Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ZBTB33P1
Plot displaying the genomic locations of a retrocopy (in chr9) and its respective parental gene (in chrX). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr9:133243031-133246351  UCSC
Coordinates (T2T) chr9:145456614-145459934  UCSC
Coordinates (hg19) chr9:136118418-136121738  UCSC
Strand -
Parental Sequence NM_006777.4
Parental seq. overlap 1592 bp
Parental seq. overlap (%) 25.6%
Genomic Region Intergenic
Retrocopy Summary ZBTB33P1, located on chr9:133243031-133246351, is a retrocopy of the parental gene ZBTB33. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ZBTB33
Full Name zinc finger and BTB domain containing 33
Also known as ZNF-kaiso|ZNF348
Coordinate chrX:120250812-120258398
Strand +
Gene summary This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.[provided by RefSeq, May 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ZBTB33P1
Bonobo Pan paniscus ZBTB33P1
Gorilla Gorilla gorilla ZBTB33P1
Orangutan Pongo abelii ZBTB33P1
Gibbon Nomascus leucogenys ZBTB33P1
Rhesus Macaca mulatta ZBTB33P2
Baboon Papio anubis ZBTB33P1
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ZBTB33P1
CATATTTAAACACTTAGAAAATAAAGTTAACACTTACTGAAGTGCCGGTACTACACTGTCCTAGTACTAAAAGGAAGCAGGTTGGAACATACATATGGCCTATCATTTATAACAGAATTAACTTGTTGAATGTCTGTAAATGATTTTTTTTTGCAAAGGAAAAAGTTGATCCTGGAAAAGATTGTTGTGCATAGTTATTAGTCATTTGTAACCTCGCTTAAGTGTTTCTCAGTTGTTCAACATAGACACTTTTTTCTCCTTACCATGTATTTTTAAAAATAGTCTATTACTTGACTTTGAACGTAAAGCTTTAATCATAATTTCCCACGTATACATAGTTCATCTGACGGTAAGCTGGATTTGAAGGTAGGGGTTTCAGCGTTACTTAAGTTGGTAGCTGAGGGTATCAGGCATCAGTTCATGCAATAAGACAAAAAAATATATATCCTTTGCTTGCCAAGGGGTAGAGTGATGTGCATTTATCTGTTTTCTGTTCTGTAAGTTTAGACTTTCAAACCATTTTGTAAACCAACCCTTGGGAAATTTGAAATTACCTTATAACTTAAGACTCTGTGGTCTCTGGAATCACCCTATCTGTTTCTTTTCTGCGTAGGTATTTATAACATTGCTGTTTGACTATAGCGTGCACTCTGAAATGTTATCAGTGGAAATTTGTTTGAGTTTCATTAATGCTATTTCACTAGTTAGACATAATTACTTCTACCAGTGTAAATGACACTGATGCGCACAGAGCTTCCAGATCTTTCAGACTCAACTACTAGGTCAATTAGTTTGCATAATAAAACTTGGCAGTTTCTACAAGCCTATTATGACAAACCAGGAGCTAATTCTGTAATGAAAAACTATCCATTCTGAATGATAGGGACGTAATTATTTGCTGCTGCTGTCCTTTGTAAATTTTGAACATGACATTATACTCTGTGCCTACTAAAGGTATCCTCTGGAGTTTTTTGAGAGGAGGGAAACTGGAAAATTAAATTGTATTTTTGCCAGAAGACTCTTACTTGCATGTGTCTCAGGGTCTTCAGTTTTTCTAGAAGTTTCCATATCCAAGGTTCAGAGTTCATGTGAAATACTTCTTTGGGAGAAAAAAATCCTTCATTCCTGGTATTCATTGGATTGGAAATCTGCAGCAAAATGCTGTTTAAAATTACTATGTGGTTTTTCTATCTTATCCTTAGCTCTCTGGCTATTGAACTTTTTTTTCTTCTTTGAAGTTAGCTTCAAATTTGCTTCTATGCTAAATTACCTGTAAATATTCTGGATAGGAACTATTTGAAATAGTATTTGTTAAAAGAAATGATAAAATGAAAATGTTCAAACTACAGAGATTTTAAAATGCCATAACGATCTTGCAAGACTAACTTTAAAATATACTATAAATGATTATTATGATTTTGGTGGTAACGATCCCCCACACACAACCGCTGTGAAGAAATGACGCCACATTTTCCCCTATTGTACCAAAAAGATAAAGATGGTAAACATTAATCAAGGTATTTTGTATTGTCAACGCGTGCATATTCTAAAGAGTTAAATGCCAACTCAGCAGCACTGGCTTCCTGGCTGGTCAACCATAGGAAACCTCGTTCATTTCTCCCAGTGTTGTGATGTTCATACTTCTACAATCTTCCCTGTCATGACTTTAACTTCTACGTTTCATTAACCATTCCTGATGTTAGTTCTCAGAGCGTTGCACGTATTTTTAATTCTGTGGCTGTCACATGATAGAGAATGGAATTGAATGGAGATTTCCCTTTTGCTTCTTAGGGTTGGAAATATTCCCATGAAAATGTTCAAATTTGGAATTTGAAAGCCACCAAATGAATCTTTATGTATAAATCCTTGTAAATGATAGATTCCATAGGTGAGACTTTTATGTATTTCAGGTGGGAGCCTACTGGCATATATTTTTAAATGTTCATATTACTTAGAATCTCCAATAGGAAGTCTTTATTTGAAATAGTTGAATCCGTGTTCTAGTATTTTCCTTTCAGCAAGATCTGTTAGGTTTTTACCCCTTCAAAAATAAGTTTTATTTCATCTGCAAATTGTGGCAATGTTATAGCGATCAGAAACTACGTAAGGAATGTTATATAGGCTTGTCAGTTCCCATTTATCTTAACAACAATAAATATCACATTTCTTCTTTTGAAAATGACACATATTTAGAGGCGGCGGCTGCGTCCACGTCGACCAAGACTGGAGCGAAGTTTAAGGAAGGGACAGAATCGCCGGGGAGTGCCCTTGTTGTTGCTGGGGGACTCCCAGCCTTCCCTGTGGCCCGAGAAGGAGAAGCAGTGGCTCTCTGAAGCAGGCATGGAGAGTAGAAAACTGGAGTTATTAGCATACCCTAGTACCTCTTACAACTTTCCCTTCCATGTTAGCACTTTAGTGCTGGCTTCTCAGTTTTCTTAACATTGAGACAATAAATGTGTGTTGTGTCTTGTAGATGGCATAAAGAGTAAATAAGAAGTTTTAGAGTTGTTCTGGAAAATGTCAGAATAAATCTCCACTTGAGTTGTGTATTCTGCTAGTCCAAGTGGACAGCAACTTCCTGCTACCCTCCCTTGCAACCTTGCAGACAAGTCTCTCCTCTGAAGAACGAATTAGATTTAGCTAATTAGAATTAATCCTTGCTTTCATCGCCATCATCTGTAAAATACTTTGTTGGGTAGACCACTTTATACCTTTGCAATACGGTCTCCGTGGGTAAAAAACAAATATCTGTAATGCAGACAGGAGGATGTGAAAAGTTCTGTTGCACGtgttttttttttttgt
>NM_006777.4
gtagcagcgttggcggcaggaggcggcggccgcgtcgacgtcgACCCAGACTGGAGCGACGTTTAAAGAAGGGGCAGAATCGCTGGGGAGTGCGGCTTCTTCTTGTTGGGGGACTCCCAGCCTTCCGCGCGTCCGGAGGAGGAGAAGCGGCGGCGCCGGGAAGCAGGCATGGAGAGTAGAAAACTGATTTCTGCTACAGACATTCAGTACTCTGGCAGTCTGCTGAACTCCTTGAATGAGCAACGTGGCCATGGACTCTTCTGTGATGTTACCGTTATTGTGGAAGACCGAAAATTCCGGGCTCACAAGAATATTCTTTCAGCTTCTAGTACCTACTTCCATCAGCTCTTCTCTGTTGCTGGGCAAGTTGTTGAACTGAGCTTTATAAGAGCAGAGATCTTTGCAGAAATTCTCAATTATATCTATAGTTCTAAAATTGTTCGTGTTAGATCAGATTTGCTTGATGAGTTAATTAAATCAGGGCAGTTATTAGGAGTGAAATTTATAGCAGAGCTTGGTGTCCCATTGTCACAGGTTAAAAGCATCTCAGGTACAGCGCAGGATGGTAATACTGAGCCTTTACCTCCTGATTCTGGTGACAAGAACCTTGTAATACAGAAATCAAAAGATGAAGCCCAAGATAATGGGGCTACTATAATGCCTATTATAACAGAGTCTTTTTCATTATCTGCCGAAGATTATGAAATGAAAAAGATCATTGTTACCGATTCtgatgatgatgatgatgatgTCATTTTTTGCTCCGAGATTCTGCCCACAAAGGAGACTTTGCCGAGTAATAACACAGTGGCACAGGTCCAATCTAACCCAGGCCCTGTTGCTATTTCAGATGTTGCACCTAGTGCTAGCAATAACTCGCCCCCTTTAACAAATATCACACCTACTCAGAAACTTCCTACTCCTGTGAATCAGGCAACTTTGAGCCAAACACAAGGAAGTGAAAAATTGTTGGTATCTTCAGCTCCAACACATCTGACTCCCAATATTATTTTGTTAAATCAGACACCACTTTCTACACCACCAAATGTCAGTTCTTCACTTCCAAATCATATGCCCTCTTCAATCAATTTACTTGTGCAGAATCAGCAGACACCAAACAGTGCTATTTTAACAGGAAACAAGGCCAatgaagaggaggaggaggaaataatagatgatgatgatgaCACTATTAGCTCCAGTCCTGACTCGGCCGTCAGTAATACATCTTTGGTCCCACAGGCTGATACCTCCCAAAATACCAGTTTTGATGGATCATTAATACAGAAGATGCAGATTCCTACACTTCTTCAAGAACCACTTTCCAATTCCTTAAAAATTTCAGATATAATTACTAGAAATACTAATGATCCAGGCGTAGGATCAAAACATCTAATGGAGGGTCAGAAGATCATTACTTTAGATACAGCTACTGAAATTGAAGGCTTATCGACTGGTTGCAAGGTTTATGCAAATATCGGTGAAGATACTTATGATATAGTGATCCCTGTCAAAGATGACCCTGATGAAGGGGAGGCCAGACTTGAGAATGAAATACCAAAAACGTCTGGCAGCGAGATGGCAAACAAACGTATGAAAGTAAAACATGATGATCACTATGAGTTAATAGTAGATGGAAGGGTCTATTATATCTGTATTGTATGCAAAAGGTCATATGTCTGTCTGACAAGCTTGCGGAGACATTTTAACATTCATTCTTGGGAGAAGAAGTATCCGTGCCGTTACTGTGAGAAGGTATTTCCTCTTGCAGAATATCGCACAAAGCATGAAATTCATCACACAGGGGAGCGAAGGTATCAGTGTTTGGCCTGTGGCAAATCTTTCATCAACTATCAGTTTATGTCTTCACATATAAAGTCAGTTCATAGTCAAGATCCTTCTGGGGACTCAAAGCTTTATCGTTTACATCCATGCAGGTCTTTACAAATCAGACAATATGCATATCTTTCCGATAGATCAAGCACTATTCCTGCAATGAAGGATGATGGTATTGGGTATAAGGTTGACACTGGAAAAGAACCTCCAGTAGGGACCACTACATCTACTCAGAACAAGCCAATGACCTGGGAAGATATTTTTATTCAGCAGGAAAATGATTCAATTTTTAAACAAAATGTAACAGATGGCAGTACTGAGTTTGAATTTATAATACCAGAGTCTTACTAAACTCCTTTGAAATACTAGAAAGTTTTGTTTTGGATGATGGGGCAGGGGTTTCAGAAGATCTGTAAAACAAATTAAGGTGCGAACAAGTTAATTTGATCTGCCACATTATCTGAAGGAAGTGTAGTGGGATTTTTGTTGATAATTTTTAGAAGCAAATTTTCCTGAAAGTTTTGAGTAGAGGTGAGACCCCCTCCCCAAGTATCTGTTTATATAGTTAGTTTTCAGCTCATTTAAAAGAGGCAAAAATTAAAAGCTTGGAGAGATAGTTTCCTGAATAGAATTTGAAGCAGTCTGAATGTTCTTTGAAAATAACTGGAGTTATTAGCATACCCTAGTACATCTTACAGCTTTCCCCTTCCATGTTAGCACTTTACTGCTGAATTCTCAATTTTCTTAACATTGAGACAATAAATGTGTGTTTTGTCTTGTATATGGCATAAAGAGTAAATAAGTTTTAGAGTTGTTCTGGAAAATGTCAGAATAAGTCAGTACTTGGGTTGTGTAATCTGCTAGTCCAAGCGAACAGCAACCTCCTGCTACCCTCCCTCTATGAAAATAGCCATGCAGACAAGTCTCTCATCTGAAGAACAAATTAGATTTAGCTAATTAGAATTAATCCTGGCTTTCATTGCCATAGTCTGTAAAAGACTTTGGTGGCTAGACCACTTTATACCTTCGCAGTGTGGTCTCTGGGGGCAAAAAACTAATGAAAACAATCTCTGTAATGGCAGATAGGAGGAGATGAAAAGTTCTGTTGCATGGATTTTTAATTCTCTGGCTACCACATAGTAGAGAATGGAATGAAGATTTCCTTTTGGCTTCTTAAGGTTAAAAATATTCCCATGAACATGAAAATTTTCAAATTTTGAATCTGAAAGCCACCAAATGTATCTTTATGTATAAATCCTTGTAAATGATAGATTCCATGGGTGAGACTTTACATATTTTGGGTGGGAGGCTACTGGCATATATTTTTAAATGTTCATATTGCGTAGAATCTCCACTAGGAAGTCTTTATTTGAAATAGTTGAATCAGTGATCTAGTATTTTCCTTTCGGCAAGATTTGTTAGGTTTTTACCCCTTCTAAAATAAGTTTTATTCCATCTGCAAATTGCTGCAATATTATAGTAATCAGAAACTACATAAGGAATGTTATATAGGCTTGTCAGTTCCCATTTTTCTTGACAACAATAAATACCACTTTTAAAAATGACACATATTTAAACACTTAGAAAATAAAGTTAACACTTACTGAagtgctagtactaaactgtgctagtactaAAAGAAAACAGGTTGGAACATACATATAGCCTAGCATTTATAACAGAATTGTTGAACGTCTGTAAATGATTTTTTTTTTTTTTGCAAAGGAAAAAATTGATACTGGAAAAGATTGTTGTGCATAGTTATTAGTCATTTGTAACCTTGCTTAAGTATTTCTTAGTCCAACATAGATATTTTCTTTCTCCTGACCATGTATTTTAAAATATAGTCTATTTCTTGACTTTGAACTTAAAGCTTTAATCATAATTTCTCATGTATACATCGTTCTTCTGATGGTAAGCTGGATTTGAAGGTAGTGGTTTCAGTGTTTCTTAAGTTGGTAGCTGAGGGTATCAGGCATCAGTTCATGCAATAATACAAGAAAAAAAATCCTTTGCTTGCCAAGAGGTAGAGTGATGTGCATTTATCTGTTTTCTGTTCTGTAAGTCTAGACCTTCAAACCATTTGTAAACTAACCCCTGGGAAATTTGAAATTACCTGATAACTTAAGACTCTGTGATCTCTGGAATCACCATATGTTTCTTTTTTGTGTAGATATTAATAACATTACTCTTTGACTATAGTGTGCACTCTGAAATGTACTCAGTGAAAATTTGTTTTGAGTTTCATTAATGCTATTTCACCAGTTAGACATAATTACTTCTACCGATGTGAATGATACGGATGCCGGCAGAGCTTCCAGATCTTTCAGACTCAACTGCTAGGTCAATTAGTTTGTCATAATAAAACTTGGCAGATTCTACAAGTCTATTATGACAAACCAGGAACTAATTCTATAATGGAAAACTATCCATTCTGAATAATAGGTATGTAATTATTTGCTGCTGCTGCTGTGCTCTGTAAATTCTGAATATGACATTTAAACTCTGTGCCTACTAAAGGTATCTTCTGGAGTTTTTGGGAGGAGAGAAACTGGAAAATTAAATTGTATTTTTGCCAGAAGACTCTTACTTGCATGTGTCTCAGGGTCTTCAGTTTTTCTATAAGTTTCCATATCCAAAGTTCAGAATTCATGTGAAATACTTCTTTGGGGCAAAAGTCCTTCATTCCTGGTATTTATTGGATTGGAAATCTGTAGCAAGATGCTGTTTAAAATTACCATATTGTTTTTTTATCTTATACTTAGCTCTCTGGCTATTGAACTTCCTTTTCTTGTTTGAAGTTAGCTTCAAATTTGCTCCTATGCTAAATTACCTGTAAATATTCTGGATAGGAACTACTTGAAATAGTAATTTGTTAAAAGATATGACAAAATGAAAATGCTTAAACTACAGAAATTTAAAAATGCCATAACAATCTTGCGAGACTAACTTTAAAATATACTTTAAATGATTATTATGATTTTGGTGGTAACGATCCCCCACACACAACCACTATGAAGAAATAATGCCGCATTTTTCCCCCATTGTACCAAAAAGATAAAAAAATGGTAAACACTGATCAAGGTATTTTGTATTGTCAAGGCATGCATATTCTAAAGAATTAAATGCTAACTTAACAGCACTGGCTTTCTGGCTGGTCAACTATATGAAACCTTGTTCATTCCTCCGAGTACTGTAATGTTCACACTTGTACAATCTTCCCTGTCATGACTTTAAGTTCTACTTTTCATTAACCATGGCCTGATATTAGTTCTTAGAGCTTCTTGTGGCAAAAATAAAATGATTTAATTCTGA

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