Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name E2F6P3
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:136096416-136097585  UCSC
Coordinates (T2T) chrX:134404817-134405986  UCSC
Coordinates (hg19) chrX:135178575-135179744  UCSC
Strand -
Parental Sequence NM_212540.3
Parental seq. overlap 891 bp
Parental seq. overlap (%) 28.1%
Genomic Region Intergenic
Retrocopy Summary E2F6P3, located on chrX:136096416-136097585, is a retrocopy of the parental gene E2F6. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name E2F6
Full Name E2F transcription factor 6
Also known as E2F-6
Coordinate chr2:11444375-11466177
Strand -
Gene summary This gene encodes a member of a family of transcription factors that play a crucial role in the control of the cell cycle. The protein encoded by this gene lacks the transactivation and tumor suppressor protein association domains found in other family members, and contains a modular suppression domain that functions in the inhibition of transcription. It interacts in a complex with chromatin modifying factors. There are pseudogenes for this gene on chromosomes 22 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes E2F6P2
Bonobo Pan paniscus E2F6P3
Gorilla Gorilla gorilla E2F6P1
Orangutan Pongo abelii E2F6P1
Gibbon Nomascus leucogenys E2F6P1
Green monkey Chlorocebus sabaeus E2F6P1
Rhesus Macaca mulatta E2F6P1
Golden snub-nosed monkey Rhinopithecus roxellana E2F6P1
Marmoset Callithrix jacchus E2F6P1
Crab-eating macaque Macaca fascicularis Without Homology
Baboon Papio anubis Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>E2F6P3
CTTCATCTGAGAGCAGACATCCAGAACACCCTGAAGAAGAAGAAAATCCTCAGCAAGGTGAAGAATTGCTTGACATGAGCAACTGATAACATTTGAGAATTCAGGTATTGTTGAGGTTTTGGGGGAACATCCTCTGCGGAGAATTACACATCACATTTGATTCTTACAGCAATGGACATGGAGTGCTCTTGTTTTCGGTTAGTAGCAGCATTACCACCAGTACTATTTTTGAGTAGTTCACGACTTAGATTCCTGAATAATTCTGGTTTCCACATTTGAAAACAACTCCATGTATAATTATGCACTGCTTTTTGTCATCGGAATAGACATCTTGCCTCCTGAAATAGCTTCGTCACAAAGGGTGTCATGAAAATGACAGTCAGGCCTGAAATGGACGGTTGTTTGCAGGCTCTACCCTTTCCTTCAGGGATTATGTCATATATCACAAAAGAAATTGCCTTACACTGGTTCATGTTTGCAGTTACTGTTGTATATTGGATCCAAATGTGATGTCTTTGTATATATCTGTGTAAAGCTTAGATTACTTATCCACTATTTCCAAGTGACACTTTTTGCCCTTGTACAGCCAAAATAGTGTATATATTGGAAAGTGACAAATTATCTAATTTCTTTGGTATCCATCACTTATTAGAATACTCTGGATGAGGGTTAGAGGAGAGTTTTTCCAAACTGCTACATGTAGAAGTATCATAAATGTGCTGTACATTTACATTCATTGATTTAACTGAAGTGTTTTAATATGGTTCTTAATGCTGAAATTGGAGTCAGATACTTCTTGATTTTAAGCTGTCTACTAAATTGCTGTGTCTCAACAGATTGATGGCATGCTCCAAGGCTTTGGGGCCAAGTATAGAAATGCTATCAAATGATAGATTAATTCATTGTGAGACATAAATTCAATTGTGGGGAAAACTGGAAACTGAAGGTTTTTGCAAGCAGATTTTGTAATGTGTTTCTGTATGCAGCCCAGCTCTTCAATCAAAGGGGTTTTACTTACAGTAAGTTCTACCGTGCCCTCTCTCCAg
>NM_212540.3
GGTGTACTGCGCATGCGGGAAGATGGCGGGCCGGGCGACTTGAGATCCGCGGGTCTCCCTCCTCTTTTTCCGTCTGCGTCGGGAGCTCCCGGGCACGTGAGGCCGTGCCGCGTTTACTGGCGGGCGGGACGGCCTAGCCGGGCGGCGCCTCGGAGGAAGCCGCGGACCCCTTAGGTGCTGGGCCCTTGGAAATCGGCGCGTGGGGGGCGGTGCTCGAGCTGAGCGCGAGAGGGCGGGAGAGCTCGTGGGGTGCGAGGGGAGCAGGACGCCCGGCCGGGCAGCATGAGTCAGCAGCGGCCGGCGAGGAAGTTACCCAGTCTCCTCCTGGACCCGACGGAGGAGACGGTTCGCCGTCGGTGCCGAGACCCCATCAACGTGGAGGGCCTGCTGCCATCAAAAATAAGGATTAATTTAGAAGATAATGTACAATATGTGTCCATGAGAAATCTGCTCCCGGGGGTATTCTTGACTTAAACAAGGTTGCAACGAAACTGGGAGTCCGAAAGCGGAGAGTGTATGACATCACCAATGTCTTAGATGGAATCGACCTCGTTGAAAAGAAATCCAAGAACCATATTAGATGGATAGGATCTGATCTTAGCAATTTTGGAGCAGTTCCCCAACAAAAGAAGCTACAGGAGGAACTTTCTGACTTATCAGCAATGGAAGATGCTTTGGATGAGTTAATTAAGGATTGTGCTCAGCAGCTGTTTGAGTTAACAGATGACAAAGAAAATGAAAGACTAGCATATGTGACCTATCAAGACATTCATAGCATTCAGGCCTTCCATGAACAGATCGTCATTGCAGTTAAAGCTCCAGCAGAAACCAGATTGGATGTTCCAGCTCCCAGAGAAGACTCTATCACAGTGCACATAAGGAGCACCAACGGACCTATCGATGTCTATTTGTGTGAAGTGGAGCAGGGTCAGACCAGTAACAAAAGGTCTGAAGGTGTCGGGACCTCTTCATCTGAGAGCACTCATCCAGAAGGCCCTGAGGAAGAAGAAAATCCTCAGCAAAGTGAAGAATTGCTTGAAGTAAGCAACTGATGGCATTTGAGAATTTATGTATCACTGAGTTTTTTGGGAATATCTTCGTGGAGAATTACGCATCAAATTTGATTCTCAGAGCAATAAATTATCCATGAAGTGCTCTCGTTCTCAGTAGCGGCATCATGGCCAGTAGTGTCTTTGAGGAGTTCACCACTTAGATTACTGAGTAATTGTGGTTTCCACATTTGAAAACAACTCCTTTTATAATTATTCACTGCTTTTTGTCAGTGAAATAGACATCTTGCCTCCTGAAGTAGCTTCATCACAGAGTGTCATGAAGACAGACAGTCAGGCTGAAATGGACAGTTCTTTGTGGACTCTACCCTTCCCTTCAAGGAGTATGTCATATATCACAAAAGAAATTGCCTTACACTGGTTCATGTTTGCAGTTACTGTTGTACATTGCATAGATGTACACACGAATTTAAATGTGATGTCTTTGTATATATCTGTATAATGTTGAGATTACTTACGAAATATGTCTGAGTGACACTTTTCACCCTTGTACAGCCAAAATAATGTATATATGGAAAGTGACAGACAAATTCTCTAATCTCTTTGGTACCTATAACTTATTAGAATCCTCTGGATGAGGGTTAGAAGAGACTTTTTCCAAACTTCTACATGTAGAAGTATCATAAATGTGCTACACATTTATGTTTGTGGATTTAATTAAAGTATTTTAATATGGTTTTCAGTGCTAAAATTGGAGTCAGATACTTCTTGGTTTTAAGCTGTCTACCTAATTGCTGTCTCCCAGCAGACTGGTGGCATGCCCAGTGGCTTTGGGGGCAAGGATAGAAATGCCATCAGGAAATAGCTGAATTCATTGTGAAACATGAATTCAGTCATGGTGATAATTGGAAACTCCTTTCAGGTTTTTGCAAGTAGATTTTGTAATGTTTGTGTATGCAGCCTTGCTGTTGAGTCAGTCCAAGGGGTTTTACTTAGGACAAGTTGTACCTTGCCCTCTCTCCAgctctgctcccacattttcacatacctagctgtttctacctcattgggtaagtcatttaccactctgtgcctcagtttactctgtagtttaccattagactgtgagctccttgagggactttgtcataatcactgttacatcccagtgcctcacaccatgcctggcccttaagaagtgctcaataaatgtctgaacaaataagtGAGTGGAGTGAGTGAATTGTAAGATCAGAATAATAATATTTGGTTTGTCTATCGTACAAGATTCCTGTATCGTTTGAATATTGCTTTTAAAGAAATATTTGAAGCGACTTCAAATTCAGACTGTGTTTAAAAAGATTTAAAATCGGAATCCAAAATCAAAGTATTAAAAAATAATGCTGAGTGTTTAGGATTCACATACCTCTGAGCTCTGGTGGCTTTTGCCAGTCCTGTCCCTCTGCTGAGCACCAGCCCTTCCTGCAGCAGTCCTGCCGGTGTGTTTCTGTGCACCTGGGGATGAAGTGTGCTCCTCCCCCAGCGGTTAGCCTCAATGCTTTTCCTCCCTCTGTTTTATTATTTGAAATTAGCCAAAGAAAAGCTGCAGGGGGCACTGCTGATCATCACTGGACTGGTGGGTCGTACTGTttgacagaatagggaatacaggaggaggagcaagcctagggtaaaacttaggtttgggacatgcttgatgaaagcaagagttgagcaggttgttgtgtgtatgtaggtcaggtgctcagcggaaaagtctgagctgtgtagtacgtcaggcagatgtcagtttagatgcgatagtttaagccacaagagtaggagaggtcatctaaagagtACAGCAGGCCTAAGGGCATCTATATTTAAGGAGAAATACAGAAGAAGTCTCCTGAGAAGGAATAATGGGGCGGGTGGGGAGGGAGAAGGCAGTGTCCCAAAAACCAACAAAGGTTTTACCAAAGGTAATACCATCAtttctgagcagcagttccttaacttgtgaatgtggcaaatgttctcctttacaaattgttctgaaggtaaaatgagatcatgtaaacgaaaatcctttgtaaattacagatgtgtgttataaatgAAGTATCTCTCGAGTCACTCCA

Publications

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