Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TCF3P1
Plot displaying the genomic locations of a retrocopy (in chr9) and its respective parental gene (in chr19). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr9:5110860-5113421  UCSC
Coordinates (T2T) chr9:5115923-5118480  UCSC
Coordinates (hg19) chr9:5110860-5113421  UCSC
Strand +
Parental Sequence XM_011528219.2
Parental seq. overlap 2176 bp
Parental seq. overlap (%) 46.6%
Genomic Region Intergenic
Retrocopy Summary TCF3P1, located on chr9:5110860-5113421, is a retrocopy of the parental gene TCF3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TCF3
Full Name transcription factor 3
Also known as AGM8|AGM8A|AGM8B|E2A|E47|ITF1|TCF-3|VDIR|bHLHb21|p75
Coordinate chr19:1609292-1652615
Strand -
Gene summary This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TCF3P1
Bonobo Pan paniscus TCF3P1
Gorilla Gorilla gorilla TCF3P1
Orangutan Pongo abelii TCF3P1
Gibbon Nomascus leucogenys TCF3P1
Green monkey Chlorocebus sabaeus TCF3P1
Crab-eating macaque Macaca fascicularis TCF3P1
Rhesus Macaca mulatta TCF3P1
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TCF3P1
CGCCGCGCCCAGCAGGGTTTCCATGTCTGAGATGCCCGCTCTGGCCCCAAGAGAATGAACCAGCCGCAGAGGATGGCATCCGTGGACACGGACAAGGAGCTCAGTAACCTGGACTTCAGCATGATGTTCCCGCTGCCCGTTGCCAACGGGAAGGGCCGGCCCGCCTCCCTGGCCGGGGCGCAATTCAGAGGTTCAGGTCTTGAGAACTGGCCCAGCTCAGGCTCCTGGGGCAGCGGCGACCAGAACAGCTCCTCCTTTGACCCCAGCTGGACGTTCAGCGAAGGCGCTCAACTTGCTGAGTCGCACGGCAGCCACTCTCCATTCACATTCCTGGGACCGGGACTCGGAGGCAAGAGCAGCTAGCGCGGGCCTATTCCTCCTTTGGTAGAGACGCAGGCGTGCGCAGCCTGACTCAGGCTGGCTTCCTGCCGGGCAAGCTGGCCCTCAGCAGCCCCGGACCCCTGTCCCCCTCAGGCATGAAGGGGACCTCCCGGTACTACCCCTCCTACGCCAGCAGCTCTGGCGGACAGAGGCGGACAGCGGCCTGGACACGCAGCCCACGAAGGTCGGGAAGGTCCCGCCTGGTCTTCCATCCTCGGCGTACCTGCCCAGCTCAGGTGAGGAGTACGGTAGGGATGCCGCCGCCTATCCATCCGCCAAGACGCCCAGCAGCGCCTGTCCCGCCCCCTTCTACATGGCAGATGGCAGCCTGCACCCCTAAGCCGAGCTCTGGAGTTCCCTGGGCCAGGTGGGCTTTGGCCCCATGCTGGGCGGGGGCTCATGCCCCTCGTCCCTCCCGCCCAGCAGCGGCCCTGTGGGCAGTGGCGGAGGCAGCAGCACGTTTGGCGGCCTGCACCAGCACGAGCGCGTGGGCTACCGGCTGCACGGAGGAGAAGTGAACGGTGGGCTTCCGGCTGCATCCACCTTCTCCTTGGCCCCCGGAGCCACGTAGGCGGCGTCTCCAGCCACACGCCTGTCGGCGGGGCCGACAACCTCCTGGGCTCCCGAGGGACCACAGCCAGCAGCTCTGGGGACGCCCTCGGGAAGGCCTGGCCTCAATCTACTCTCCGGATCACTCAAGCAATAACTTGTGGTCCAGCCCCTCCACCGCCGTGGGCTCCCCCCAGGGCCTGGGAGGGACGTCGCACTAGCCTGGAGCAGGAGTCCCTGGTGCCTTATCACCCAGCTACGACGGGGGTCTCCACGGCCTGGAGAGTAAGATAGAAGACCACCTACCTGAACGAGGGCATCCACGTGCTCTGCAGCCACGCCATGGGCACGGCTAGCAACGTGCACACGCTGCTACCCGGCCACCGGGCGCTGGCCTTGGGCTTCGCCGGCCCCATGCTGCTGGTGGGGGCAGCACGCAGGCCTGGTTGGAGGCGAACACCCTGAGGACGGCCCTGCGGGCAGCGCCAGCCTCATGCACATCCATGTTGCCCTCTCCAGCTAGCCAGGCGCCCTCCCCGACCTCTCTTGGCCTTCCGACTCCTGCAGTGGGCTAGGGCGAGCAGGCCACTGGGGAAATCAAGCGAACACGTCGGCGGCTGACCACTCAAGAGGAGAAGAAGGAGCTGAAGGACCCCCGGGACCGGACCAGCCCAGACAAGGACGAGGAGGAAGATGACCTTTTCCCCCCAGAGCAGAAGGCCGAGTGGGAGAAGCAGGTGGCCAATAACGCCAGGGAGCGGCTGCGGGTCCCTTAAGAGGGCTCTTAAGGAGCTGGGGCGCATGTGGCAACTGCACCTCAACAGCGAGAAGCCCCAGACCAAACTCCTTATCCTGCACCAGGCCGTCTCGGTCATCCTGAATTTGGAGCAGCAAGTGCGAGAGCGGAACCTGAATCCCAAAACAGCCTGTTTGAAACGGCGAGAAGAGAAGGTGTCGCGCGTGTTCGGAGGCCCCCAGATGGTGCTTTCAGCTGCCCACCTGGGCTTGAGTGAAGCCCACAACCCCGCTGGGCACGTGTGAAAGGTACGCCTCCGTGGGACGAGCCACCCGCCCTCAGCCCCGTGGGCTGGGCCCAGAACGCCCACTTGAGGCCCTGGGCTTCATCCACATCCACACCTCACACAACTGTTGTCAGCATTGAGCCAACACCGACCTGATGAGGCTCAGAGTGATGGGGGCAAGGAAGGTGAGTGATGGGGGTGAGGAAGGTGACGCTGGGTCCAGGAGCTCCCTGGGACCCCGGCTCACCCCTCACTGCCCTCGCTCCCCCTGCCCCCGTATCTCAGCCACCATGTCACCCTGTGACCTGCCCCATGGACCCTGAAACTGCATCTTGGCCCTGTTGTCTGGGCTGGCAGGAGCCCAGTAAACAAAACCTGAATGCAAGCAACAAAACATACACTTTGTCAGAAAAGAAAAAAATGCCTTAACTATAAAATGTGGAGAAATCGTAACATATCACTTGAGGGAGATGcGTAATTTTTTTTAAGGAAAATAAAAAGAACATTAGTTA
>XM_011528219.2
gccgccCACGCGCGACCCTCGGGGGCCCGGCCGCGACGCACCTTTGTCCGGGGGGGGGCCCCCCCGCTTCATGCCGCCGCCCCCCCCCACGCGCCGCGTGCCCGGCCGCGCCCAGCAGGGTTTCCAGGCCTGAGGTGCCCGCCCTGGCCCCAGGAGAATGAACCAGCCGCAGAGGATGGCGCCTGTGGGCACAGACAAGGAGCTCAGTGACCTCCTGGACTTCAGCATGATGTTCCCGCTGCCTGTCACCAACGGGAAGGGCCGGCCCGCCTCCCTGGCCGGGGCGCAGTTCGGAGGTTCAGGTCTTGAGGACCGGCCCAGCTCAGGCTCCTGGGGCAGCGGCGACCAGAGCAGCTCCTCCTTTGACCCCAGCCGGACCTTCAGCGAGGGCACCCACTTCACTGAGTCGCACAGCAGCCTCTCTTCATCCACATTCCTGGGACCGGGACTCGGAGGTGAGTGCCTGGCCTGGTGCGGTCCCTCTGCTGTGCACAGATGTGCAGACGTGGGCCTTGGCATGGTCAGTGCACGCACAGCGCCAGGCAAGAGCGGTGAGCGGGGCGCCTATGCCTCCTTCGGGAGAGACGCAGGCGTGGGCGGCCTGACTCAGGCTGGCTTCCTGTCAGGCGAGCTGGCCCTCAACAGCCCCGGGCCCCTGTCCCCTTCGGGCATGAAGGGGACCTCCCAGTACTACCCCTCCTACTCCGGCAGCTCCCGGCGGAGAGCGGCAGACGGCAGCCTAGACACGCAGCCCAAGAAGGTCCGGAAGGTCCCGCCGGGTCTTCCATCCTCGGTGTACCCACCCAGCTCAGGTGAGGACTACGGCAGGGATGCCACCGCCTACCCGTCCGCCAAGACCCCCAGCAGCACCTATCCCGCCCCCTTCTACGTggcagATGGCAGCCTGCACCCCTCAGCCGAGCTCTGGAGTCCCCCGGGCCAGGCGGGCTTCGGGCCCATGCTGGGTGGGGGCTCATCCCCGCTGCCCCTCCCGCCCGGTAGCGGCCCGGTGGGCAGCAGTGGAAGCAGCAGCACGTTTGGTGGCCTGCACCAGCACGAGCGTATGGGCTACCAGCTGCATGGAGCAGAGGTGAACGGTGGGCTCCCATCTGCATCCTCCTTCTCCTCAGCCCCCGGAGCCACGTACGGCGGCGTCTCCAGCCACACGCCGCCTGTCAGCGGGGCCGACAGCCTCCTGGGCTCCCGAGGGACCACAGCTGGCAGCTCCGGGGATGCCCTCGGCAAAGCACTGGCCTCGATCTACTCCCCGGATCACTCAAGCAATAACTTCTCGTCCAGCCCTTCTACCCCCGTGGGCTCCCCCCAGGGCCTGGCAGGAACGTCACAGTGGCCTCGAGCAGGAGCCCCCGGTGCCTTATCGCCCAGCTACGACGGGGGTCTCCACGGCCTGAGTAAGATAGAAGACCACCTGGACGAGGCCATCCACGTGCTCCGCAGCCACGCCGTGGGCACAGCCGGCGACATGCACACGCTGCTGCCTGGCCACGGGGCGCTGGCCTCAGGTTTCACCGGCCCCATGTCACTGGGCGGGCGGCACGCAGGCCTGGTTGGAGGCAGCCACCCCGAGGACGGCCTCGCAGGCAGCACCAGCCTCATGCACAACCACGCGGCCCTCCCCAGCCAGCCAGGCACCCTCCCTGACCTGTCTCGGCCTCCCGACTCCTACAGTGGGCTAGGGCGAGCAGGTGCCACGGCGGCCGCCAGCGAGATCAAGCGggaggagaaggaggacgaggagAACACGTCAGCGGCTGACCACTCGGAGGAGGAGAAGAAGGAGCTGAAGGCCCCCCGGGCCCGGACCAGCCCAGACGAGGACGAGGACGACCTTCTCCCCCCAGAGCAGAAGGCCGAGCGGGAGAAGGAGCGCCGGGTGGCCAATAACGCCCGGGAGCGGCTGCGGGTCCGTGACATCAACGAGGCCTTTAAGGAGCTGGGGCGCATGTGCCAACTGCACCTCAACAGCGAGAAGCCCCAGACCAAACTGCTCATCCTGCACCAGGCTGTCTCGGTCATCCTGAACTTGGAGCAGCAAGTGCGAGAGCGGAACCTGAATCCCAAAGCAGCCTGTTTGAAACGGCGAGAAGAGGAAAAGGTGTCAGGTGTGGTTGGAGACCCCCAGATGGTGCTTTCAGCTCCCCACCCAGGCCTGAGCGAAGCCCACAACCCCGCCGGGCACATGTGAAAGGTATGCCTCCGTGGGACGAGCCACCCGCTTTCAGCCCTGTGCTCTGGCCCCAGAACGGCCACTCGAGACCCCGGGCTTCATCCACATCCACACCTCACACACCTGTTGTCAGCATCGAGCCAACACCAACCTGACAAGGTTCGGAGTGATGGGGGCGGCCAAGGTGACACTGGGTCCAGGAGCTCCCTGGGGCCCTGGCCTACCACTCACTGGCCTCGCTCCCCCTGTCCCCGAATCTCAGCCACCGTGTCACTCTGTGACCTGTCCCATGGATCCTGAAACTGCATCTTGGCCCTGTTGCCTGGGCTGACAGGAGCATTTTTTTTTTTTCCAGTAAACAAAACCTGAAAGCAAGCAACAAAACATACACTTTGTCAGAGAAGAAAAAAATGCCTTAACTATAAAAAGCGGAGAAATGGAAACATATCACTCAAGGGGGATGCTGTGGAAACCTGGCTTATTCTTCTAAAGCCACCAGCAAATTGTGCCTAAGCGAAATATTTTTTTTAAGGAAAATAAAAACATTAGTTACAAGATTTTTTTTTTCTTAATGTAGATGAAAATTAGCAAGGATGCTGCCTTTGGTCTCTGGTTTTTTTAAGCTTTTTTTGCATATGTTTTGTAAGCAACAAATTTTTTTGTATAAAAGTCCCGTGTCTCTCGCTATTTCTGCTGCTGTTCCTAGACTGAGCATTGCATTTCTTGATCAACCAGATGATTAAACGTTGTATTAAAAAGACCCCGTGTAAACCTGAGcccccccgtccccccccccccccGGAAGCCACTGCACACAGACAGAACGGGGACAGGCGGCGGGTCTTTTGTTTTTTTGATGTTGGGGGTTCTCTTGGTTTTGTCATGTGGAAAGTGATGCGTGGGCGTTCCCTGATGAAGGCACCTTGGGGCTTCCCTGCCGCATCCTCTCCCCTCAGGAAGGGGACTGACCTGGGCTTGGGGGAAGGGACGTCAGCAAGGTGGCTCTGACCCTCCCAGGTGACTCTGCCAAGCAGCTGTGGCCCCCAGGGCTACCCTACACAACGCCCTCCCCAGGCCCCCCTAAGCTGCTCTCCCTTGGAACCTGCACAGCTCTCTGAAATGGGGCATTTTGTTGGGACCAGTGACCCCTGGCATGGGGACCACACCCTGGAGCCCGGTGCTGGGGACCTCCTGGACACCCTGTCCTTCACTCCTTTGCCCCAGGGACCCAGGCTCATGCTCTGAACTCTGGCTGAGAGGATGCTGCTCAGGAGCCAGCACAGGACACCCCCCACCCCACCCCACCATGTCCCCATTACACCAGAGGGCCATCGTGACGTAGACAGGATGCCAGGGGCCTGGCCAGCCTCCCCCAATGCTGGGGAGCATCCCTGGGCCTGGGGCCACACCTGCTGCCCTCCCTCTGTGTGGTCCAAGGGCAAGAGTGGCTGGAGCCGGGGGACTGTGCTGGTCTGAGCCCCACGAAGGCCTTGGGCTGTGCGTCCGACCCTGCTGCAGAACCAGCAGGGTGTCCCCTCGGGCCCATCTGTGTCCCATGTCCCAGCACCCAGGCCTCTCTCCAGGTCTCCTTTTCTGGTCTTTTGCCATGagggtaaccagctcttcccagctggctggggactgtcttgggtttaaaactgcaagtctcctaccctgggatcccatccagttccacacgaactagggcagtggtcacTGTGGCACCCAGGTGTGGGCCTGGCTAGCTGGGGGCCTTCATGTGCCCTTCATGCCCCTCCCTGCATTGAGGCCTTGTGGACCCCTGGGCTGGCTGTGTTCATCCCCGCTGCAGGTCGGGCGTCTCCCCCCGTGCCACTCCTGAGACTCCCACCGTTACCCCCAGGAGATCCTGGACTGCCTGACTCCCCTCCCCAGACTGGCTTGGGAGCCTGGGCCCCATGGTAGATGCAAGGGAAACCTCAAGGCCAGCTCAATGCCTGGTATCTGCCCCCAGTCCAGGCCAGGCGGAGGGGAGGGGCTGTCCGGCTGCCTCTCCCTTCTCGGTGGCTTCCCCTACGCCCTGGGAGTTTGATCTCTTAAGGGAACTTGCCTCTCCCTCTTGTTTTGCTCCTGGCCCTGCCCCTAGGTCTGGGTGGGCAGTGGCCCCATAGCCTCTGGAACTGTGCGTTCTGCATAGAATTCAAACGAGATTCACCCAGCGCGAGGAGGAAGAAACAGCAGTTCCTGGGAACCACAATTATGGGGGGTGGGGGGTGTGATCTGAGTGCCTCAAGATGGTTTTCAAAAAAATTTTTTTAAAGAAAATAATTGTATACGTGTCAACACAGCTGGCTGGATGATTGGGACTTTAAAACGACCCTCTTTCAGGTGGATTCAGAGACCTGTCCTGTATATAACAGCACTGTAGCAATAAACGTGACATTTTATAACGAT

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