Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name HSPB1P2
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:49233799-49234530  UCSC
Coordinates (T2T) chrX:48645662-48646390  UCSC
Coordinates (hg19) chrX:49090261-49090989  UCSC
Strand -
Parental Sequence NM_001540.5
Parental seq. overlap 671 bp
Parental seq. overlap (%) 86.2%
Genomic Region Intergenic
Retrocopy Summary HSPB1P2, located on chrX:49233799-49234530, is a retrocopy of the parental gene HSPB1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name HSPB1
Full Name heat shock protein family B (small) member 1
Also known as CMT2F|HEL-S-102|HMN2B|HS.76067|HSP27|HSP28|Hsp25|SRP27
Coordinate chr7:76302673-76304292
Strand +
Gene summary This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. [provided by RefSeq, Aug 2017]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes HSPB1P1
Bonobo Pan paniscus HSPB1P1
Gorilla Gorilla gorilla HSPB1P2
Orangutan Pongo abelii HSPB1P1
Green monkey Chlorocebus sabaeus LOC103246661P1
Crab-eating macaque Macaca fascicularis HSPB1P2
Rhesus Macaca mulatta HSPB1P2
Baboon Papio anubis HSPB1P4
Golden snub-nosed monkey Rhinopithecus roxellana HSPB1P1
Gibbon Nomascus leucogenys Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>HSPB1P2
AGCAGACGTCCCCAGCAGAGCCAGCCAGCATGACCGAGCGCCGCGTCCCCTTCTCGCTCCTGCGGGACCCCAGCTGGGACCCCTTCCGCGACTGGTACCCGCACAGTCGCCTCTTTGACCAGGCCTTCGGGCTGGTCGCAGTGGTTGGGCACCAGCTGCTGGCCCCGCTACGTGCGTCCCCTGCCCCCGCCGCGGTCGAGAGCCCCGCGGTGGCCGCGCCCGCCTACAGCTACGCGCTCAGCCGGCAGCTCAGCGGCGGGGTCTCGGAGAATCGGCCCACAGCGGACCGCTGGCGCGTATCCCTGGACATCAACTACTTCGCCTCCGACGAGCTGACGGTCAAGACCAAGGATGGCATGGTGGAGATCACCAGCAAGCACGAGGAGCGGCAGGACGAGCATGGCTACATCTCCCGATGCTTCACCCGGAAATACACGCTGCCCCCCGGTGTGGACCCCACCAAGGTCTCCTCCTCCCTGTCCCCTGAGGGCACACTGACCGTGGAGGCCCCCATGCCCAAGCTAGCCACGCAGTCCAACGAGATCACCTTGGAGTCACGGGCCCAGCTTGGGGGCCTAGGAGCTGCGAAATCCGACCAGTCTGCAGCCAAGTAAAAGCCTTAGCCCGGATGCCCACCCCGGCCGCCGCCACTAGCCGTGCCCCCGCACCCACCTGTGTGTTCTTTTGATAGGTTTATCTTCTGTTGTTCTCAAATAAAGTTCGAAGCAACCC
>NM_001540.5
GCACTTTTCTGAGCAGACGTCCAGAGCAGAGTCAGCCAGCATGACCGAGCGCCGCGTCCCCTTCTCGCTCCTGCGGGGCCCCAGCTGGGACCCCTTCCGCGACTGGTACCCGCATAGCCGCCTCTTCGACCAGGCCTTCGGGCTGCCCCGGCTGCCGGAGGAGTGGTCGCAGTGGTTAGGCGGCAGCAGCTGGCCAGGCTACGTGCGCCCCCTGCCCCCCGCCGCCATCGAGAGCCCCGCAGTGGCCGCGCCCGCCTACAGCCGCGCGCTCAGCCGGCAACTCAGCAGCGGGGTCTCGGAGATCCGGCACACTGCGGACCGCTGGCGCGTGTCCCTGGATGTCAACCACTTCGCCCCGGACGAGCTGACGGTCAAGACCAAGGATGGCGTGGTGGAGATCACCGGCAAGCACGAGGAGCGGCAGGACGAGCATGGCTACATCTCCCGGTGCTTCACGCGGAAATACACGCTGCCCCCCGGTGTGGACCCCACCCAAGTTTCCTCCTCCCTGTCCCCTGAGGGCACACTGACCGTGGAGGCCCCCATGCCCAAGCTAGCCACGCAGTCCAACGAGATCACCATCCCAGTCACCTTCGAGTCGCGGGCCCAGCTTGGGGGCCCAGAAGCTGCAAAATCCGATGAGACTGCCGCCAAGTAAAGCCTTAGCCCGGATGCCCACCCCTGCTGCCGCCACTGGCTGTGCCTCCCCCGCCACCTGTGTGTTCTTTTGATACATTTATCTTCTGTTTTTCTCAAATAAAGTTCAAAGCAACCACC

Publications

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