Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name CLDN7P1
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr17). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:40759842-40761486  UCSC
Coordinates (T2T) chrX:40161059-40162703  UCSC
Coordinates (hg19) chrX:40619095-40620739  UCSC
Strand -
Parental Sequence NM_001307.6
Parental seq. overlap 616 bp
Parental seq. overlap (%) 34.5%
Genomic Region Intergenic
Retrocopy Summary CLDN7P1, located on chrX:40759842-40761486, is a retrocopy of the parental gene CLDN7. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CLDN7
Full Name claudin 7
Also known as CEPTRL2|CLDN-7|CPETRL2|Hs.84359|claudin-1
Coordinate chr17:7259903-7263213
Strand -
Gene summary This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes CLDN7P1
Bonobo Pan paniscus CLDN7P1
Gorilla Gorilla gorilla CLDN7P1
Orangutan Pongo abelii CLDN7P1
Gibbon Nomascus leucogenys CLDN7P1
Green monkey Chlorocebus sabaeus CLDN7P1
Crab-eating macaque Macaca fascicularis CLDN7P1
Rhesus Macaca mulatta CLDN7P1
Golden snub-nosed monkey Rhinopithecus roxellana CLDN7P1
Marmoset Callithrix jacchus CLDN7P1
Baboon Papio anubis Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>CLDN7P1
AGGCATGATTAGAGGTGTCATTTTCATCATGGCAGGTCTTGCTGACTTGGTAGCTTTCTTCTGGTATGGCCATCAGATTGTCACGGACTTTTACAACCCCTTGATCCCCTTGAATATTAGGTATGAGTCTGGTCCTGCTATCTTTATTGGCTGGGCAGAGTCTTCTCTGACCCCCCTAGGAGGTGTACTATTCTCTTGCTCTTGTTCTGGGAATAAGAGCAAAACTGGGTACTGTGTACCTCACTCTTACTCTAAGTCCAACTCTGCCAAGGAGTACATGTGAGCTGGGACACCTTTGCCCCAGCCTGACAGGCTACGGGTGTATCTAAATGCCTGAAAAGACCTGGGGCAGAGCTTAGCCTGTGGGCAGGGTGCAGGATAAAAGCCTCCTGGTCACTCCATCCCTGCACACCATGTACTCCCTGTGCTGTGAGACTATCACTTCACCAGAGGGGTCAATTTGTGTGTACTTCGGGTGACAAGATTTGCGGTCACCCAGCCAAAAACTTCTTTGTCTCTTTGGATGACTTAAAAACTCTACCCCAAGATGTCTTTCGTGGGGATGCCCCAAAGTTTTATTTGTTTTACTGTAGGGTTGCCTGCCCAGCACCCCCAGTTTCTTTCTGAGAGTGGAAATGGCCAATTTGGGCCTGCAGTTGCTGAACTTTTCCGTGGCTCTGCTAGGCTGGGTGGGCCTTGTGGCCTGCACCGCCATCCCGCAGTGGCAGATGAGCTCATGTGTGGGCAACAGCATCATCACAGCCCAGGCCATGTACAAGGGACTGTGGATGGACTACATCATGCAGAGCATGGGCTTGATGAGCTGTGAAATGTATGACTTGGTGCTCACCCTGCCAGCAGCCATGCAGGACCTTTGAGCCCTAATGGTGGCATACCTGGTGCTGGGCTTCCTGACCATATGTGTGTGGCCACGATGGGCATGAAGTGCATGTGTTGTGGGGGAAATGACAAAGTGAAGAAGGCCTGTATAGCTCa
>NM_001307.6
GCCCGCACCTGCTGGCTCACCTCCGAGCCACCTCTGCTGCGCACCGCAGCCTCGGACCTACAGCCCAGGATACTTTGGGACTTGCCGGCGCTCAGAAACGCGCCCAGACGGCCCCTCCACCTTTTGTTTGCCTAGGGTCGCCGAGAGCGCCCGGAGGGAACCGCCTGGCCTTCGGGGACCACCAATTTTGTCTGGAACCACCCTCCCGGCGTATCCTACTCCCTGTGCCGCGAGGCCATCGCTTCACTGGAGGGGTCGATTTGTGTGTAGTTTGGTGACAAGATTTGCATTCACCTGGCCCAAACCCTTTTTGTCTCTTTGGGTGACCGGAAAACTCCACCTCAAGTTTTCTTTTGTGGGGCTGCCCCCCAAGTGTCGTTTGTTTTACTGTAGGGTCTCCCCGCCCGGCGCCCCCAGTGTTTTCTGAGGGCGGAAATGGCCAATTCGGGCCTGCAGTTGCTGGGCTTCTCCATGGCCCTGCTGGGCTGGGTGGGTCTGGTGGCCTGCACCGCCATCCCGCAGTGGCAGATGAGCTCCTATGCGGGTGACAACATCATCACGGCCCAGGCCATGTACAAGGGGCTGTGGATGGACTGCGTCACGCAGAGCACGGGGATGATGAGCTGCAAAATGTACGACTCGGTGCTCGCCCTGTCCGCGGCCTTGCAGGCCACTCGAGCCCTAATGGTGGTCTCCCTGGTGCTGGGCTTCCTGGCCATGTTTGTGGCCACGATGGGCATGAAGTGCACGCGCTGTGGGGGAGACGACAAAGTGAAGAAGGCCCGTATAGCCATGGGTGGAGGCATAATTTTCATCGTGGCAGGTCTTGCCGCCTTGGTAGCTTGCTCCTGGTATGGCCATCAGATTGTCACAGACTTTTATAACCCTTTGATCCCTACCAACATTAAGTATGAGTTTGGCCCTGCCATCTTTATTGGCTGGGCAGGGTCTGCCCTAGTCATCCTGGGAGGTGCACTGCTCTCCTGTTCCTGTCCTGGGAATGAGAGCAAGGCTGGGTACCGTGTACCCCGCTCTTACCCTAAGTCCAACTCTTCCAAGGAGTATGTGTGACCTGGGATCTCCTTGCCCCAGCCTGACAGGCTATGGGAGTGTCTAGATGCCTGAAAGGGCCTGGGGCTGAGCTCAGCCTGTGGGCAGGGTGCCGGACAAAGGCCTCCTGGTCACTCTGTCCCTGCACTCCATGTATAGTCCTCTTGGGTTGGGGGTGGGGGGGTGCCGTTGGTGGGAGAGACAAAAAGAGGGAGAGTGTGCTTTTTGTACAGTAATAAAAAATAAGTATTGGGAAGCAGGCTTTTTTCCCTTCAGGGCCTCTGCTTTCCTCCCGTCCAGATCCTTGCAGGGAGCTTGGAACCTTAGTGCACCTACTTCAGTTCAGAACACTTAGCACCCCACTGACTCCACTGACAATTGACTAAAAGATGCAGGTGCTCGTATCTCGACATTCATTCCCACCCCCCTCTTATTTAAATAGCTACCAAAGTACTTCTTTTTTAATAAAAAAATAAAGATTTTTATTAGGTA

Publications

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