Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ACTG1P19
Plot displaying the genomic locations of a retrocopy (in chr9) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr9:100731174-100733289  UCSC
Coordinates (T2T) chr9:112903166-112905281  UCSC
Coordinates (hg19) chr9:103493456-103495571  UCSC
Strand +
Parental Sequence NM_001101.5
Parental seq. overlap 1559 bp
Parental seq. overlap (%) 84.6%
Genomic Region Intergenic
Retrocopy Summary ACTG1P19, located on chr9:100731174-100733289, is a retrocopy of the parental gene ACTB. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ACTB
Full Name actin beta
Also known as BRWS1|PS1TP5BP1
Coordinate chr7:5527148-5530601
Strand -
Gene summary This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins that are ubiquitously expressed. Mutations in this gene cause Baraitser-Winter syndrome 1, which is characterized by intellectual disability with a distinctive facial appearance in human patients. Numerous pseudogenes of this gene have been identified throughout the human genome. [provided by RefSeq, Aug 2017]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ACTBP12
Bonobo Pan paniscus ACTG2P5
Gorilla Gorilla gorilla LOC101127752P12
Orangutan Pongo abelii ACTBP14
Green monkey Chlorocebus sabaeus ACTG1P8
Crab-eating macaque Macaca fascicularis ACTBP16
Rhesus Macaca mulatta ACTBP18
Golden snub-nosed monkey Rhinopithecus roxellana ACTBP22
Marmoset Callithrix jacchus ACTBP2
Gibbon Nomascus leucogenys Without Homology
Baboon Papio anubis Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ACTG1P19
ACCCGCGAGCACAGAACCCCGCCCTTGCCGCTCTGCCGCCCAGTCCACACCCGCCGCCAGCTCACCATGGATGATGATATCGCCCCACTTGTCATTGACAACGGCTCAGGCATGTGCAAGGCCGGCTTTGCAGGTGATAATGTCCCCCTGGGCCATCTTCCCCCTCCATCGTGGAGCTCCCTAGGCGCCAGGGTGTGATGGTGGGCATGGGTCAGAAGGACTTGTACGTGGGGCGGCAAGGCCCAGAGCAAGAGAGGCATCCTGACCCTGAAGTACCCCATCGAGCACACATCGTCACCACCTGGGATGACATGGAGAAGATCTGGCTCTACAATGAGCTGGGTGTGGCTCCTGAGGAGCACCCGTGCAGCTGACTGAGGCCCCCATGAACCACAAGGCCAACTGCAAGAAGATGACCCAGATCATGTTTGAGACCTTCAACACCCCAGCCATATACGTGGCCATCCAGGCCTTGTGGTCCCTGTACGCCTCTGGCCGTACCACTAGCATCATGATGGACTCCGTGGATGGGGTCACCCACACTGTGCCCATGTACAAGGGGCATGCCCTCCCCCATGCCATCCTGTATCTGGACCTGGCCGGCTGGGACCTGACTGGCTACCTCATGAAGATCCTCACCCAGCGCGGCTACAGCTTCACTACCAGGGCAGAGCAGGAGATTGTGCATGACATCAAGGAAAAGCTGTGCTACGTCGCCCTGGACTTCGAGCAGGAGATGGCCACGGCAGCCTCCAGCTCCTCCCTGGAGAAGATCTAGGAGCTGCCCTACTGCCAGGTCATCACCATCGGCAACGAGTGTTTCCTCTGCCCCAAGGTGCTCTTCCAGCCTTCCTTCCTGGGCATGGAATCCTGTGGCATTCACGAAACTGCCTTCGACTCCATCATGAAATGTGACGTGGACATCCACAAAGACCTGTATGCCAACCCAGTGCTGTCTGACGGTACTACCATGAACCCTGGCAACCCTGACAGGATGCAGAAAGAGATCACTGCCCTGGCGCCCAGCACAATGAAAATCAAGATTATTGCTCCTCCCGAGCTCAAATACTCTGTGTGGATTGGCTCCATCCTGGCCTCGCTGTCCACTTTCCAGCAGATCAGATATGGACCAGCAAGCGGGGGTATGACGAGTCGGCCCCTCCATCCTCCAAATGCTTCTAGGCAGACTGTTAATTGCGTTACACCCTTTCTTGATAAAACCTAACTGGTGCAGAGAACAAGATGAGATTGGCATGGCGTGGCTTGACTCAGATTTAAAAACTGGAACGGTGAAGGTGACAGCAGTCTGTTTGAGCAAGCATCCTCCAAAGTTCTACAATGTGGCCGAGGACTTTGATTGTACATTGCTCTTGTTCTTTTTTTAATAGTAATTCCAAATAACATGAGATGCATTGTCACAGGAAGCCCCTTGCCCTCCTAAAAGCCACCCCACTTCTCTCTAAGGAGAATGGCCCAGTTCTCTCCTGAGTCCACACAGGGGAGGTGATAGCATTGCTTTCATGTAAATTATGTAATGCAAcTAGCACAATTTTTTAAATCTTTGCCTTAACACTTTTAAAATTTTGTTTTATTTTAAATGATCAGCCTTCATGGCTCCCCCTTTTTTGGCCCCCAACTTGAGATATATGAAAGCTTTTGGTGTCCCTGGGAGTGGGCGGAGGGCAGCCAGGGGCTTACCTGTACACTGACTTGAGACCAGTTGAAAAAAAGTGCACACCTTAAAAA
>NM_001101.5
ACCGCCGAGACCGCGTCCGCCCCGCGAGCACAGAGCCTCGCCTTTGCCGATCCGCCGCCCGTCCACACCCGCCGCCAGCTCACCATGGATGATGATATCGCCGCGCTCGTCGTCGACAACGGCTCCGGCATGTGCAAGGCCGGCTTCGCGGGCGACGATGCCCCCCGGGCCGTCTTCCCCTCCATCGTGGGGCGCCCCAGGCACCAGGGCGTGATGGTGGGCATGGGTCAGAAGGATTCCTATGTGGGCGACGAGGCCCAGAGCAAGAGAGGCATCCTCACCCTGAAGTACCCCATCGAGCACGGCATCGTCACCAACTGGGACGACATGGAGAAAATCTGGCACCACACCTTCTACAATGAGCTGCGTGTGGCTCCCGAGGAGCACCCCGTGCTGCTGACCGAGGCCCCCCTGAACCCCAAGGCCAACCGCGAGAAGATGACCCAGATCATGTTTGAGACCTTCAACACCCCAGCCATGTACGTTGCTATCCAGGCTGTGCTATCCCTGTACGCCTCTGGCCGTACCACTGGCATCGTGATGGACTCCGGTGACGGGGTCACCCACACTGTGCCCATCTACGAGGGGTATGCCCTCCCCCATGCCATCCTGCGTCTGGACCTGGCTGGCCGGGACCTGACTGACTACCTCATGAAGATCCTCACCGAGCGCGGCTACAGCTTCACCACCACGGCCGAGCGGGAAATCGTGCGTGACATTAAGGAGAAGCTGTGCTACGTCGCCCTGGACTTCGAGCAAGAGATGGCCACGGCTGCTTCCAGCTCCTCCCTGGAGAAGAGCTACGAGCTGCCTGACGGCCAGGTCATCACCATTGGCAATGAGCGGTTCCGCTGCCCTGAGGCACTCTTCCAGCCTTCCTTCCTGGGCATGGAGTCCTGTGGCATCCACGAAACTACCTTCAACTCCATCATGAAGTGTGACGTGGACATCCGCAAAGACCTGTACGCCAACACAGTGCTGTCTGGCGGCACCACCATGTACCCTGGCATTGCCGACAGGATGCAGAAGGAGATCACTGCCCTGGCACCCAGCACAATGAAGATCAAGATCATTGCTCCTCCTGAGCGCAAGTACTCCGTGTGGATCGGCGGCTCCATCCTGGCCTCGCTGTCCACCTTCCAGCAGATGTGGATCAGCAAGCAGGAGTATGACGAGTCCGGCCCCTCCATCGTCCACCGCAAATGCTTCTAGGCGGACTATGACTTAGTTGCGTTACACCCTTTCTTGACAAAACCTAACTTGCGCAGAAAACAAGATGAGATTGGCATGGCtttatttgttttttttgttttgttttggttttttttttttttttGGCTTGACTCAGGATTTAAAAACTGGAACGGTGAAGGTGACAGCAGTCGGTTGGAGCGAGCATCCCCCAAAGTTCACAATGTGGCCGAGGACTTTGATTGCACATTGTTGTTTTTTTAATAGTCATTCCAAATATGAGATGCGTTGTTACAGGAAGTCCCTTGCCATCCTAAAAGCCACCCCACTTCTCTCTAAGGAGAATGGCCCAGTCCTCTCCCAAGTCCACACAGGGGAGGTGATAGCATTGCTTTCGTGTAAATTATGTAATGCAAAATTTTTTTAATCTTCGCCTTAATACTTTTTTATTTTGTTTTATTTTGAATGATGAGCCTTCGTGCCCCCCCTTCCCCCTTTTTTGTCCCCCAACTTGAGATGTATGAAGGCTTTTGGTCTCCCTGGGAGTGGGTGGAGGCAGCCAGGGCTTACCTGTACACTGACTTGAGACCAGTTGAATAAAAGTGCACACCTTAAAAATGA

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