Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name KPNA2P4
Plot displaying the genomic locations of a retrocopy (in chr9) and its respective parental gene (in chr17). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr9:107169305-107171148  UCSC
Coordinates (hg19) chr9:109931586-109933429  UCSC
Strand -
Parental Sequence NM_002266.4
Parental seq. overlap 1383 bp
Parental seq. overlap (%) 60.4%
Genomic Region Intergenic
Retrocopy Summary KPNA2P4, located on chr9:107169305-107171148, is a retrocopy of the parental gene KPNA2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name KPNA2
Full Name karyopherin subunit alpha 2
Also known as IPOA1|PTAC58|QIP2|RCH1|SRP1-alpha|SRP1alpha
Coordinate chr17:68035735-68046854
Strand +
Gene summary The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes KPNA2P4
Bonobo Pan paniscus KPNA2P4
Gorilla Gorilla gorilla KPNA2P4
Orangutan Pongo abelii KPNA2P4
Gibbon Nomascus leucogenys KPNA2P1
Green monkey Chlorocebus sabaeus KPNA2P2
Crab-eating macaque Macaca fascicularis KPNA2P4
Rhesus Macaca mulatta KPNA2P5
Baboon Papio anubis LOC101007523P1
Golden snub-nosed monkey Rhinopithecus roxellana KPNA2P5
Marmoset Callithrix jacchus KPNA2P2
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>KPNA2P4
ACAAAGACAACTTAATCTGGGCTGGTTTGATTCCAAAATTTGTGTCTTTCTTAGGCAGAACTGATTGTAGTCCCATTCAGTTTGAATCTGCCTGGATGCTCACTAACATTGCTTCTGGGAATCAGAACAAGCCAAGGTTGTGGTAGATGGAGGTGCCATCCTAGCATTCATTTCTCTGTTGGCATCTCCCCATGCTCACATCAGTGAACAAGTTGTATCGGCTCCAGGAAACATTGCAGGTGATATAGCTCAGTTTTCCGAGACTTGATTACTAAGTACAGTGCCGTTGACCCACTGTTGGCTCTTCTTGCAGTTCCTGATATGTCATCTTTAGCATGTGGTTACTTATGTAATCTTACCTGGACACTTTCAAATCTTTGCTGCAACAAGAATCCTGCACCCCGGTTAGATGCTGTTGAGGAAATTCTTCCTATCTGAGTTCGGCTCCTGCATCATGATGATCCAGAACTATTAGCAGATGCCTGCTGGGCTATTTCCTACCTGACTGATGGTCCAAATGAATGAATTGACATTGTCATGGAAACAGGAGTTGTGCCCCAACTTGTGAAGCTTCTAGGAGCTTCTGAATTGCCAATTGTGACTCCTGCACTAAGAGCCATAGGGAATATTGTCACTGGTACAGGTGAACAGACTCAGGTTGTGATCGATGCAGAGGCACTTGCTGTCTTTCCCAGCCTGCTCACCGACCCCAAAACTAACACTTGGAAGGAAGCTATGTGGACAATGTCAAACATCACAGCTGGCCGTCAGGACCAGATACAGCAAGTTGTGAATCATGGATTAGTCCTATTCCTTGCCAATGTTCTAAGTCAGATCTTAAGACACAAAAGGAAGCTGTATGGGCCGTGACCAACTATACCAGTGGCGAAACAGTTGAACAGATTGTGTAGCTCATTCATTGTGGCATAATAGAACCATTGATGAACTTCTTAACTGTAAAGATACCAAGGTTATTCTGGTTATCCTGGATGCCATTTCAAGTATCTTTCAGGCTGCTGAGAAACTAGGTGAAACTGAGAAACTTAGTATAATGATTGAAGAATGTGGAGGCTTAGACAAAATTGAAGCTCTCCAAAATCATGAAAATGAGTGTGTATAAGGCTTTGTTAAGCTTAATTAAGTATTTCTCTGTAGAGGAAGAGGAAGATGAAAACATGGTGCCAGAAACTACCTCTGAAGGCTATACCTTCCAAGTTCAGGATGGGACTCCTGGGAACTTTTAACTTGTAGATCACATAGCTGAGGCATAAATTTGTTGTGTACTATGTTTGGTATAAGTTTGTTTCTCTACTATGTTTGTATAAGTACTGTTTCTCTACAAAGAACTCTTTTTAAATATGGTTTGGTATTGTAGCACTTTTTACACTGAAACTATACTTGAACAGTTCCAACCTGTAAATACCGTATAAAGCTTGTCCTCTGAATGGGTTTCTTATTTCTTTGTGGAATTTTATATCTCGCAGTGTCCTGTAAATAAAGACTAAAGTCCACCCCCCAGCTGCCCGACTTAACAGATTCAAGAACAAGGGAAAAGACAGTACAGAAATGAGGTGTCACAGAATAGAAGTCAATGTGGAGCTGGGGAAAGCTAAGAATGACCAGATGCTGAAGAGGAGAAATGTAAGCTCATTTCCTGATGATGCTACTTGTCCGCTGCAGAAAAACCACAACAATCAGGGCACTGTAAATTAGTGTGTTGATGACATTGTCAAAGGCATAAATAGCAACAATGTGGAAAGTTAGCTCCAAGCTACTCAAGCTGCCAGGAAACTACTTTCTAGAGGAAAACAGc
>NM_002266.4
ACACGGTCTTTGAGCTGAGTCGAGGTGGACCCTTTGAACGCAGTCGCCCTACAGCCGCTGATTCCCCCCGCATCGCCTCCCGTGGAAGCCCAGGCCCGCTTCGCAGCTTTCTCCCTTTGTCTCATAACCATGTCCACCAACGAGAATGCTAATACACCAGCTGCCCGTCTTCACAGATTCAAGAACAAGGGAAAAGACAGTACAGAAATGAGGCGTCGCAGAATAGAGGTCAATGTGGAGCTGAGGAAAGCTAAGAAGGATGACCAGATGCTGAAGAGGAGAAATGTAAGCTCATTTCCTGATGATGCTACTTCTCCGCTGCAGGAAAACCGCAACAACCAGGGCACTGTAAATTGGTCTGTTGATGACATTGTCAAAGGCATAAATAGCAGCAATGTGGAAAATCAGCTCCAAGCTACTCAAGCTGCCAGGAAACTACTTTCCAGAGAAAAACAGCCCCCCATAGACAACATAATCCGGGCTGGTTTGATTCCGAAATTTGTGTCCTTCTTGGGCAGAACTGATTGTAGTCCCATTCAGTTTGAATCTGCTTGGGCACTCACTAACATTGCTTCTGGGACATCAGAACAAACCAAGGCTGTGGTAGATGGAGGTGCCATCCCAGCATTCATTTCTCTGTTGGCATCTCCCCATGCTCACATCAGTGAACAAGCTGTCTGGGCTCTAGGAAACATTGCAGGTGATGGCTCAGTGTTCCGAGACTTGGTTATTAAGTACGGTGCAGTTGACCCACTGTTGGCTCTCCTTGCAGTTCCTGATATGTCATCTTTAGCATGTGGCTACTTACGTAATCTTACCTGGACACTTTCTAATCTTTGCCGCAACAAGAATCCTGCACCCCCGATAGATGCTGTTGAGCAGATTCTTCCTACCTTAGTTCGGCTCCTGCATCATGATGATCCAGAAGTATTAGCAGATACCTGCTGGGCTATTTCCTACCTTACTGATGGTCCAAATGAACGAATTGGCATGGTGGTGAAAACAGGAGTTGTGCCCCAACTTGTGAAGCTTCTAGGAGCTTCTGAATTGCCAATTGTGACTCCTGCCCTAAGAGCCATAGGGAATATTGTCACTGGTACAGATGAACAGACTCAGGTTGTGATTGATGCAGGAGCACTCGCCGTCTTTCCCAGCCTGCTCACCAACCCCAAAACTAACATTCAGAAGGAAGCTACGTGGACAATGTCAAACATCACAGCCGGCCGCCAGGACCAGATACAGCAAGTTGTGAATCATGGATTAGTCCCATTCCTTGTCAGTGTTCTCTCTAAGGCAGATTTTAAGACACAAAAGGAAGCTGTGTGGGCCGTGACCAACTATACCAGTGGTGGAACAGTTGAACAGATTGTGTACCTTGTTCACTGTGGCATAATAGAACCGTTGATGAACCTCTTAACTGCAAAAGATACCAAGATTATTCTGGTTATCCTGGATGCCATTTCAAATATCTTTCAGGCTGCTGAGAAACTAGGTGAAACTGAGAAACTTAGTATAATGATTGAAGAATGTGGAGGCTTAGACAAAATTGAAGCTCTACAAAACCATGAAAATGAGTCTGTGTATAAGGCTTCGTTAAGCTTAATTGAGAAGTATTTCTCTGTAGAGGAAGAGGAAGATCAAAACGTTGTACCAGAAACTACCTCTGAAGGCTACACTTTCCAAGTTCAGGATGGGGCTCCTGGGACCTTTAACTTTTAGATCATGTAGCTGAGACATAAATTTGTTGTGTACTACGTTTGGTATTTTGTCTTATTGTTTCTCTACTAAGAACTCTTTCTTAAATGTGGTTTGTTACTGTAGCACTTTTTACACTGAAACTATACTTGAACAGTTCCAACTGTACATACATACTGTATGAAGCTTGTCCTCTGACTAGGTTTCTAATTTCTATGTGGAATTTCCTATCTTGCAGCATCCTGTAAATAAACATTCAAGTCCACCCTTTTCTTGACTTCA

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