Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Summary

Retrocopy Name DUTP4
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Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr15). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:149817394-149817781  UCSC
Coordinates (T2T) chrX:148083138-148083525  UCSC
Coordinates (hg19) chrX:148899056-148899443  UCSC
Strand +
Parental Sequence NM_001025249.1
Parental seq. overlap 323 bp
Parental seq. overlap (%) 17.6%
Genomic Region Intergenic
Retrocopy Summary DUTP4, located on chrX:149817394-149817781, is a retrocopy of the parental gene DUT. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name DUT
Full Name deoxyuridine triphosphatase
Also known as BMFDMS|dUTPase
Coordinate chr15:48331095-48343373
Strand +
Gene summary This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes DUTP9
Gorilla Gorilla gorilla DUTP9
Orangutan Pongo abelii DUTP9
Gibbon Nomascus leucogenys DUTP7
Baboon Papio anubis DUTP10
Bonobo Pan paniscus Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Adipose SubcutaneousMuscle SkeletalArtery TibialArtery CoronaryHeart Atrial AppendageAdipose VisceralUterusVaginaBreast Mammary TissueSkin Not Sun ExposedMinor Salivary GlandBrain CortexAdrenal GlandThyroidLungSpleenPancreasEsophagus MuscularisEsophagus MucosaEsophagus Gastroesophageal JunctionStomachColon SigmoidSmall Intestine Terminal IleumColon TransverseProstateTestisNerve TibialSkin Sun ExposedHeart Left VentricleBrain CerebellumWhole BloodArtery AortaPituitaryBrain Frontal CortexBrain CaudateBrain Nucleus AccumbensBrain PutamenBrain HypothalamusBrain Spinal CordBrain HippocampusBrain Anterior Cingulate CortexOvaryBrain Cerebellar HemisphereLiverBrain Substantia NigraKidney CortexBrain AmygdalaCervix EctocervixFallopian TubeCervix EndocervixBladderKidney Medulla00.10.20.30.4
log10(TPM+1)

Massive Mining of Publicly Available RNA-seq Data from Human and Mouse - (ARCHS4)

AdiposeBone MarrowBreast Mammary TissueBrain CerebellumColonColon Colonic MucosaEsophagusHeartHeart VentricleKidneyLiverBrain MidbrainOvaryPancreasBrain PonsKidney CortexEye RetinaMuscle SkeletalSkinSmall IntestineBrain Spinal CordSpleenTestisThymusTracheaHeart ValveMuscle Smooth0123
log10(TPM+1)

Related Sequence

>DUTP4
AATGGATGAGTGGCTCAGTGGTCTGGCCTGGCTGCAAAACACTTTATAGATACAGGAGCTGGTGTCACAGACGAAGGTTATAGAGGAAATGGTGGGACTGTAGTGCTTAATTTGGGTAAAGAAAGGTTTGAAGTCAAAAAAAGTGATCAAATTGCACCAGTTTTCTGTGAATGGATTTTTTATCCGTAAACAGAAGTTCAAGCTCTGGATGAAACTGAAAGGCCTTCAGAAGGTTTAGGTTCCACTGGAAAGAATTAAAATCTATGCCAAAATAGAAAATGTGAAATCATACTGTTTTCTGAAAAATGAAGAGTTTTGCTTAAAGTGATTTGTTGTTTGGTACTTCTCTAAATTTAATAGCTATAACCTTCTAAAAAGACTGCATTTT
>NM_001025249.1
GTCATGTTCCCAGGACGGGCGCGTCTTCAGGGTGGAAGCCTGGCGCACGTCCGGAGAGACACCCGCCATTTCACCCAGTAAGCGGGCCCGGCCTGCGGAGGTGGGCGGCATGCAGCTCCGCTTTGCCCGGCTCTCCGAGCACGCCACGGCCCCCACCCGGGGCTCCGCGCGCGCCGCGGGCTACGACCTGTACAGTGCCTATGATTACACAATACCACCTATGGAGAAAGCTGTTGTGAAAACGGACATTCAGATAGCGCTCCCTTCTGGGTGTTATGGAAGAGTGGCTCCACGGTCAGGCTTGGCTGCAAAACACTTTATTGATGTAGGAGCTGGTGTCATAGATGAAGATTATAGAGGAAATGTTGGTGTTGTACTGTTTAATTTTGGCAAAGAAAAGTTTGAAGTCAAAAAAGGTGATCGAATTGCACAGCTCATTTGCGAACGGATTTTTTATCCAGAAATAGAAGAAGTTCAAGCCTTGGATGACACCGAAAGGGGTTCAGGAGGTTTTGGTTCCACTGGAAAGAATTAAAATTTATGCCAAGAACAGAAAACAAGAAGTCATACCTTTTTCTTAAAAAAAAAAAAAAAGTTTTTGCTTCAAGTGTTTTGGTGTTTTGCACTTCTGTAAACTTACTAGCTTTACCTTCTAAAAGTACTGCATTTTTTACTTTTTTTTATGATCAAGGAAAAGATCATTAAAAAAAAACACAAAGAAGTTTTTCTTTGTGTTTGGATCAAAAAGAAACTTTGTTTTTCCGCAATTGAAGGTTGTATGTAAATCTGCTTTGTGGTGACCTGATGTAAACAGTGTCTTCTTAAAATCAAATGTAAATCAATTACAGATTAAAAAAAAAAGCCTGTATTTAACTCATATGATCTCCCTTCAGCAACTTATTTTGCTTTAATTGCTTTAAATCTTAAGCAATATTTTTTATTCAGTAAACAAATTCTTTCACAAGGTACAAAATCTTGCATAAGCTGAACTAAAATAAAAATGAAAAGGAGAGATTAAAGGTATTCCTTGTTCTTCCCTTCTCTTCACTAGTCTAAAAACTTCTTTTTAATCTTAAGATTCTTTGTGATGAGGGTGAGAAAAAGAATCCTCAGTTTATTTTTCCACTATTAATCTTTCTTTTGATAAATCCTCTATTGACTGGGTAGAGGTATGTTTGTGAAAGACATGTAACTTGGGGATTTGTTACTTTAGGTTTGTTCCCTTGAATTTCATCTCATCAGGCAAATTGTACTAGTTGTAGTTACGAGTTTTCCCTCAGTGAAGTAGCAATAGGCTGTAATCAAGAAAATATGCCATTTATAGAGATAAGATAAATGAAATAATACTTCAGCCACCAGGTTTTTCTGTCTCACATACATAAGCAGCATTTCATTGCAGATATGGGACTGATTCTGTGGCTTACCTTGATTAACATCTTTTGGAAGTTTTGCTAGTGTGCTTTCCTTTCTTTACTATGTTTCTCAGATTCCTTTGTATCAGGGTTTTGGGTGTCACTTAGGTTTTGTCCATCAGATTCTGTGAGACACCAGGCATCGTTTTGAGGATGTGGGTTATACACATGGAGTGCTTCTGGAACTATCAGCCCACTTGACCACCCAGTTTGTGGAAGCACAGGCAAGAGTGTTCTTTTCTGGTGATTCTCCAGGCCATTTAATACCCTGCAATGTAATTGTCCCTCTGTGGCTCACATTTcattagtgagccatgaaatcaactcagtgggacatagccagcatttttGCATACCAGGTTGGGCTATAAAATATTTCTGTTGTCAATAAATTTTAAATGTTTTCCTGCTAAACTAA

Publications

PMID - Link Title
No publications available for this retrocopy