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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TIMM8BP2
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:134166668-134167082  UCSC
Coordinates (T2T) chrX:132491815-132492229  UCSC
Coordinates (hg19) chrX:133300698-133301112  UCSC
Strand +
Parental Sequence NM_012459.4
Parental seq. overlap 396 bp
Parental seq. overlap (%) 50.8%
Genomic Region Intergenic
Retrocopy Summary TIMM8BP2, located on chrX:134166668-134167082, is a retrocopy of the parental gene TIMM8B. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TIMM8B
Full Name translocase of inner mitochondrial membrane 8 homolog B
Also known as DDP2|TIM8B
Coordinate chr11:112084800-112086756
Strand -
Gene summary This gene encodes a member of a well-conserved family of proteins with similarity to yeast Tim mitochondrial import proteins. This gene is encoded by a nuclear gene and is transported into the intermembrane space of the mitochondrion. When formed into complexes, these proteins guide membrane-spanning proteins across the mitochondrial intermembrane space before they are added into the mitochondrial inner membrane. This gene is adjacent to succinate dehydrogenase, subunit D (SDHD), in which mutations have been found in affected members of families with hereditary paraganglioma.[provided by RefSeq, Aug 2009]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TIMM8BP1
Bonobo Pan paniscus TIMM8BP1
Gorilla Gorilla gorilla TIMM8BP1
Orangutan Pongo abelii TIMM8BP1
Gibbon Nomascus leucogenys TIMM8BP1
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TIMM8BP2
TCTGAGGTGAACAAAGGCGGAGCTGGGTGAAGCCGATGGAGCGGAGTTGCAGCACCTGGTGGCCGCCGAACAGCAGAAGGCGCAGTTTACTGCACAGGTGCATCACTTCATGGAGTTATGTTGGGATAAATGTGTGGAGAAGCCAGGGAATCGCCTGGACTCTTGCACTGAAAATTGTCTCTCCAGCTGTGTAGACCACTTCATTGACACCACTCTTGCCATCACCAGTCGGTTTGCCCAGATTGTACAGAAAGGAGGGCAGTAGGCCATCCCCCAGGAGAATGACAGAAGCAAAGGACTTATTATTAAGCAGACTTAAGGGCCAGTGGGGGAAGGCTGTCAACCCATTGTCAGATCAGCATCAGGCTGTTATCAAGTCTGTTGGTCCTAAAAAGTAAAAGATGAAATGTTC
>NM_012459.4
AGCTGTCGGAAGGTGGCGAGCCTGAGGCGAACAATGGCGGAGCTGGGCGAAGCCGATGAAGCGGAGTTGCAGCGCCTGGTGGCCGCCGAGCAGCAGAAGGCGCAGTTTACTGCACAGGTGCATCACTTCATGGAGTTATGTTGGGATAAATGTGTGGAGAAGCCAGGGAATCGCCTAGACTCTCGCACTGAAAATTGTCTCTCCAGCTGTGTAGACCGCTTCATTGACACCACTCTTGCCATCACCAGTCGGTTTGCCCAGATTGTACAGAAAGGAGGGCAGTAGGCCATCCCCCAGGAGAATGACAGAAGCAAAGGACTTGTTACTAAGCAGATTTAAGGGTCAGTGGGGGAAGGCTATCAACCCATTGTCAGATCAGCATCAGGCTGTTATCAAGTCTGTTGGTGCTAAAAAGTAAAAGATGAAATGTTCAAAGAGTGAAATTTATTTATTTGGAATTCAGAAATTCCAGGTTGTATGACATCAGTTACTCAATAAGTGTGAATTCTCCAACTCTTCTTTTAATCCCATTTTAGAATTTAATATAGAGATCTCTGATTGGCAGGAACACTAGAAATAAATGTTCCATGGCCAGTAGTGCAAATGGGGGATTGTAGGTTTTGAAAAACCACCCTAAGCCATATTAAGGGGGTTGGAAGAACCATCGAAGCCTAAGGCATAGAAGAAAATTTGGGGTTAAGAAAGATGAAGAACAAAAAACAGCTTTATTGCTTATACATGACCAAGAAAAGGAAAACATGGCaaaaaaaaaaaaaaaaa

Publications

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