Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name UBN1P1
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr16). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:44468380-44468518  UCSC
Coordinates (T2T) chrX:43874726-43874864  UCSC
Coordinates (hg19) chrX:44327626-44327764  UCSC
Strand +
Parental Sequence XM_017023192.2
Parental seq. overlap 121 bp
Parental seq. overlap (%) 5.1%
Genomic Region Intergenic
Retrocopy Summary UBN1P1, located on chrX:44468380-44468518, is a retrocopy of the parental gene UBN1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name UBN1
Full Name ubinuclein 1
Also known as VT|VT4
Coordinate chr16:4846665-4882401
Strand +
Gene summary Cellular senescence is a hallmark of tumor suppression and tissue aging. Senescent cells contain domains of heterochromatin, called senescence-associated heterochromatin foci (SAHF), that repress proliferation-promoting genes. The protein encoded by this gene binds to proliferation-promoting genes and is required for SAHF formation, enhancing methylation of histone H3. [provided by RefSeq, Oct 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>UBN1P1
ATCTGAAGGAGCCTCTAGAGAAACTCGAAGAAGCCACTGGCAGGGCAATGCCAGAGCAGATGGCCACGCACCAGGATGAATGCCAGGCATAGACACATGCAAAGATTGCAAAGATGCTGGAAGAGGAGAAGGACAAGGA
>XM_017023192.2
ATTCCCGAGCCCGAGGCGCTGGTCGGCCCCGTCGCAGCGCCAGTGAGCTACCCTGACGGAGCTCGGCGCGGCCTGGAACTCAGCCTCCGCCGGGTCTGGGCTCCCGCGCCCGGCAACTCTGCTTGGCCGCAGGCCGGGAGGCCCCGGTGTCCGCGCCCGTCCGCTCCCGCCGCCCGTGTTCTTTGGAGCGCTCCTCCCGACGGCCGCTTTCGGAGGCGCCGTCTGAGCGCGGGGTCCCGCGCCGCAAGTTCTCCTGGGGCGACCGGAGGCTGCTCCCCCGACCCCCTGGTGTCCCCGGAGTGGCTGCGCGGACGTCGAGTTGGCATTTCTTCGCTTCCTCCTGGGCCGGCGCGCGGCGCGGCACACCAGGCTCCCCTGGGCTCGGGGACCCGGCCATGGGCCGAGGCGCGGGCCGCCCGCCCGCTGGGAGCCACGGCTTAGCAGCCGACCGCTAGCTGCGCCGCCGCCCGGGGACCGGCATGAGGACCGCCGCGGGGGGACGTCTGCGGCCCGCGTCGGCGCTGGGGACAAAGAAGCCATGCAGTGACACCCGCTAAGACTTGTTGGTAGCCATGTCGGAGCCCCACAGGGTCCAGTTCACCTCTCTCCCAGGTTCCCTGAATCCTGCGTTTTTGAAGAAGTCCCGGAAGGAGGAGGCTGGGGCAGGAGAACAGCATCAGGACTGTGAGCCGGCTGCAGCAGCTGTTCGGATTACACTCACCCTCTTTGAACCAGATCACAAACGCTGCCCAGAGTTCTTCTACCCAGAGCTGGTGAAGAATATCCGAGGGAAGGTAAAAGGCCTTCAGCCTGGAGATAAGAAGAAAGATCTGTCAGATCCTTTCAATGACGAAGAAAAGGAAAGGCATAAAGTAGAGGCCCTTGCCCGAAAATTTGAAGAAAAATACGGTGGAAAGAAACGTAGAAAAGACCGAATACAGGACTTGATCGATATGGGGTATGGTTATGATGAATCCGACTCCTTCATCGATAACTCTGAGGCGTATGATGAGCTTGTTCCTGCTTCTTTGACTACGAAGTATGGAGGATTTTACATTAACTCGGGAACCCTGCAGTTTAGACAAGCATCAGAGTCTGAAGATGACTTCATTAAAGAAAAGAAGAAAAAATCTCCAAAGaagcggaagttgaaggaaggtggtgagaagataaagaagaagaaaaaagatgaCACTTATGACAAGGAGAAGAAATCGAAAAAGTCCAAGTTTTCCAAAGCCGGCTTCACAGCCCTCAATGCCAGTaaggagaagaagaagaagaaATATTCTGGGGCTTTAAGCGTTAAAGAGATGCTAAAGAAATTTCAGAAAGAGAAAGAGGCTCAGAAAAAAAGGGAGGAGGAGCATAAGCCTGTTGCGGTCCCATCAGCGGAAGCTCAGGGCCTGCGGGAACTGGAGGGTGCCTCTGACCCCTTGCTCTCACTCTTTGGCTCTACTTCTGACAACGACTTGCTCCAGGCGGCCACTGCCATGGACTCGCTGACGGATTTGGACTTGGAGCATCTGCTCAGTGAGTCTCCAGAAGGAAGTCCCTTCCGAGATATGGATGATGGAAGTGATTCCCTTGGGGTGGGATTGGACCAGGAATTCAGGCAGCCCTCTTCTCTCCCCGAAGGCCTGCCAGCACCCCTGGAGAAGCGCGTTAAGGAGCTGGCTCAGGCTGCCAGAGCTGCTGAGGGGGAGAGCAGACAGAAGTTCTTCACCCAGGATATTAATGGAATCCTATTAGACATAGAGGCGCAGACTCGGGAGCTGAGCAGTCAGGTCCGCTCTGGGGTGTATGCCTATCTTGCGTCATTCCTGCCCTGCAGCAAGGATGCCCTGCTCAAGCGTGCTCGGAAACTTCACCTCTATGAACAGGGGGGCCGTCTGAAGGAGCCTCTCCAGAAGCTCAAGGAAGCCATTGGCAGGGCGATGCCAGAGCAGATGGCCAAGTACCAGGACGAATGCCAGGCACACACGCAGGCAAAGGTTGCCAAGATGCTGGAAGAGGAGAAAGACAAGGAGCAGAGGGACCGGATTTGTTCGGATGAGGAAGAAGATGAAGAAAAAGGGGGCAGGAGGATAATGGGACCTCGGAAGAAGTTCCAATGGAATGATGAGATCAGGGAGCTACTGTGCCAGGTGGTGAAGATCAAACTGGAGAGCCAGGACCTGGAGAGGAACAACAAAGCCCAGGCTTGGGAGGACTGTGTGAAGGGCTTTCTGGATGCGGAAGTCAAGCCCCTCTGGCCCAAAGGCTGGATGCAGGCCAGGCTGGACTCATACGAAGAACGTTTTTGTTGAGTTTCTCTGGACAAAGACATGCTGGGTCACTCCACATTTTATTCCTGGAATGGAGGGACTA

Publications

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