Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name DPP3P2
Plot displaying the genomic locations of a retrocopy (in chr9) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr9:73473959-73476077  UCSC
Coordinates (T2T) chr9:85625429-85627547  UCSC
Coordinates (hg19) chr9:76088875-76090993  UCSC
Strand -
Parental Sequence NM_005700.5
Parental seq. overlap 1211 bp
Parental seq. overlap (%) 39.1%
Genomic Region Intergenic
Retrocopy Summary DPP3P2, located on chr9:73473959-73476077, is a retrocopy of the parental gene DPP3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name DPP3
Full Name dipeptidyl peptidase 3
Also known as DPPIII
Coordinate chr11:66480434-66509657
Strand +
Gene summary This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2012]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes DPP3P2
Bonobo Pan paniscus DPP3P2
Gorilla Gorilla gorilla DPP3P2
Orangutan Pongo abelii DPP3P2
Green monkey Chlorocebus sabaeus DPP3P2
Crab-eating macaque Macaca fascicularis DPP3P2
Rhesus Macaca mulatta DPP3P2
Baboon Papio anubis LOC110742130P1
Golden snub-nosed monkey Rhinopithecus roxellana DPP3P2
Gibbon Nomascus leucogenys Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>DPP3P2
CACGTATTAATTTTATAACCTGGCAAATAAATATTAGAGACAACCACCAGCTTGGACCTTGGTACTACCTCAGCTGAGGGTGGTGACACAGCTGGTATCGGAGCATGAAGACCTGGGACAGCAAGTTCAGCACCATTGTCTCCAGCTACGAAGAGTGCCGGGCTGAGAGCGTGGGCCTCTACCTCTGTCTCCACCCGCAAGTGCTGGAGACCTTTGGCTTTGAGGGGGCTGATGCAGAGGAGGTGATCTCCGTGAACTGGCTCAACATGGTTGGGGCTGGGCTGCTCGCTCTGGAGTTCTACACACCTGAGGCCTCCAACTGGCAGCAGGCCCATATACGGGCCCGGATTGTGATCCTGAGAGTCTTACCAGAGGCTGGCGAGGGACTCGGTACCATCACTCCCACCGCAGGCTCCGATGGGCGCCCGGAAGCCCAGGTCCGTCTCGACCGCAGCAAGATCCAGTCTGTGGGCAACCCTGCCCTAGAGCGCTTCCTGCGGAGGTGCTGGTCCACAGGGGATGTGGCCGGAGGGTGGACCCTGTACGAGAGGTATGCAGCAGTCGCTGATGCGCCCCCTGAGGGCTTTCTCACCCTCAGGGACAGGGTGCTGCTGCGTAAGGAATCTTGGAAGCTCATCGTTCAGCCCAACATTCGCCTTGAAGGCTCAGACGTGCAGCTTCTGGAATACGAGGTCTCAGCTGCTGGCCTCATCAGATCCTTCTCTGAGCATTTCCCAGAGGATGGACTCGAGTTGGAGGACATCCTAACACAGCTGGCAACAGCCGATGCCCAATTCTGAAAGGGCCCCAGTGAGGCCCCATCTGGCCAGGCTTGTGGAAGAAGTGTGTGGCCTCTCCCCCAACTGCATCAAACCAAGGCTGCAAGTGGCCCTCCATTCGTGTTGTATTTAGAATCACCACCTATTTCTTTGGTAATTGTACCATGGAAGATGGCAAACTGGCCCAAGACTTTCTGGACTCACAGAACCTCAGTGCGTGTACAACACCTGGCTCTTCAAAGAGGTCGATGGAGAAGGGAAGCCCCACTACGAGGTGCAGCTGGCTTCTGTGCTCGGCACAGAGCCTTCCCTGGACTCCGAGGTGATTCCAAGCTGAAGAGCTAGGAATTCCGGGGAAGCCCTTTCCAGGTGACTTGGGGGAACTACATGCCCATCCTCCAGAAGGTGGTGGAGCAGCTGGAGAAAGCCAAGACGTATGCAGCCAACAGCCACCAGGAGCAAATGCTGGCCCAGTACATAGAGAGCTTCACCCAGGGCTCCACAGAGGCCCACAAGAAGGGGTCCCGCTTCTGGATCTAGGACAAAGGCCCCATCGTGGAGAGTTACATCGAGTTCATCCAGAGCTACCGTGACTCCTTTGGTTCCCGAGGAGTATGTGAAGGCTTCGTAGCCGTGGTGAACAAGGCCATGAGTGCCAAGTTTGAGTGGCTGGTGGTGAGCGCAGAGCAGCTGCTGAAGGAGTTGCCCTGGTCCCCAGCCTTTGAGAAAGACAAGTTCCTCACCCCTGACTTCACCTCCGTGGATGTTCTTACCTTCGCTGGCTCTGGCATCGCTGCCGGCATCAACATCTCCAACTACAATGACCTGAAGCAGACGGAAGGCTTTAAGAACGTGTCACTGGGGAACGTCCTGGCTGTGGTCTAAGCCACGCAGTGGGAGAAGCTCACCGTTCTGGAGGAGAGTGACAAGGACTTGTACATCGTCCTGATGGGGCCCTCCTTCGATGTACAGGTGGGCCTGCACGAACTGCTGGGCTATGGCAGCGGCAAGCTCATCGAGCAGGATGAAAAAGGAGCATt
>NM_005700.5
AAGTGAGTTTGCGAACGGAGCAGCTGCTGCAGGGCCCATGGCGGACACCCAGTACATCCTGCCCAATGACATCGGCGTGTCTAGCCTGGACTGCCGTGAGGCCTTCCGCCTGCTGTCACCCACAGAGCGCCTCTATGCCTACCACCTGTCCCGTGCCGCCTGGTACGGAGGCCTGGCTGTGCTGCTTCAGACCTCCCCTGAGGCCCCCTACATCTATGCTCTGCTCAGCCGCCTCTTCCGCGCCCAGGACCCCGACCAGCTGCGCCAACATGCCCTGGCTGAAGGCCTTACCGAGGAGGAGTATCAGGCGTTCCTGGTCTATGCCGCGGGTGTTTACTCCAACATGGGCAACTACAAGTCCTTTGGTGACACCAAGTTTGTTCCCAACTTGCCCAAGGAAAAGCTGGAACGGGTGATCCTAGGGAGTGAGGCTGCTCAGCAGCACCCAGAAGAAGTCAGGGGCCTCTGGCAGACCTGCGGGGAGCTTATGTTCTCTCTGGAGCCAAGGCTTCGACACCTCGGACTGGGGAAGGAGGGAATCACCACCTATTTCTCTGGGAATTGTACCATGGAAGATGCCAAATTGGCCCAGGACTTTCTGGACTCACAGAACCTCAGTGCCTACAACACCCGGCTCTTCAAAGAGGTCGATGGAGAAGGGAAGCCCTACTACGAGGTGCGGCTGGCTTCTGTGCTTGGCTCAGAGCCTTCCCTGGACTCTGAGGTGACTTCCAAGCTGAAGAGCTATGAATTCCGGGGAAGCCCTTTCCAGGTGACCCGGGGGGACTACGCGCCCATCCTCCAGAAGGTGGTGGAGCAGCTGGAGAAAGCCAAGGCCTATGCAGCCAACAGCCACCAGGGGCAGATGCTGGCCCAGTATATAGAGAGCTTCACCCAGGGCTCCATCGAGGCCCACAAGAGGGGCTCCCGCTTCTGGATCCAGGACAAAGGCCCCATCGTGGAGAGTTACATCGGGTTCATCGAGAGCTACCGCGACCCCTTTGGTTCCCGAGGAGAATTTGAAGGTTTCGTAGCTGTGGTGAACAAGGCCATGAGTGCCAAGTTTGAGCGGCTGGTGGCGAGCGCAGAGCAGCTGCTGAAGGAGCTGCCCTGGCCCCCAACCTTTGAGAAGGACAAGTTCCTCACCCCTGACTTCACCTCCCTGGATGTTCTCACCTTCGCTGGCTCCGGCATCCCTGCCGGCATCAACATCCCCAACTACGATGATCTGAGGCAGACGGAAGGCTTTAAGAACGTGTCGCTGGGGAATGTGCTGGCTGTGGCCTACGCCACGCAGCGGGAGAAGCTTACCTTTCTGGAGGAGGATGACAAGGACCTGTACATCCTCTGGAAGGGGCCCTCCTTCGATGTGCAGGTGGGCCTGCACGAGCTGCTGGGCCATGGCAGTGGCAAGCTCTTCGTACAGGACGAAAAAGGAGCATTCAACTTTGACCAGGAAACAGTGATCAACCCAGAGACGGGCGAGCAGATTCAGAGCTGGTATCGGAGCGGGGAGACCTGGGATAGCAAGTTCAGCACCATCGCCTCCAGCTACGAAGAGTGCCGGGCTGAGAGCGTGGGTCTCTACCTCTGTCTCCACCCGCAAGTGCTGGAGATCTTTGGCTTTGAGGGGGCTGATGCGGAGGACGTGATCTACGTGAACTGGCTCAACATGGTTCGGGCCGGGCTGCTCGCTCTGGAGTTCTACACACCTGAGGCCTTCAACTGGCGACAGGCCCATATGCAGGCCCGGTTTGTGATCCTGAGAGTCTTGCTGGAGGCTGGCGAGGGACTCGTTACCATCACTCCCACCACAGGCTCCGATGGGCGCCCAGATGCCCGGGTCCGCCTCGACCGCAGCAAGATCCGGTCTGTGGGCAAGCCTGCTCTAGAGCGCTTCCTGCGGAGACTTCAGGTGCTGAAGTCCACAGGGGATGTGGCCGGAGGGCGGGCCCTGTACGAGGGGTATGCAACAGTCACTGATGCGCCCCCCGAGTGCTTCCTCACCCTCAGGGACACGGTGCTGCTGCGTAAGGAATCTCGGAAGCTCATTGTTCAGCCCAACACTCGCCTTGAAGGCTCAGACGTGCAGCTTCTGGAATACGAGGCGTCAGCTGCTGGCCTCATCCGATCCTTCTCTGAGCGTTTCCCAGAGGATGGACCCGAGTTGGAGGAGATCCTCACACAGCTGGCCACAGCCGATGCCCGATTCTGGAAGGGCCCCAGTGAGGCCCCATCTGGCCAAGCTTGAGGAAGATGTGTGGCCTTGCCCCCAATTCCATCAGACCAAGGCTGCAAGTGGCCCTCCATTCGTGTGTGTATTTAGGGGCTGGGGAGGGGGAGGGGCAGGAGCTTGGACCTTGGTACTACCTCAGCTGAGGGTGGTGACacaaccccttccatttgtcagcactttccagcctgccaattgcttcccctctgtgatctcatttcatctgcactgccatacgtggagtgagcaagacagggcttaccatcctgtctaccagatgaggaaatggcagttctgagaagtcactggtctagatcccgcaggtggcacgtgacagctagggttcaaaacgttctcaccaaatccaatgctcctCACATATTAATTTTATAACCAGACAAATAAATATTAGAGACAACCACCA

Publications

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