Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name AKR7A2P2
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:118877656-118879184  UCSC
Coordinates (T2T) chrX:117255430-117256960  UCSC
Coordinates (hg19) chrX:118011619-118013147  UCSC
Strand -
Parental Sequence NM_003689.4
Parental seq. overlap 707 bp
Parental seq. overlap (%) 39.3%
Genomic Region Intergenic
Retrocopy Summary AKR7A2P2, located on chrX:118877656-118879184, is a retrocopy of the parental gene AKR7A2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name AKR7A2
Full Name aldo-keto reductase family 7 member A2
Also known as AFAR|AFAR1|AFB1-AR1|AKR7
Coordinate chr1:19302708-19312146
Strand -
Gene summary The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes AKR7A2P1
Bonobo Pan paniscus LOC100981962P1
Gorilla Gorilla gorilla LOC101140061P1
Orangutan Pongo abelii AKR7A2P1
Gibbon Nomascus leucogenys LOC100591666P1
Crab-eating macaque Macaca fascicularis LOC102142158P1
Rhesus Macaca mulatta AKR7A2P1
Baboon Papio anubis LOC101010515P1
Golden snub-nosed monkey Rhinopithecus roxellana LOC104679831P1
Marmoset Callithrix jacchus AKR7A2P1
Green monkey Chlorocebus sabaeus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>AKR7A2P2
GTAATAAATAAATAAATAAGAGCAAAGGCTGGATCCTGCCCACTGTGTACCATGGCATGTACAATGCCACCACCCGGCAGGTGGAAATGGAGCTCTTCCCCTGCCTTGGGCACTTTGGACTGAGGTTCTATGCCTACAACCCTCTGGCTGGGGGTCTGCTGACCGGCAAGTACAAGTATGAGGACAAGGGCAGGAAACAGTCTGGGGGCCACTTCTTTGGGAATAGCTGGGCTGAGACCCACAGGAATCGCTTCTGGAAGGAGCACCACTTTGAGGCCATTTCCCTGATGCAGAAGGCCACACAGGCCGTGTATGGTGTCAGTGCCCCCAGCATGACCTTGGCCACCCACCCTCTGGTGGATGTACCACCACTCACAGCTGCAGGGTGCCCACAGAGACGTGGTCATCCTGGGCATGTCCAGCCTGGAGAAGCTGGAGCAGAACTTGGCAGTGATGGAGGAAGGGCCCATGGACCCGGCTGTCATGGACACTTTTAATCAAACCTGGCATTTTGTTGCCCACGAATGTCCCAACTACTTCCGCTAGGCCCATCATGGCCCAGGCTGCCCAAGGCTTTTCCGTCACCTCTTTTATTCTCTCACGCTGACCAGTCTTGGCCTTGAGCTGACTTAACAGGGTCTTTCTGGATCGTCTAGATCCATGTGTTATTTTTCTAGCTTCCTGCCTTGCTCCCTGCTCATTTACACTGTGAAAGGTGGGGGTGAGTCCCACTTGGGCATTTCCTGTTGAATAAAGCAGGCACTTGACCCGGTGCTGGGCATCATGGAGATGGGGCGCCACATGGACACATCTGCCAGCGCCACGGCCGTGCACGCTTTCCTGGAGCGTGGCCACACCGAGCTGGACATGGCCTTCATGTACAGCGATGGCCAGTCCAAAATCATCCTGGGCGGCCTGAGGCTGGGGCTGGGCGGCGGCGACTGCTGAGTGAAATTGGCCACCAAGGCCAACCCTTGAGAGGGAAAATCACTAAAGCCTGACAGTGTCTGGTCCCAGCTAGAGACGTCACTGAAGAGGCTGCAGTGTCCCCGATTGGACCTCTTCTACCTACATGCACCTGACCACGGCACCCCAGTGGAAGAGACGCTGTGTGCTTGCCACCAGCGACACCAGGAGGGCAAGTTCGTGGAGCTTGGCCTCTCCAACTATGCCGGCTGGGGGAAGTGGCCGAGATCTGTACCCTCTGCAAGAGCAAAGGCTGg
>NM_003689.4
AACGCGCAGGCGCCGCTGCTATGCTGAGTGCCGCGTCTCGCGTAGTCTCCCGCGCCGCCGTCCACTGCGCGCTTCGCTCTCCGCCGCCCGAGGCCCGCGCGCTCGCCATGTCCCGGCCACCGCCACCGCGGGTCGCCTCGGTGCTGGGCACCATGGAGATGGGGCGCCGCATGGAcgcgcccgccagcgccgcggccgtgcgcgccTTTCTGGAGCGCGGCCACACCGAACTGGACACGGCCTTCATGTACAGCGACGGCCAGTCCGAGACCATCCTGGGCGGCCTGGGGCTCGGGCTGGGCGGTGGCGACTGCAGAGTGAAAATTGCCACCAAGGCCAACCCTTGGGATGGAAAATCACTAAAGCCTGACAGTGTCCGGTCCCAGCTGGAGACGTCATTGAAGAGGCTGCAGTGTCCCCAAGTGGACCTCTTCTACCTACACGCACCTGACCACGGCACCCCGGTGGAAGAGACGCTGCATGCCTGCCAGCGGCTGCACCAGGAGGGCAAGTTCGTGGAGCTTGGCCTCTCCAACTATGCTAGCTGGGAAGTGGCCGAGATCTGTACCCTCTGCAAGAGCAATGGCTGGATCCTGCCCACTGTGTACCAGGGCATGTACAACGCCACCACCCGGCAGGTGGAAACGGAGCTCTTCCCCTGCCTCAGGCACTTTGGACTGAGGTTCTATGCCTACAACCCTCTGGCTGGGGGCCTGCTGACTGGCAAGTACAAGTATGAGGACAAGGACGGGAAACAGCCTGTGGGCCGCTTCTTTGGGAATAGCTGGGCTGAGACCTACAGGAATCGCTTCTGGAAGGAGCACCACTTCGAGGCCATTGCGTTGGTGGAGAAGGCCCTGCAGGCCGCATATGGCGCCAGCGCCCCCAGTGTGACCTCGGCTGCCCTCCGGTGGATGTACCACCACTCACAGCTGCAGGGTGCCCACGGGGACGCGGTCATCCTGGGCATGTCCAGCCTGGAGCAGCTGGAGCAGAACTTGGCAGCAACAGAGGAAGGGCCCCTGGAGCCGGCTGTCGTGGATGCCTTTAATCAAGCCTGGCATTTGGTTGCTCACGAATGTCCCAACTACTTCCGCTAGGCCCATCATGGCTCAGGCTGCCCAAGGCTTTTCTGTCACCTCTTTTGTTCTCTCACACTGACCAGTCTTGGCCTTAAGCTGACTTAGAAGGGTTTTTCTGAATTGTCTAGATCCATGCATTATTTTTCTAGCTTCCTGCCTTGCTCCCTATTCACTTTACACTGTGAAAGGTGGGGGGTGAGTCCCACTTGAGCGCTTCCTGTTGAATAAAGCAGGCACTTGACCTGGCTGTAGCCTAGGTCTTGAGTGAACCCCAAAAA

Publications

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