Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name EEDP1
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:140397056-140398589  UCSC
Coordinates (T2T) chrX:138708983-138710516  UCSC
Coordinates (hg19) chrX:139479221-139480754  UCSC
Strand +
Parental Sequence NM_003797.5
Parental seq. overlap 1390 bp
Parental seq. overlap (%) 66.4%
Genomic Region Intergenic
Retrocopy Summary EEDP1, located on chrX:140397056-140398589, is a retrocopy of the parental gene EED. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name EED
Full Name embryonic ectoderm development
Also known as COGIS|HEED|WAIT1
Coordinate chr11:86244753-86285420
Strand +
Gene summary This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes EEDP1
Bonobo Pan paniscus EEDP1
Gorilla Gorilla gorilla EEDP1
Orangutan Pongo abelii EEDP1
Gibbon Nomascus leucogenys EEDP1
Green monkey Chlorocebus sabaeus EEDP1
Crab-eating macaque Macaca fascicularis EEDP1
Rhesus Macaca mulatta EEDP1
Baboon Papio anubis EEDP1
Golden snub-nosed monkey Rhinopithecus roxellana EEDP1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>EEDP1
GGAAATGTCAACTGTGCTGGTGGGATTAGACACGCCTGCAGTGAAGAAGCAGAAGCTGAGCAGTGACGAGACCAGCAACCCTCACCTCTCTGGAGAGGAGAATGATGATGCTGTCAGTAGAAAGTGGTACAATCACTGAACACCCTGATATACCTACAAACATGCCAAATGCACCTGGAAGGCAAAGTTGGGGAAAGGGAAAATGGAAGTCAAAGAAATGCAAATGTGCTTTCAAATGTGTAAATAGTCTCAAGGAACATCATAACCAACCACTGTTTGGAGTTCAATTTAATTAGCACAGTAAAGAAGAAGATCCATTACTGTTTGCAACTGTAGGAAGCAACAGAGTTACCTTGTATGAATGTCATTGACAAGGAGAAATTCGGTTGTTGCAATCTTGTGTGGACGCTGATGCTGACGAAACTTTTACACTTGTGCATGGACCTATGATAGCAATAGAAGCATAATTGGGATGATTAATCCCACAACAACGCAGTGTAAAAAGCACTATATTGGCCACGGAAATGCTATCAATGAGCTGAAATTCCACCTTAGAGATCCAAATCTACTCCTATCAGTAAGTAAAGATCATGCTTTATGATTATGGAATAATGGACACACTGGTGGCAATATTTGGAAGCATAGAAGGGCACAGAGTTGAAGTTCTAAGCGCTGGTTGTGATCTTTTGCGTGAAAAAATAATGTCCTGTGGTATGGATCACTCAAACTTTGGTGGATCAATTCAAAGAGAATGATGAATTCAATTAGGAAATCTTATGATTATAACCCAAGTAAAACTTACAGGCCATTTAATTCTCAGAAAATCCATTTTCTGATTTTTCTATCAGAGACATACACAGGAATTATGTTGATCGTCTGTGATGGTTAGGTGATTTGATACTTTCTAAGTCTTGTGAAAATGCAGTTGTGTTGGAAACCTGGCAAAACGGAAGGTGATATAGATACAATTCAACCTGGTGACTCTAATGTGACTATTCTTAGGTGATTTGATTGTAGCCAGTGTGATATTTGGTACATGAGATTTTCTATGAATTTCTGGCAAAAGATGCTTACATTGGGCAATCAAGTTGGAAAACTTTATGTTTGAAATTCAGAAGTTTAAGATCCTCATAAAGCCAAATGTACAACACTAACTCATCGTAAATGTGATGCTGCTATTCAACAAACCAGTTTTAGCAGGGATAGCAGCATTCTTATAGTTGTTTGTGATGATGCCAGTATTTGGCTCTGGGTTTGACTTTGATAAAACACTTTCACCTAATCAAAATTAGAGTGTATTGTCTGTATAAAATAGAATTCATGTAGTTTGCTAGTAAGGGCACATAGAGCATTTAGAGTTGTCTTTCGGCATTCAATCAGGTTGAGCTGAATGTAGTGATGTTTACACCGTTTACATTCTTTGTACTGTCTTCCTGCTCAGATTCTACTGCTTTCTAATAAAAATTTGTTTTTGTAAAGCTGTGTGTTGCTTTTGTTATTTTCATTGTGATGGAAAAAAGTTGAA
>NM_003797.5
ATTCCACAGACTTTCGCTCCCTAGCAGCGGGTCGGAGATCGAAGGAACGGGCCAATTGCGGCTGAAACGTCTTTGGAAGGAGGAAGGGGGTGAGGGAGCATCCCTTTGAGTTTCGCCTCTTCTCGAGGCGGTGGTGGGAAGGGAGACATACTTAATACTGCCCTCTTAATCCAACGGACCTTACATCGTGTAGACTGCCGGGAGGGCGGCGGGAAAAGGGCAAGACGGGAGTTGGGGAAGGGAAGGAGCCAGGAAGCcgcgcgggagggcgcgcgcgcgcgcCCCTTTTTCAGCAGTGTGGCGGGGTCGCACGCACGCCCGCCTcggcggctgggcgcgatttgcgacagtggggggggcggtggaggtggcggcggcagcggcAACTTTGCGGCAAGCTCGGGCCGGGCTTGCTTGACGGCGGTGTGGCGGAGGCCCCGCCCCAGGCGGCAGGAACCTGGAGGGAGGCGGAGGAATATGTCCGAGAGGGAAGTGTCGACTGCGCCGGCGGGAACAGACATGCCTGCGGCCAAGAAGCAGAAGCTGAGCAGTGACGAGAACAGCAATCCAGACCTCTCTGGAGACGAGAATGATGACGCTGTCAGTATAGAAAGTGGTACAAACACTGAACGCCCTGATACACCTACAAACACGCCAAATGCACCTGGAAGGAAAAGTTGGGGAAAGGGAAAATGGAAGTCAAAGAAATGCAAATATTCTTTCAAATGTGTAAATAGTCTCAAGGAAGATCATAACCAACCATTGTTTGGAGTTCAGTTTAACTGGCACAGTAAAGAAGGAGATCCATTAGTGTTTGCAACTGTAGGAAGCAACAGAGTTACCTTGTATGAATGTCATTCACAAGGAGAAATCCGGTTGTTGCAATCTTACGTGGATGCTGATGCTGATGAAAACTTTTACACTTGTGCATGGACCTATGATAGCAATACGAGCCATCCTCTGCTGGCTGTAGCTGGATCTAGAGGCATAATTAGGATAATAAATCCTATAACAATGCAGTGTATAAAGCACTATGTTGGCCATGGAAATGCTATCAATGAGCTGAAATTCCATCCAAGAGATCCAAATCTTCTCCTGTCAGTAAGTAAAGATCATGCTTTACGATTATGGAATATCCAGACGGACACTCTGGTGGCAATATTTGGAGGCGTAGAAGGGCACAGAGATGAAGTTCTAAGTGCTGATTATGATCTTTTGGGTGAAAAAATAATGTCCTGTGGTATGGATCATTCTCTTAAACTTTGGAGGATCAATTCAAAGAGAATGATGAATGCAATTAAGGAATCTTATGATTATAATCCAAATAAAACTAACAGGCCATTTATTTCTCAGAAAATCCATTTTCCTGATTTTTCTACCAGAGACATACATAGGAATTATGTTGATTGTGTGCGATGGTTAGGCGATTTGATACTTTCTAAGTCTTGTGAAAATGCCATTGTGTGCTGGAAACCTGGCAAGATGGAAGATGATATAGATAAAATTAAACCCAGTGAATCTAATGTGACTATTCTTGGGCGATTTGATTACAGCCAGTGTGACATTTGGTACATGAGGTTTTCTATGGATTTCTGGCAAAAGATGCTTGCATTGGGCAATCAAGTTGGCAAACTTTATGTTTGGGATTTAGAAGTAGAAGATCCTCATAAAGCCAAATGTACAACACTGACTCATCATAAATGTGGTGCTGCTATTCGACAAACCAGTTTTAGCAGGGATAGCAGCATTCTTATAGCTGTTTGTGATGATGCCAGTATTTGGCGCTGGGATCGACTTCGATAAAATACTTTTGCCTAATCAAAATTAGAGTGTGTTTGTTGTCTGTGTAAAATAGAATTAATGTATCTTGCTAGTAAGGGCACGTAGAGCATTTAGAGTTGTCTTTCAGCATTCAATCAGGCTGAGCTGAATGTAGTGATGTTTACATTGTTTACATTCTTTGTACTGTCTTCCTGCTCAGACTCTACTGCTTTTAATAAAAATTTATTTTTGTAAAGCTGTGTGTTTAGTTACTTTCATTGTGGTGAAAAAAAGTTAAAAGTAATAAAATTATGCCTTATCTTTTTA

Publications

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