Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Advanced Search

Summary

Retrocopy Name PES1P2
Plot displaying the genomic locations of a retrocopy (in chr9) and its respective parental gene (in chr22). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr9:13986149-13988320  UCSC
Coordinates (T2T) chr9:13995607-13997778  UCSC
Coordinates (hg19) chr9:13986148-13988319  UCSC
Strand +
Parental Sequence NM_014303.4
Parental seq. overlap 1900 bp
Parental seq. overlap (%) 83.7%
Genomic Region Intergenic
Retrocopy Summary PES1P2, located on chr9:13986149-13988320, is a retrocopy of the parental gene PES1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PES1
Full Name pescadillo ribosomal biogenesis factor 1
Also known as NOP7|PES
Coordinate chr22:30576625-30607013
Strand -
Gene summary This gene encodes a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the long arm of chromosome 4 and the short arm of chromosome 9. [provided by RefSeq, Aug 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PES1P2
Bonobo Pan paniscus PES1P2
Gorilla Gorilla gorilla PES1P2
Orangutan Pongo abelii PES1P2
Gibbon Nomascus leucogenys PES1P1
Green monkey Chlorocebus sabaeus PES1P2
Crab-eating macaque Macaca fascicularis PES1P2
Rhesus Macaca mulatta PES1P2
Baboon Papio anubis PES1P2
Golden snub-nosed monkey Rhinopithecus roxellana PES1P2
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PES1P2
TCTAGTCGGCTCCTCAACGTGGAGCCATGGGAGGCCTTGGGAAGAAGAATTATGAACGAGGCTCAGCCACCAACTACATCACCCAGAATAAAGCCCAGAAGAAGCTCCAGCTGAGCCTGGCTGACTTTAGGCAGTTGTGCATTCTGAAGCGCATTTATCCCCATGAACCCAAACACAAGAAGAAGGTTAACAAACGTTCTACAGCAGCCCAAACTTTTTACCTTATCGAAGACATCAGGTTTCTCCTCCATGAACCCATTGTCAACAAGTTCTGGGAATACAAGGTGTTAATCCGGAAGCTCCTGAAGGCCTATAGGAAGAGCAAGTGGAAACACTGTAGAGTATCTAAAGGACAATAAGCCCAACTACAAACTTGACCGCATCATCAAGGAATGGTACCCTACGTTCACTGATGCCCTGCGAGACCTGGACAACGCCCTCTCCATGTGCTTCCTCTTTTCCACCTTCCCACGGACTGGCAAGGGCCATGTGCAGACCATTCACCATGGAGTTCATGCACTACATCATCGCTGCTAGTGCCCTGCCACAAGGTCTTCCTGTCCATCAAAGGCATTTACTACCAGGTCAAGGTCCTGGGACAGCCCATCACGTGAATCACCACTTATGCCTTCTCCCATGACCACCCAACAGACATGGACTACAGGGTCATGGCCACCTTCACCGAGTTCTACAGCACCCTGCTGGGCTTCATCAACTTCCACCTCTACCAGTGGCTCAACCTCCACTACCCACTGAAGCTCGAGGGTCAGGCCCAAGAAGAGGCAAAGGCCAGTGAGGGCACCCATGCATTGGACTCTGAGAGCTCCATGGAGAAAATGGCTGCCCTCACTGCCAGCCTGGCCCGCGTGGTGGTGCCTGCCACAGAGGAGGAGCCCGAGGTGGATGAGTTTCCTGCCAATGGGGAGATGTCAGCACAGGAGGAAGAACGCAGGAAGGAGCTGGAGGGGCAGGAGAAGCACAAGAAGTTTTCTGAGGGCCTAAAGTTCTTCCTGAACCAAGGGGTGCCCCGTGAAGCCCTGGCCTTCGTCATCAGTTTTTGGGGGGAAGTGTCCTGGGACAAGTCTTTGTGCATCGGGGCCACCTATGACATCACGGACTCCCGCATCACCCACAAGATTGTCAACTGGCCTGGGCAGCAGACCTCCATCATTGGCAGGTGCTACATGCAGCCCCAGTGGGTGATTGACTCGGTGAACGCTAGGCTTCTCCTCCTCATGGCAGAGTACTTCCCTGGGGTGCAGCTGCCCCCACACCTTTCACCTTTTGTGACCAAGAAGGAAGGAGATTACATCCCACCTGAAAAACTGAGGCTGCTGGCTCTGCAGCAGGGAGAGGACCCAGGAATCCTGAATGCACCCCTGGTTCAAAAAAGGAGGAAGAGGCCCAGCTGGCAGCCCTGGAGGAGCAGAGAATGAAGGGGAAGACAGGCACCTTGAAGGTGGAGGATGAGCAGTGACTAGCCCAAGAGGAGGAGAGCGAGGCCAAGCACCTGGCCATTATGATGATGAAGAAGTGGGAGAAGTACCTGTACCAGAAGATCATGTTTGGCAAGAGGCGAAAAATCCGAGAGGCCAACAAGCTGGCAGAGAAGCGGAAAGCCCACGATGAGGCGGTGACATCTGAGAAGAAGGCCAAGAAGGCAAGGCTGGAGTGAGTGCCAGTGGCCCCTCACAGGGCTGAGGCCAGCTCCTGGCAGCTGGACGTGGCAGAAGCAGGCCAGAGGACCTAAGTGTGATGGACATAGTCGCTTCTCTCCTCCTCCTTTCTCCAGCCAGCCCTGACCCCTCATGCTCTCTGAGGGCAGCCCTGGCCTCTCTTGGATGGAGCTGCCCTGCCGGTGCCTAGGCAAAGAAGAGGCCTCTGTGCCCAGCCTGATTCTGTGCTCCCAGGAGCCAGTGACAGGAGGTGCAGGGGCCCACCCAACCCCTTACCTGCTGCCCCCATTCACCCTGGCTTTCCACAGCCCCCTGCCACACAGTTGGACCCATGATTCTCACGGTGCTGTGATGGGGTGAGGGTGGGGGGAGCATTTGTTATTAGATGACTGGATTTTGTGCC
>NM_014303.4
GTCCTTGGCAGGGCACGTGCGGGAGGAAGTGGAGCTCCCTGTACGCGCGGCCCTAGTCGGCTCCTCAACGTGGAGCGATGGGAGGCCTTGAGAAGAAGAAGTATGAACGAGGCTCGGCCACCAACTACATCACCCGGAACAAAGCCCGGAAGAAGCTCCAGCTGAGCTTGGCTGACTTTAGGCGGCTGTGCATTCTGAAGGGCATTTATCCCCATGAACCCAAACACAAGAAGAAGGTTAACAAGGGTTCTACAGCAGCCCGAACGTTTTACCTTATCAAAGACATCAGGTTTCTCCTCCACGAACCCATTGTCAACAAGTTCCGTGAATACAAGGTGTTCGTCCGGAAGCTCCGGAAGGCTTATGGGAAGAGCGAGTGGAACACTGTAGAGCGTTTAAAGGACAATAAGCCCAACTACAAACTCGACCACATCATCAAGGAACGGTATCCCACGTTCATCGATGCCCTGCGGGACCTGGACGATGCCCTCTCCATGTGCTTCCTGTTTTCCACCTTCCCGCGGACTGGCAAGTGCCACGTGCAGACCATTCAGCTGTGCCGCCGGCTCACTGTGGAGTTCATGCACTACATTATCGCTGCCCGTGCCCTGCGCAAGGTCTTCCTGTCCATCAAAGGCATTTACTACCAGGCCGAGGTACTGGGGCAGCCCATCGTGTGGATCACTCCCTATGCCTTCTCCCATGACCACCCGACAGACGTGGACTACAGGGTCATGGCCACCTTCACCGAGTTCTACACCACGCTGCTGGGCTTTGTCAACTTCCGCCTTTACCAGTTGCTCAACCTCCACTATCCCCCGAAGCTCGAGGGTCAGGCCCAAGCAGAGGCAAAGGCCGGTGAGGGCACCTACGCGTTGGACTCCGAGAGTTGTATGGAGAAACTGGCAGCCCTCAGTGCCAGCCTGGCCCGCGTGGTGGTGCCTGCCACAGAGGAGGAGGCCGAGGTGGATGAGTTTCCCACCGATGGGGAGATGTCAGCGCAGGAGGAAGACCGCAGGAAGGAGCTGGAGGCGCAGGAGAAGCACAAGAAGCTTTTTGAGGGCCTGAAGTTCTTCCTGAACCGAGAGGTGCCCCGTGAGGCCCTGGCCTTCATCATCAGGAGTTTTGGTGGGGAAGTGTCCTGGGACAAATCTTTGTGCATTGGGGCCACCTATGACGTCACAGACTCCCGCATCACCCATCAGATTGTCGACCGGCCTGGGCAGCAGACCTCAGTCATTGGCAGGTGCTACGTGCAGCCCCAGTGGGTGTTTGACTCAGTGAACGCCAGGCTCCTTCTCCCCGTGGCAGAGTACTTCTCTGGGGTGCAGCTGCCCCCACACCTTTCACCCTTTGTGACCGAGAAGGAAGGAGATTACGTTCCACCTGAGAAGCTGAAGCTGCTGGCTCTGCAGCGGGGAGAGGACCCAGGAAACCTGAATGAGTCAgaagaggaggaggaagaggacgacaacaacgaaggtgatggtgatgaagagggagaaaatgaggaggaggaggaagatgcagaggctggttcagaaaaggaggaagaggCCCGGCTGGCAGCCCTGGAAGAGCAGAGGATGGAGGGGAAGAAGCCCAGGGTGATGGCAGGCACCTTGAAGCTGGAGGATAAGCAGCGGCTGGCCCAGGAGGAGGAGAGTGAGGCCAAGCGCCTGGCCATTATGATGATGAAGAAGCGGGAGAAGTACCTGTACCAGAAGATCATGTTTGGCAAGAGGCGAAAAATCCGAGAGGCCAACAAGCTGGCGGAGAAGCGGAAAGCCCACGATGAGGCGGTGAGGTCTGAGAAGAAGGCCAAGAAGGCAAGGCCGGAGTGAGTGCCTGCGGCCCCTCACAGGGCTGAGGCCAGCCCCTAGCAGCTGGATGTGGCAGAGGCAGGCCAGAGGACCTAAGTGTGATGGACCAGAGTCACTTCTCCTCCTCCTTTCTCCAGCCAGCCCTGACCCCTCATGCTCTCTGGCTGGGCCAGTGGGCAGCCCTCGCTTCCCTTGGATGGAGCTGCCCTGCTGGTGCCTGGTCAGAGAAGAGGCCTCTGTGCCCAGCCTGATTCTCTGCTCCCAGGAGCCAGTGACATGAGGTGCAGAGGCCCACCCAGCCCCCTACCTACTGCCCCCATTCATCCTGGCTTTCCACAGCCCCCTCCCACACAGTTGGACCCGTGATTCTCAGGGTGCTGTGATGGGGTGAGGGTAGGGGGAGCATTTGTTATTAAATGACTGGACTTTTGTGCCAATTGCA

Publications

PMID - Link Title