Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RDXP3
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:27517882-27519767  UCSC
Coordinates (T2T) chrX:27108184-27110069  UCSC
Coordinates (hg19) chrX:27535999-27537884  UCSC
Strand +
Parental Sequence NM_001260492.2
Parental seq. overlap 1461 bp
Parental seq. overlap (%) 54.7%
Genomic Region Intragenic (DCAF8L2)
Retrocopy Summary RDXP3, located on chrX:27517882-27519767, is a retrocopy of the parental gene RDX. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RDX
Full Name radixin
Also known as DFNB24
Coordinate chr11:110174922-110296614
Strand -
Gene summary Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RDXP2
Bonobo Pan paniscus RDXP2
Gorilla Gorilla gorilla RDXP2
Orangutan Pongo abelii RDXP1
Gibbon Nomascus leucogenys RDXP2
Green monkey Chlorocebus sabaeus RDXP1
Crab-eating macaque Macaca fascicularis RDXP1
Rhesus Macaca mulatta RDXP1
Baboon Papio anubis RDXP1
Golden snub-nosed monkey Rhinopithecus roxellana RDXP1
Marmoset Callithrix jacchus RDXP1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RDXP3
TGCCCAATACAACTGGCAGACAACTTTTTGACCAGATGGTGAAAACAGTTGGTTTGCGTGAGGTCTGGTTTTTTTGGGCTGCAGTATGTAGACAGCAAAGGTTATCCTACATGGCTTAAACTAAATAAAAAGGTGACACAGCAAGATGTTAAAAAAGTGAATCCTTTACAGTTCTAGTTTAGAGCTAAATTCTTTCCTGAAGATGTTTCTGAGGAATTAATTCAAGAAATAACCCAGAGACTCTTCTTGCAAGTTTAAGAAGCCATCTTAAAGGATGAAATATATTGCCCGCCAGAAACTGCAGTTCTTTTGGCTTCCTATGCTGTCCAAGCCAAGTATGGAGGTTATAATAAAGAGATTCATAAGCCAGGCTACCTGGCTAATGATAGAATCCTACCCCAGCGTGTTTATTGGAACAACACAAACTAACAAAAGAACAGTGGGAAGAAAGAATACAGAACTGGCATGAAGAACATAGAGGAATGCTAAGGGAGGATTCTATGATGGAAAACCTGAAGGTTGCACAAGATCTAGAAATATATGGTGTCAACTATTTTGAAATGAAAAACAAAAAGGGGGGAACTGAATTGTGGCTAGGTGTTGATGCTTTGAGTCTGAATATTTATGAGCATGATGACAAGTTGACATCTAAAATTGGTTTTCCCTGGAGTGAAATCAGAAATATTTCATTTAATGACAAAAAAATTGCTATAAAGCCAATAGACAAAAAGGCACCTGATTTTGTTTTTTATGCACCTCATCTGAGAATCCATAAGGGGATTTTGGCCTTATGTATGGGAAACCATGAACTATACATGCGAAGAAGGAAGCCTGATACTATTGAAGTACAACAGATGAAGTCTCAGGCTAGGGAGGGGAAACATCAGAAGCAGTTGGAAAGGGCACAATTACAGAATGAAAAGAAGAAAAGAGAAATAGCAGAAAAGGAAAAGGAAAGAATAGAACGTGAAAAGGAAGAGCTAATGGAACGTCTAAGACAGATTGAAGAACGGACAATTAAAGCCCAGAAATAACTAGAAGAACAGACTCAAAAAGCTCTAGAACTGGATCAAGAATGAAAACGAGCAAAAGAAGAAGCAGAGCGGCTTGAAAAGGAGCGTCGAGCTGCTGAAGAGGCGAAGTCTGCCGTAGCAAAACAAGCTGCCGACCAGATGAAGAATCAGGAGCAGCTAGCAGCACTTGCTGAATTCACTGCCAAGATTGCACTTCTgCTACTGAGTTGCAACACAAAGCTTTTGCAACCCAGGAAGACTTGGAAAAGACCAAAGAAGAGTTAAAAACTGTGATGTCTACCCTCTCTCCACCTCCACCACCAGTCATTCCTCCGACAGAAAACGAACATGATGAGAATAATGCTGAGGCTAGTGCTGAATTATCAAATGAAGGGGTAATGAACCATAGAAGCGAGGAAGAACGTGTAACAGAAACACAGAAAAATGCGCGTGTTAAGAAGCAACTTCAGGCATTAAGTTCAGAATTAGCCCAAGCCAGAGATGAAACCAA
>NM_001260492.2
ATATTGCGGAGCTGTCTGCGGTGGCGGCGGCGCCTCTCGTCTCCCGCGGGCCAGCGCTCGCACCACCGCTTCTCCCTCCCTGTCGCAGCCGCGCCGCCGCGCAGCGCCCCAGCCACACGCCGGCGGGCAGAAGCCGCCCGCTCTCCGGAAAGTGATAACAGAATTCATTGAAGTGGAGAATTTTTAAAGAAGGTAACAAAAAGAGAAAGAAAATGCCGAAACCAATCAACGTAAGAGTAACTACAATGGATGCTGAGCTGGAATTTGCCATTCAGCCCAATACAACTGGCAAACAACTTTTTGACCAGGTGGTGAAAACAGTTGGTTTGCGTGAGGTCTGGTTTTTTGGGCTGCAGTATGTAGACAGCAAAGGTTATTCTACATGGCTTAAACTAAATAAAAAGGTAACACAGCAGGATGTTAAAAAAGAGAATCCTTTACAGTTCAAGTTTAGAGCTAAATTCTTTCCTGAAGATGTTTCTGAGGAATTAATTCAAGAAATAACCCAGAGACTCTTCTTCTTGCAAGTTAAAGAAGCCATCTTAAATGATGAGATATATTGCCCGCCAGAAACTGCAGTTCTTTTGGCTTCCTATGCTGTCCAAGCCAAGTATGGAGATTACAATAAAGAGATTCATAAGCCAGGCTACCTGGCTAATGATAGACTCCTACCCCAGCGTGTATTGGAACAACACAAACTAACAAAAGAACAGTGGGAAGAAAGAATACAGAACTGGCATGAAGAACATAGAGGAATGTTAAGGGAGGATTCTATGATGGAATACCTGAAGATTGCACAAGATCTAGAAATGTATGGAGTCAACTATTTTGAAATAAAAAATAAAAAAGGAACTGAATTGTGGCTAGGTGTTGATGCTTTGGGTCTGAATATTTATGAGCATGACGACAAGTTAACACCTAAAATTGGTTTTCCCTGGAGTGAAATCAGAAATATTTCATTTAATGACAAAAAATTTGTTATAAAGCCAATCGACAAAAAGGCACCTGATTTTGTGTTTTATGCACCTCGTCTGAGAATCAATAAGCGGATTTTGGCCTTATGTATGGGAAACCATGAACTATACATGCGAAGAAGGAAGCCTGATACTATTGAAGTACAACAGATGAAGGCTCAGGCTAGGGAGGAGAAACATCAGAAGCAGTTGGAAAGGGCACAATTAgagaatgaaaagaagaaaagagaaatagcagaaaaggaaaaggaaagaatagaacgtgaaaaggaagagctaatggaaCGTCTAAAACAAATTGAAGAGCAGACAATTAAAGCTCAGAAAGAACTAGAAGAACAGACTCGAAAAGCTCTAGAACTGGATCAAGAACGAAAACGAGCAAAAGAAGAAGCAGAACGACTTGAAAAGGAGCGTCGAGCTGCTGAAGAGGCAAAGTCTGCCATAGCAAAACAAGCTGCCGACCAGATGAAGAATCAGGAGCAGCTAGCAGCAGAACTTGCTGAATTCACTGCCAAGATTGCACTTCTAGAGGAAGCCAAGAAGAAAAAGGAAGAGGAAGCTACTGAGTGGCAACACAAAGCTTTTGCAGCCCAGGAAGACTTGGAAAAGACCAAAGAAGAGTTAAAAACTGTGATGTCTGCCccccctccacctccaccaccaccaGTCATTCCTCCAACAGAAAACGAACATGATGAACACGATGAGAATAATGCTGAAGCTAGTGCTGAATTATCAAATGAAGGGGTAATGAACCATAGAAGCGAGGAAGAACGTGTAACCGAAACACAGAAAAATGAGCGTGTTAAGAAGCAACTTCAGGCATTAAGTTCAGAATTAGCCCAAGCCAGAGATGAAACCAAGAAAACACAAAATGATGTTCTTCATGCTGAGAATGTTAAAGCAGGCCGTGATAAGTACAAGACTCTGCGACAGATTCGACAAGGCAATACAAAGCAGCGTATCGATGAGTTTGAAGCAATgtggggacccaaactgtatgcattgttccagatgcgctcttgccaaagcagcataaagcaaatgtaaccCTTAGGAAGAAGGCTCCCTCCCTCACTAGGCCCCTGGCTACTGACTTATGGGAAGCTTTAGGATAAGGACATACCTGGTGTTCTGAATGTGTATATCCCCCAAAGTCTGCAATCTCAGCTGGAACTGGATGGACCAGTATTCCATTACCCAGGGCCCTGGCTCATGGTTCTCTCCTCTTCTCAGTTTACTGTTGGATTTCCCTTTCTTGCTATTCTCTTTCTCTCCAGACCCCTCTCAATTGCCTTTCCTAAAGACAGACCTTAGCAAGATGGGCCAGGACTTGGGACTTCGCACAGCACCCTGCAGTCCCAAGCCAGCATCTACTGCACCCCATCTTCAGGACTCTATCCCCCAAACATGCTGGAAGGCATCAGCTTATGAGAACCCACTTTTTTCTGCATGACTAGCTTGTAAGGAAGAATCTATGGACAGGATTTCCAAGAATTTCCCACTTTTTCAAAAAATGTATGTGACTTATATTTGGCTTCAATCCAAGAGCAAACTCAGTGGTGAACAGCTCCATTTCTGTGCACATGTTGGTGGAATCTGCAGAAATCGATGCAACATTTCTTTCCTGTCTGGGCTGTTTGTATAATTGTATATAAATGTAGCAATAAATATATTCTAACATCA

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