Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name IL6RP1
Plot displaying the genomic locations of a retrocopy (in chr9) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr9:90081280-90082392  UCSC
Coordinates (T2T) chr9:102246381-102247493  UCSC
Coordinates (hg19) chr9:92843562-92844674  UCSC
Strand -
Parental Sequence NM_181359.3
Parental seq. overlap 926 bp
Parental seq. overlap (%) 16.3%
Genomic Region Intergenic
Retrocopy Summary IL6RP1, located on chr9:90081280-90082392, is a retrocopy of the parental gene IL6R. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name IL6R
Full Name interleukin 6 receptor
Also known as CD126|HIES5|IL-1Ra|IL-6R|IL-6R-1|IL-6RA|IL6Q|IL6QTL|IL6RA|IL6RQ|gp80
Coordinate chr1:154405343-154469450
Strand +
Gene summary This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been identified in this gene. A pseudogene of this gene is found on chromosome 9. [provided by RefSeq, Aug 2020]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes IL6RP1
Bonobo Pan paniscus IL6RP1
Gorilla Gorilla gorilla IL6RP1
Orangutan Pongo abelii IL6RP1
Gibbon Nomascus leucogenys IL6RP1
Green monkey Chlorocebus sabaeus IL6RP1
Crab-eating macaque Macaca fascicularis IL6RP1
Rhesus Macaca mulatta IL6RP1
Baboon Papio anubis IL6RP1
Golden snub-nosed monkey Rhinopithecus roxellana IL6RP1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>IL6RP1
GCAGGCTCACGCCCCAGCAGATGGGCTGGTGTGGGAAGGAGGCTGCTTCTGAGGTTGGTGCAGCTCTGCGACTCTGGAAACTATTCTTGCTGCCGGGCTGGCTGCCCAGCAGGTCTGTGCTTTGTTGGTGGATGTTTCTCCTGAGGAGCCTCAGCTCTCCTGCTTCTGGAAGAGCCCCCTCAGTGACATTGGTTGTGAATAGAGTCCTTGGAGTCAAGGTTCTGAGTCAAAGCTGTGCTATTGCTGAGAAAGTTTCAGAACTGTCAGGCAGAACTCTTCCAGGAGCCGTGTCAGTATTCTCAGGAGTCCCAGAAGTTCTGCCAGTTGGCAGTGCCAGAGGGAGATTACTCTTTCTATACAGTGTCCCTGTGTGTCACCAACAGTATTGGGAGCAAGTTCAGCAAAACCCAAATATTAGAGGGTTATGGAATCCTGCAGTCCGACCCACCTGTCAACATCACAGTCATTGCTGTGGCCAGAAAGCCCTGCTGGCTCAACGTCACCTAGCAAGACCCCCACTCCTGGAACTTATATTTCTACAGACTATGGTTTGAGCTTTGATACCTGGCTAAATAGTCAAAAATGTTCATAACATGGATGGCCAAGGATCTCCAACATCAGTGTGTCATTCACAACACCTGGAAAGGCATGAGGCACCAGACACAGCTTCAGGCCCAGGAGGAGCTGGGGCAAGGCTTGTGAAGTAAGTGGAGCCCAGAGGTCATGGGAATCCTTTGGGCAGACTCCAGGAGTCCTCCAGCTGAGACCACCTCCATGCAAACACCTACTACTAATAAAGATGATGATAATATTCTCCCCAGAGATTCTGCAAATGCAACAAGCTTTCTGGGTTAAAGAAGACGTGGAAGTTGCAGGGTCTGAAAGAAGATAAGATCAGGATGCACTGGTTGTGTTCTTTGGGGTGGCTGGTCCTAGAGAGACCTAGAACCACCCCAGTGCTTGTTCCTCTCATCTCCCTTCAGTGTCCCCCAGCAGCCTTGGAATGGACACCACCCCCAGCCACGGCTGACCAGATGCCAGGGACCCGTGGAGGCCTTATGACATCAGCAATAGAGATTACTTCTTCCCCATATAGCAGGCCAGGTGGCACCT
>NM_181359.3
AAATGTTTTCCTGCGTTGCCAGGACCGTCCGCCGCTCTGAGTCATGTGCGAGTGGGAAGTCGCACTGACACTGAGCCGGGCCAGAGGGAGAGGAGCCGAGCGCGGCGCGGGGCCGAGGGACTCGCAGTGTGTGTAGAGAGCCGGGCTCCTGCGGATGGGGGCTGCCCCCGGGGCCTGAGcccgcctgcccgcccaccgccccgccccgcccctgccacccctgccGCCCGGTTCCCATTAGCCTGTCCGCCTCTGCGGGACCATGGAGTGGTAGCCGAGGAGGAAGCATGCTGGCCGTCGGCTGCGCGCTGCTGGCTGCCCTGCTGGCCGCGCCGGGAGCGGCGCTGGCCCCAAGGCGCTGCCCTGCGCAGGAGGTGGCGAGAGGCGTGCTGACCAGTCTGCCAGGAGACAGCGTGACTCTGACCTGCCCGGGGGTAGAGCCGGAAGACAATGCCACTGTTCACTGGGTGCTCAGGAAGCCGGCTGCAGGCTCCCACCCCAGCAGATGGGCTGGCATGGGAAGGAGGCTGCTGCTGAGGTCGGTGCAGCTCCACGACTCTGGAAACTATTCATGCTACCGGGCCGGCCGCCCAGCTGGGACTGTGCACTTGCTGGTGGATGTTCCCCCCGAGGAGCCCCAGCTCTCCTGCTTCCGGAAGAGCCCCCTCAGCAATGTTGTTTGTGAGTGGGGTCCTCGGAGCACCCCATCCCTGACGACAAAGGCTGTGCTCTTGGTGAGGAAGTTTCAGAACAGTCCGGCCGAAGACTTCCAGGAGCCGTGCCAGTATTCCCAGGAGTCCCAGAAGTTCTCCTGCCAGTTAGCAGTCCCGGAGGGAGACAGCTCTTTCTACATAGTGTCCATGTGCGTCGCCAGTAGTGTCGGGAGCAAGTTCAGCAAAACTCAAACCTTTCAGGGTTGTGGAATCTTGCAGCCTGATCCGCCTGCCAACATCACAGTCACTGCCGTGGCCAGAAACCCCCGCTGGCTCAGTGTCACCTGGCAAGACCCCCACTCCTGGAACTCATCTTTCTACAGACTACGGTTTGAGCTCAGATATCGGGCTGAACGGTCAAAGACATTCACAACATGGATGGTCAAGGACCTCCAGCATCACTGTGTCATCCACGACGCCTGGAGCGGCCTGAGGCACGTGGTGCAGCTTCGTGCCCAGGAGGAGTTCGGGCAAGGCGAGTGGAGCGAGTGGAGCCCGGAGGCCATGGGCACGCCTTGGACAGAATCCAGGAGTCCTCCAGCTGAGAACGAGGTGTCCACCCCCATGCAGGCACTTACTACTAATAAAGACGATGATAATATTCTCTTCAGAGATTCTGCAAATGCGACAAGCCTCCCAGGTTCAAGAAGACGTGGAAGCTGCGGGCTCTGAAGGAAGGCAAGACAAGCATGCATCCGCCGTACTCTTTGGGGCAGCTGGTCCCGGAGAGGCCTCGACCCACCCCAGTGCTTGTTCCTCTCATCTCCCCACCGGTGTCCCCCAGCAGCCTGGGGTCTGACAATACCTCGAGCCACAACCGACCAGATGCCAGGGACCCACGGAGCCCTTATGACATCAGCAATACAGACTACTTCTTCCCCAGATAGCTGGCTGGGTGGCACCAGCAGCCTGGACCCTGTGGATGATAAAACACAAACGGGCTCAGCAAAAGATGCTTCTCACTGCCATGCCAGCTTATCTCAGGGGTGTGCGGCCTTTGGCTTCACGGAAGAGCCTTGCGGAAGGTTCTACGCCAGGGGAAAATCAGCCTGCTCCAGCTGTTCAGCTGGTTGAGGTTTCAAACCTCCCTTTCCAAATGCCCAGCTTAAAGGGGCTAGAGTGAACTTGGGCCACTGTGAAGAGAACCATATCAAGACTCTTTGGACACTCACACGGACACTCAAAAGCTGGGCAGGTTGGTGGGGGCCTCGGTGTGGAGAAGCGGCTGGCAGCCCACCCCTCAACACCTCTGCACAAGCTGCACCCTCAGGCAGGTGGGATGGATTTCCAGCCAAAGCCTCCTCCAGCCGCCATGCTCCTGGCCCACTGCATCGTTTCATCTTCCAACTCAAACTCTTAAAACCCAAGTGCCTTAGCAAATTCTGTTTTTCTAGGCCTGGGGACGGCTTTTACTTAAACCGCCAAGGCTGGGGGAAGAAGCTCTCTCCTCCCTTTCTTCCCTACAGTTGAAAAACAGCTGAGGGTGAGTGGGTGAATAATACAGTATCTCAGGGCCTGGTCGTTTTCAACAGAATTATAATTAGTTCCTCATTAGCATTTTGCTAAATGTGAATGATGATCCTAGGCATTTGCTGAATACAGAGGCAACTGCATTGGCTTTGGGTTGCAGGACCTCAGGTgagaagcagaggaaggagaggagaggGGCACAGGGTCTCTACCATCCCCTGTAGAGTGGGAGCTGAGTGGGGGATCACAGCCTCTGAAAACCAATGTTCTCTCTTCTCCACCTCCCACAAAGGAGAGCTAGCAGCAGGGAGGGCTTCTGCCATTTCTGAGATCAAAACGGTTTTACTGCAGCTTTGTTTGTTGTCAGCTGAACCTGGGTAACTAGGGAAGATAATATTAAGGAAGACAATGTGAAAAGAAAAATGAGCCTGGCAAGAATGTGTTTAAACTTGGTTTTTAAAAAACTGCTGACTGTTTTCTCTTGAGAGGGTGGAATATCCAATATTCGCTGTGTCAGCATAGAAGTAACTTACTTAGGTGTGGGGGAAGCACCATAACTTTGTTTAGCCCAAAACCAAGTCAAGTGAAAAAGGAGGAAGAGAAAAAATATTTTCCTgccaggcatggtggcccacgcacttcgggaggtcgaggcaggaggatcacttgagtccagaagtttgagatcagcctgggcaatgtgataaaaccccatctctacaaaaagcataaaaattagccaagtgtggtagagtgtgcctgaagtcccagatacttggggggctgaggtgggaggatctcttgagcctgggaggtcaaggctgcagtgagccgagattgcaccactgcactccagcctgggtgacagagcaagtgagaccctgtctcaaaaaaagaaaaagaaaaagaaaaaaTATTTTCCCTATTAGAGAAGAGATTGTGGTTTCATTCTGTATTTTGTTTTTGTCTTAAAAAGTGGAAAAATAGCCTGCCTCTTCTCTACTCTAGGGAAAAACCAGCGTGTGACTACTCCCCCAGGTGGTTATGGAGAGGGTGTCCGGTCCCTGTCCCAGTGCCGAGAAGGAAGCCTCCCACGACTGCCCGGCAGGGTCCTAGAAATTCCCCACCCTGAAAGCCCTGAGCTTTCTGCTATCAAAGAGGTTTTAAAAAAATCCCATTTAAAAAAAATCCCTTACCTCGGTGCCTTCCTCTTTTTATTTAGTTCCTTGAGTTGATTCAGCTCTGCAAGAATTGAAGCAGGACTAAATGTCTAGTTGTAACACCATGATTAACCACTTCAGCTGACTTTTCTGTCCGAGCTTTGAAAATTCAGTGGTGTTAGTGGTTACCCAGTTAGCTCTCAAGTTATCAGGGTATTCCAGAGTGGGGATATGATTTAAATCAGCCGTGTAACCATGGACCCAATATTTACCAGACCACAAAACTTTTCTAATACTCTACCCTCTTAGAAAAACCACCACCATCACCAGACAGGTGCGAAAGGATGAAAGTGACCATGTTTTGTTTACGGTTTTCCAGGTTTAAGCTGTTACTGTCTTCAGTAAGCCGTGATTTTCATTGCTGGGCTTGTCTGTAGATTTTAGACCCTATTGCTGCTTGAGGCAACTCATCTTAGGTTGGCAAAAAGGCAGGATggccgggcgcggtggctcacgcctgtaatcctagcactttgggaggccaaggtgggaggattgcttgagctcaggagtttgagaccaacctgggtaacatagtgagacaccatctctaTTATGAACAATAACAGTTAAGAAAAAAAAAGGCAGGCAGGCGGTTATGGTGGTTCCCTCCCATCCCACCACATAAAGTTTCTGAGACTTGAGAACAGCAAAATGCTGTTAAAGGGAAATATTAAGAATGAGAATCTGCAGTAAGGGTGATTCTGTGCCCACAGTTCTTCAATTCTTTATACCGTTTTACCCACATGTGGTGTTACCAAAGCCGGGCAGAACCATGCTAGCGGAAGATGTGAAATCCAGATAGCTCATTATTGCCAAGAGCTAGGCAGCTTTGATCTCCAAAttgttattgctttcatttttattgtaatggaattgctttgttttgtttttttgtttttgtattgAAGAGGGTTGTTTTCCCTTTATTTTTCATAAGCTAATGTAAATGAAGAAAAAATGTCTTCTCTGGGCTGTAGGCCTGGCTCAGCGTACACAGGTATACATCCTAAGCTCTCTATGTTCTCTAATCTGTGGTGACTGAACATGTGTCTCAATGCACGGGGCATTTCTACCTGTGTTTCTGCAGCACCCCCACTGCCTTGAGTCCCCAGCAGTGCTGTTATTTGCCTAACACCTGTAGCCATCTGCCACGCAGCCAGACGTGAAACGCTGAGACAGAGACCATTTAGGTTAAATACGACAGCTTATCCTGCTGGGTGGGGAAAGTAAAAAATATGCTGGTTCAAGGCCTAAAGTAAAATGATCAATAATGTTTGTAGCATTAATGAAATATTTTCAAGAAATGTGTCCAGGGGTAGCACTGGCTATGTTGACGAGGCCTTTGGTAACTCAGAGAGCTCTTGGCCCTGATGGGGACTTGCCCTTACGCTTTCTTTATCAGGCTCTGAGTTCACACGGAGCCTCTGGCACTTCCCTGCTGTCTTGGGAGAAAGGAAACTGGTTGCCGCGGCAGGTTGTGGAATCTGTTGCTGGAACCAGGCTGGAAGCCCACCTGGTAGTGAACAGGGCCCAGTGGGGCAGGCTGGGCATGTTGTGGTCTATGGGTTTGTTTCCTGGAGAATGTTCAGGAATGTCTTCCCAGCTGCTTTGGTGCTGAGCTCTATTATCTCACAGCACGTCCAGAAGGCTAACCCAGGTGGGGAGGATGCTGACACCAGCTCCAGGTGGAGTTGGTGGTCTTAATTTGGAGATGCAGGGGCAACCTGTGACCCTTTGAGGCAAGAGCCCTGCACCCAGCTGTCCCGTGCAGCCGTGGGCAGGGGCTGCACACGGAGGGGCAGGCGGGCCAGTTCAGGGTCCGTGCCAGGCCCTCCTCAGTGCCCTGTGAAGGCCTCCTGTCCTCCGTGCGGCTGGGCACCAGCACCAGGGAGTTTCTATGGCAACCTTAGTGATTATTAAGGAACACTGTCAGTTTTATGAACATATGCTCAAATGAAATTCTACTTTAGGAGGAAAGGATTGGAACAGCATGTCACAAGGCTGTTAATTAACAGAGAGACCTTATTGGATGGAGATCACATCTGTTAAATAGAATACCTCAACTCTACGTTGTTTTCTTGGAGATAAATAATAGTTTCAAGTTTTTGTTTGTTTGTTTTACCTAATTACCTGAAAGCAAATACCAAAGGCTGATGTCTGTATATGGGGCAAAGGGTCAGTATATTTTTCAGTGTTTTTTTTTCTACCAGCTATTTTGCATTTAAAGTGAACATTGTGTTTGGAATAAATACTCTTAAAAAATA

Publications

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