Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PDSS1P1
Plot displaying the genomic locations of a retrocopy (in chr9) and its respective parental gene (in chr10). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr9:5084703-5086231  UCSC
Coordinates (T2T) chr9:5089784-5091312  UCSC
Coordinates (hg19) chr9:5084703-5086231  UCSC
Strand -
Parental Sequence NM_014317.5
Parental seq. overlap 1289 bp
Parental seq. overlap (%) 75.7%
Genomic Region Intragenic (INSL6)
Intragenic (JAK2)
Retrocopy Summary PDSS1P1, located on chr9:5084703-5086231, is a retrocopy of the parental gene PDSS1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PDSS1
Full Name decaprenyl diphosphate synthase subunit 1
Also known as COQ1|COQ10D2|COQ1A|DPS|SPS|TPRT|TPT|TPT 1|hDPS1
Coordinate chr10:26697424-26747246
Strand +
Gene summary The protein encoded by this gene is an enzyme that elongates the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. The protein may be peripherally associated with the inner mitochondrial membrane, though no transit peptide has been definitively identified to date. Defects in this gene are a cause of coenzyme Q10 deficiency. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Gorilla Gorilla gorilla PDSS1P1
Orangutan Pongo abelii PDSS1P1
Gibbon Nomascus leucogenys PDSS1P1
Green monkey Chlorocebus sabaeus PDSS1P1
Crab-eating macaque Macaca fascicularis PDSS1P1
Rhesus Macaca mulatta PDSS1P1
Baboon Papio anubis PDSS1P1
Golden snub-nosed monkey Rhinopithecus roxellana PDSS1P1
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PDSS1P1
ACCCTATTTTAATCTTGTGAAGCATTTAACACCTGCCTGTCCAAATGTATATAGTATATCACAGTTTCATCACACAACCCCGTACAGCAAAACACACAGTGGTGAGAAATACACCGATCCTTTCAAACTCGGTTGGAGAGACTTGAAAGGTCTGTATGAGGGTATTAGAAAGGAACCGCTCATATCAACAACAGAACTTAAGGAAATCTCTGAGTACTACTTTGATGTAAAAGGAAAAGCCTTTCGATCAATTATTGTGGTACTAATGGCCCGAGCATGTAATATTCATCATAATAACTCCCGACATGTGCAAGCTAGCCAGCGCGCCACAGCCTTAATTGCAGAAATGATCCACACTGCTAGTCTTGTTCACGATGACGTTATTGATAATGCACGTTCTCGAAAAGGAAAACACACAAGATCTGGGGTGAAAAGAAGGCTGTCCTTGCTGGAGATTTAATTCTTTCTGTAGTATCTATAGGTGGGGCACAAACTGGAAATACAGCTGTTATATCTATTTTAACCCGAGTTATTGAAGATTTGGTGTGTGGTGAATTTCTTCAGCTCGGGTCAAAAGAAAATGAGCATGAGAGATTTGCACAATACCTTGAAAAGACCTTCAAGAATACTGCGAGCCTGATAGCCAACAGTTGTAAAGCAGTCTCTGTTCTAGGATGCCCCGACCCAGTGGTGCATGAGATCACCTATCAGTACGGAAAAAATGTAGGAATAGCTTTTCAGCTAATAGATGATGTATTCGACTTCACCTCATGTTCTAACATAGGCAAACCAACATCAGCTGATGTGAATCTCAGGTTAGCCACTGGTCCTGTCCTATTTGCCTGTCAGCAGTTCCCAGAAATGAATGCTATGATCATGAGATGGTTCAGTTTGCCGGGAGATGTAGACAGAGCTCCACAGTATGTATTACAGAGTGATGGTGTAAAACAAACAACCTACCTTGCCCAGCAGTACTGCCATGAAGCAATAAGAGAGAGCAGTAAACTTCTCATCCCCAGAAAGAGACGCCCTCATTCAACTTTCAGAAATTGTACTCACAAGACATAAATGACAACTCTTTCTGTTCTTTCTGGCAGCTATCTCAGACTGTGCCTAAGAATTTTGTGGAATACACTTTGTTTGCTTCATGTGCAGATAACCAAAAATCATTTTAAAAGATATCAAACTTATTGATGGGCAATTTGTTTTATTGCAAAAGTTTTTTCAGAAAACTTTTTAAATGTAATTAAACCATCTGAATCTGTCATTCTAGTCCTATAAATTCTAATTGAGGTGTCTTGATGGTTATATGTGGTACTGTTTACACTGTTAATATCCACATGTAAGGCTATTACACAAATAATAGACTCCGACCGTGGCCTCGCGCTGGTGGCGGGGGCGGCGCGGCTGTTGCTGGAGACCGGCGGCGTGGAGACCGCTCCCCGAGCCTTGCGGGGCCGCCGGGGCCGCGCGCCGCTGCCGATGCCCGCGc
>NM_014317.5
AGACTCCGACCATGGCCTCGCGCTGGTGGCGGTGGCGGCGCGGCTGCTCCTGGAAGCCGGCGGCGCGGAGCCCCGGGCCCGGCTCCCCCGGCCGTGCGGGACCGTTGGGGCCGAGCGCCGCTGCCGAAGTCCGCGCGCAGgttcataggcggaagggacttgacttgtctcagATACCCTATATTAATCTTGTGAAGCATTTAACATCTGCCTGTCCAAATGTATGTCGTATATCACGGTTTCATCACACAACCCCAGACAGTAAAACACACAGTGGTGAAAAATACACCGATCCTTTCAAACTCGGTTGGAGAGACTTGAAAGGTCTGTATGAGGACATTAGAAAGGAACTGCTTATATCAACATCAGAACTTAAGGAAATGTCTGAGTACTACTTTGATGGGAAAGGGAAAGCCTTTCGACCAATTATTGTGGCGCTAATGGCCCGAGCATGCAATATTCATCATAACAACTCCCGACATGTGCAAGCCAGCCAGCGCGCCATAGCCTTAATTGCAGAAATGATCCACACTGCTAGTCTGGTTCACGATGACGTTATTGACGATGCAAGTTCTCGAAGAGGAAAACACACAGTTAATAAGATCTGGGGTGAAAAGAAGGCTGTTCTTGCTGGAGATTTAATTCTTTCTGCAGCATCTATAGCTCTGGCACGAATTGGAAATACAACTGTTATATCTATTTTAACCCAAGTTATTGAAGATTTGGTGCGTGGTGAATTTCTTCAGCTCGGGTCAAAAGAAAATGAGAATGAAAGATTTGCACACTACCTTGAGAAGACATTCAAGAAGACCGCCAGCCTGATAGCCAACAGTTGTAAAGCAGTCTCTGTTCTAGGATGTCCCGACCCAGTGGTGCATGAGATCGCCTATCAGTACGGAAAAAATGTAGGAATAGCTTTTCAGCTAATAGATGATGTATTGGACTTCACCTCGTGTTCTGACCAGATGGGCAAACCAACATCAGCTGATCTGAAGCTCGGGTTAGCCACTGGTCCTGTCCTGTTTGCCTGTCAGCAGTTCCCAGAAATGAATGCTATGATCATGCGACGGTTCAGTTTGCCTGGAGATGTAGACAGAGCTCGACAGTATGTACTACAGAGTGATGGTGTGCAACAAACAACCTACCTCGCCCAGCAGTACTGCCATGAAGCAATAAGAGAGATCAGTAAACTTCGACCATCCCCAGAAAGAGATGCCCTCATTCAGCTTTCAGAAATTGTACTCACAAGAGATAAATGACAACTCTTTCTGTTCTTTCTGGCAGCTATCTTACCAGACTGTGCCTAAAGAATTTTGTGGAATACACTTTGTTTGCTTCATGTGCAGATAACCAAAAATCATTTTAAAAGATATCAAACTTATTGATGGGCAATTTATTTTTTTTTATTGCAAAAGTTTTTTCAGAAAACTTTTTAAATGTAATTAATAAACCACCTGAATCTGTCATTCTAGTCCTATAAATTATAATCAAGGTATCTTGATGGTTATATGTGGTATTGTTTACACTGTTAATATCCACATGTAAGGCCATTACACAAATAAATAACCAATGTTAAAATTCAAA

Publications

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