Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name M6PRP1
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:110636883-110637888  UCSC
Coordinates (T2T) chrX:109084797-109085802  UCSC
Coordinates (hg19) chrX:109880111-109881116  UCSC
Strand +
Parental Sequence NM_001207024.2
Parental seq. overlap 618 bp
Parental seq. overlap (%) 25.1%
Genomic Region Intergenic
Retrocopy Summary M6PRP1, located on chrX:110636883-110637888, is a retrocopy of the parental gene M6PR. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name M6PR
Full Name mannose-6-phosphate receptor, cation dependent
Also known as CD-M6PR|CD-MPR|MPR 46|MPR-46|MPR46|SMPR
Coordinate chr12:8940361-8949645
Strand -
Gene summary This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes M6PRP1
Bonobo Pan paniscus M6PRP1
Gorilla Gorilla gorilla M6PRP1
Orangutan Pongo abelii M6PRP1
Gibbon Nomascus leucogenys M6PRP2
Golden snub-nosed monkey Rhinopithecus roxellana M6PRP1
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>M6PRP1
GCTACTCCTGGCTGTGGCAGAAAGACAGTGCTGTCACACCAAAGAAAAAACCTGTGACCTGGTAGAGAAAAAGGTAAAGAGTCAGGGAACAAGTTGGCTCTACTGAAGTGGCTGAAACCAGTGTTTAACAAAAGCTTTGAGAGCACTGTGGACCAGGGCCCAGATATATACATATACATGTTCAGGGCATGCTGGGAAGCTAGTAATCACATATCTGGGGCAGGCCTAGTGCCAATCAATAAAAGTAACAGGGAGGAGGTAGGCAGACCCAACCAGACTCATGTCTTCAATGGAAGTAACTGGATCATGCTGATCTATAAAGAGGGTGATGAATACAACAACCACTGTAGCCAGAAGCAGCATTGTCATGCAGCAGTGATAATAGGAGTAAAGACTATCAACACACCCTAGTGGGCAATTTTAACCCTGTGTCTGAGGAGGAAGACAAAGTCCAAGATTGTTTCTACCTCTTTGAGATGGATAGGAGCCTGGTCTATTCCCCGGAGATCTCCCACCTCGGGATGGGTTCTGTCTTACTTATCATGTTTGCATCACTGATGGCTGTCTATGTCATTAGGGGGTTCCTATTCCAGCAACTGATGGTGGGAGCCAATGGAATTGAACAGATTCCCTGGCTTAGCCTTCTGGCAAGCTCTTCACAACCTTGTAAAAGATGGTTGTTACTTGGTGTGTCATTCTAAGCCCTGAAATGTGCCTGCTGTATATGGTTGTGTGAGGGATGACCAGTTGGGGAAGGAGTCACAAGAAAAGGATGGTCATTTATCACCAATGGGATTGTACTTTAAATATCTAACCTCTTCTTCAATTTCCCAAACCAGAGCATACTCTGACGTATTTCTCAAGCATCTCCACTTCAGTCTCTCACCACACCCTTAATATCGCTCTTGCTTTCCAGTTTGCTTTTAATTTGCATCCTCTTTTCATTAGTCAAATTGCCTTACCTTTGTTCCCTATTTTCTATTTTTTTCTCTAGAGAGTTACAGTT
>NM_001207024.2
AGAGTGGGGCACAGCGAGGCGCTAGGGGGAACGCTGGCCTCTGAAACTAGCTCTGGGACCGGGGTCTGCGGCCGGCCCCTAGCTGGCCCCGTCTCCCATCCCCAGAAGGGTATTCACTGGGGATTCTGAGCTTTGGCTACTCCAGTTTCCCACGACACGATGTTCCCTTTCTACAGCTGCTGGAGGACTGGACTGCTACTACTACTCCTGGCTGTGGCAGTGAGAGAATCCTGGCAGACAGAAGAAAAAACTTGCGACTTGGTAGGAGAAAAGGGTAAAGAGTCAGAGAAAGAGTTGGCTCTAGTGAAGAGGCTGAAACCACTGTTTAATAAAAGCTTTGAGAGCACTGTGGGCCAGGGTTCAGACACATACATCTACATCTTCAGGGTGTGCCGGGAAGCTGGCAACCACACTTCTGGGGCAGGCCTGGTGCAAATCAACAAAAGTAATGGGAAGGAGACAGTGGTAGGGAGACTCAACGAGACTCACATCTTCAACGGAAGTAATTGGATCATGCTGATCTATAAAGGGGGTGATGAATATGACAACCACTGTGGCAAGGAGCAGCGTCGTGCAGTGGTGATGATCTCCTGCAATCGACACACCCTAGCGGATGGCTGTGACTTTGTCTGCCGTTCTAAACCTCGAAATGTGCCTGCAGCATATCGTGGTGTGGGGGATGACCAGCTGGGGGAGGAGTCAGAAGAAAGGGATGACCATTTATTACCAATGTAGATTGCACTTTATATGTCCAGCCTCTTCCTCAGTCCCCCAAACCAAAGCTACACAGCCAGATTTCTCAAGCAGTCTCAACTCCAGTCCCTCATCTCACCCttactattgctcttgctttccagtttgcttttgatttGCATCTTCTCACTAGTAAAACTGCCTTCCCTTTGTTCCTTATTTTCTGTTTTTTCTCTAGAGAGGTACAGTTGTAAGTCAGAGTTAATATAATAGGGCCTGTGAAAACAGAGGCTTTTGCATTGTCTCTTGACATCAGAAGTTACAATAGGCATATGGGCAAAATGGTGTAGCAGGCTCACTGGCCGTTTGTTTTTTAAACACATTTTCACAAGTTTTTGAGACACTGGATTTCTTTAATTAAAAAAAAAATGCCAAGAAACATTATTTATACAGGGTTGATTGCTTTCATGTTGTTATTCTGTACCCTATAGTAGCCTCCATGAGAATCTGGTATTTCTTGCTGCTTGGAACTACTTTGCAGTGATTACTTGGTTGCAGTCCAAGTACTCTCGTTTAGTCTGAGCCTGGAGATGTTCTAGACTTGCTTCTCCCACCTCTGAGATTAGGACAGGAAAAATGTGAAATTTCCCAATTACAGGATTATACGGTACCATCACATCATTTGTGGAAATTGGGGTGACTGTATAGCTGGGATTGGGCTAAGGACTGTGGTCTTATCTGTCCACATACAGCCAAAATGCCTATCCAGAAATCCAGTTCGTTGGAAAGGAAAATTGGTACTCCTGTGCCACAGGGGTTCCAGAAAAGGGAAGTCACTTTACCTTGCGGTGGTGGGATCCTGATGTCTTTCATCCATTTGTAGTAAAAGCTGGTAAAGCTTTTCTTACTCCTGGTTCCCTACCAGTATTTCTAAACATGTCGCACTTTCTCCACAGGCATGTGGTTTTGACCTTTTTTTCAATCTTCTAGAAAGGGAACGGAAGCAGAAGTGGGACATCGAGGGCTCTGCTGTCCTCTGCGCTGGGTGTGGAATGCTGCTGCACCTGTCCCTTCTGCTGGCTCAGGGAAGTGTCTTCTTGCCCACATTTCTGTGGGGAAAGGTTTTTAATCCTCTGATGCTTCCATCTTCCTGTTTAGGCCATGTGCCCAGAAACCTGGACTGATCTTTCTTTAATAGTGAACCCCTGGGCCACTGAAGAGTAACATGGCTCCACTGGACACAAAAGAGGGATGGAATCAACAGGCAGGGGGCCTTTTATAAGCCTTAGGAAAAGAAAATGAAACTATTTCATCTTTGGACTTTTCAATACTATTGGAGTGATTTTTTTCTTTCTAAACAGGGAAAATAATGTTACAAAAGCATCTTTTTTGTTATTTGTTTGCATCCCTCCCCCACACCCTGGTGTTTTAAAATGAAGAAAAAAAACCATCACCTTTTGTACAAAAACTCTTAATGATTAAAAAACAAACAAAACATA

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