Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name YWHABP1
Plot displaying the genomic locations of a retrocopy (in chr9) and its respective parental gene (in chr20). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr9:38643039-38644928  UCSC
Coordinates (T2T) chr9:38667241-38669131  UCSC
Coordinates (hg19) chr9:38643036-38644925  UCSC
Strand +
Parental Sequence NM_139323.4
Parental seq. overlap 1418 bp
Parental seq. overlap (%) 46.6%
Genomic Region Intergenic
Retrocopy Summary YWHABP1, located on chr9:38643039-38644928, is a retrocopy of the parental gene YWHAB. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name YWHAB
Full Name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
Also known as GW128|HEL-S-1|HS1|KCIP-1|YWHAA
Coordinate chr20:44885705-44908532
Strand +
Gene summary This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes YWHABP1
Bonobo Pan paniscus YWHABP1
Gorilla Gorilla gorilla YWHABP1
Orangutan Pongo abelii YWHABP1
Green monkey Chlorocebus sabaeus YWHABP3
Crab-eating macaque Macaca fascicularis YWHABP2
Rhesus Macaca mulatta YWHABP2
Baboon Papio anubis YWHABP2
Golden snub-nosed monkey Rhinopithecus roxellana YWHABP3
Marmoset Callithrix jacchus YWHABP1
Gibbon Nomascus leucogenys Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>YWHABP1
CTGACAATGGATAAAAGTGTGCTGGTACAGAAAGCCAGGCCCGCTGAGCAGGCTGAGCGCGGTGATGATGTGGCTGCAGCCGGGAAGGCAGCCATGCCACAGGGGCATGCGCCCCCAGCTGAAGACAGCAATCTGCCCTCTGCCGCCTACAAGAATACGGTGGGGCCCACTGTTCTTCCTGGATTCTCATCTCCAGCACTGAGCAGAGAACAGGAGGAATGAGAAGCAGCAGATGGGCAAAGAGTACCATGGAAGACAGAGGCAGAGCTGCTGGACATCTGCAATGAGGTTCCGGAGCTGTTGGACAAGTCTCTTATTCCCCATGCTACACAACCTGAAAGCAAGGCGTTCTCCTTGAAAATGAAAGGAGATTGTTTCGGGTATCTTTCTGGGGTGGCGTCTGGAGACAATAAACAAACCACACTGTTGAACTCCCAGCAGGCTTACCAGGAAACATCTGAAATTAGTAAGAAAGATATGCAGCCTACACACCCAATTCGACTGGGCCTGGCACTTAATTTCTCAGTCTTTTGCTACGGGATTCTAAACTCTCCTGAAAAGGCCTGCAGCCTGGCAAACGTGGCATTTGATGAAGCAATTGCTGAGTTGGATACACTGAATGAAGAGTCTTATAAAGACAGCACTCCCACCATGCAGTGACTTCGGGACAATCTCACTCTGGGGACATCGGGAAACCAGGGAGATGCAGGAGATGCTGGGGAGGGAGAGAACTGTGTCTGCCATGCCTCACAATCTGTTCAGTGTCACCCTGTACCATCCACGTAAATCCCTTTGTGTGATTAAAAAAAAAAAAGAATTGTACATTGTCTTGCGATTTTTCACAGCCTCAGCCTAGCAAGAATGGTTCGTGGGATAAACAGCTGGCACTTGTATCTAAAACCTAGATTGGTTGCATAAACACCATGGCATTCTGAAGTTTTGGTTTTGATTGACATTGGCAAGATTACTGTGTGTTTAATTTTCTTAAAGCTGAGCACTGTGGTGATGGGTTTTGTAATTCAGCATAATTCTTACTGATAAGAAAAATAGACCTGAATGTTATGTAACTCTTTGGAAAGTTTAATCCAATATTAAAATAGTCACTGAAATACAATTTCATTGTAAAGTTGTACAGAAAGTTACAGAGGTTATGTCGTGATGCTGGGATGTGGAGTGAGACACCATCATTTGGCATTCAAGTTTAATGGTAATTCACAGTGATGCTGCCTGTTCAGAGCTTATAGACACTGGACCTGTTTGGGCTATTGCCACTCAAAAGTTCATGACCACAAATGTCCACAGCGTCTTCCTCTGAGGAAATGCAAATCCTGAAGCTGAAATTCCTTGTGACAGATAACTGGCTGTGACACCTTGAAAAGTTCTGGTGCTCATATGACACACCTGACTAAACCCCCCTTCCTACAGCAATAGGAATATGTTACTGATTTGAAACTTGTGCCTCAATAATGGAATAGTTTTTCATTGTTAACACTGAGCTAGTGCTGTAAATGCTGTCTGTTTTATGAATGCTCTTTTCTGTTTCCTGGCTAATATCTCCTTCTTTTTTTTTTTTCAGTCTCATTATAGCACAGATGTCCCTTCCCCCACATGCCTTTGCCCCACATTCCTGGATAATACCTTTAAGAATAATGTTCTGA
>NM_139323.4
GGAAGTGGAGCTAccgccaccgccgccgccgattccggagccggggtagtcgccgccgccgccgccgctgcagccactgcaggcaccgctgccgccgccTGAGTAGTGGGCTTAGGAAGGAAGAGGTCATCTCGCTCGGAGCTTCGCTCGGAAGGGTCTTTGTTCCCTGCAGCCCTCCCACGGGAATGACAATGGATAAAAGTGAGCTGGTACAGAAAGCCAAACTCGCTGAGCAGGCTGAGCGATATGATGATATGGCTGCAGCCATGAAGGCAGTCACAGAACAGGGGCATGAACTCTCCAACGAAGAGAGAAATCTGCTCTCTGTTGCCTACAAGAATGTGGTAGGCGCCCGCCGCTCTTCCTGGCGTGTCATCTCCAGCATTGAGCAGAAAACAGAGAGGAATGAGAAGAAGCAGCAGATGGGCAAAGAGTACCGTGAGAAGATAGAGGCAGAACTGCAGGACATCTGCAATGATGTTCTGGAGCTGTTGGACAAATATCTTATTCCCAATGCTACACAACCAGAAAGTAAGGTGTTCTACTTGAAAATGAAAGGAGATTATTTTAGGTATCTTTCTGAAGTGGCATCTGGAGACAACAAACAAACCACTGTGTCGAACTCCCAGCAGGCTTACCAGGAAGCATTTGAAATTAGTAAGAAAGAAATGCAGCCTACACACCCAATTCGTCTTGGTCTGGCACTAAATTTCTCAGTCTTTTACTATGAGATTCTAAACTCTCCTGAAAAGGCCTGTAGCCTGGCAAAAACGGCATTTGATGAAGCAATTGCTGAATTGGATACGCTGAATGAAGAGTCTTATAAAGACAGCACTCTGATCATGCAGTTACTTAGGGACAATCTCACTCTGTGGACATCGGAAAACCAGGGAGACGAAGGAGACGCTGGGGAGGGAGAGAACTAATGTTTCTCGTGCTTTGTGATCTGTTCAGTGTCACTCTGTACCCTCAACATATATCCCTTGTGCGATaaaaaaaaaaaaaaaaaaaaaaaGAGAATCGTACGTCGACTTTCGATTTTTCACAGCCTCAGCCTAGGAAAAATGGTTCATGGGATAAACAGCTGGTATTTGTATCTAAAACTCAGATTGGTCACATAAATGCCACGGCATTCCGAAGTTTTGATTTTGATTAACATTGACAGGATTACTGTGTGTTTAATTTTTTAAAAACTGAACACTGTGATTATGGGGTTTTGTAATTTAGCAGAACTCTTACTGGTAGAAAAAATAGACCTGAATTATGTGTAACTTTTTGGAAGGTTTAATCTGATATCAAAATAATCATTGAAATACAATTCCATTGTAAAGTTGTACAGAAAGTTATAGAGATTATATTGTGATGCTGGAACTTGGAGTGAGACACACATCATTTGGCATTTGAGTTGAATGGTAATTCACAGTAATGCTGCCGTTGTTCGGGACTTAAAGACACTTGACCTGTTTGGGCTGTTGCCACTTAAAAGTTCATGACCACAAATGTCCACAGTGTCTTCCTCTGAGGAAACTCGAATCCTGAAATGGAAATTCTTTGTGGCAGATAACTGGCTTATGACACCTTGAAAAGTTCAAGTGCTCATATAACACACCACACTGAACCCCCTTTCCTACAGCAATATGTTCACTATGTTACCAATTTGCAACTTGTGCTTCAATAGTGGAATCTACTTTCATTGTTAACACTGAGCTAAAGAAAAAAAGCCGTGTGTTTTATGAATGACCTTATCTGTTTCCTGGATAATACCTTTAAGAATAATGTCCTGAgtcaggcgtggtggtgcgtgcatctagtcccaactatttgggaggctgaggcaggaggatcgcttgagcccaggagtttaaagctgcagtgccctgtggttgcacctgtgaataactgcactccagcctgggcaacatagcgagacctcatctccaaaaaagaaaacaaaaaacaaaaaaaGGAATGATGTTCTGTAGAGATGGCCTTTCACTTGAGGAGTACTCAGTTTTCAGGTTCTTCCTAGCTCGGGGCTTTTAAATTTTGAAATCTAAACATTCTTTCCCACCATCCTTTTTGACTGTTGACCTTGGTTTTCTCTTCTAAGTTTCTGTCCCTCTGCTTCCTTACTTTTTTTCCTTTTTGAATTCTATCTTTATCTGTCTTTTGTTCACTTTTTAATGCTATATATGGGCAGGGGTGAGAGACATTACTGAGCACCTTGGTGAGCAAGCCTGGCTTTAAAGATTGGAGAAGAGCTTCTGGCACCAGAACCCTGTCTTCCTCCAGTTCTCAACACGGTGTTGCTCTTCAGTCATACCGGAATCTGAATCAAAAAAGTATTTTTAAATATCCATGATTTCTCCCTGTATTGAGGCTAGCCCTGATCATGCTTTTTGTGCCTGTCACCAGGTCTCCCAAGTGCACTCATCCAGGTCAGTGCTCAGATGTGTTTAAGGAGACCCTATATTCAGGGAAGTTGCGTGAACACTGCAGTGGGGAGAATTGAGAATAGTCAGGCCTATCAGTCTCACAGAATCACCCCTCTACCTTTGATATTCCACTTAGCTGTAGAGTCCATCTGTTTGTCCATCTGCTGaaatgagaaaagaaaaatttatgcactgatttaaaacaaaccaaaaaaaaagaaaaaaacaaaaaaaaaaaTCCCTCCTTTCTAGCTGAACAAAAATGTGCAGTTAATACTTGGCGCTTGAAAATGCAGTAGTGAATGTGGAACCAAGCCTGTCTGTATATCTGGTAGCTCTTTTCTTGCTTTGTTTTTTCTTACCAGTATTCTGCCTAACGTTTGCTTCTGTGATGGTTATATTGCCTAGCAAGCACACCCGTGGTTGTGAAAATAGTATAGCAAAAAAGAAAAATCCCCGGTTATTGATGTACTAGATTTGTGTATGTCTTTTAAACAGTTCTAGTTTCACCTTACACAGAATAATCAGGAAAAGTGTAAAAATTCAAAAGTGAAATAAAAATTTTATCAGTTAGTTGCCTGTGAA

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