Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PAICSP1
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Plot displaying the genomic locations of a retrocopy (in chr9) and its respective parental gene (in chr4). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr9:37878095-37879495  UCSC
Coordinates (T2T) chr9:37902005-37903405  UCSC
Coordinates (hg19) chr9:37878092-37879492  UCSC
Strand +
Parental Sequence NM_001079524.2
Parental seq. overlap 1131 bp
Parental seq. overlap (%) 17.6%
Genomic Region Intergenic
Retrocopy Summary PAICSP1, located on chr9:37878095-37879495, is a retrocopy of the parental gene PAICS. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PAICS
Full Name phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
Also known as ADE2|ADE2H1|AIRC|PAICSD|PAIS
Coordinate chr4:56435752-56464578
Strand +
Gene summary This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PAICSP5
Gorilla Gorilla gorilla PAICSP5
Orangutan Pongo abelii PAICSP3
Gibbon Nomascus leucogenys LOC100580950P3
Green monkey Chlorocebus sabaeus LOC103235650P3
Crab-eating macaque Macaca fascicularis PAICSP3
Rhesus Macaca mulatta LOC694743P3
Baboon Papio anubis PAICSP3
Golden snub-nosed monkey Rhinopithecus roxellana PAICSP3
Bonobo Pan paniscus Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Related Sequence

>PAICSP1
TCCCACTCAGGATAATAGTGAGAGCTGAGGTACTGAACATTGCTAAAAAACTATGTGAGGGTAAAACAAAAGAGGTCTATGAATTGCTTGTTAGATAGGCCAGGAAAAGTCCTGCAATCTAAGGACCAGATTACAGCAGGAAATGCAGTCAGAATCACCTGGAAGGAAAAGCTGCAATCTCAAATAAAATTACCAGTTGCATTTTTCTGTTGTTACAGGAAGCAGGTATTAAAACTGCTTTCACCAGAAAATGTGAGGAGACAGCTTTCATTGTGCCCCAGTGTGAAATAATTCCAACTGAATGGTTTGCAGAAGAATACCAACTGGTTCTTCACTCGAAAGAAATCCTGGTGTCAAGGAAGGATGTGAGTTTTGCCCACCTAAAGTGGAGATGTTTTTCAAGGATGATGCCAATCATGACCCACAGTGGTCTAGGCAACAGCTAATTGCAGCAAAATTTGGCTTTGCTGCACTTGGTATAAAACTGAAGTGGATATCATGAGTCATGCCACATAGGCTGTTTTTGAAATCCCGGAGAAATCCCGGTTGCTCCCAGAACTGTACACCGGTTGATATGAAGATTGAATTTGGTGTTCATGTGACCAGCAAAGAAATTCTCACTGATGTTATTGATAATGACTCCTAGAGACACTCACCATCGGGGGAGCAAAGCCAATAGAAAGACAGTCTTTTAATCATACTTTTAAAAATGTTATTTTAAAAAAATAGAGCCAcTGAAACAGTCTTATCAAGGCTTCAGTGTAACTCCTGAAGGGTTCCAAATGGTAAGGAAAAACTTTGCGTGGGTTGTAGAGAGTAGAGTTGCTTTTGAAATCAGAAAGTCAGTGCAGTGTTATAGTATTGATGGGTTCTACTTCTGATCTTAATCACCGTGAAAAAAATCAAGGCCTGTGGAAATTTTGGCATTCCATGTAGACTTTGAGTAACATCTGCACATAAAGGACCAGAAGAAATGCTGAGGATTAAAGCTGAGTATGAAGGGGTGGCAGTCGTACTGTATTTGTGGCAGTGGCAGGCAGAAGCAATGGTTTGGGATCAGTGATGTTTGGGAACACTACACATCCAGTTATCTATTGTCCTCCCCTCACACCAGACTGAGGAGTTCAGGATGTGTGGTCTTCTCTGCGACTACTCAGTGGTCTCGGCTATTCAACCATACTTTCTCCAGAAGGATCAGCTCAGTTTGCTACTCAGATATTTGGATTAAACAACCATTTATTATGGGGCAAACTGCAAGCAAGCACTTTGAACACATGGATTTTTTGGAAGAAAGGTGACAAGAAAATCAGAGAA
>NM_001079524.2
AGAGTTCTGCCTCGCTTCCCGGCGCGGTCGCAGCCCTCAGCCCACTTAGGATAATGGCGACAGCTGAGGTACTGAACATTGGTAAAAAATTATATGAGGGTAAAACAAAAGAAGTCTACGAATTGTTAGACAGTCCAGGAAAAGTCCTCCTGCAGTCCAAGGACCAGATTACAGCAGGAAATGCAGCTAGAAAAAACCACCTGGAAGGAAAAGCTGCAATCTCAAATAAAATCACCAGTTGTATTTTTCAGTTATTACAGGAAGCAGGTATTAAAACTGCCTTCACCAGAAAATGTGGGGAGACAGCTTTCATTGCACCGCAGTGTGAAATGATTCCAATTGAATGGGTTTGCAGAAGAATAGCAACTGGTTCTTTTCTCAAAAGAAATCCTGGTGTCAAGGAAGGATATAAGTTTTACCCACCTAAAGTGGAGTTGTTTTTCAAGGATGATGCCAATAATGACCCACAGTGGTCTGAGGAACAGCTGATTGCTGCAAAATTTTGCTTTGCTGGACTTCTTATAGGCCAGACTGAAGTGGATATCATGAGTCATGCTACACAGGCTATATTTGAAATACTGGAGAAATCCTGGTTGCCCCAGAATTGTACACTGGTTGATATGAAGATTGAATTTGGTGTTGATGTAACCACCAAAGAAATTGTTCTTGCTGATGTTATTGACAATGATTCCTGGAGACTCTGGCCATCAGGAGATCGAAGCCAACAGAAAGACAAACAGTCTTATCGGGACCTCAAAGAAGTAACTCCTGAAGGGCTCCAAATGGTAAAGAAAAACTTTGAGTGGGTTGCAGAGAGAGTAGAGTTGCTTTTGAAATCAGAAAGTCAGTGCAGGGTTGTAGTGTTGATGGGCTCTACTTCTGATCTTGGTCACTGTGAAAAAATCAAGAAGGCCTGTGGAAATTTTGGCATTCCATGTGAACTTCGAGTAACATCTGCGCATAAAGGACCAGATGAAACTCTGAGGATTAAAGCTGAGTATGAAGGGGATGGCATTCCTACTGTATTTGTGGCAGTGGCAGGCAGAAGTAATGGTTTGGGACCAGTGATGTCTGGGAACACTGCATATCCAGTTATCAGCTGTCCTCCCCTCACACCAGACTGGGGAGTTCAGGATGTGTGGTCTTCTCTTCGACTACCCAGTGGTCTTGGCTGTTCAACCGTACTTTCTCCAGAAGGATCAGCTCAATTTGCTGCTCAGATATTTGGGTTAAGCAACCATTTGGTATGGAGCAAACTGCGAGCAAGCATTTTGAACACATGGATTTCCTTGAAGCAGGCTGACAAGAAAATCAGAGAATGTAATTTATAAGAAAGAATGCCATTGAATTTTTTAGGGGAAAAACTACAAATTTCTAATTTAGCTGAAGGAAAATCAAGCAAGATGAAAAGGTAATTTTAAATTAGAGAACACAAATAAAATGTATTAGTGAATAAATGCTTCTCTAGATCCATATTAATAAACATGAGCATCTAACCCCTCCTTTCTTAGGCTAGACACCAAGATATTTCAGCCAGCCTTTATCATTCCTCTTACTTTATCCTTTTTCCTTAAGTATTGGTGGTCACTACTATTGAGTTTCTTCCTTAACACTGATTAAATGATCTTAACTCCCTCAGCTAAAACTGGCATTACtgactcccagctatatttctccagacttgcatttttttttttttttttgagacagggtctcactgtcgcccaggctggagtgcagtggcgtgatctcagttcactgctgctttccctcctgggctcaagcagttctcccacctcagcctctcgactaacagggactataatcttgcagcaccatgccgagctaattttattttttgtagagatgagctctcactatgtcacccaggttcgtctcaaactcctgaaccctagtaattctcctatctcagcctcccaaagtgctagggttacagacatgagccactgtgcctgtctagacttgtactttcaactgtccatttctccctgtctgtcccatgggcactcatgaaaaaacagaatgctcccaactttattcatcttccaagcctgtagctcttggtatactcactgttgcaagtcagaagcttgatttcatcattgatgtttttctcacgtttcacatctcactcatcaccaagtcatgttggtgttaatttctgattaacccttgaatttaccgtcttctcatcctctgtacAAAAGCCTCAAGTGAGGGTCAAATTCAACATTATCCTGATCTAGACAGCCCCCATTCTCAATCCACCCTTTTCCAAGTTGATTGCCCAAGGACTTCTAACAATAAACTctcttttgcaccacagacttctttgaaaatatacatgctgttgaccctctctgtagaaaaccgcacacataaaacttaccaacagatttcattggttcttgggttctcccgaagcctatccatggtttatagattaagaaTTGATGAGGTAgctgggcacagtggctcacacctacgatcacagcacttcgggaggctgaagcaagcagatcacttgaggtcaggagtttgagaccagcctggccaacatggtgaaaccctgtctctactaaaaatacaaaaagtagccagccgtgatgacaggcacctgtaatcccagctactcgggaggctgaggcatgagaattgcttgaacccgggaggcggaggttgcagtgagcctagatcatgccactgcactccaacctgggcagcagagcaagactctgtctcaaaaggggaaaaaaaaaaTTGCTGATGTGACCCATGAAGGGAACTCATTTTCCTCGTAATTTTGGACTGCCACACATTGGTACCTTTAGTTCTCTGAAGGCCCACGTTTTTATCATTAAGACCTATTTGTTAGCTAGTAGAGCTTTATGTTCGCTGTCCATGAAACCTTCTGTAACCACAGTGACTACAAGTAGTTCTTTCTCTATTGAATTATTAGGTCCAGAATAGAAGATGTCATTGTACACTTTATTTCCCTCACACTGTGTTATGCTCTGATGTGCTATGCTTAGCTATCTGTCAGAGATTAGTAAATTATAAAACTCATGTGTACTACTTAAGTTTATATCTTATGCTAGTTTATAAGAACAATTAAAAGGACTTAGAAGATTAACTTTGGTTTCATGGTCTCTGAAGTCACTGACTGCTATTTCAGCTTGTTTACCCTTACCTAGCATTAAGACTCCATCTACTTCTGTGCAGTATATGAAAATTTTTAAACTTTCATTTAGACTGGTGGATAGGACTGACCATTACAAATTGTCGTTATCAAttttttttcctttttttttttaagagccaagttctcactgtctcccaggctggagtgcagtggcatgattatggctccctgcagccttgaactcctggactcaagctgcagcctctcgagtagctgggtgcatgtgctaccacacccaattaTGAATTTCATCATTAGTTTCTTAGTAGAGTCCACATGTCCTCAGTAGTAAGTTCATCAGTGCTAAATATTTGAAGGTATTTCTACTGTTTTGTAAAAGTAACTTAAGCCTACCTGGTCTGCTATCTTTTGAGTATTTATACTTTCTACGGGCTTGTAGGTAAACATAAAAAGAGAAAAAATATCCCAATAATACAGTTTTTAACCTTTTATGATAAAGACATGCTTAGAATTGCTGTTAAGCTTTCTGAGATTTAACCACTGAAACTAAGTAAAAGACAAAGCACTTAGGTAAAGCttcattcagtatccattcacccaatactggtttgattctagggcctaggaaaataggactgagcaaagcccttgtccagatggaacttatgttttagaggggaaaacaaaccataaaaaggtaaacagtataaaatcaggaaaggataaatgtatatgaagaatcaaaatgaggacggtgatggggataagaggggaaggtttttgaggagagcagagcaatgatgtaaaagcaagacacacagatagggaaatagctttccatactaagggaatgggaaataaagctgagttttgccttgaggacctccaaacatgagaattgctagagctctgtgaacaaggatgagagtggaagacaatataagcaaaggctacatcacttagggcctataggccacactgaagtgtgacaggaaaaactcagtttgagcagaggcttgacatacttaacatatttaaaggttctctggctgttgtgtggacaagaggagaagcagagattagttaagaggctattgtagcccaggtgagggatgatgtatgatcttcaacatgtctaatttttttgtgcctcaatttcatgaaatgaaaatgcgactaataccacctcataaagttgtgagaattacatgagtcaatatatgtaaggcccatcatggcacacaAATGTGTTATGTAATATCCATTTGGCAGACTGAAGAACAACAGTATGAATGGAATTCATTCACCATGAGAATTACCTGGAATTCTctgggcatggtagctcatgcctgtaatcccagcactttgggtggccgaggcaggtggatcacctgagatcaggagttcgagaccagcctgaccaacatggagaaacccagtctctaataaaaatacaaaactagccgggcatggtggcacattcctgtaatcccagcgactcaggaggctgaggcaggagaatcgcttgaacctgggaagcggaggttgtggtgagccgaggttgcgccattgtactccagcctgggcaacaagagcaaaactctgtttcaaaaaaaaagaaagaaagaaaaTTACCTGGAATTCAATATTGCCATCGGCTGATTTAATTTCTAATATGAAGAAAGGGGCAGTGTGATGTGCCACGGAGCATCCACAACCTGCCATTTCAGCCCAGCCAACCTTAGAAAGCCATTGAAAAGAGTTGTTTTTAATGGTGTTTTTACATCCAGCTTCCCACACCTCAAATACTTGGGGTGGAATTGTTAATCTCACATTGCAGTACAATGAAAATAGTGGAATGGAAATCAAGTTATAAAATGGAGCTAAATATTTCTTCTGCTTGCCTCTGAGTTGATAAGATACCATAAGATACTGTACATGAGGCTGGGCGCGGTGGCTCACGTCTTATTTCTTCTGCTTGCCTCTGAGTTGACAAGATACCATAAGATACTGTACATGAggctgggtgcagtggctcacgcctgtaatcccagcactttgggagggtgaggtgggcagatcacctgaggtcgggagttcaagaccagcctgactgacatggagaaaccccctctttactaaaaatacaaaattagccaggcatggtggtgcatgcctataattccaactactcgggaggctgaggcaggagaatcgcttgaacctggaaggcagaggttgtggtgagctgagatcgaaccattgcactccagcctgggcaacaagagcgaaaatctgtcgccaaaaaaaaaaaaaaaaaGATACTGTACATGGAAGCTTCTCAGGCTAAATCCATTAATATAAAAATACATTGTGGATACTGAtgagatggctaattctgtcaacttgactaggctacgggatgccttgatagctggtcaaacaacatttctaggtacatctgtgatggtgtttctggaagagactagcacttgaatcagtagacttgagtaaagaagactgccttcacccatgtgggtgagcgtcatctaatccattgagggcctgaatagaacaaaaaaggggaagaagggtgaactgctgggacatccatttcgtgcccccagatgttggtgctcctggtcctcaggccttcagactaggacttaacgttattgcctcccctgattctcaagccctcgggtttggaactacactggctttcctgggccttcagcctgcagaaggcagactgtgggacttcacctccattttgcagagccaatttctcataatctgtacatatcctattggttctgtattttttagagaacAAATACAgcctattatgtatatataagaccctgggaatgcaaagatgaacaaaattaaccttctgctctcaatgaatcttggaagtctccagaggcagacaatttcaaaacaccgtatatagtcttaatatggaattaacaatagggtattgtgaatacacaaaagtaggAAGGACTCTGATCTCTAGAAAACAATTGTATACTGTGAATGAAAAAGACTAATTCTCCACAGTCTATActcaatctctcttacctttccataattttcttcagcaaacttattaccaccaaacatagtacatgtttatttattacccatctctcccaactagaaaataaatgtattacactgg

Publications

PMID - Link Title
No publications available for this retrocopy