Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Advanced Search

Summary

Retrocopy Name DNAJA1P3
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr9). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:107350559-107352974  UCSC
Coordinates (T2T) chrX:105786905-105789326  UCSC
Coordinates (hg19) chrX:106593789-106596204  UCSC
Strand -
Parental Sequence NM_001539.4
Parental seq. overlap 1842 bp
Parental seq. overlap (%) 68.2%
Genomic Region Intergenic
Retrocopy Summary DNAJA1P3, located on chrX:107350559-107352974, is a retrocopy of the parental gene DNAJA1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name DNAJA1
Full Name DnaJ heat shock protein family (Hsp40) member A1
Also known as DJ-2|DjA1|HDJ2|HSDJ|HSJ-2|HSJ2|HSPF4|NEDD7|hDJ-2
Coordinate chr9:33025273-33039907
Strand +
Gene summary This gene encodes a member of the DnaJ family of proteins, which act as heat shock protein 70 cochaperones. Heat shock proteins facilitate protein folding, trafficking, prevention of aggregation, and proteolytic degradation. Members of this family are characterized by a highly conserved N-terminal J domain, a glycine/phenylalanine-rich region, four CxxCxGxG zinc finger repeats, and a C-terminal substrate-binding domain. The J domain mediates the interaction with heat shock protein 70 to recruit substrates and regulate ATP hydrolysis activity. In humans, this gene has been implicated in positive regulation of virus replication through co-option by the influenza A virus. Several pseudogenes of this gene are found on other chromosomes. [provided by RefSeq, Sep 2015]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes DNAJA1P6
Bonobo Pan paniscus DNAJA1P6
Gorilla Gorilla gorilla DNAJA1P6
Orangutan Pongo abelii DNAJA1P7
Gibbon Nomascus leucogenys DNAJA1P7
Green monkey Chlorocebus sabaeus DNAJA1P8
Crab-eating macaque Macaca fascicularis DNAJA1P6
Rhesus Macaca mulatta DNAJA1P6
Baboon Papio anubis DNAJA1P8
Golden snub-nosed monkey Rhinopithecus roxellana DNAJA1P5
Marmoset Callithrix jacchus DNAJA1P17
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>DNAJA1P3
CTTGACCAGTATTTGTTATTTGCACCCCTTCTTGTCTGTGGACCATGATAAACCTGAGTAGTGACTTCAGAGCTGGGTAATGTAGAAATTAAAATGAAAAGAACTTTACATGGAGAAATAATTTGTATGGGTAATATAGGAAGGTATTCTTTAGGTATGTTACAGGATTACTTTAAACCATTTGACTTATGCTCCAAAGTAACTAATGTTGTTAGCATAGCAAATTATGATGAATAGCTTTAACTGTATGTTTAAAAGTCTCATCATATGTTTACATGCTTAAATCTGGGTATCAGAATTTAAGCAATTCTTGAAATGTATTGTCTCCTTAATATACTAATTACAAAGCAAGGAATTTTCCAGAATGCTCCGTGAGAGGCAGGAGGCAGAGAAGTGGTAGCTGCCCAAGCTGCACACATCTCCGGGCTCCTTCCTGCTCCCTCACACACTGGCCTCAGCCTGCTCACCGGCAGAAGATGGTGGATGGTGAAAGAAACCACTTACTATGATGTTTTGGGGGTCAAACCCAATCAATGCTACTCAGGAAGAATTGAAAAAGGCTTATAGGAAACTGGCCTTGAGGTACCATCCTGATAAGAATCCAAATGAAGGGGAGAAGTTAAACAGATTTCTCAAGCATATGAAGTTCTCTCTGATGCAAAGAAAAGGGAATTAATTATATGACAAAGGAGGAGAACAGACAATTAAAGAGGATGGAGCAGGTGGCGGTTTTGGCTCCCCCATGGACATCTTTGATATGTTTTTTTGGAGGAGGAGGAAGGATGCACAGAGAAAGGAGAGGTAAAAATGTTGTACATCAGCTCTCAGTAACCCTAGAAGACTTATATAATAGTGCAACAAGAAAACTGGCTCTGCAAAAGAATGCAATTTGTGACAAATGTGAAGATAGAGGAGGTAAGAAAGGAGGAGTAGAGTACTGTCCCAATTGCCGAGGTACTGGAATGCAAATAAGAATTCATCAGATAGGACCTGGAAAGGTTCAGCAAATTCAGTCTGTGTGCGTGGAGTGCCAGGGCCATGGGGAGCAGATCAGTCCTAAAGATAGATGTGAAAGCTGCAATGGAAGGAAGATACTTCGAGAGAAGAAGATTCTAGAATTTCATATTGACAAAGGCATGAAATATGGCCAGAAGATAACATTCCATGGTGAAGGATACCAAGAACCAGGACTGGAGGGAGAAGATATTATCATTGTGTTAGATCAGAAGGACGATGCTGTTTTTACTCGACAAGGAGAAGACCTTTTCATGTGTATGGACATACAGCTGGTTGAAGCATTCCAGAAGCCAATATCTACTCTTGACAACTGAACCATAGTCATCACCTCTCATCCAGGTCAGATTGTCAAGCATGGAGATATCAAGTGTGTAATAAATGAAGGAATGCCAATTTATCCTAGGCCATATGAAAAGGGTCGCCTAATCATTGAATTCAAGGTAAACTTGCCTGAGAATGACTTTCTCTCTCCTGATAAACTGTCTTTGCTGGAAAAACTCCTACCCAAGAGGAAGGAAGTGGAAGAAACTGATGAGATGGATCAAGTAGAACTGGTGGACTTTGATCCAAATCAGGAAAGATGGCACCATTACAATGGAGAAGCATATGAGGATGATGAACATCATCCCAGAGGTGGTGTTCGGTGTCAGACCTCTTAATGGGCCAGTGAATAACACCCACTGGTGGCATTTTATGTGCAGTAGTAAATGAGTGAAGGACTGTGATCATAACATGCTCACTACTTGCTCTTGTTTTTGTTTAATATTCAACTATAGTAGTGTTTTAAAAAGTTAAATGAAGAATAAATGCAAATGTAAAAGCTCTGACTTTGCCCTGTATGTATGATGACTTCGGTGTGCAAGATGAAGTTTAATACCTGTAAAGACTACTTTACAAAGAAGTTCCCCTAGCATTTATAGGCCAAACCTTGTAATTGACTTCAGCTATGTATGTGGACAAGCTTAGACTGAAATGCTAGGTATGTGTATTGGCTTCAGTGTATGACCCTTCATTGTTAAGCTATGAAAGTAAAACTCTGTATTTAACTGGCAATGAGGAAAAAAAAATATGTAGAGAAGTTTTGATCTGTATAGTTCTTTGTGTTAAGTGGGATTCATTGTAATGCCTCTGCATTTATTCTATTGCCTCAGCTGTTACTTGAAGATGGCATAATATATAATTTGTCCTGTGGCATCAGTGATAAAAATGATACCTTTCTGTAGGAGAGGATTATCATAATAATGCTGCTTCTTGAAGGCTTGCACTTCCAGAATTGTGTTTCCTTCTGCTGTGCCATCCa
>NM_001539.4
GCGGAACTTTCCAGAACGCTCGGTGAGAGGCGGAGGAGCGGTAACTACCCCGGCTGCGCACAGCTCGGCGCTCCTTCCCGCTCCCTCACACACCGGCCTCAGCCCGCACCGGCAGTAGAAGATGGTGAAAGAAACAACTTACTACGATGTTTTGGGGGTCAAACCCAATGCTACTCAGGAAGAATTGAAAAAGGCTTATAGGAAACTGGCTTTGAAGTACCATCCTGATAAGAACCCAAATGAAGGAGAGAAGTTTAAACAGATTTCTCAAGCTTACGAAGTTCTCTCTGATGCAAAGAAAAGGGAATTATATGACAAAGGAGGAGAACAGGCAATTAAAGAGGGTGGAGCAGGTGGCGGTTTTGGCTCCCCCATGGACATCTTTGATATGTTTTTTGGAGGAGGAGGAAGGATGCAGAGAGAAAGGAGAGGTAAAAATGTTGTACATCAGCTCTCAGTAACCCTAGAAGACTTATATAATGGTGCAACAAGAAAACTGGCTCTGCAAAAGAATGTGATTTGTGACAAATGTGAAGGTAGAGGAGGTAAGAAAGGAGCAGTAGAGTGCTGTCCCAATTGCCGAGGTACTGGAATGCAAATAAGAATTCATCAGATAGGACCTGGAATGGTTCAGCAAATTCAGTCTGTGTGCATGGAGTGCCAGGGCCATGGGGAGCGGATCAGTCCTAAAGATAGATGTAAAAGCTGCAACGGAAGGAAGATAGTTCGAGAGAAGAAAATTTTAGAAGTTCATATTGACAAAGGCATGAAAGATGGCCAGAAGATAACATTCCATGGTGAAGGAGACCAAGAACCAGGACTGGAGCCAGGCGATATTATCATTGTGTTAGATCAGAAGGACCATGCTGTTTTTACTCGACGAGGAGAAGACCTTTTCATGTGTATGGACATACAGCTCGTTGAAGCACTGTGTGGCTTCCAGAAGCCAATATCTACTCTTGACAACCGAACCATCGTCATCACCTCTCATCCAGGTCAGATTGTCAAGCATGGAGATATCAAGTGTGTACTAAATGAAGGCATGCCAATTTATCGTAGACCATATGAAAAGGGTCGCCTAATCATCGAATTTAAGGTAAACTTTCCTGAGAATGGCTTTCTCTCTCCTGATAAACTGTCTTTGCTGGAAAAACTCCTACCCGAGAGGAAGGAAGTGGAAGAGACTGATGAGATGGACCAAGTAGAACTGGTGGACTTTGATCCAAATCAGGAAAGACGGCGCCACTACAATGGAGAAGCATATGAGGATGATGAACATCATCCCAGAGGTGGTGTTCAGTGTCAGACCTCTTAATGGGCCAGTGAATAACACTCACTGCTGGCATTTAATGTGCAGTAGTGAATGAGTGAAGGACTGTAATCATAATATGCTCACTACTTGCTCTTGTTTTTGTTTTAATAAACTATAGTAGTGTTTTAAAAAGTTAAATGAAGAATAAACGCAAATATAAAAGCTCTGATTTTGCCCTGTATGTATGATGACTTCAGTGTGCAAGATGAAGTTTAATACCTGTAAAAACTACAAAGAAGTTCCCCTAGCATTTCTAGGCCAAACCTTGTAATTGACTTCAGCTATGTACGTGGACAAGCTTAGACTGAAATGCTAGGTATATGTATTGGCTTCAGTGTATGACCCTTCATTGTTAAGCTATGAAAGTAAAACTCTGTATTTAACTGGCAATGAGGAAAAAAAAATTTTGTAGAGAAGTGTTGGTCTGTATAGTTCTTTATATTAAGTGGGATTCATTGTAATGCCTCTGCATTTATTCTGTTGCCTCAGCTGTTACTTGAAGATGGCGTAATATATAATTTATCCTGTGGTATCAGTGATAAAAATGATACCTTTCTGTAGGAGGGGTTTATCATAATATGCTGCTTCTTGAAGGCTTGCACTTCCAGAATTGTGTTTCCTTCTGCTGTGCCATTCatatatatatacatatatatatataATCTTGACCAGTCCTGGTCATTTGCTCCCCTCCTTGTCTGTGGACCATGATAAGCCCAAGTAGTGACTTCAGAGCTGGGTAACAGAAATTAAAGTGAAAAGACCTTTACGTGGAGAATTTGCATGCGTAATATAGGAAGGTGTTCTTTAGGTATGTTACAGGATTACTTTAAACCATTTGACTTTCGCTCCAAAGTTATGTTGGTAGTATAGCAAATTATGATGAATAGCTTTAATTGTATGTTTAAAAGTCTCATATGTTCACATGCTTAAATCTGGGTATCAGAATTTAAGCAATTCTTGAAATGTATTGTCTCCTTAATATACTAATTACAAAGCATCTCCAA

Publications

PMID - Link Title