Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PSMA6P2
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr14). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:12825820-12826996  UCSC
Coordinates (T2T) chrX:12407317-12408493  UCSC
Coordinates (hg19) chrX:12843939-12845115  UCSC
Strand +
Parental Sequence NM_002791.3
Parental seq. overlap 794 bp
Parental seq. overlap (%) 76.3%
Genomic Region Intergenic
Retrocopy Summary PSMA6P2, located on chrX:12825820-12826996, is a retrocopy of the parental gene PSMA6. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PSMA6
Full Name proteasome 20S subunit alpha 6
Also known as IOTA|PROS27|p27K
Coordinate chr14:35278558-35317493
Strand +
Gene summary The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome. [provided by RefSeq, Aug 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PSMA6P3
Gorilla Gorilla gorilla PSMA6P2
Orangutan Pongo abelii PSMA6P2
Gibbon Nomascus leucogenys PSMA6P2
Green monkey Chlorocebus sabaeus PSMA6P3
Crab-eating macaque Macaca fascicularis PSMA6P4
Rhesus Macaca mulatta PSMA6P4
Baboon Papio anubis PSMA6P3
Golden snub-nosed monkey Rhinopithecus roxellana PSMA6P1
Marmoset Callithrix jacchus PSMA6P8
Bonobo Pan paniscus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PSMA6P2
GAAAGTAGTGGTTCTACCAGCATGTCCCGTGGTTCCAGCGCTGGTTTTGCCCACCACATTAACATTTTTTTCGCCCGAGGGCCAGCACTACCAAGTAGAATATGCATATGCTTTTAAGGCTATTAACCTGGGTGGCCTTCCATCAGTATTTGTCAGAGGAAAAGACTGCTGTAATTATCATACAGAAGAAATGCTTGACAAATTATCGGATTCCAGCACAGTGACTCACTTACTCAAAATAACTGAAAACATTGGCTGTCACTGTGATGACCGGAATGACAGAGGTACAGAGGGCACGCTATGGGGCAGCTAACTGGAAATACAAGTACGGCTATGAGATTCCTGTGGACATTCTGTGTGGAATTGCTGATACTACTCAGAATGCTACAATGAGGTCTCTTGGTTGTATGATTTTCATTGGTATAGATGAAGAACAAGGCCCTCAGGTGTGAAAGTATGATCCTGCAGGTTACTGCTGTGATTTAAAGCCACTGCAGCAGGAGTTAAACAAACTGAGTTAACCAGCTTCCTTGAAAAAAAAAAGTGaGTGCAAAAGAAATTTGATTGGACATTTGAACAGACAGTGGAAACTGCAATTACATGCCTGTCTACTGTTCTATCAATTGATTTCAAACCTTCAGAAATAGAAGTTGGAGTAGTGACAGTTGAAAATCCTAAAGTCGGGATTCTTACAGAAGCAGAGATTGATGCACTCACATTGTTGTTAGTTTACCAAATCCATGATGCCACTTACCTGTGTGTTTGGTAACAAAAAAAACAACATTATGGAGGTCCCTGGATTGAAAAAGGAGCCTCTCCCACTCCTCCTACTACTGAATTGATTAGGACTCTATAAATAAAAGCAATGCTTTTGG
>NM_002791.3
GGAAGCAGTCGCTGCAACTTCCGGGAGGTGCTTGTGTGCCTGGTGCGGGAGCTACGGGGCCCAGGGATTGTGTTTAAAGTAGTGCTTCTACCAACATGTCCCGTGGTTCCAGCGCCGGTTTTGACCGCCACATTACCATTTTTTCACCCGAGGGTCGGCTCTACCAAGTAGAATATGCTTTTAAGGCTATTAACCAGGGTGGCCTTACATCAGTAGCTGTCAGAGGGAAAGACTGTGCAGTAATTGTCACACAGAAGAAAGTACCTGACAAATTATTGGATTCCAGCACAGTGACTCACTTATTCAAGATAACTGAAAACATTGGTTGTGTGATGACCGGAATGACAGCTGACAGCAGATCCCAGGTACAGAGGGCACGCTATGAGGCAGCTAACTGGAAATACAAGTATGGCTATGAGATTCCTGTGGACATGCTGTGTAAAAGAATTGCCGATATTTCTCAGGTCTACACACAGAATGCTGAAATGAGGCCTCTTGGTTGTTGTATGATTTTAATTGGTATAGATGAAGAGCAAGGCCCTCAGGTATATAAGTGTGATCCTGCAGGTTACTACTGTGGGTTTAAAGCCACTGCAGCGGGAGTTAAACAAACTGAGTCAACCAGCTTCCTTGAAAAAAAAGTGAAGAAGAAATTTGATTGGACATTTGAACAGACAGTGGAAACTGCAATTACATGCCTGTCTACTGTTCTATCAATTGATTTCAAACCTTCAGAAATAGAAGTTGGAGTAGTGACAGTTGAAAATCCTAAATTCAGGATTCTTACAGAAGCAGAGATTGATGCTCACCTTGTTGCTCTAGCAGAGAGAGACTAAACATTGTCGTTAGTTTACCAGATCCGTGATGCCACTTACCTGTGTGTTTGGTAACAACAAACCAACATCATGGAGGTCCCTGGATTGAAAAAGGAGCCTCTCCCACTCCTCCTACCACCGAAGTGGTTAGGACTCTATATAAATAAAAACAAGGCTTTTGGAAAATAATTGCATCCTGTTGTTTTCA

Publications

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