Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name IMPDH1P2
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:40358456-40360778  UCSC
Coordinates (T2T) chrX:39760040-39762362  UCSC
Coordinates (hg19) chrX:40217709-40220031  UCSC
Strand -
Parental Sequence NM_001142573.2
Parental seq. overlap 1879 bp
Parental seq. overlap (%) 71.1%
Genomic Region Intergenic
Retrocopy Summary IMPDH1P2, located on chrX:40358456-40360778, is a retrocopy of the parental gene IMPDH1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name IMPDH1
Full Name inosine monophosphate dehydrogenase 1
Also known as IMPD|IMPD1|IMPDH-I|LCA11|RP10|sWSS2608
Coordinate chr7:128392277-128409989
Strand -
Gene summary The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes IMPDH1P10
Bonobo Pan paniscus IMPDH1P10
Gorilla Gorilla gorilla IMPDH1P10
Orangutan Pongo abelii IMPDH1P10
Gibbon Nomascus leucogenys IMPDH1P10
Green monkey Chlorocebus sabaeus IMPDH1P10
Crab-eating macaque Macaca fascicularis IMPDH1P8
Rhesus Macaca mulatta IMPDH1P10
Baboon Papio anubis IMPDH1P9
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>IMPDH1P2
CTCAGCCATGTGGCACTTCTGAGCTCCTGACCTAGGCCAGCGGGAGGTCTCTGCCCGCTTCTCCGGCACTGGGCTCCAATTGAGTCCTGCTCCTCAGGCCACTCCCCTGTCCCTGGCCCTGGGGAGGACACTGCCCTGGTCATGGCCACCTGCCCATCGTTCCTGACTCACCACCGTCCCCAGGTGTGCCATTCCTGCCCTCTCCTCAGCTGCAGTTTAAGGCTTTAACTTTGCACACTTTGGGATCACAGTTGCGACATTGTGGGTATTAAATAATTGGAATAAATCAAGCAGATCTCAACGCCTCCAAGGCGGGTGGCGGCGCGGGTGTTTACGTCAGGTCGCAGGGTGTCGCTGGCAGCATGGCGGACTACCTCATCAGCGGCGGCACCCGCTACCAGCCCGAGGATGGGCTCACCGCACAGCAGCTCTTTGCCAGCGCTGACGACCTCACCTACAACGATTTCCTGATTCTCCCAGGATTCATAGACTTCCTAGCTGGTGAGGTGGACCTGACCTCAGCCCTGACCCGGAAGATCACGCTGAAGACGCCACTGATCTCCTTTCCCACGGACACTGTGATAGAGGCCGACATGGCCATCGCGATGGCTCTGATGGGAGGTATTGGTTTCATTCACCACAACTGCACCCCAGAGTTCCAGGCCAACAAGGTGCAGAAGGTCAAGAAGTTTGAACAGGGCTTCATCACAGACCCTGTGGTACTGAGCCCCTTGCACACTGTGGGTGATGTGCTGGAGGCCAAGATGCGGCATGGCTTCTCTGGCATCCCCATTACTGAGACCGGCACCATCGGCAGCAAGCTGGTGGGCATCCTCACCTCCCGAGACATCGACTTCCTTGCTGAGAAGGACCACACACCCTCCTCAGTGAGGTGATGACGCCAAGGATGGAGCTAGTGGTGGCTCCAGCAGGCGTGACGTTCAAAGAGGCAAATGAGATCCTGCAGCGTAGCAAGAAAGGGAAGCTGCCTGTTGTCAATGATCATGATGAGCTGGTGGCCATCATCGCCCGCACGGACCTGAAGAAGAACCGAGACTACCCTCTGGCCTCCAAGGATTCCCACAAGCAGCTGCTGTGCGGGGCAGTTGTGGGCACCTGTGAAGATGACAAATTCCGCCTGGGCCTGCTCACCCAGGCGGGCGTCGATGTCATAGTCTTGGACTCGTCCCAAGGGAACTCGGTGTATCAGATTGCCATGGTGCGTTACATCAAACAGAAGTACCCCCACCTCCAGGTGATTGGGAGGAATGTGGTGACAGCAGCCCAGGCCAAGAACCTGATTGACGCTGGTGTGGATGGGCTGCACGTGGGCATGGGCTGCGGCTCCATCTGCATCACCCTGGAAATGATGGCCTGTGGTCGGACCCACGGCACTGCTGTGTACAAGGTGGCCGAGTATGCCTGGCGTTTTGGTGTGCCCATCATAGCTGATGGTGGCATCCAGACCGTGGGGCACGTGGTCAAGGCCCTGGCCCTTGGAGCCTCCACAGTGATGATGGGCTCCCTGCTGGCCACCACCACGGAGGCCTCCGGTGAATACTTCTTCTCAGACGGGGTGCCGCTCAAGAAGTATCAGGGCATGGGCTCTGTGGATGCCATGGAGAAGAGCAGTAGCAGCCAGAAACGATACTTCAGCGAGGCGGATAAGGTGAAGTTCTCGCAGGGTATCTTGGGCTCCATCCAGGACAAAGGGTCCATTCAGAAGTTCGTGCCCTACCTCATAGCGGGCATCCAGCACAGTTGCCAGGATATCGGGGCCCGAAGCCTGGCTGTCCTTCGGTCCATGATGTACTCAGGAGAGCTCAAGTTTGAGAAGGGGACCGTGTCGGCCCAGATCGAGGGTGGCGTTCATGGCCTGCACTCTTACGAGAGGTGGCTGTACTGAGGAGAGTGGTGGAGGCCGAGGTGGTTGAAGGGGCGTGCCCCGCTTTCCCCCTTTGGGCACAGCCTCCCTCCTTAACTGAGTGATCCACAGATTTACACTATGGGTTCCCCAGCTCCTTTCCAGGGAGAGAGGACGGGAGGCCCTGAGGGTACTGTTGCCCCTCGCTGGGCATCTCCCACAAAGTCAGGACCGCTCCCTGGGCCAGGCTGCCCTGGGAAGCCCAGCCCAGCCAGCCAGGCTCTCAGGCCCTGCGCCTGCCTCAGGTCTTTCTTGCTGCAGCCTGCTCCAGCCCGGCCCCCACCCCAGGGGCAGGCCGCCCCTCCTGGCTTCTCCTGTAGGACACCTCCCTGCCCCCCAGCTCCCCAAGAAATGGCACTCTc
>NM_001142573.2
gcccccggcccgcccggcccgcggcagcagcgtggccgcggcgcggcgtcagcagtagcagcagcagcagcggcggcagcggcgggcggccgcgCGGGTGTTTATGTCGGGTCGCGGGGTCTCGCGGCAGCATGGCGGACTACCTGATCAGCGGCGGCACCGGCTACGTGCCCGAGGATGGGCTCACCGCGCAGCAGCTCTTCGCCAGCGCCGACGGCCTCACCTACAACGACTTCCTGATTCTCCCAGGATTCATAGACTTCATAGCTGATGAGGTGGACCTGACCTCAGCCCTGACCCGGAAGATCACGCTGAAGACGCCACTGATCTCCTCCCCCATGGACACTGTGACAGAGGCTGACATGGCCATTGCCATGGCTCTGATGGGAGGTATTGGTTTCATTCACCACAACTGCACCCCAGAGTTCCAGGCCAACGAGGTGCGGAAGGTCAAGAAGTTTGAACAGGGCTTCATCACGGACCCTGTGGTGCTGAGCCCCTCGCACACTGTGGGCGATGTGCTGGAGGCCAAGATGCGGCATGGCTTCTCTGGCATCCCCATCACTGAGACGGGCACCATGGGCAGCAAGCTGGTGGGCATCGTCACCTCCCGAGACATCGACTTTCTTGCTGAGAAGGACCACACCACCCTCCTCAGTGAGGTGATGACGCCAAGGATTGAACTGGTGGTGGCTCCAGCAGGTGTGACGTTGAAAGAGGCAAATGAGATCCTGCAGCGTAGCAAGAAAGGGAAGCTGCCTATCGTCAATGATTGCGATGAGCTGGTGGCCATCATCGCCCGCACCGACCTGAAGAAGAACCGAGACTACCCTCTGGCCTCCAAGGATTCCCAGAAGCAGCTGCTCTGTGGGGCAGCTGTGGGCACCCGTGAGGATGACAAATACCGTCTGGACCTGCTCACCCAGGCGGGCGTCGACGTCATAGTCTTGGACTCGTCCCAAGGGAATTCGGTGTATCAGATCGCCATGGTGCATTACATCAAACAGAAGTACCCCCACCTCCAGGTGATTGGGGGGAACGTGGTGACAGCAGCCCAGGCCAAGAACCTGATTGATGCTGGTGTGGACGGGCTGCGCGTGGGCATGGGCTGCGGCTCCATCTGCATCACCCAGGAAGTGATGGCCTGTGGTCGGCCCCAGGGCACTGCTGTGTACAAGGTGGCTGAGTATGCCCGGCGCTTTGGTGTGCCCATCATAGCCGATGGCGGCATCCAGACCGTGGGACACGTGGTCAAGGCCCTGGCCCTTGGAGCCTCCACAGTGATGATGGGCTCCCTGCTGGCCGCCACTACGGAGGCCCCTGGCGAGTACTTCTTCTCAGACGGGGTGCGGCTCAAGAAGTACCGGGGCATGGGCTCACTGGATGCCATGGAGAAGAGCAGCAGCAGCCAGAAACGATACTTCAGCGAGGGGGATAAAGTGAAGATCGCGCAGGGTGTCTCGGGCTCCATCCAGGACAAAGGATCCATTCAGAAGTTCGTGCCCTACCTCATAGCAGGCATCCAACACGGCTGCCAGGATATCGGGGCCCGCAGCCTGTCTGTCCTTCGGTCCATGATGTACTCAGGAGAGCTCAAGTTTGAGAAGCGGACCATGTCGGCCCAGATTGAGGGTGGTGTCCATGGCCTGCACTCTTACGAAAAGCGGCTGTACTGAGGACAGCGGTGGAGGCCGAGGTGGTGGAGGGGATGCACCCCAGTGTCCACTTTTGGGCACAGCCTCCCTCCATAACTGAGTGGTCCACAGATTTGCACTACGGGTTCTCCAGCTCCTTTCCAGGCAGAGAGGAGGGGAGGTCCTGAGGGGACTGCTGCCCCTCACTCGGCATCCCCTGCAGAGTCAGGACTGCTCCCGGGGCCAGGCTGCCCTGGGAGCCCCCCTCCGAGCCCAGCCAGCCAGGCTCTCAGGCCCTGCGCCTGCCTCAGGTCTTTCTTGCTGCAGCCTGCTCCAGCCTGGCCCCCACCCCAGGGGCAGGCGGCCCCTCCTGGCTTCTCCTGTAGGGCACCTCCCTGCCCCTAGCCTCCCAGGAAATGGTGCTCTCCTGGCCCTGCCTCTGGCCCTTCCCGGGCCGCTGCCCCTCAGCCATGTGGCACTTCTGAGCTCCTGACCTAGGCCAAGGGGAGGTCTCTGCCCCCTTCCCCGGCCCTGGGCTACCCTTGGGTCCTGCTCCTCAGGCCGCTCCCCTGTCCCTGGCCATGGGTAGGAGACTGCCCTGGTCATGGCCGCCTGCCTGTCATTCCTGACTCACCACCGTCCCCAGGTGAACCATTCCTCCCTTCTCCTCAGCTGCAGTCGAAGGCTTTAACTTTGCACACTTGGGATCACAGTTGCGTCATTGTGTATTAAATACTTGGAATAAATCAAGCAGGTCTCAACGCCTCCACTA

Publications

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