Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Summary

Retrocopy Name PCNAP3
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr20). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:46058449-46059622  UCSC
Coordinates (T2T) chrX:45465856-45467029  UCSC
Coordinates (hg19) chrX:45917884-45919057  UCSC
Strand -
Parental Sequence NM_182649.2
Parental seq. overlap 1084 bp
Parental seq. overlap (%) 84.6%
Genomic Region Intergenic
Retrocopy Summary PCNAP3, located on chrX:46058449-46059622, is a retrocopy of the parental gene PCNA. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PCNA
Full Name proliferating cell nuclear antigen
Also known as ATLD2
Coordinate chr20:5114953-5126622
Strand -
Gene summary The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PCNAP3
Bonobo Pan paniscus PCNAP3
Gorilla Gorilla gorilla PCNAP3
Orangutan Pongo abelii PCNAP3
Gibbon Nomascus leucogenys PCNAP2
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PCNAP3
TTCGCCTGCTTGCTCTGAGGCTCGTGAAGCCAAAACTGGCTAGACTTTCCTACTTTCCGCCCGCCTGTAGCCGCGTTGTTGCCACTCTGCCACCATGTTCGAGGTGCCCCTGGTCCAGGGCTCCATCCTGAAGAAGGTGTTGGAGGCACTCAAGGACCTCATCAACGAGGCCTGCTGGGACATCAGCTCGAGCGGCGTGAACCTGCAGAGCATGGATTCGTCCACGTCTCCTTGCTGCAGTTCACCCTGCCGTCTGAGGGCTTTGACACTTACCGCTGTGACTGCAACCTGGCCATGGGCGTGAACCTCACTATTATGTCCAAAATACTAAAATGTGCTGGCAATGAAGATATCGTTACACTAAGGATTGAAGATAATGTGAATACCTTGGTGCTAGTATTTGAAGCTTCAAATCAGGAGAAGGTTTCAGACTATGAAATTAAGTTGATGGATTTGGATGTTGAACAACTTGGAATTGCAGAACAAGAGTACCACTATGTAGTAAAGATGCTTTCTGGTGAATTTGCAAGTATATGCTGAGATCTCAGCCATATTGGAGATGCTGTTGTAATTTCCGGTGTAAAAGATGGAATTATATTTTCTGCAAGTGGAGACCTTGGAAATAGAAAACAAATTGTCACAGACAAGTACTGTCGATAAAGAGGAGGAAGCTGTTACCATGGAGATGAATGAACCAGTTCAACTAACTTTTGCACTGAGGTACCTGAACTTCCTTACAAAAGCCACTCCACTCTCTTCAATGGTGACACTCAATATGTCTGCAGACATACACCTTGTTGTAGACTATAAAATTGCTGATGTGGGACACTTAAAGTACTACTTGGCTCCCAAGATGGAGGATGAAGAAGGACCTTAGGCATTCATAAAATTCAAGAAAATAAAACTAAGCTCTTTGAGAACTGCTTCTGAGATGCCAGCATATACTGAAGTCTTTTCTGCCACCAAATTTGTACCTCTAAGTACATATGTAGATATTGTTTTCTGTAAATAACCTTTTTCTCTATTCTCTGCAATTTGTTTAAAGAATAAAGTCCAAAGTCAGTCAGATCTGGTCTAGTTAACCTAGAACTATTTTTCTCTCTTAGAAATACTTGTGATTTTTACAATACAATAGGGTCTTGACTCTAAATGCAGTTTTAAGATTTGTTTTTGc
>NM_182649.2
ATTAAACGGTTGCAGGCGTAGCAGAGTGGTCGTTGTCTTTCTAGGTCTCAGCCGGTCGTCGCGACGTTCGCCCGCTCGCTCTGAGGCTCCTGAAGCCGAAACCAGCTAGACTTTCCTCCTTCCCGCCTGCCTGTAGCGGCGTTGTTGCCACTCCGCCACCATGTTCGAGGCGCGCCTGGTCCAGGGCTCCATCCTCAAGAAGGTGTTGGAGGCACTCAAGGACCTCATCAACGAGGCCTGCTGGGATATTAGCTCCAGCGGTGTAAACCTGCAGAGCATGGACTCGTCCCACGTCTCTTTGGTGCAGCTCACCCTGCGGTCTGAGGGCTTCGACACCTACCGCTGCGACCGCAACCTGGCCATGGGCGTGAACCTCACCAGTATGTCCAAAATACTAAAATGCGCCGGCAATGAAGATATCATTACACTAAGGGCCGAAGATAACGCGGATACCTTGGCGCTAGTATTTGAAGCACCAAACCAGGAGAAAGTTTCAGACTATGAAATGAAGTTGATGGATTTAGATGTTGAACAACTTGGAATTCCAGAACAGGAGTACAGCTGTGTAGTAAAGATGCCTTCTGGTGAATTTGCACGTATATGCCGAGATCTCAGCCATATTGGAGATGCTGTTGTAATTTCCTGTGCAAAAGACGGAGTGAAATTTTCTGCAAGTGGAGAACTTGGAAATGGAAACATTAAATTGTCACAGACAAGTAATGTCGATAAAGAGGAGGAAGCTGTTACCATAGAGATGAATGAACCAGTTCAACTAACTTTTGCACTGAGGTACCTGAACTTCTTTACAAAAGCCACTCCACTCTCTTCAACGGTGACACTCAGTATGTCTGCAGATGTACCCCTTGTTGTAGAGTATAAAATTGCGGATATGGGACACTTAAAATACTACTTGGCTCCCAAGATCGAGGATGAAGAAGGATCTTAGGCATTCTTAAAATTCAAGAAAATAAAACTAAGCTCTTTGAGAACTGCTTCTAAGATGCCAGCATATACTGAAGTCTTTTCTGTCACCAAATTTGTACCTCTAAGTACATATGTAGATATTGTTTTCTGTAAATAACCTATTTTTTTCTCTATTCTCTGCAATTTGTTTAAAGAATAAAGTCCAAAGTCAGATCTGGTCTAGTTAACCTAGAAGTATTTTTGTCTCTTAGAAATACTTGTGATTTTTATAATACAAAAGGGTCTTGACTCTAAATGCAGTTTTAAGAATTGTTTTTGAATTTAAATAAAGTTACTTGAATTTCAAACATCA

Publications

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