTGTTGGAACCACACTGTGGTGTGGTGCAGCTGCTGCAGCTGCCTGACTCCAGAGGCCACTGGGCCAGGCTAGGGCAGGAAGGTGCCCCCTTGTGTGTGTCCTCCCATCTCGGCTGCCCTGCCCCCAGGGAAGAGAATGAGGACCACGCGGACTCTGCCCACACAGAGCTGTCAGCTGCGCCCACCCTCAGAGGTTCATGAGACACAGCCCAGCCTCCTCGGGGCTGAAGATGCCTCTGTTCATCTGTGAATCTTGATTTCTAGATATTGGTGTCAATAGATCTCTCTTCCTGCACAC
>NM_012318.3
GCCCCGCGCCTCCGGACGTCTGTGCCGGGACAAGGCCGCCGCTGGTGCCGGGTCCTTGAGGAGAGCGCCTCCCGTCCGAGGCCAGCCGCCTCTGTCAGCCGTCCGCGCGGGCCGGGTCTGAAGCGCCGCCGGGACGGCGAAGAGCCGCGGCCGCCGCGGAGAAGGAGGCAGCGCAGGAGGCCGGAGCGGCCGCCGCGCCCGAGCACATGGCGTCCATCTTACTGAGGAGCTGCCGCGGCCGGGCGCCCGCCCGCCTCCCGCCGCCGCCTCGGTACACCGTCCCGCGGGGTAGTCCAGGGGATCCTGCTCATCTCAGCTGTGCCAGCACCCTGGGGTTGAGGAACTGCCTGAATGTTCCATTTGGCTGCTGCACTCCCATCCACCCTGTGTACACATCCTCCAGAGGCGATCACCTCGGCTGTTGGGCTCTGAGGCCCGAGTGCCTTCGCATAGTGTCGAGAGCGCCATGGACCTCTACCTCTGTGGGTTTTGTGGCTGTGGGACCTCAGTGCCTTCCTGTGCGTGGCTGGCACTCTTCGCGCCCTGTTCGCGATGACTCGGTAGTAGAGAAGTCCCTCAAGTCCTTGAAGGACAAGAACAAGAAGCTGGAGGAAGGCGGCCCGGTGTACAGCCCCCCCGCAGAGGTGGTGGTGAAGAAGTCCCTGGGGCAGCGGGTGCTGGACGAGCTGAAGCACTACTACCATGGCTTCCGCCTGCTATGGATCGACACCAAGATCGCGGCACGCATGCTCTGGCGCATCCTCAACGGCCACAGCCTGACCCGCCGGGAGCGCAGGCAGTTTCTCCGGATCTGCGCTGACCTCTTCCGCCTGGTGCCGTTCCTTGTGTTCGTGGTGGTGCCGTTCATGGAGTTTCTGCTGCCTGTTGCTGTGAAGCTCTTCCCCAACATGTTGCCATCCACATTTGAGACTCAGTCACTCAAGGAGGAGAGGCTGAAGAAGGAGCTTCGGGTCAAGCTGGAGCTGGCCAAGTTCCTCCAGGACACCATCGAGGAGATGGCCTTGAAGAACAAGGCAGCCAAGGGCAGCGCCACCAAAGACTTCTCTGTGTTTTTCCAGAAGATCCGGGAAACAGGGGAGAGGCCCAGCAATGAGGAAATCATGCGTTTTTCCAAATTATTTGAGGATGAGCTGACCCTGGACAACCTGACACGGCCGCAGCTGGTGGCCCTGTGCAAGCTGCTGGAGCTACAGTCCATCGGCACCAACAACTTCCTGCGCTTCCAGCTTACCATGCGGCTGCGCTCCATAAAGGCAGACGACAAGCTGATTGCTGAGGAAGGGGTGGACAGCCTGAATGTCAAGGAGCTGCAGGCAGCGTGTCGGGCACGAGGCATGCGGGCCCTGGGCGTCACGGAAGACCGCCTGAGGGGTCAGCTGAAGCAGTGGCTGGACCTGCACCTGCATCAGGAGATCCCCACATCGCTGCTCATCCTGTCCCGGGCCATGTACCTCCCGGACACCCTCTCTCCAGCCGACCAGCTCAAGTCCACACTGCAGACCCTCCCAGAGATTGTGGCAAAGGAAGCACAGGTGAAAGTGGCCGAGGTGGAGGGCGAGCAGGTGGACAACAAGGCCAAGCTGGAGGCCACGCTGCAGGAGGAGGCGGCCATCCAGCAGGAGCACCGTGAGAAGGAGCTGCAGAAGCGCTCGGAGGTGGCGAAGGATTTTGAGCCCGAACGTGTGGTAGCTGCTCCCCAAAGGCCGGGGACCGAGCCACAGCCAGAAATGCCTGACACAGTCCTGCAGTCAGAGACCTTGAAGGACACTGCCCCGGTGCTGGAGGGCTTGAAGGAGGAAGAGATCACGAAGGAGGAAATCGACATCCTCAGCGATGCCTGCTCTAAGCTGCAGGAGCAGAAGAAGTCACTCACCAAGGAGAAGGAGGAGCTGGAGCTGCTGAAGGAGGATGTGCAGGACTACAGCGAGGACTTGCAGGAGATCAAGAAGGAACTTTCAAAGACTGGTGAAGAAAAGTACGTGGAAGAATCTAAAGCCAGCAAGAGATTGACAAAAAGGGTGCAGCAAATGATCGGGCAGATCGATGGCTTGATCTCGCAGCTGGAGATGGACCAGCAGGCTGGCAAGCTGGCCCCGGCCAACGGCATGCCCACGGGGGAGAACGTCATCAGTGTCGCTGAGCTCATCAACGCCATGAAGCAAGTCAAGCACATTCCCGAAAGCAAGCTCACCAGCCTGGCCGCAGCACTGGATGAAAACAAGGATGGCAAGGTCAACATCGACGACCTCGTCAAGGTGATTGAGCTGGTGGACAAAGAAGATGTTCACATCTCCACCAGCCAGGTGGCTGAGATTGTAGCAACACTGGAAAAAGaggagaaggtggaggagaaggagaaggccaaagagaaggcagagaaggagGTCGCAGAGGTGAAGAGCTAGAACCACTGGCCTGGGCACCTGTCCTCCTGCTGTGCCGTCACCCTGGCAAGGGCCGTGAGGGCGATTGCTTTGTGGTGATTCTCAGTGGCTCATCTAATATTTTGGCTGGAATAAATCAGAGACTTCCATAATCAAGTAAATTTTAATTTTCATCATTCCACGGAGATTCAGTCTGTCTGGAATCCCGGAACCCCTCCACAGAATCGTGTCTGGATCCACACTGTGGTGTGGCTGCCACGGCCTCCTGGCTCCAGAGGCAGCTGGGCTGGGCCAAGGCAGGAAGGCGCCCCCATGTGTGTGGCCTCAGTCTCAGCATCTGACTGTGCTGCCCTGTCCCCAGGGAAGAGAATGAGGACCACGTGGACTCCGCCCACACAGAGCTGGCTGCTGTGCCCACCCTCAGGGGCGTCAGGAGACACAGCCTGGCCTCCTCAGGGCTGAAGATGCCTCCATTCGCCTGTGGACCTTGATTTCTAGATTTCAGTGTCAATAGACCTGTCTTCCTGCACACTTTCAGTTGGATGTGGGTCATTGTGGAGACAGAGGTGTCTGCCATCTCTGTGGCCTCTGGAGAGTGACGTCTCCCTGCTGGGAGTGCTGGTTCTCACGTGCGGTTTCCCTTGTGTATCGGAGCTCTTTCTCGGCTTTCTATTTCCCCCAGTTCTTTAAGCAGTCAATTGGCACAGAGTTTCCCACGGGGGCTGCAGTGGATTCACTGTGTCAGGGATGAGCCTGGCTTGGGGGTTGGTGGGGCTCTGAAGCGCATTTGGGGTTCTTTGTAGCTTCTAATGTGAGGTTTGAGTCCAGTGCGCCCACAGCAGCATGCCCTTCTCACCCCTTGCAGTGTTGCAGGCTCAGGCCCCTGGGCTCCTTCAGCAAGCAGGCTAGTCAATGAGGCATGAGGATCCGGCACAGGGCATCCCCTGGGGCTTCAAGGGCAATACCCCCGTGCTTAGGGTTTGCCCTGTGCCCTCTGGGTGGGGTGGCCTCCCCGCACTCGGCAGCATGGCCAGGCTGGCCAGGGCGTGGGCAGGTGGTGTCCTGTGGCACCTCCATCCTCCTGCCCAGCCGGCTGTGTCACACTCATCTTTTTAAGGTCAGGTTGGTTCCTGGCAAAAATGTACCTCCAGGGGCCTCCAAGCATAGGATTTGGAAGACAGGAACGGCACAGGCGTCCAGGAAAGCAGCTGCACTCAGACAATGCCTTCTCCATTACTTGAAGCTTCTTTCTGTTCAGCCATTAAAGAAACTTGACAAAATAGGAACAGGAGATATTTCTCAATTGTAAACCTTTGTGCAGGGACAGTTGGCTTCCAGAGGCTTTCAGCTTTCAGTTATTTGAGAAGTTTGTTTTAGATCCTTAACTAATATTTATGAATTCTCTCACCCTGTGTAAGTAGCCTGGTGTTCGTTTGTCCAAGTGTACTTACCCTTGAGAACAAGTCTTGCAGTTGCCAGGTGTGTGCAGACGCCTCTCCTGTGAGCGGCATCGCGGGCCCAGTCAGCTGCCCCGGCTCTCATCCTCGTCCTCACTGCCTTGGCTGAGCACTGTTGACGTGAACAGCCACTGCAACAGGCAGCCCATCCCACTGTCCCCTCTGCCCTGGACTCCGCATGGCCTCCAAAAGCCAGCTTGCCCTCCGGGTGCTGCAGGGGCTTTGCAGGTGGGGAAGGCTCTGGTGGGTGCCTTTGGTGGCTTCCGTGACATCAGCCGTGCTCTGATGCAGGCTTGCTCCCTCGTCATTCTCCCTCGTCATTCTCCCTCATCGTTCTGTGTGCATTTTTCTCTATGTCCTGACCTTTCTTCTTGCACCTAAAAGTGGTGTCTGGGTGCAAATGTAAGCAGTGGTGGATCCAGAAATATGAGCTTTGTGTAATAAGCTTCTTAAAACAGTCCTTTCTTACACCTGCCCAGGGCCAGACCCTCGGTCTTGGCCTTTTTCAGGAGCTAGGATATCTGCGCCTGGTGAAAATGAAACGAATTCCTGATTTAGGAATTCAGTGTTTCCTCCTCACTCCAGCTAAGCACTCACttttttttttttttttttttttttttgatacagagtctcgctctgtcacccaggctggagtgcagtggtgcgatctcggctcactgcaagctccacctcccgggttcaagcgattcttctgcctcagcctcctgagtaattgggattacaggcatgcgccaccatgcccagctaatttttttttttttttttgagacagagtcttgctctgtctcccaggctggagtgcaatggcgtgatctcggctcactgccagctccgcttcctgggttcacgccattctcctgcctcagcctcccgagtagccaggactacaagcacccgccaccacacctggctaatttttttgtatttttattagagacagtgttttaccgtgttagccaggatggtctcgatctcctgacttcgtgatctactcacctcggcctcccaaagtgctgggattacgggcaagtttttattagagatggggtttcatcatgttggtcaggctggtcttcaactcctgacctcaggtgatccacccgcctcagcctcccaaagtgctgggattacaggcatgagccaccgcgcccggccTGAACTCTCAGTTCTAACGCAGGGATTCAGGAATTGGGCTTTCAGACTCCTTCTGCAGTGTCACAGTCCAGACTTTTTTTAAATGAAGGACACCCCGCAGTGGCTCACAGTGGGTCCCAGGGCTAGCAGGAGCGTGCTGGGGAGCCGGCTCTGTCTTTGTTCGCAGTGGGTCCCGGTGCTGGCAGGAGTGTGCTGGTGAGCCGGCTCTGTCTTTGTAAATCCTTCAGGGGTCCTACGGCTGACTCCACCGGACAGCCCGTCCTGGGCCGTGTTAAGCACCTTTTGTAGAAATCGTATTTTTATTAAAACATCAAATCTGTGTTCCTGTAA

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