Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Advanced Search

Summary

Retrocopy Name TRMT1P1
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr19). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:145630118-145632440  UCSC
Coordinates (T2T) chrX:143887168-143889491  UCSC
Coordinates (hg19) chrX:144711636-144713958  UCSC
Strand +
Parental Sequence NM_001351761.2
Parental seq. overlap 1847 bp
Parental seq. overlap (%) 89.7%
Genomic Region Intergenic
Retrocopy Summary TRMT1P1, located on chrX:145630118-145632440, is a retrocopy of the parental gene TRMT1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TRMT1
Full Name tRNA methyltransferase 1
Also known as MRT68|TRM1
Coordinate chr19:13104907-13116740
Strand -
Gene summary This gene encodes a tRNA-modifying enzyme that acts as a dimethyltransferase, modifying a single guanine residue at position 26 of the tRNA. The encoded enzyme has both mono- and dimethylase activity when exogenously expressed, and uses S-adenosyl methionine as a methyl donor. The C-terminal region of the encoded protein has both a zinc finger motif, and an arginine/proline-rich region. Mutations in this gene have been implicated in autosomal recessive intellectual disorder (ARID). Alternative splicing results in multiple transcript variants encoding different isoforms. There is a pseudogene of this gene on the X chromosome. [provided by RefSeq, May 2017]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TRMT1P1
Gorilla Gorilla gorilla TRMT1P1
Orangutan Pongo abelii TRMT1P1
Gibbon Nomascus leucogenys TRMT1P1
Green monkey Chlorocebus sabaeus TRMT1P1
Rhesus Macaca mulatta TRMT1P1
Baboon Papio anubis TRMT1P1
Golden snub-nosed monkey Rhinopithecus roxellana TRMT1P1
Bonobo Pan paniscus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TRMT1P1
TGTACCAACATGGTGGCGCCCAGGTCCTAATTTGAGAAACGTGCATCTTGACTAATTCGGTTTTCTGTGGTTACGAGAGAAGAGCCCGGTTTATCGCGAGGGGCAGTCCCCAGGGCTGCCGAATCCAGCAGCGATGGAGAGCGGCACCGGGCCCTGCGGAGAAGAGCGCCCACGTGAAGTCCAGCAGACGACAGTCACTGAGGGGGCTGCCAAAATCCCAGCGCCAACGAGGTCTTTTATAACCTTGTGCAGGAATTCAGTCGGGACATGACGTGCTGTGATCATCCAGTTTGCTCGCATTCAGCTTGGGGCCAAAGGAATCCAGATCAAGGTGCCAGGAGAGAAGGATACACAAAAGGTGGTCGTGGACTTGTCAAAGCAAGAGGAGGAAAAGGTTGAACCGAAAGGGAGTGAAAACCTGGCCTCAGGAGACCAGCCTCGCACAGCGACCGTGTGGGAGATCTGTGAGGAAGGCCTGCATGTGCTGGAAGGCCTGGCAGCTTCAGGCCTACTTTCCATTCGATTTGCCCTAGAGGTGACTGGGGCTCAGATCTGTGGTTGCAAACGATACCTCTGCGGGGGCTGTGGATCTCATACGCTGGAATGTGCAGCTCAATGACGGGCCCACCTGGTACAGCCCAGCCAAGTAGATGCCTGGATGCTGATGTACCAGCACCAGAGGGTGTCAGAGAGGTTCGACGTCATCCATCTGGACCCCTATGGCAGTCCTGCCCCCTTCCTGGATGCAGCTGTGCTGGCTGTGAGTGAAGGAGAGTTGCTGTGCGTGACCCGCACGGACACGGCGGTGCTGGCGCGGAACAGTGGGGAGATGTGTTACAGCAAATTCGGTGCCATGGCCCTCAAGAGCCGGGCCTGCCACGAGATGGCCCTGAGAATTGTCCTGCACAGCCTGGACCTCCGCGCCAACTGTTACCAGCGCTTCGTGGTACCGCTGCTTAGCATCAGCGCCGACTTCTACGTGCGTGTTTTTGTCCGTGTCTTCACCGGCCAGCCCAAGGTTAAGGCCTCAGCCAGCAAGCAGGCCCTGGTGTTCCACTGAGTGGGCTGCGGGTGCTTCCACCTTCAGCGCCTCGGCAAAGCGTCAGGAGTCCCCCGCGGCCGGGTCAAGTCCTCTGTAGCCTGTGTTCCCCCCGTGACCCCGAGCGTGAACACTGTGGGCAGCGACACCAGCTTGGTTGCTCCATGTGGGCAGAGCCCATCCATGACCTGGATTTCGTGGGCTGTGTCCTAGAGGCTGTGAGCGCTAACCCCGGCCGCTTCCACACCTCGGAGCGGATGCCAGAGGGTCCTGAGCGTCATGACTGAGGAGCTCCCACAGGTGCCTCTGTACTACACCCTGGACCAGCTGAGCAGCACCATCCTCTGCAACACGCCCAGCCTCCTGCCGTGGCGGTCGGCCCTCCTCCACGCTCACTTCCGGGTTTCGCTCTCCCACGCCTGTAAGAACGCTGTGAAGACGTATGCCCCGCCTCCGCCCTCTGAAACATCATGCGCTGCTGGAAGAAGGAATGTCCGGTGAAACAGGAGCGACTCTCAGAGACCAGCCCAGCGTCCCGCATTCTCAGTGTGGAGCCCAGGCTGCAGGCCAACTTCACCATCCGGGAAGATGCCAACCCCAGCTCCCGCCAGCGACGACTCAAGCGCTTCCGGGCCAACCCGGAAGCCAACTGGAGCCCGCAGCCTCATGCCTGGCCAGGGAGCAAGGCTGCTGGCGAAGCTATGGAGGAGAGACGCAGGCTGCTTCCTAAGGAGTGGAAGGAGCCGCCTGAGGACAGGGCCCAGCGAGCTGCCCTGCTCAAGACATTTCCTTGCAAAAGGGTTAAGGAGGGGaGGGGGTTAAGGAGGGTACCTGTCAATGCGGGGACCAGTGCTGCTACTCCCACAGCCCTCTGACACCCGGGGTCTCTGCTGATGCTGCGCTTCACTGTCCAGAGACCTCCAATCACAGACCCCCTGGACCTGGGGCTGCCACTGGGCCCGGAATAGACTGAACCAATAAAGAGATGTC
>NM_001351761.2
ACCCACTGTGCCAACATGGCGGCGCCCAGGTCCTAATTCGGGAAACGTGCACCTTGACTAATTCGGTTTTCTGTGGCTACGAGAGCAGAGCCCGGTTTTTCGAGTGGCAGTCTCCAGGGCTGCCGAATACAGCAGCGATGGAGAACGGCACCGGGCCCTACGGAGAAGAACGTCCACGTGAAGTCCAGGAGACGACAGTCACCGAGGGGGCTGCCAAAATCGCCTTTCCCAGTGCCAACGAGGTCTTTTATAACCCGGTGCAGGAATTCAATCGGGACCTGACATGTGCTGTGATCACCGAGTTTGCTCGCATTCAGCTTGGGGCCAAAGGAATCCAGATCAAGGTTCCAGGAGAGAAGGACACGCAAAAAGTGGTCGTGGACTTGTCAGAGCAAGAGGAGGAAAAGGTTGAACTGAAAGAGAGTGAAAACCTGGCCTCAGGAGACCAACCTCGCACAGCGGCCGTGGGGGAGATCTGTGAGGAAGGCCTGCATGTGCTGGAAGGCCTGGCAGCTTCAGGCCTACGTTCCATTCGATTTGCCCTAGAGGTGCCTGGGCTCAGATCTGTGGTTGCAAACGATGCCTCCACCCGGGCTGTGGATCTCATACGCCGGAATGTCCAGCTCAATGACGTGGCCCACCTGGTACAGCCGAGCCAAGCAGATGCCCGGATGCTGATGTACCAGCACCAGAGGGTGTCGGAGAGGTTTGACGTCATCGATCTGGACCCCTATGGCAGCCCAGCCACCTTCCTGGATGCAGCTGTGCAGGCTGTGAGTGAAGGAGGGTTGCTGTGTGTGACCTGCACAGACATGGCGGTGTTGGCGGGGAACAGCGGGGAGACGTGCTACAGCAAGTACGGGGCCATGGCCCTCAAGAGCCGGGCCTGCCACGAGATGGCCCTGAGAATCGTCCTGCACAGCCTGGACCTCCGCGCCAACTGCTACCAGCGCTTCGTGGTGCCGCTGCTCAGCATCAGCGCTGACTTCTACGTGCGTGTTTTTGTCCGTGTCTTCACCGGCCAGGCCAAGGTCAAGGCCTCAGCCAGCAAGCAGGCGCTGGTGTTCCAGTGTGTGGGCTGCGGGGCCTTCCACCTTCAGCGTCTCGGCAAAGCGTCAGGAGTCCCCAGCGGCCGGGCCAAGTTCTCTGCAGCCTGTGGTCCCCCTGTGACCCCCGAGTGTGAACACTGTGGGCAACGACACCAGCTTGGTGGCCCCATGTGGGCAGAGCCCATCCATGACCTGGATTTTGTGGGCCGTGTCCTGGAGGCTGTGAGCGCTAACCCCGGCCGCTTCCACACCTCGGAGCGGATCCGAGGGGTCCTGAGCGTCATCACTGAGGAGCTCCCGGACGTGCCTCTGTACTACACCCTGGACCAGCTGAGCAGCACCATCCACTGCAACACACCAAGCCTCCTGCAGTTGCGGTCGGCCCTCCTCCACGCTGACTTCCGGGTCTCACTCTCCCACGCCTGTAAGAACGCTGTGAAGACGGATGCCCCTGCCTCTGCCCTCTGGGACATCATGCGTTGCTGGGAGAAGGAATGTCCGGTGAAACGGGAGCGACTATCAGAGACTAGCCCAGCGTTCCGCATTCTCAGTGTGGAGCCCAGGCTGCAGGCCAACTTCACCATCCGGGAAGATGCCAACCCCAGCTCCCGACAGCGAGGACTCAAGCGCTTCCAGGCTAACCCGGAGGCCAACTGGGGTCCCCGGCCTCGTGCCCGGCCAGGGGGCAAGGCGGCCGACGAAGCTATGGAGGAGAGACGCAGGCTGCTTCAGAACAAGCGGAAGGAGCCGCCGGAAGATGTGGCCCAGCGGGCTGCCCGGCTCAAGACATTTCCTTGCAAGAGGTTTAAGGAGGGCACCTGTCAACGCGGGGACCAGTGCTGCTACTCCCACAGCCCCCCGACACCCAGGGTTTCTGCTGATGCTGCCCCTGACTGTCCAGAGACCTCCAACCAGACCCCCCCTGGACCTGGGGCTGCCGCTGGGCCAGGCATAGACTGAACCAATAAAGAGATGTCACGTCACCTTC

Publications

PMID - Link Title