Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TUBB4AP1
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr19). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:123561547-123563822  UCSC
Coordinates (T2T) chrX:121872007-121874282  UCSC
Coordinates (hg19) chrX:122695398-122697673  UCSC
Strand +
Parental Sequence NM_001289123.2
Parental seq. overlap 2024 bp
Parental seq. overlap (%) 81.7%
Genomic Region Intergenic
Retrocopy Summary TUBB4AP1, located on chrX:123561547-123563822, is a retrocopy of the parental gene TUBB4A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TUBB4A
Full Name tubulin beta 4A class IVa
Also known as DYT4|TUBB4|beta-5
Coordinate chr19:6494319-6502848
Strand -
Gene summary This gene encodes a member of the beta tubulin family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Mutations in this gene cause hypomyelinating leukodystrophy-6 and autosomal dominant torsion dystonia-4. Alternate splicing results in multiple transcript variants encoding different isoforms. A pseudogene of this gene is found on chromosome X. [provided by RefSeq, Jan 2014]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TUBB4AP1
Bonobo Pan paniscus TUBB4AP1
Gorilla Gorilla gorilla TUBB4AP1
Orangutan Pongo abelii TUBB4AP1
Gibbon Nomascus leucogenys TUBB4AP1
Crab-eating macaque Macaca fascicularis TUBB4BP2
Rhesus Macaca mulatta TUBB4AP1
Baboon Papio anubis TUBB4AP1
Green monkey Chlorocebus sabaeus Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TUBB4AP1
AGTGCTCCGCCGTCTCCACAGCATCTTCCACCCACGCCGCTGCAGCTCCCCACGCTCACGTGCAGGAGATCATGCACCTGCAGGCCGGCCAGTGTGGCAGCCAGATCAGGGCCAAGTTTTGGGAGGTTATCAGTGACAAACATGGGCATCGACCCCACAGGCACATACTATAGGGACAGTGACCTGCAACCGGAAAGGATCAACGTGTACTACAATGAGGCCAGAGGAGGAAATTATGTCCCCAGAGCGGTGCTGGTGGACCTGGAACCCAGCACCATGGACTCTATCCTTTCCGGCCCCTTCGGTCAGATCTTTCGGCCGGACAACTTCGTGTTTGGCCAGTCCAGAGCCGGCAACAACTGGGTGAAGGGGCACTACACGGAGGGCACAGAGCTGGTAGGCACTGTCCTGGACGTGGTCCAGAAGGAGGCCTAGAACTGCGACTGCCTTCAAGGCTTCCAGCTGACGCACTTGCTGGGGGGTGGCACGGGGTCCGGGATGGGCACACTGCTCATCAGTAAGATCCGTGAGGAGTTCCCAGACCGCATCATGAACACCTTCAGCATGGTGCCCTCGCCCAAAGTGTCAGATACGGTGTGGAGCCCTACAATGCCACACTGTCTGTGCACCAGCTGGTGGAGAATACGAATGAGACCTACTGCATCAACAATGGGGCACTCTATGACATCTGCTTCCGCACCCTCAAGCTGACCACCTCCACCTACGGGGACCTCAACCACCTGGTGTCAGCCACCATGAGCAGAGTCACCACCTGCCTGTGCTTCCTGGGCCAGCTGAACACCAACCTGCACAAGCTGGCCGTCAACATGGTCCCCTTTCCTTGCCCGCACTTCTTCATGCCTGGCTTCGCACCCCTGACCAGCCGGGGCAGCCAGCAGTACCAGGCCCTGAGGGTGCCTGAGCTCACACAGCAGATGTTCGATGCCAAGAACATGATGGCCATGTGCAACCCGCGACATGGCCGCTACCTGACCATGGCCACCGTGTTCCGGGCCGCATGTCCATGAAGGAGGTGGACAAGCAGATGCTGAGCCTGCAGAGCAAGAACAGCAGCTACTTCGTGCAGTGGATCCCCAACAACATGAAGACGGCCGTGTGCGACATCTCGCCCCACGGCCTGAAGATAGCCGCAACTTTCATCAGCAACAACACAGACTTCCAGGAGCTGTTCAAGTGCATCTCTGCGCAGTTCACGGCCATGTTGTGGTGCAAGGCGTTCCTGCACTGGTACACAGGCGAGGGCATGGACGAGATGGAGTTCACCGAGACTGACAGCAACATGAATGACCTGGTATCTGAGTACCAGCAGTACCAGGATGCCACAGCCGAGGAGGGCGAGTTCAAGCAGGAGGCCGAGGAGGAGGTGGCCTAGGCTGCTCCCATCGCTTCCTGTCTGTCCCCTCGAGGCTTCTGACCTTTGACCCCCTAGGCCCTCCATCTCTGACCCCTAGACCCCCGCTTTCCCTCCcAATACCTTCGGAGCTCGCTTTACCTCTGGCTACTTCATCTCCGACCCTGGCTCCCCATTGACCCTTGAGCCCTAATTTATCTTTGACCCCCTTGAGCTCTTCCAACCTTGACATTCCTAGGAGGAGCCCCGCTTCACCCCTTCTGACTCTGGAAACCACACCTTTAACTTTGAGGGCCCTCTTTCACCCCTGACCTCTGCTTCACCTTTGACCCCTGCCCCCCATGAATCCCATTTTACCTCTAGACCCATAAGTCCTGGCTTATGTTTGACCCCTCCCTCTGAGCTGCACTTCACCTCTGACCTTGCCTCACCTTTAACCCCCGACCTGAGCCCCAGCTCCTACCTCTAACCCCAACTTCTCTTTCACCCGTGAATCCCCTCTGACCCCAACTTCTCTTTCACCCCCTACGAATCTCATTTTACCTCTCCACCTATAAGTCCTGGTTTACACTGCACCCCTCCCTCCGAGCTGCAGTTCACCTTTGACCTTGCTTCACCTTTCACCCCCCCACAGCCCCAGCTCCTACCTGACTCCAGCTTCTCTCTGGCTCCCACAGACCCCATGCATCCTCCCTGCCTCACTCCCCTCAGCCCCTGCCAACCTTAGCTTATCTGGGAGAGAAACAAGGCCTGGTCCCTGTGAGGAAGAGAGGTCGCCCTTGCCCTCCCTCCCCGCTTCCTGCCTCGCCTTCAATAAATAAATT
>NM_001289123.2
ACTATGCAGCTTCAGGACAAGCCCTCCAGGAACCTACCGCCCCCCACCCGCAAACCAGATCGCCGCTCCGGAGCCCCCAGCCCACTGGGAGGGCTCGCGGTTACTGCAAGGATTCTGGCGAATGAGGTCTAAATAGAATGAGAAGGGGGGCTGCGGACCGAGAAACTGAGCGGCTCCCGGGGGCGCAGGGACCGTGCTCCGCCGTCTCCGCCGCATCTTCCACCCTCGCCGCCGCCGCAGCTCCCCGCGCTCGTGCCACCGCCGCCGCGTCCACCCTCAGCGCCACCGCCATGCGGGAGATCGTGCACCTGCAGGCCGGCCAGTGCGGCAACCAGATCGGGGCCAAGTTTTGGGAGGTTATCAGTGACGAACATGGCATCGACCCCACAGGCACATACCATGGGGACAGTGACCTGCAACTGGAGAGGATCAACGTGTACTACAACGAGGCCACAGGAGGAAATTATGTCCCCAGAGCGGTGCTGGTGGACCTGGAACCCGGCACCATGGACTCTGTCCGTTCTGGCCCCTTCGGTCAGATCTTTCGGCCGGACAACTTCGTGTTTGGCCAATCCGGAGCCGGCAACAACTGGGCAAAGGGGCACTACACGGAGGGCGCAGAGCTGGTGGACGCTGTCCTGGACGTAGTCCGGAAGGAGGCCGAGAGCTGCGACTGCCTTCAGGGCTTCCAGCTGACCCACTCGCTGGGGGGTGGCACGGGGTCCGGAATGGGCACGCTGCTCATCAGTAAGATCCGCGAGGAGTTCCCAGACCGCATCATGAACACCTTCAGCGTGGTGCCCTCGCCCAAAGTGTCAGACACGGTGGTGGAGCCCTACAACGCCACGCTGTCTGTGCACCAGCTGGTGGAGAATACGGATGAGACCTACTGCATCGACAACGAGGCACTCTACGACATCTGTTTCCGCACCCTCAAGCTGACCACCCCCACCTACGGGGACCTCAACCACCTGGTGTCGGCCACCATGAGCGGGGTCACCACCTGCCTGCGCTTCCCGGGCCAGCTGAACGCCGACCTGCGCAAGCTGGCCGTCAACATGGTTCCCTTTCCTCGCCTGCACTTCTTCATGCCCGGCTTCGCACCCCTGACCAGCCGGGGCAGCCAGCAGTACCGGGCCCTGACGGTGCCCGAGCTCACCCAGCAGATGTTCGATGCCAAGAACATGATGGCGGCGTGCGACCCGCGCCACGGCCGCTACCTGACCGTGGCCGCCGTGTTCCGGGGCCGCATGTCCATGAAGGAGGTGGACGAGCAGATGCTGAGCGTGCAGAGCAAGAACAGCAGCTACTTCGTGGAGTGGATCCCCAACAACGTGAAGACGGCCGTGTGCGACATCCCGCCCCGCGGCCTGAAGATGGCCGCGACCTTCATCGGCAACAGCACGGCCATCCAGGAGCTGTTCAAGCGCATCTCCGAGCAGTTCACGGCCATGTTCCGGCGCAAGGCCTTCTTGCACTGGTACACGGGCGAGGGCATGGACGAGATGGAGTTCACCGAGGCCGAGAGCAACATGAATGACCTGGTATCTGAGTACCAGCAGTACCAGGACGCCACGGCCgaggagggcgagttcgaggaggaggcggaggaggaggtggCCTAGGCTGCTCCCATCGCTTCCCACCTGTCCCCTCGAGGCTTCTGACCTTTGATCCGCTAGGCCCCCCATCTCTGAACCCTAGAGCCCCGCTTTCCCTCCAAGGCTGACTCCCCGCTGACCCTAACAATACCTTTGGAGCTCGCTTTACCTCTGGCTACTTCATCTCCGACCCTGGCTCCCCTTTGAGCCCTAATTTATCTTTAACCCCCTTGAGCTCTTCCAACCTTGACATTCCCAGGAGGAGCCCCGCTTCACCCCTTCTGACTCTGGAAACCGCACCTTTAACTTTGCAGACCTTCCTTCACCCCTGACTTCTGCTTCACCTTTGACCTCTGCCCCCCATGAATCCCATTTTACCTCTAGACCTATAAGTTCTGGTTTATGTTTGACCCCTCCCTCTGAGCTGCACTTCACCGCTGACCTTGCCTCACCTTTAACCCCCCACCTGAGCCCCAGCTCCTACCTCTGACCCCAACTTCTCTTTGATCTCTGAATCCCCTCTGACTCCAACTTCTCTTTCACCCTCTATGAGTCCCATTTTACTTCTACACCTGCAAGTCCTGGTTTATATTGGACCCCTCCCTCCGAGCTGCAGTTCACCTTTGACCTTGCCTCACCTTTCACCCCCCACCCCCCACAGCGTCAGCTCCTACCTCTGACCCCAGCTTCTCTCTGATTCCCACAGGCCCCATGCATCCTCCCTGCCTCACTCCCCTCAGCCCCTGCCGACCTTAGCTTATCTGGGAGAGAAACAAGGCCTGGTGCCTGTGAGGAAGAGAGGTCACccctaccctccctccccgcttccctgcctcACCCTCAATAAATAAATTAATTGTTGTCATGGA

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