Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name OATP2
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr10). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:52612655-52613768  UCSC
Coordinates (T2T) chrX:51897469-51898582  UCSC
Coordinates (hg19) chrX:52641705-52642818  UCSC
Strand +
Parental Sequence NM_001322970.2
Parental seq. overlap 710 bp
Parental seq. overlap (%) 29.7%
Genomic Region Intergenic
Retrocopy Summary OATP2, located on chrX:52612655-52613768, is a retrocopy of the parental gene OAT. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name OAT
Full Name ornithine aminotransferase
Also known as GACR|HOGA|OATASE|OKT
Coordinate chr10:124397303-124418923
Strand -
Gene summary This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Alternatively spliced transcript variants encoding different isoforms have been described. Related pseudogenes have been defined on the X chromosome. [provided by RefSeq, Jan 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes OATP2
Bonobo Pan paniscus OATP2
Gorilla Gorilla gorilla OATP2
Orangutan Pongo abelii OATP2
Gibbon Nomascus leucogenys OATP2
Green monkey Chlorocebus sabaeus OATP1
Crab-eating macaque Macaca fascicularis OATP1
Rhesus Macaca mulatta OATP1
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>OATP2
TGGTTCTGTTCATTGCTGATGAAATACAGATAGGATTGGCCAGAACTGGTAGAGGGCTGGCTGTTGATCATGAAAATGTCAGACCTGATATAGTCCTCCTTGGAAAGGCCCTTTCTAGGGGCTGATACTCTGTGTCAGTGGTGCTGTGAGACAATGACATAATGCTGACCATTAAGCCAGGGGAACGTGGGTCCACATACGGTGGCAATCCACTAGGCTGCTGAGTGACCATCGCAGCCCTTGAGGTTTTAGAAGAAGAAAACCTTGCTGAAAATGCAGAAAAAAAATGGGTATTCTCTTGAGAAATGAACCCATGAAGCTACCTTCTGATGTTGTGACTGCCGTAAGAGGAAAATGATTGTTTTATTTATTCATTTAGTTAcTCTCCCTAGGAGGAAAAGAATTATTAAATGCTATTGTTATTCAAGACAACAAAGACTGTGATGCTTGGAAGGTGTATCTACAACTTCGAGATTATGGATTTCTGGCCCAGCCAATCCATGGTGACATCATCAGTTTTTGCCTCTGCTAGTGGTCAAGGAGGATGAGATTCGAGAGTCCAGTGAAATCAATAACAAGACCATCTTGTCGTTCTGAGTGTAGCAGCCATTTTCAGTGGTCCCTGGGAGCCGACTAGAGACAGGTGGTCCTGTAAAAGCTCTGCTCTTAATGTGGGCACATTCCACTCCCATGTGTCTTCAAAACCTTTTTCTGGAATATATTTTTTTTTCAGTTGATACATAATAGAATAGTGTTTATGAAGCTGCCTTTTGCTTTGTAACATAAGTAAGAGAATGTAATGGCATCTATATTCAGTGAAAGTGTTTTGATGTGCA
>NM_001322970.2
GTTGCGCTTCATAGACGCCGCGTGTACCCGGTTGTCCTCAGGCGCTGTCAGcgctttgtagcccaggctggagtgctggtggcacagatcgtggctcactgcagcccagaactcagggctcaagagatctttccaccttagtcttagtctcctaagtaccagatactacaggagattttggactctctgcagactgtccctggatcttgggttaaaaatcTGTATTCTAGACTGAACCGTGGGAAGAAAAAATAGTCAGTGAGTCTTTGGCAAACCGGAGTACTGGATTTTGTTTAGCAATTGCAAATTCCTGAACATACTGGATTTACTGGGTAGTGCCAAGTTTAAAGGGAAATCTGTGGTTTTTCTACTTGAAGGACACAATGTTTTCCAAACTAGCACATTTGCAGAGGTTTGCTGTACTTAGTCGCGGAGTTCATTCTTCAGTGGCTTCTGCTACATCTGTTGCAACTAAAAAAACAGTCCAAGGCCCTCCAACCTCTGATGACATTTTTGAAAGGGAATATAAGTATGGTGCACACAACTACCATCCTTTACCTGTAGCCCTGGAGAGAGGAAAAGGTATTTACTTATGGGATGTAGAAGGCAGAAAATATTTTGACTTCCTGAGTTCTTACAGTGCTGTCAACCAAGGGCATTGTCACCCCAAGATTGTGAATGCTCTGAAGAGTCAAGTGGACAAATTGACCTTAACATCTAGAGCTTTCTATAATAACGTACTTGGTGAATATGAGGAGTATATTACTAAACTTTTCAACTACCACAAAGTTCTTCCTATGAATACAGGAGTGGAGGCTGGAGAGACTGCCTGTAAACTAGCTCGTAAGTGGGGCTATACCGTGAAGGGCATTCAGAAATACAAAGCAAAGATTGTTTTTGCAGCTGGGAACTTCTGGGGTAGGACGTTGTCTGCTATCTCCAGTTCCACAGACCCAACCAGTTACGATGGTTTTGGACCATTTATGCCGGGATTCGACATCATTCCCTATAATGATCTGCCCGCACTGGAGCGTGCTCTTCAGGATCCAAATGTGGCTGCGTTCATGGTAGAACCAATTCAGGGTGAAGCAGGCGTTGTTGTTCCGGATCCAGGTTACCTAATGGGAGTGCGAGAGCTCTGCACCAGGCACCAGGTTCTCTTTATTGCTGATGAAATACAGACAGGATTGGCCAGAACTGGTAGATGGCTGGCTGTTGATTATGAAAATGTCAGACCTGATATAGTCCTCCTTGGAAAGGCCCTTTCTGGGGGCTTATACCCTGTGTCTGCAGTGCTGTGTGATGATGACATCATGCTGACCATTAAGCCAGGGGAGCATGGGTCCACATACGGTGGCAATCCACTAGGCTGCCGAGTGGCCATCGCAGCCCTTGAGGTTTTAGAAGAAGAAAACCTTGCTGAAAATGCAGACAAATTGGGCATTATCTTGAGAAATGAACTCATGAAGCTACCTTCTGATGTTGTAACTGCCGTAAGAGGAAAAGGATTATTAAACGCTATTGTCATTAAAGAAACCAAAGATTGGGATGCTTGGAAGGTGTGTCTACGACTTCGAGATAATGGACTTCTGGCCAAGCCAACCCATGGCGACATTATCAGGTTTGCGCCTCCGCTGGTGATCAAGGAGGATGAGCTTCGAGAGTCCATTGAAATTATTAACAAGACCATCTTGTCTTTCTGAGGGTAGCCAGCTGTTTTCAGTGGTCCCTGGGAGCCAGCTGGAGACAGGTGGTCCTGTAAAAGCTTTATTCCTAATGTGGGCACATTCCACTCCCATGAGTCTTCAAAAACTTTTTTTTTGAATATATTTTTTTCAGTTGATACATAATAGAACAACGTTTATGAACCTGCCGTTTGCTTTGTAACGTAACTAAATAATGTAATGGCATCTATATTCAGTTGAAGTGTTTTGATGTGCATGTGTACTTCCTAAGGTGAAATGCATCTATATACAGACAGCCTCTAAATCAAGTCCTTCAGTATAATTGATATATGTTTTTATAATTTCCTCACTGGTATAAGTGTTTCATATTTGAAAAAGTTATCTCTGGGTATTGCATAAAAGGCTTCATCTTATAAAGTGAAATCATTGTTATTGAATTTTAGGAAGGATTAATGGTTAAGTGTATATAAAATACTAATATTAAGTAAACTTCATATTGGCCAACACCAGGGTTGTATTCTATGGATGTCATTATTTTGAATTAAGAATTAGTGTTTAACATTCCTAAATTGTTTTGAGTGCTTGATTATAATTTGTAAAAAATGTTTATTTTCAATACTTCTTTAAATTTAAAATAAAGCTTATATTTCAAATGTC

Publications

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