Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SKP1P8
Plot displaying the genomic locations of a retrocopy (in chr9) and its respective parental gene (in chr5). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr9:66879314-66879924  UCSC
Coordinates (T2T) chr9:78651441-78652051  UCSC
Coordinates (hg19) chr9:40812916-40813526  UCSC
Strand -
Parental Sequence NM_170679.3
Parental seq. overlap 525 bp
Parental seq. overlap (%) 5.6%
Genomic Region Intergenic
Retrocopy Summary SKP1P8, located on chr9:66879314-66879924, is a retrocopy of the parental gene SKP1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SKP1
Full Name S-phase kinase associated protein 1
Also known as EMC19|OCP-II|OCP2|SKP1A|TCEB1L|p19A
Coordinate chr5:134148935-134176950
Strand -
Gene summary This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Gorilla Gorilla gorilla SKP1P1
Orangutan Pongo abelii SKP1P6
Gibbon Nomascus leucogenys SKP1P5
Crab-eating macaque Macaca fascicularis SKP1P8
Rhesus Macaca mulatta SKP1P8
Baboon Papio anubis SKP1P7
Golden snub-nosed monkey Rhinopithecus roxellana SKP1P9
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SKP1P8
TGCAGAGTTCTGATGGAGAGATATTTGAAGTTGATTTGGAAATTGAGAAATAATCTGTGATTATCAAAACCATGTTGGAAGATTTTGAGTGGATGATGAATGATGAAGGATATGATGACCTAGTTCCTCTACCAAATATTAATGCAGCAGTGTTTAAAAAGGTCATTCAGTGGTGCACTCACCACAAGGACGACCCTCCTCCTCCCCAGGGTGATGAGAACAAAGAAAGGGGAACAGACCATACTCCTGTCTGGGATCAGGAATTCCTTAAAGTTGACCAAGGAGCACTTTTTAAACTTATTCTGGCTGCAGACTACTTAGACATCAAGTTTCCTTGATGTTACATACAGCACTCTTGCCAATATGATCAAGGGGAAAGCTCCTAAGGAAACTGACAAGTCCTTCAATATCAAAATGACTTTATGGAAGAGAAGGAAGCCGAGGTGCACTAAGAGAACTGTGGTGTGATGAGAAGCAAAATGTGTCTGACACTGTAACACTATAAAGACAGCTCCAAACACTAGTTGTACTGCTGTGCTTACAGTTTCTAATGTTAGACAAATGCAGCAGCAAATCAATTCTGTTAGCAGAATACTGTCATCATTGCATGA
>NM_170679.3
GCTGTAGTGGCTTCGTCTTCGGTTTTTCTCTTCCTTCGCTAAcgcctcccggctctcgtcagcctcccgccggccgtctccTTAACACCGAACACCATGCCTTCAATTAAGTTGCAGAGTTCTGATGGAGAGATATTTGAAGTTGATGTGGAAATTGCCAAACAATCTGTGACTATTAAGACCATGTTGGAAGATTTGGGAATGGATGATGAAGGAGATGATGACCCAGTTCCTCTACCAAATGTGAATGCAGCAATATTAAAAAAGGTCATTCAGTGGTGCACCCACCACAAGGATGACCCTCCTCCTCCTGAAGATGATGAGAACAAAGAAAAGCGAACAGATGATATCCCTGTTTGGGACCAAGAATTCCTGAAAGTTGACCAAGGAACACTTTTTGAACTCATTCTGGCTGCAAACTACTTAGACATCAAAGGTTTGCTTGATGTTACATGCAAGACTGTTGCCAATATGATCAAGGGGAAAACTCCTGAGGAGATTCGCAAGACCTTCAATATCAAAAATGACTTTACTGAAGAGGAGGAAGCCCAGGTACGCAAAGAGAACCAGTGGTGTGAAGAGAAGTGAAATGTTGTGCCTGACACTGTAACACTGTAAGGATTGTTCCAAATACTAGTTGCACTGCTCTGTTTATAATTGTTAATATTAGACAAACAGTAGACAAATGCAGCAGCAAGTCAATTGTATTAGCAGAATATTGTCCTCATTGCATGTGTAGTTTGAGCACAGATCCCAAACCTTACGGCCAAGTTTCTTCTAGTATGATGGAAAGTTTCTTTTTTCTTTGCTCTGAATAAAACTGAACTGTGGGTTCTCTATAAGTGGCATTTTGGGCTTTCCCTCTTTTTTGTAAAGCAATGTCTGCCTAGTTTATTGTCCAGTTAACTTTAGTGACCTTTTAAAAGTTGGCATTGTAAATAAAACAACTTGCAAAAAAGTTTTCTGGAATAGAATTAACAAAATATTATCTTTATTCATGAGTTGGAAACTGGAAAAAGGCTTCTTGAAGTAAATGTTCTGAGTGGAGCTACTAGGATGTCTTCCAGCCTCCTGCAGTCAAGGAGTACCACTGTATTGATTAGCCTGTATGTAGCAGGGCTCCCTTCATTGCATCTGAGGACTTGTTTTCTTTTTCTTTATTTTTAATCCTCTTAGTTTTAAATATATTGCCTAGAGACTCAGTTACTACCCAGTTTGTGGTTTTTTGGGAGAAATGTAACTGGACAGTTAGCTTTTCAATTAAAAAGACACTTAACCCATGTGGGATGTCATCTTTTTATAATTAGTGTTCCCATGTGGAGAAAATTATTCACACTACTTGCATGTAAAGAATAATTTAACTTTTAACATTAAAATATGTGGTAAAACCCAGAAAGCATCCATCATGAATGCAAGATACTTTCAATAAAAAGTAAGTTATATAGTAGGTAGTTAAGTTTGCTTTTGTGGACTTAAATGTGTCTCTTCACTTAAATGGGTTGAATGTGTATATATTTGTTCAGCTTGAAAAGACTTAGTTTATATCCTAGCTCACTGGAGGCTGCTGACATAACCATAACTTCTGTCCCTTCTAATTGTCATTTATATGCCTAACTGGAGCTAGTACTTTAATTCTTAACACAAAATTACTCTGCCATTGTTTCCAGCTTCCCTCCTACAATAGAATGAAGTTTTTTTGATGGCTTGAGATGGCTCACAAATTTTGATTTTTTTTTCTTCCTTGTGCTCCCTTTTTTTCTCCTTGCTTTTCCAGTTAACATCTATATTCACATGTAATCTTGTTTTCTCTTCACATTCACTGAGTTGTTCAGGCTCAGATCATCCCTTGACAGTAGTTTGCCTTCATCTCACCTTTCATTTGTCCCAAATTCACCTTATTTAATAAAGTCCCATATGTTGTCTCACTTAATTCCAATTTGTTGTCTGTACcagagataggaaactataatgtgtgggtcaaatcaggcccatagcctgtttttgtagtctttgagctaaaaatggtttttacgttgtaaagagttatttaaaATtctctctctctctctctctctctctcAGGAGATAAGCTTGTTTTCTGTTTGTCCTGGTTTTAGTGGGGAAGGTAGCGGTGTATAGTCCTAGCTGAATTGTCTCATCTACCAATTCCTGCTATTATAAGATCAACTTCTGCAAAAACCTTATCCACCTCAAGTATCCTTAGCAgctgggcatggtggcttatgcctgtaatctcaacattttgggaggacaagacaggaggatcgtttgagcccaggagttcaagaccagcctgggcaacacagaaagtccctgtctctccaaaaaaaaaaaaaaaaattagcagtcatatggtgcatgcctataatcccaactacttgagaggctgaggtgggaagatggcttgagcctgagaggtcgaggctgcagtgagctggcattgcaccactgcactccagtctaggcaatagagcgagaccttgtctcaaaaacaaaCCAGAAGTATCCTTAGCAGTATTATGACAAACAAATCTTCACTGAAGGTCCAGGATTACTGCCATATGCCATGTTTAACTTGTAAAGGAAGTATCACCTTCTAAGAAACTGGAGCTTGTTATTACCACTTGATCTGTATAATACTCAGCAGTAGTTAGAATTATATGAGTAAATAACGTCACTATCCGTATTTAAAGGATAATGAGATCTTTCAGAAAGATTGGATGGACAGACAATATAGTAGTAATTTAAATTTTTGTTTCCTGACTTTCTGTAGTCCCTAAACAAACAACAAAAAATCCTAGTAATCTTAAACTTTTACATTAATAGAGATCCAAGAGAAAATAAGCCATTTTTCACCATTGTGGACCCAAATAAATCATAGACATGGTATTAAGAAGCCCTTTTCAGTCTGGTTGCAGTATTATTTTCCTACCTTTCTTTTTCCTGTTCCCTGCTGTATGCCCACTATTCCTTTAATATATCTACTAGAACTTTTCTAGGCTTTCACCTGGAGTGAGTGGTCCTTTCTCATTATCACAGTAGCCAAACCTCAGTCTTCAAAACTCCACTCATTTCTGGCTACTCTCTTACTTCCCAACTATTCTTCTAAACTAATATTGTGGCATTAAGTCATACCTTGAGGCTGGAGTTTTAGTGTCTTCATGGCCTTGGGCAAGTTGGAAATAGGTACTACGGTTTTATAGATCTAGTGCAGTCTGCTTTATATTAGTTCCAGAACTTCATTGGAAGTCACTTGACAGCAGGATTTAACTTGTATTTAGCAGCACTACTCCATGAATTTCAGTATAAGTAACAGAAGTGAAAAGTCCTTGTGAAATGCAGGTACAGGGCATAATGAAAACAAGAAGAGTAGTTTTAATGCATGAGAGGGGAGAGCTTGATAATAGCTGATAATAGCCTTGGTTTGGAGAGTGGTTACTGATGAATTATGAAGACTTTCTCTAATTACTGTTATAGTAGTAAAGGAAAGAAAACCCTTGTTGATAAAGTAAACTTAGGGATTAATTAGGAAATGCCTTTTATTTCACCAGGAAAGAGAATGAGAGGAAGAAGGTATTTGGCAGATTTGGGTGATTGAAGGATGTTTGTCGGTTTCCTCTGTAAACAACATGCTGCTTTCTGCAGTGTGCTGCTTTTAATGATGAAGTCCTTTCAAGGACTCCATGGCAGTCCTTTGGCTTCTCACCTTTTCATTGATTATGTCACTTGTGATCTAAAAGTAAACCAAAACCTTCCTGAATGTTAGCTTATTATTTTCTCCTTAACATTGTCATAGGCTAAAGATGTGCCCCCTCAAATTCTAATAAtttttttttttttttttttttttttgagacagagtctcactctgtcgcccagactggaatgcagtggtgcgatctcagctcactgcaacctccgcctcctgggttcaagtgattctcctgcctcagcctcccgagtagctgggattacaggcacatgccaccatgcctggctaatttttttgtgtttttattagagatggagttttaccatattggccaggctggtcttgaactcctgaccttgtgatccgcccgccttagcctccgaaagtgctgaggttacacgtgtgacccaccgcacacggccCTAATAATTCTTAAGTTGTAGAAGCAAGTTACTCTTTTGAAGTGCCATGTGTTAGCTTGCCTTAATCTATTCTTGGTATACAAAATAGATACTGCTTTACAGTTCTTATATTTTCTCAGAGATTCACAAAATCATCCTGTAGCTCCCTGTGTGGGATTATAGCTGTGACTTTTTACTCTACAACTGTCAGAATACACCAGCTCCTGGAATTAAGCAAGAACTATATTGTGACTTGGTTGGACAGGTAACTGCAGCCTTGTAACATGACATCATAGTAATGCTGAGCTTATCTTAAAACTAGCTGGGGAGGGAGGATAGTAACAGTGAGTCACTGTGGGCATCTCACTTAGGGCAGGCAGATATTCCAAATCACATTGATTTTTCAGTTTACGTAAAAATTGACCAATCCTATGGGCTGTGTTCTGATCCCAACATAAATTTTGTTTAAGTTAATTTGCCTAGGCTCTCAATAAGGCAGTTTGGGAATATAAGGTGATTTTCCACCAGAAAAGAGAAAATTGAGAGAGCAGCAGACCTCTTGCTCTCAGCACCCTTTACAAGCTTAACTTTTGCTTGCCACCATTAGCTTTTGAAGATTTTTTTTAactgctccttgcagagcaggactaccccataggcagtgtgcccagagtagcCCGAAGAGCtttttgattcttcttttaagagacaaggtctcacctctgccccccaggctggagtgcagtgatgtgatcacagctcattgcagcctcgaactcttgggctccaacagtcctcctgcctcagcctcctgaatagctaggactacatgtgtgtgctaccatgccttgctagtttttgtttttttaaattgatttttatagagatgaggtctcctcatgttgcccaggctgttttcgaattcctgggctcaagatcctcctgcctcaacctcccaaagtgctggtattacagatgtgagccacagcacccACCAATTTTTCCTTTTCTAAAGCTCAGTGTACATTCTGGTAGGAAGGAATCAACCAAGTAAATGTTCTCCCTACAAAGTTGTTTGAGGATTTGAAAAGTTAATCTTCAATTATCTGGATTTGAAACCAGTCTATAACTTTTTAAGCTAGGAAGAAGTCAAGAATAAGAAGATTGCAAGCAAAGGGAAAGCTTACAAAATGGCTGAATCCTTAAAGTGTAGCTCCTGGCTTCTCCTTGGTAGGAAGCATTAGACATGGTTTCCCTCTAGGGAGCTGGGAGCTTTTGGTGTAGTTCAGGAGAGAAGGCATAAATACTGCTGGGAGGGAGTGGATAACTCTAATAAAAATGTTCCTGggctgggcacggtggctcacgcctgtaatcccaacattttcagaggctgaggtgtgcagatcacgaggtcaagagatcgagaccatcctggccaacatggtgaaacctcatctctactaaaaatacaaaaattagctgggcgtggtggcacatgcctgtagtcccagcaactcgggaggctgaggcaggagaaccgcttgaacccgggaggcggaagttgcagtgagccgacatcacgccactgactgcagtccagcctggcgacagagcgagactccgtttcaaaaaaaaaaaGTTTCTGGACAGAACAGATTAATGAGCCAATGGGGGGCTACAGAGCTGAAAGGTGCTACGAAAGGTTTTGTAAAGTGAAACTAATTTGGTTTCAAGAATCAAGTTGGATTTGTTTGGGGGTGGACAGATGCCAAAGTGAGGAAAAAGCAGTGCACAGTCAGGAACTAACAGCAGAAGGTTGGGTGTTGGTACATTTCCCTGAGAATATAGACTAAAGAGAAATTAGGGCAGGATTAGTCACAGTACTTTGCTGACACTCAGTAGTATTTTATCAGCATTTATTCATCAGACCCACATTAGGCAGGGCAATTTTTGAGTGAGCtaaattctaatttttttaattttaatttttatttatttattttttGGCTGTTCAACTAAACCAGTCTTTTGAATGTTGGGGGTTTTACAGTTAGAGTCCTGATGACTTTTTCTTGTTTACTGTTGTTAAAAATCACTACCTCCAGTGGTCACAGAGAATGAGTAAGAGAACTGGCTGTGCATATCAAGATGAAGTATGGTGTAAGAAATATTTCAGAGCATGTCCTTTGGCCCAAGATTGAGCCATTTGGACACCTAAGCAGGATTGGCTGAATGTTATCCTTTCTGCTGAGGCATCAGTGGAGATGATCATTAGTGGTGGCCGAAAAGTGTTGTCGAAGGTGCTCTTGCTTGACACACTTCCAATGCGGGACATAGTTTGAGTGATAGATGGCTAATTCATTGATAATGTACTTGTTGCCTTGCAGTCTTGTGTACTGCTGGCTACCTCTGGTCTGTGTGCCAGTATTGAGCAGCATTCTATGGGAGGAATGTAGTTGCTCATAACAGTGTCTGCTTCCACATCTGTAGTTCTTGCGACCTTCTGATATCTGTCAACTTTAAATTTTCTGGAAGTATTTAAGTATATTCAGACCTTCTGATATCTCTTAACTTCAAATTTTCAACCTGCTATATAGCAGCCTCTTATTGCACACTGAGGATCAGCTTATTTCCTTAAAGTGCTCTCACTTTGAATACCTCCCACCTATCTGGTGAAAATTCTTATTTGTCCTTTCTTTCCTGAATGTACCATTTCACAACCTCTAACTGCCTTCTTCAGTTGCTTTGCAGATTTTTCTGTTCCAGGAAGCTTACGGAAAGGGGTGGGAAAATAGAGAAGCTGTACTCTATCCTCAAGTACTCAAGCAGGGTTTCCAGAGTGGCTTTGTAAAAATTtttatttatttatttatttatttTTGGTGAGTGGAACCTGGCTTTTCCTCTTCCCTCCCCAAGCCCCACCCCGCTTCCTGACATTGCACATGCCTGAAAGAACTAGGCTTCAGATAAAAGAATGAGAACACTTGAATGAAAAAGGAAGACTTGGTCCAGAGCCCCTGGTGAATATGAAAGAAGTATTGGCCTGGACTATCTCCCGCATAATTCACAGCTGCTATCTTGTCTTCAGAAGTGAAACATCCCTTACCAATAGTGACCTAACTTGTGAGGACTGCTTGTGATAGTATAGTTCCCACCCCCAGGACATAAGTTTTCCCTTTCCAGTTAACATGCCTAATCCCATGCTATCTTTAAGAGCTTGAAAATCCTTCCTGACCTGAGCTAGGCTTTTATTCTAAGGGACTGTGTATGTGAACATCCCCACCATCTATGTTTCCTGTTTTCAAACTCGGTGCCGTTTTGAGTATTTTCAGATGCTCACTGCCAGTAATGGTTTGTTAGTAGCTCCAAACTATTAGAGAAGAGCTCAGGAGTCAGAATTTGAAAGATGCCCATAGGGTGATTTGAGATTTGGAACAAGGTTATCACAATAAGTTGGGATTGGGGGAGTTGACACAACCAGGGTCTGCTTGGGTGGGCAGCTGTTTCAGAAACCCTTGGTGAACTCTTAAAGCCCTGAAGAGCTTAAAAAATGCTCTGAAGAGATCTGAGAGTCGCAGTTAAGGACTCTCAAAGAACCTCAAAGAAAAGCCAACTTAGCCTTTTTATACAATTAACTAGATTTGGGTCTTAAATTCTACTTTGACATATAGGCCTAAGAGGTAGTTTAACATGGCCTTGTTACCCTTACCCCTTCTGTTCTGTGCTGTTTTCTGAGAAACGGATGCAGGAACTGATTCCCTTTCTTCCTCTCTGGAACAGGATATAAAGAACCCTTCCGCTTCCCTTTACTTGTGGCCTTCCTGGCCAGGCTTATGTATACTGAACAAAGCTAGGGTGCAGTGCTTCTGAGCTAGCTGTTAGGGGTCCACAGCCAGAAGGAATGGGAGACCACAGGAGCCATTCAAAAGATAATTACATGTCAGAAGAGAGTCCATCCATGGGGTTCTGTTAAAGTAGACACCTTCACGTTGGGAGACATAGGCTTTGTCTGCTTGCTGGGCTGAACCCTCACCATATCCACAGAGAACAAAATGGGGAGCAGCTGTACCAGGGGAGGGATGAACGTCTTTCACCCAAGTTGCCAGTCTGCTAGTTGTCTGGAAATGTTCAAGGGAGGCTAAGGTATCTTGTCTTATGATGTCTCAGGAAACAGGGTTGGTTCTCAGCTGGCAGTGAAGGGGGACTGGTGTGGTATTAGCAGTTGAACTTGAGGTTGCAATCTCAAGTCACCCTCTGGCCTCGCAGGAATGCACCAGGGTGATTTGGGAGGATCTGAGTTTCCTTTATGAAGTCAGATTAAAAAAAAAAAAAGCTGATCTGATTTAAACAGAGTTGCCAAAGACTTCCCCGCCAATACACAAAGACTGCATTGTTCAGGTACCCTGTGTACTCTAAGTGAGACACCAAATCAGATGCAGCAACCTGGTCTTGCATAAGCCCTGGTTAGAATGTAGGTTTTTTAAACAACTAGGCCAGTAGCCAGAACAGAATTCTTTAAAATGGGACAGATGTCCAGAGAATGGCTAGTGTCCTCTAGCACTCTCTCAGAAGCAAAAGCAAGTCTGGGGTTACAACTTCCAGTGGCCTACTTTAAATAGACGCTGTTCTGGAAAATGACTTTATACTTTAAACACAAAATCCAAAAAATAGAACTCAGTGGAGTGACAATGACAATGCATGATGGTGGCCCAGTGGCTGTCCCATGTGAAATACTTCTTGCCTGACATGTATCATCTACTTGTTGACTGACCTATTGAGGTGCCTTCATGACACCTTTTACATTCATGATAGGTCTCAGGAAGACAGCAGTGTACTTGGTGGAAACTCATGTAAAAAGTGGGTTGTAgggagctaaacagtgagtacacatggtatatggatacggaatggaataatagacattggagacttcaaaaggtgggagatgaaagggggatgaggtatgaaatcctacctgttgagtacaatgtacactacttacgtgcacagtacactgtttgggtgagaggcacactaaaagcccggacctcaccgctacccagtatgttcatgtaacacagctgcacttgtaccccctaaatgtatacaaataaTctaaaaatagcccggacctcaccgctacacaatatattcatgtaacacagctgcatttgtaccccctaaatgtatacaaataatctaaaaaTAAAGTGGATATGGTGGCTGTCGTGTCCACCAACAGCGTA

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