Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RAB1C
Plot displaying the genomic locations of a retrocopy (in chr9) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr9:37635442-37637334  UCSC
Coordinates (T2T) chr9:37659165-37661057  UCSC
Coordinates (hg19) chr9:37635439-37637331  UCSC
Strand -
Parental Sequence NM_030981.3
Parental seq. overlap 1116 bp
Parental seq. overlap (%) 43.1%
Genomic Region Intragenic (FRMPD1)
Retrocopy Summary RAB1C, located on chr9:37635442-37637334, is a retrocopy of the parental gene RAB1B. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RAB1B
Full Name RAB1B, member RAS oncogene family
Also known as -
Coordinate chr11:66268526-66277492
Strand +
Gene summary Members of the RAB protein family, such as RAB1B, are low molecular mass monomeric GTPases localized on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB1B functions in the early secretory pathway and is essential for vesicle transport between the endoplasmic reticulum (ER) and Golgi (Chen et al., 1997 [PubMed 9030196]; Alvarez et al., 2003 [PubMed 12802079]).[supplied by OMIM, Jan 2009]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RAB1BP1
Bonobo Pan paniscus RAB1BP1
Gorilla Gorilla gorilla RAB1BP1
Orangutan Pongo abelii RAB1BP1
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RAB1C
AGCCGTCCAGCTGCGGTGGGGTCTGAGTATATCGAGGGCGGCTGGGCGGGTAGCGGCGCTGGGCCTGTGTCTTGAGCCTGGAGAAAGTCTGCTCCTGCCGCCCTCTGCCCTGCCAGAGACAGACCCACGCGCTGCCTGCCCACCGTGCCCCTTAGTCCCCATGTCAGGCGGAGGCGGAAGGCCCACCGTGCCAGAGGCTGGGCACCAGCCTTAACCCTCTCACTGCTAACACCTCCTCCCTTTCCCCGAGGCAGCACACCTGGCTCACTCTCCCCTCGGTCTCTGGAGCCCACCAGGGAAGGCCCTCATCCCCTGCCGCTACTTCTCTGGGGAATGTGGGTTCCATCCAGGGTTGGGGGCCTCTCTGCCCACCCACTCTGCACCCAGGATCCTAGTCCCCTGCCCTCTGGTACAGCTGCTTCCTGCAGGAAAGCAAGTCTTTGGTCTCCCTGAGAAGCCATGTCCCTCGTGCTGTCTCTTGCCTGTCCCACCTGTGCCCTGCCCTCCAGCTTGTATTTAAGTCCCTGGGCTGCCCCTTGGGGTGCCCCCCGCTCCCAGGTTCCCCTCTGGTGTCATGTCAGGCATTTTGCAAGGAAAAGCCACTTGGGGAAAGATGGAAAAGGACAAAAAAATTAATAAATTTCCATTGGCCCTCGGGTGAGCTGAGGGTTTTTGCAAGGAGAGCCGACTGGGAGCGACTGAGCGGGCTTCCGCCGCCGCCATGAACCCCGGATATGACTGCCTGTTTAAGCTGCTTTTGATTGGCGACTCAGGCGTGGGCAAGTCATGCCTGCTCCTGCGGTTTGCTGATGACCCTTACACAGAGAGCTACATCAGCACCATCGGGGTGGACTTCAAGATCCAAACCATCGAGCTGGATGGCAAAACTATCAAACTTCAGATCTGGGACACGGCGGGCCAGGAACGGTTCTGGACCATCACTTCCAGCTACTACCGGGGGGCTCATGGCTTCCTCGTGGTATATGACGTCACTGACCAGGAATCCTATGCCAACGTGAAGCAGTGGCTGCAGGAGATTGACCGCCATGCCAGCGAGAACGTCAATAAGCTCCTGGTGGGCAACAAGAGCGACCTCACCACCAAGAAGGTGGTGGACAACACCACAGCCAAGGAGTTTGCAGACTCTTTGGGCATCCCCTTCTTGGAGACGAGTGCCAAGAATGCCACCAATGTCGAGCAGGCGTTCATGACCATGGCTGCTGAGATCAAAAAGCAGATGGGGCCCGGAGCAGCCTCCGGGGGCGAGCGGCCCAATCTCAAGATCGACAGCACCCCTGTAAAGCCGGCTGGCGGTGGTTGTTGCTAGGAGGGGCACTGGAGTGGGACAGGAGGGGGCACCTTCTCCAAATGATGTCCCTGGAGGGGACAGGAGGTGCCTCCCTCTTCCTCTCCTGGGGCATTTGAGTCTGTGGCTTTGGGGTGTCCTGGGCTCCCCATCTCCCTCTGGCCCATCTGCCTGCTGCCCCGAGCCGCTATTCTGTCAGGGTCCCTAAGGGAGGACACTCAGGACCTGTGGCCAGGCAGGGCGGGGGCCTGCTCTGCTGCTGCCTCTAGGTGACTTTCCAAGATGCCCCCCCTACACACCTTTCTTTGGAACTAGGGCTCTTCTGTCGGTCTCCCTCCCACCCCCATGTGTGCTGCACTGGGTTTCTCTCCTTCCCCTTCTTCCTGCTGTCCTTCTGCCCAAGAGCTGAGGGTCTCCCCGGCCTCTACTGCCCTGGCTGCAGTCAGTGCCCAGGGCCAGGAGTGTGACCAGGGGATCCAGGGCCCTGGGCTGGACCTCAGGACAGCCATGGAGGCCACAGGGGCCCAGCAGCCCACCCTTTc
>NM_030981.3
AGAGTCGACTGGGAGCGACCGAGCGGGCCGCCGCCGCCGCCATGAACCCCGAATATGACTACCTGTTTAAGCTGCTTTTGATTGGCGACTCAGGCGTGGGCAAGTCATGCCTGCTCCTGCGGTTTGCTGATGACACGTACACAGAGAGCTACATCAGCACCATCGGGGTGGACTTCAAGATCCGAACCATCGAGCTGGATGGCAAAACTATCAAACTTCAGATCTGGGACACAGCGGGCCAGGAACGGTTCCGGACCATCACTTCCAGCTACTACCGGGGGGCTCATGGCATCATCGTGGTGTATGACGTCACTGACCAGGAATCCTACGCCAACGTGAAGCAGTGGCTGCAGGAGATTGACCGCTATGCCAGCGAGAACGTCAATAAGCTCCTGGTGGGCAACAAGAGCGACCTCACCACCAAGAAGGTGGTGGACAACACCACAGCCAAGGAGTTTGCAGACTCTCTGGGCATCCCCTTCTTGGAGACGAGCGCCAAGAATGCCACCAATGTCGAGCAGGCGTTCATGACCATGGCTGCTGAAATCAAAAAGCGGATGGGGCCTGGAGCAGCCTCTGGGGGCGAGCGGCCCAATCTCAAGATCGACAGCACCCCTGTAAAGCCGGCTGGCGGTGGCTGTTGCTAGGAGGGGCACATGGAGTGGGACAGGAGGGGGCACCTTCTCCAGATGATGTCCCTGGAGGGGGCAGGAGGTACCTCCCTCTCCCTCTCCTGGGGCATTTGAGTCTGTGGCTTTGGGGTGTCCTGGGCTCCCCATCTCCTTCTGGCCCATCTGCCTGCTGCCCTGAGCCCCGGTTCTGTCAGGGTCCCTAAGGGAGGACACTCAGGGCCTGTGGCCAGGCAGGGCGGAGGCCTGCTGTGCTGTTGCCTCTAGGTGACTTTCCAAGATGCCCCCCTACACACCTTTCTTTGGAACGAGGGCTCTTCTGTCGGTGTCCCTCCCACCCCCATGTATGCTGCACTGGGTTCTCTCCTTCTTCTTCCTGCTGTCCTGCCCAAGAACTGAGGGTCTCCCCGGCCTCTACTGCCCTGGCTGCAGTCAGTGCCCAGGGCGAGGAATGTGGCCAGgggatccaggacctgggatccagggccctgggctggacctCAGGACAGGCATGGAGGCCACAGGGGCCCAGCAGCCCACCCTTTCCTCTCCCCACTGCCTCCTCTCCCTTCCTACACTCCCAGCTCGAGCCGTCCAGCTGCGGTGGGATCTGAGTATATCTAGGGCGGGTGGGCGGGTAGCAGTGCTGGGCCTGTGTCTTGAGCCTGGAGGGAGTCTGCTCCTGCCGCCCTCTGCCCTGCCAGAGACAGACCCATGCGCTGCCTGCCCACCGTGCCCCTTTGTCCCCATGTCAGGCGGAGGCGGAAGGCCCACCGTGCCAGAGGCTGGGCACCAGCCTTAACCCTCACTCTGCTAGCACCTCCTCCCTTTCCCCAAGGTAGCACATCTGGCTCACTCCCCACTCCGTCTCTGGAGCCCACCAGGGAAGGCCCTCATCCCCTGCCGCTACTTCTCTGGGGAATGTGGGTTCCATCCAGGATTGGGGGCCTCTCTGCTCACCCACTCTGCACCCAGGATCCTAGTCCCCTGCCCTCTGGCACAGCTGCTTCCTGCAAGAAAGCAAGTCTTTGGTCTCCCTGAGAAGCCATGTCCCTCGTGCTGTCTCTTGCCTGTCCCACCTGTGCCCTGCCCTCCAGCTTGTATTTAAGTCCCTGGGCTGCCCCCTTGGGGTGCCCCCCGCTCCCAGGTTCCCCTCTGGTGTCATGTCAGGCATTTTGCAAGGAAAAGCCACTTGGGGAAAGATGGAAAAGGACAAAAAAAATTAATAAATTTCCATTGGCCCTCGGGTGAGCTGAGGGTTTTTGCAAGGAA

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