Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SERPINH1P1
Plot displaying the genomic locations of a retrocopy (in chr9) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr9:34318366-34320323  UCSC
Coordinates (T2T) chr9:34336922-34338879  UCSC
Coordinates (hg19) chr9:34318364-34320321  UCSC
Strand +
Parental Sequence NM_001207014.3
Parental seq. overlap 1815 bp
Parental seq. overlap (%) 86.2%
Genomic Region Intergenic
Retrocopy Summary SERPINH1P1, located on chr9:34318366-34320323, is a retrocopy of the parental gene SERPINH1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SERPINH1
Full Name serpin family H member 1
Also known as AsTP3|CBP1|CBP2|HSP47|OI10|PIG14|PPROM|RA-A47|SERPINH2|gp46
Coordinate chr11:75562253-75572783
Strand +
Gene summary This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone. Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis. Expression of this gene may be a marker for cancer, and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes SERPINH1P1
Bonobo Pan paniscus SERPINH1P1
Gorilla Gorilla gorilla SERPINH1P1
Orangutan Pongo abelii SERPINH1P1
Gibbon Nomascus leucogenys SERPINH1P1
Green monkey Chlorocebus sabaeus SERPINH1P1
Crab-eating macaque Macaca fascicularis SERPINH1P1
Rhesus Macaca mulatta SERPINH1P1
Baboon Papio anubis SERPINH1P1
Golden snub-nosed monkey Rhinopithecus roxellana SERPINH1P1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SERPINH1P1
ACAGGTCCATCGTGGTGCACGCAAACCACCTCCCAGCCACGCGCTCCCTCCTGCTCCTCAGCGCCTTCTGCCTCCTGGCGGTGGCCTTGGCGACCGAGGTGAAGAAACCTGCAGCCACAGCAGCTCCTGGCACCGCAGAGAAGCTGAGCCCCAAGGCAGCCACGCTGGCCGAACACAGCGCCGGCCTGGCCTTCAGCCTGTACCAGGCCATGGCCAAGGACCAGGCGGTGGAGAACATCCTGGTGTCGCCCGTGGTGGTGGCCTCGTCGTTGGGGCTCGTGTCGCTGGGCGGCAAGGCGACCACGGCGTCGGAGGCCAAGGCAGTGCTGAGTGCCAAGCAGCTGAGCGACGAGGAGGTGCACGCCGGCGTGGGCGAGCCGCTGCGTTCACTCAGCAACTCCACCGCGCGCAACGTGACCTGGAAGCTGTGCAGTCGCCTGTAGGGACCCAGCTCAGTGAGTTTCGCTGATGACTTCGTGCGCAGCAGCAAGCAGCACTACAACTGCGAGCACTCCAAGATCAATTTCCATGACAAGCGCAGTGCGCTGCAGTCCATCCACGAGTGGGCCGTGCAGACCACCGACGGCAAGCTGCCCAAGGTCACCAAGGACATGGAGTGCATGGATGGCGCCCTGCTTGTCAACACCATGTTCTTCAAGCCACACTGGAATGAGAAATTCCACCACAAGATGGTGGAAAACCGTGGCTTCATGGTGACTCGGTTCTATACCGTGGGTGTCATGGTGATGCACCAGACAGGCCTCTACAACTACTATGACAATGAGAAGGAAAAGCTGCAAATCGTGGAGATGCCCCTGGCCCACAAGCTCTCCAGCCTCATCATCCTCATGCCCCACCACGTGGAGCCCCTCGAGGCCTTAAAAAGCTGGTAACCAAAGAGCAGCTGAAGATCTGGATGGGGAAGAAGCAGAAGCCTGTCGCCATCTCCTTGCCCAAGCGGGTGGTGGAAGTTCCCATGACCTGCAGAAACTCCTGGCTAGGCTTGGCCTGACTGAGGCCATTGACAAGAACAAGGCAAACTTGTCACGCATGCCACACAAGAAGGACCTGTACCTGACCAGCGTGTTCCACGCCACCGCCTTTGAGTTGGACACAGACGGCAACTCCTTTGACCAGGACATCTATGGGAGCAAGGAGCTGCGCAGCCCCAAGCTGTTCTACTCCGACCACCCCTTCATCTTCCTGGTGTGGGACACCCAGAGCGGCTCCCTGCTGTTCACTGGGCACCTGGTCCGGCCTAAGGTTGACAAGATGCAAGACGAGTTTTAGGGCCTCAGGGTGCACACAGGATGGCAGGAGGCAGCCAAAGGCTTCTGAGACACATGGGTGCTACTGGGATTCGGGGGAGGTGAGGTACCAGCTTGGATACTCCATGGGTGGGGGTGGACAAACAAACCAGGGTTCCCGTGTGCTTGAACGGCCCTTCCCAGCTAGAATTTACTCCACTTGGACGTGGGCCCCAGATACCATGATGCTGAGCCCAGAAACTCCACATCCTGTGGTACCTGGGCCATAATCATCCTGCCTGCCCTCAAAGTCCCAGATCAAGCCTGCCTCAATCAGTGTTCATATTTATAGCCAAGTACCTTCTCACCTGTGAGACCAAATGGAGCTAGGGGGGTCAGCCAGCCCTCTTCTCCTGACACTAAACCACCTCAGCCACCTCCCCAGCTCTATCCCAGTCTCTCCCAACTACAAAACTAGGTGCTGCAGCCCCTGGGACCAGGCATCCCCAGAATGACCTGGCCCCATTGAGGCAGATCGAGAAAGAGCTCACAGGACAGGCTTCTGGGCAGACTCTGGTCAAGAATGGCGTCATGGGGATGAACTTTTTGTTTCTTTTTTAGTTCTTCAAAGATGGGGAGGGAAGGGGGAACATAAGCCTTTGTTACTATCAAACCAAGAACTTATTTATACAGTTTTTCTTTTCAATAAAA
>NM_001207014.3
AAGAGTAGAATCGTGTCGCGGCTCGAGAGCGAGAGTCACGTCCCGGCGCTAGCCCAGCCCGACCCAGAATGAAAAAGGCAGGCATTGACCTCCCTCTGAGGCAGTTTCCAGGCCCACCGTGGTGCACGCAAACCACTTCCTGGCCATGCGCTCCCTCCTGCTTCTCAGCGCCTTCTGCCTCCTGGAGGCGGCCCTGGCCGCCGAGGTGAAGAAACCTGCAGCCGCAGCAGCTCCTGGCACTGCGGAGAAGTTGAGCCCCAAGGCGGCCACGCTTGCCGAGCGCAGCGCCGGCCTGGCCTTCAGCTTGTACCAGGCCATGGCCAAGGACCAGGCAGTGGAGAACATCCTGGTGTCACCCGTGGTGGTGGCCTCGTCGCTAGGGCTCGTGTCGCTGGGCGGCAAGGCGACCACGGCGTCGCAGGCCAAGGCAGTGCTGAGCGCCGAGCAGCTGCGCGACGAGGAGGTGCACGCCGGCCTGGGCGAGCTGCTGCGCTCACTCAGCAACTCCACGGCGCGCAACGTGACCTGGAAGCTGGGCAGCCGACTGTACGGACCCAGCTCAGTGAGCTTCGCTGATGACTTCGTGCGCAGCAGCAAGCAGCACTACAACTGCGAGCACTCCAAGATCAACTTCCGCGACAAGCGCAGCGCGCTGCAGTCCATCAACGAGTGGGCCGCGCAGACCACCGACGGCAAGCTGCCCGAGGTCACCAAGGACGTGGAGCGCACGGACGGCGCCCTGCTAGTCAACGCCATGTTCTTCAAGCCACACTGGGATGAGAAATTCCACCACAAGATGGTGGACAACCGTGGCTTCATGGTGACTCGGTCCTATACCGTGGGTGTCATGATGATGCACCGGACAGGCCTCTACAACTACTACGACGACGAGAAGGAAAAGCTGCAAATCGTGGAGATGCCCCTGGCCCACAAGCTCTCCAGCCTCATCATCCTCATGCCCCATCACGTGGAGCCTCTCGAGCGCCTTGAAAAGCTGCTAACCAAAGAGCAGCTGAAGATCTGGATGGGGAAGATGCAGAAGAAGGCTGTTGCCATCTCCTTGCCCAAGGGTGTGGTGGAGGTGACCCATGACCTGCAGAAACACCTGGCTGGGCTGGGCCTGACTGAGGCCATTGACAAGAACAAGGCCGACTTGTCACGCATGTCAGGCAAGAAGGACCTGTACCTGGCCAGCGTGTTCCACGCCACCGCCTTTGAGTTGGACACAGATGGCAACCCCTTTGACCAGGACATCTACGGGCGCGAGGAGCTGCGCAGCCCCAAGCTGTTCTACGCCGACCACCCCTTCATCTTCCTAGTGCGGGACACCCAAAGCGGCTCCCTGCTATTCATTGGGCGCCTGGTCCGGCCTAAGGGTGACAAGATGCGAGACGAGTTATAGGGCCTCAGGGTGCACACAGGATGGCAGGAGGCATCCAAAGGCTCCTGAGACACATGGGTGCTATTGGGGTTGGGGGGGAGGTGAGGTACCAGCCTTGGATACTCCATGGGGTGGGGGTGGAAAAACAGACCGGGGTTCCCGTGTGCCTGAGCGGACCTTCCCAGCTAGAATTCACTCCACTTGGACATGGGCCCCAGATACCATGATGCTGAGCCCGGAAACTCCACATCCTGTGGGACCTGGGCCATAGTCATTCTGCCTGCCCTGAAAGTCCCAGATCAAGCCTGCCTCAATCAGTATTCATATTTATAGCCAGGTACCTTCTCACCTGTGAGACCAAATTGAGCTAGGGGGGTCAGCCAGCCCTCTTCTGACACTAAAACACCTCAGCTGCCTCCCCAGCTCTATCCCAACCTCTCCCAACTATAAAACTAGGTGCTGCAGCCCCTGGGACCAGGCACCCCCAGAATGACCTGGCCGCAGTGAGGCGGATTGAGAAGGAGCTCCCAGGAGGGGCTTCTGGGCAGACTCTGGTCAAGAAGCATCGTGTCTGGCGTTGTGGGGATGAACTTTTTGTTTTGTTTCTTCCTTTTTTAGTTCTTCAAAGATAGGGAGGGAAGGGGGAACATGAGCCTTTGTTGCTATCAATCCAAGAACTTATTTGTACATTTTTTTTTTCAATAAAACTTTTCCAATGACA

Publications

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