Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name HAUS1P2
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr18). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:18865770-18866744  UCSC
Coordinates (T2T) chrX:18448388-18449362  UCSC
Coordinates (hg19) chrX:18883888-18884862  UCSC
Strand +
Parental Sequence NM_138443.4
Parental seq. overlap 930 bp
Parental seq. overlap (%) 86.5%
Genomic Region Intergenic
Retrocopy Summary HAUS1P2, located on chrX:18865770-18866744, is a retrocopy of the parental gene HAUS1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name HAUS1
Full Name HAUS augmin like complex subunit 1
Also known as CCDC5|HEI-C|HEIC|HsT1461
Coordinate chr18:46104385-46128333
Strand +
Gene summary HAUS1 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes HAUS1P3
Bonobo Pan paniscus HAUS1P3
Gorilla Gorilla gorilla HAUS1P3
Orangutan Pongo abelii HAUS1P3
Gibbon Nomascus leucogenys HAUS1P3
Crab-eating macaque Macaca fascicularis HAUS1P3
Rhesus Macaca mulatta HAUS1P3
Baboon Papio anubis HAUS1P3
Golden snub-nosed monkey Rhinopithecus roxellana HAUS1P2
Green monkey Chlorocebus sabaeus Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>HAUS1P2
TATATATGGAGATCATCCCATTCCACAGTATGAGGTGAACCCACGGACCACAGAGATTTTACATCACCTTTCAGAACGCAACAGGGTCCAGAACAGGGATGTCTACCTGGTAATAGAGGACTTGAAGCAGAAAGCAAGTGAATACCAGTCAGAAGCCAAGTATCTCCAAGACCTTCTCATGGAGAGTGTGAATTTTTTCCCCTGCCAATCTCTCTAGCACTGGTTCCAGGTATCTGAATGCTTTGGTTGGCAGTGCGGTGGCCCTTGAAACGAAGGATGCCTCACTAACTAGTTTTATCCCTGTAGTGAATGATTTGACCTCTTACCTCTTTCGTACCAAATCCAAAAGTGAAGAAATCAAGATTGAACTGGAAAATTTTGAAAAAAAATCTAACTGCAACTTTAGTATTAGAAAAATGTCTACAAGAGGATCTCAAGAAAGCAGAGTTGCATCTGTCTACAGAAAGGGCCAAAGTTGATAATCGTCATCAGAACATGGACTTTCTAAAACCAAAGTCAGTGGAATTCAGATTTGGAATCAAGGCTGCAGAGGGAGCAACTTTCAGCCAGAGGCATGGATGCTTCTCTGTCTCATCAGTCCCTAGTAGCACTGTCAGAGAAACTGGCAAAATTAAAACAACAGACTATACCTTTGAAGAAAAAATTGGAGTCCTAGTTAGATTTAATGCCGAATCCATCCTTGCTCAAGTGAAAATTGAAGAAGCAGAGTGAGAATTAGATAGCATTGAAGCTGAACTTACAAGAAGAGTAGACATGATGGAACTGTGACAAGAGCCAAATAAACAGCCTTTTCCCTAACAAAGTAAATTGAATAGGACTTCACAGAGTTCTTTTTCCTCTTGGCATTTCTTAATAACAAAATTTTCTGTGTTCTTAGATTACAGAATATCATAATTGATAGAATATGGTTTCTAACTGTATTTCATTTTTGTGCCCAAATACATCGTTTTCATA
>NM_138443.4
CCTAGTAAAGTGGCGGGAGCCGCAGCTATGGAGCCGCAGGAGGAGAGAGAAACGCAGGTTGCTGCGTGGTTAAAAAAAATATTTGGAGATCATCCTATTCCACAGTATGAGGTGAACCCACGGACCACAGAGATTTTACATCACCTTTCAGAACGCAACAGGGTCCGGGACAGGGATGTCTACCTGGTAATAGAGGACTTGAAGCAGAAAGCAAGTGAATACGAGTCAGAAGCCAAGTATCTTCAAGACCTTCTCATGGAGAGTGTGAATTTTTCCCCCGCCAATCTCTCTAGCACTGGTTCCAGGTATCTGAATGCTTTGGTTGACAGTGCGGTGGCCCTTGAAACAAAGGATACCTCGCTAGCTAGTTTTATCCCTGCAGTGAATGATTTGACCTCTGATCTCTTTCGTACCAAATCCAAAAGTGAAGAAATCAAGATTGAACTGGAAAAACTTGAAAAAAATTTAACTGCAACTTTAGTATTAGAAAAATGTCTACAAGAGGATGTCAAGAAAGCAGAGTTGCATCTGTCTACAGAAAGGGCCAAAGTTGATAATCGTCGTCAGAACATGGACTTTCTAAAAGCAAAGTCAGAGGAATTCAGATTTGGAATCAAGGCTGCAGAGGAGCAACTTTCAGCCAGAGGCATGGATGCTTCTCTGTCTCATCAGTCCTTAGTAGCACTATCAGAGAAACTGGCAAGATTAAAGCAACAGACTATACCTTTGAAGAAAAAATTGGAGTCCTATTTAGACTTAATGCCGAATCCGTCTCTTGCTCAAGTGAAAATTGAAGAAGCAAAGCGAGAACTAGATAGCATTGAAGCTGAACTTACAAGAAGAGTAGACATGATGGAACTGTGACAAAAGCCAAATAAACATCCTTTTCCCTAACAAAGTAAATTGAATAGGACTTTACAGAGTTCTTTTTCCTCTTGGCATTTCCTAATAACAAAACTTTCTGTGTTCTTAGATTACAGAATATCATAATTGATAGAATATGGTTTCTTACTGTGTGTTGCATTTTTGTGCCCAAATACATAGTTTTCATATTAAAAAGCCTTTTCTCTTA

Publications

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