Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PRDX1P1
Plot displaying the genomic locations of a retrocopy (in chr9) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr9:12972559-12973494  UCSC
Coordinates (T2T) chr9:12981863-12982798  UCSC
Coordinates (hg19) chr9:12972558-12973493  UCSC
Strand -
Parental Sequence NM_181697.3
Parental seq. overlap 862 bp
Parental seq. overlap (%) 90.3%
Genomic Region Intergenic
Retrocopy Summary PRDX1P1, located on chr9:12972559-12973494, is a retrocopy of the parental gene PRDX1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PRDX1
Full Name peroxiredoxin 1
Also known as MSP23|NKEF-A|NKEFA|PAG|PAGA|PAGB|PRX1|PRXI|TDPX2
Coordinate chr1:45511051-45522890
Strand -
Gene summary This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PRDX1P1
Bonobo Pan paniscus PRDX1P1
Gorilla Gorilla gorilla PRDX1P1
Orangutan Pongo abelii PRDX1P1
Gibbon Nomascus leucogenys PRDX1P1
Green monkey Chlorocebus sabaeus PRDX1P1
Crab-eating macaque Macaca fascicularis PRDX1P1
Rhesus Macaca mulatta PRDX1P1
Baboon Papio anubis PRDX1P1
Golden snub-nosed monkey Rhinopithecus roxellana PRDX1P1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PRDX1P1
TGCCTGGTGTTGGTGGTTTGTTCTCAGAGGCTTGTGTCAGGACTGCTGATAGGAAGATGTCTTCAGGAAACGCTAAAATTGGGCACCCTGCCCCCAACTTCAAAGCCACAGCCATTATGCCAGACAGTCAGTTTAAAGATATCAGCCTGTCTGACTACAAAGGAAATATGTTGTATTCTTCTTTTACCGGCTTGACTTCACTTTTGTGTGCCCCACAGAGAACATTGCTTTCAGTGATACAGAAGAATTTAAGAAATTCAACTGCCAAGTGATTGGTGCTTCTGTGGATTCTCACTTCTGTCAGCTGGCATGGATCCACACCCCTAAGAAACAAGGAGGACTGGGACCCAGGAACATTCCTTTGGCCTCAGACCCGAAGTGCACCATTGCTCAGGATTATGGGATCTTAAAGGCTGAAGAAGGCATCTCATTCAGGGGCCTCTTTATCGTTGATGATATGGGTATTCTTCGGCAGATCACTGTAAATGACCTCCCTGTTGACTGCTCTGTGGATGAGACTTTGAGACTAGTTCAGGCCTTCCAGTTCACTGACAAACATAGGGAAGTGTGCCCAGCTGGCTGGAAACCTGGCAGTGATACTATCAAGACTGATGTCCAAAAGAGCAAAGAATATTTATCCAAGCAGGAGTGAGTGCTGGGCTGTTTTAGTGCCAGGCTGCAGTGGGAACCCCTGAGAACAAAGTCTCTTTTGTGGTTTTTTTTTTCCATGAGTAAAATACAAGACTTCAGATTCAGCCGAACTGTGGTGTGTTACAAGGCAGGCCTTTCCTACAGGGGGTGGAGAGACCAGCCTTTCTTCTTTTGGAAGGGATGGCCTGAGTCGTATTGTGGGGAGGCCACTGATTTGTATGATGTGTCAGTAGAGGGCATCAACCCATTGATCTTTTGTAGTTTGTATTAAACTTGAACTGAGAA
>NM_181697.3
GCGTCTTGTTCTTGCCTGGTGTCGGTGGTTAGTTTCTGCGACTTGTGTTGGGACTGCTGATAGGAAGATGTCTTCAGGAAATGCTAAAATTGGGCACCCTGCCCCCAACTTCAAAGCCACAGCTGTTATGCCAGATGGTCAGTTTAAAGATATCAGCCTGTCTGACTACAAAGGAAAATATGTTGTGTTCTTCTTTTACCCTCTTGACTTCACCTTTGTGTGCCCCACGGAGATCATTGCTTTCAGTGATAGGGCAGAAGAATTTAAGAAACTCAACTGCCAAGTGATTGGTGCTTCTGTGGATTCTCACTTCTGTCATCTAGCATGGGTCAATACACCTAAGAAACAAGGAGGACTGGGACCCATGAACATTCCTTTGGTATCAGACCCGAAGCGCACCATTGCTCAGGATTATGGGGTCTTAAAGGCTGATGAAGGCATCTCGTTCAGGGGCCTTTTTATCATTGATGATAAGGGTATTCTTCGGCAGATCACTGTAAATGACCTCCCTGTTGGCCGCTCTGTGGATGAGACTTTGAGACTAGTTCAGGCCTTCCAGTTCACTGACAAACATGGGGAAGTGTGCCCAGCTGGCTGGAAACCTGGCAGTGATACCATCAAGCCTGATGTCCAAAAGAGCAAAGAATATTTCTCCAAGCAGAAGTGAGCGCTGGGCTGTTTTAGTGCCAGGCTGCGGTGGGCAGCCATGAGAACAAAACCTCTTCTGTATTTTTTTTTTCCATTAGTAAAACACAAGACTTCAGATTCAGCCGAATTGTGGTGTCTTACAAGGCAGGCCTTTCCTACAGGGGGTGGAGAGACCAGCCTTTCTTCCTTTGGTAGGAATGGCCTGAGTTGGCGTTGTGGGCAGGCTACTGGTTTGTATGATGTATTAGTAGAGCAACCCATTAATCTTTTGTAGTTTGTATTAAACTTGAACTGAGA

Publications

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