Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SC4MOP
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr4). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:37945849-37946941  UCSC
Coordinates (T2T) chrX:37349434-37350526  UCSC
Coordinates (hg19) chrX:37805102-37806194  UCSC
Strand +
Parental Sequence NM_006745.5
Parental seq. overlap 950 bp
Parental seq. overlap (%) 42.4%
Genomic Region Intragenic (SYTL5)
Retrocopy Summary SC4MOP, located on chrX:37945849-37946941, is a retrocopy of the parental gene MSMO1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MSMO1
Full Name methylsterol monooxygenase 1
Also known as DESP4|ERG25|MCCPD|SC4MOL
Coordinate chr4:165327669-165343164
Strand +
Gene summary Sterol-C4-mehtyl oxidase-like protein was isolated based on its similarity to the yeast ERG25 protein. It contains a set of putative metal binding motifs with similarity to that seen in a family of membrane desaturases-hydroxylases. The protein is localized to the endoplasmic reticulum membrane and is believed to function in cholesterol biosynthesis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes MSMO1P1
Bonobo Pan paniscus MSMO1P1
Gorilla Gorilla gorilla MSMO1P1
Gibbon Nomascus leucogenys MSMO1P1
Crab-eating macaque Macaca fascicularis MSMO1P1
Rhesus Macaca mulatta MSMO1P1
Baboon Papio anubis MSMO1P1
Golden snub-nosed monkey Rhinopithecus roxellana MSMO1P1
Marmoset Callithrix jacchus MSMO1P2
Orangutan Pongo abelii Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SC4MOP
CCAGAATTAGAAGGCTCTATGCAGAGATTTGAGAAATGGCAACAAATGAAAGTGCCAGCATCTGTAGTTCAGCATTTGTAGCTGTGGAGTATGTAGATTCACTTTTACCTGACAGTCCTCTGCAAGAACCATTTTAAAATGCTTGGAATTGTATGTTAATAATTATACAATGTTCTAGATTGCAACATGGGGATCTGCTATTGTTCATGAAAACTTTTATTTCTTGTTCTTTTTACCTGGGTTTCTATTTCAATTTATACCTTGCATTAAAAAGAATAACATTGAAAAATATAAACCAGAGACATAGGAAAACCAACGGAAGTGCTTTAAATTACTTCTCTTTAATCACTTTTGTATCCAGCTGCTTTTATGTGTGGAACCTATTATTTTACAGAGTATTTCAATATTCTTTATGATTGAAAAAGAATGACAAAATGGTATATGCTTTTGGTAAGGTGCTTTGGCTATACTACAGTCTTTGATACTACTTGGCACTATTTCTAAGCCTGCATAGATTCTTTTACCACAAAAAGAATATGTAAATAGATTCATAAAATTCATCATGAGTTTCAAGCTCCATTTGGAATAGAAGCTGAATATGCACATCCTTTGGAAATTCTAATTCTTGGAACTGGATTTTTCATTGGAATCATGCTTTTGTGTTACCATGTAATTAATTCTTCTTTGGACATGGGTGACAATTTATTTGATAGAAACTATTGATGCCCATCGTGGTTATGATATTCCTCTCAAACCTTTAAATCTCATCCTTTTCTATGCTGGTTCTCAGCATCATGATTTACACCACATAAACTTCATCAGAAAGTATGCTTCTACATTTTCATGGTGGAATACAATTTTTCGAACACACTTTCAGTTTAATGTTTATAGTGAAAATATGAAGAAGTTTGAGAAAAAGCTGAATAAATATCTCATATAAACCTTTCTGAAGATATACATTTTCCTGAATTGAAACTAGTAGCTAACATTGCTTCTGGGGAGCAGAAATAAGCATGTGTCTTGGTTGCTAAGTGATAAAAGGAATATTGATAACCTCTAATTATCTTCCTAGTGGAGACTTTTTCTACTTTAC
>NM_006745.5
GGCTCCACCCCCAAGCCAGGCGAGGCAGGTTCCGAGGTTGGAACACCTGGCGAGTCCTCGGTGTCGGTGGCCGGCAGTCATCTCGCGGCCGTTCAGAATTATAAGGCTGTCTGCAGAGATTTGAAAAATGGCAACAAATGAAAGTGTCAGCATCTTTAGTTCAGCATCCTTGGCTGTGGAATATGTAGATTCACTTTTACCTGAGAATCCTCTGCAAGAACCATTTAAAAATGCTTGGAACTATATGTTGAATAATTATACAAAGTTCCAGATTGCAACATGGGGATCCCTTATAGTTCATGAAGCCCTTTATTTCTTATTCTGTTTACCTGGATTTTTATTTCAATTTATACCTTATATGAAAAAATACAAAATTCAAAAGGATAAGCCAGAGACATGGGAAAACCAATGGAAGTGTTTCAAAGTTCTTCTCTTTAATCACTTCTGTATCCAGCTGCCTTTGATTTGTGGAACCTATTATTTTACAGAGTATTTCAATATTCCTTATGATTGGGAAAGAATGCCAAGATGGTATTTTCTTTTGGCAAGATGCTTTGGTTGTGCAGTCATTGAAGATACTTGGCACTATTTTCTGCATAGACTCTTACACCACAAAAGAATATACAAGTATATTCATAAAGTTCATCATGAGTTTCAGGCTCCATTTGGAATGGAAGCTGAATATGCACATCCTTTGGAGACTCTAATTCTTGGAACTGGATTTTTCATTGGAATCGTGCTTTTGTGTGATCATGTAATTCTTCTTTGGGCATGGGTGACCATTCGTTTATTAGAAACTATTGATGTCCATAGTGGTTATGATATTCCTCTCAACCCTTTAAATCTGATCCCTTTCTATGCTGGTTCTCGGCATCATGATTTCCACCACATGAACTTCATTGGAAACTATGCTTCAACATTTACATGGTGGGATCGAATTTTTGGAACAGACTCTCAGTATAATGCCTATAATGAAAAGAGGAAGAAGTTTGAGAAAAAGACTGAATAAATATCTCACGTAAACCTTCCTGAAAGATAAACGTTTTCCTGAATTCAGAAACTAGTAGCTAACATTGCTTCTGGAGAGCAGAAATAAGCATGTCTTCTGGCTACTAAGTGATAAAAAGAACATTAACAACCTTTAATTACCTTCCTAGTGGGAACTTTTTCTACTTTACCTACAAGTTCTATATATGTAGAAATGAATAAATATATATTTAAGTACAGTTTTCATGAGGAAGTTTTAAAAGACCATGTTCCTAAGCTTCCAAGAAGGTTTTGGATACTAGAAGTATTAATCTATGGCTTTTCTCCCAGTAAAACCATAGGCCTGAAGTTCACATTGGGTCTTTAAATCTTTTAGATATATACTGGTCATTTCAGAAAATTCTTCATAGTGGTATTGGCCTTATATTTAACtttttttttattttttttttgagacaaagccacactctgtctccttggctggagtgtggtggcacagtctcagctcactgcaacctctgcctcccagttcaagcaattcttctgcctcagcctcccaagtagctgggattacaggcacccgccaccacgcccagctaatttttgtatttttgtagagatggggtttcacgatgttggccaggctggtctcaaacttctgacctcaagtgatctgcccaccttggcctcccaaagtgctgggattacaggtgtaagccactgcgcccggccTTTTTAACTTTAAACATGTTTTAGAATTCACCTAAAGATCAAAATATCATGGATTGAACCTCATCAATTGATAGCAGTGAGTGACTGAAGCTTCCAAATCAAGAAAAGCCGGCACCAAGAACTTCCATTCTAATCTAGAGCTGACCAGTTTGAGCTGATTCTCTCTTTGAAGAGTCCTTCTTGATTGCAGTGCAGTACTGGCATTTCTGAATGGATGTAAGTGGAGTATTTTAGTCTAAAGGCTTTTCAAATTACTTGAATTTTTTTAAAAATTGAGGAGCTTTATTTCTATTTACCCTTCCATTTTTGTATATCAAATTTCCATTGTCATTAAAAACTGTATCTTGAAACTTTGTGAACTGACTTGCTGTATTTGCACTTTGAGCTCTTGAAATAAATGTGATTTTTGTGTGATTATCTGGTTTCCAGTTTTAAACATTAACTGTCACCTTTTATTCTTAAACTTGAAAGTACAGAAATCATTAAATTATTAAGTTGTACAATAAAA

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