Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name HADHBP1
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:5305184-5307080  UCSC
Coordinates (T2T) chrX:4857554-4859450  UCSC
Coordinates (hg19) chrX:5223225-5225121  UCSC
Strand -
Parental Sequence NM_000183.3
Parental seq. overlap 1747 bp
Parental seq. overlap (%) 86.7%
Genomic Region Intergenic
Retrocopy Summary HADHBP1, located on chrX:5305184-5307080, is a retrocopy of the parental gene HADHB. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name HADHB
Full Name hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
Also known as ECHB|MSTP029|MTPB|TP-BETA
Coordinate chr2:26244917-26290465
Strand +
Gene summary This gene encodes the beta subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the beta subunit catalyzing the 3-ketoacyl-CoA thiolase activity. The encoded protein can also bind RNA and decreases the stability of some mRNAs. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. Mutations in this gene result in trifunctional protein deficiency. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes HADHBP1
Gorilla Gorilla gorilla HADHBP1
Orangutan Pongo abelii HADHBP1
Gibbon Nomascus leucogenys HADHBP1
Green monkey Chlorocebus sabaeus HADHBP2
Crab-eating macaque Macaca fascicularis HADHBP2
Rhesus Macaca mulatta HADHBP2
Baboon Papio anubis HADHBP2
Golden snub-nosed monkey Rhinopithecus roxellana HADHBP1
Marmoset Callithrix jacchus HADHBP1
Bonobo Pan paniscus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>HADHBP1
CTTCTCACTGCATCAGAATGGTCCCTCAGATTTTCCATAAGACCTCTGAGCTATTCCTCCCAGTTGCGAGCTGCCCAGCCATCCAGACCGAAACGAGGAAGACATTAGCCAAACCCAATATAAGGAATATTGTGGTGGTGGATGGTGTTCGCACTCCATTTTTGCTGTCAGGCACTTCGTATAAAGACCTGATACCACATGATTTGGCTAGAGCAACACTTACGGGTTTGTTGCATCAGCCCAGTGTCCCCAAGGAAGTAGTTGATTATATCATCTTTGGCACAGTCATTCAGGAAGTGAAAACAAGCCATGTGGCTGGAGAGGCTGCCCTTGGAACTGCCTTCTCTGACAAGACTCCTGCTCACACTGTCACCATGGCTTGTATCTCTGCCAACCAAGCCATGACCACAGGTGTTGGTTTGATTGCTTCTGGCCAGTGTGATGTGATCATGGCAGGTGGTGTCGAGTTGATGTTCCATGTCCCTATTCGTCAGTCAAGGAAAATGAGAAAACTGATGCTTGATCTAAGTAAGGCCAAATTTGTGGGCCAGTGACTGTCTTCAATCTCTAAATGCCAATTGAATTTCCCAGCACCTGAGCTCCCTGAGGTTTCTGAGTTCTCCACCAGTGAGACCACGGGCCACTCTGCAGACCAATTGGCTGTTTCTCGACTGGAACAGGATGAATATGCACTGCGCTGTCCCAGTCTGGCCAAGAAGGCACAGGATGAAGGACTCCTTTCTGATGTCGTACCCTTCAAAGTACCAGGAAAAGATACAGTTACCAAACATAATGGCATCCGTCCTTCCTCACTGGAGCAGATGGCTAAACTAAAACCTGCATTCATCAAGCCCTACGGCACAGCGACAGCTGCAAATTCTTCTTTCTTGACTGATGGCGCATCTGAGGCAGAGGAAAAGGCTCTGGCAATGGGTTATAAGCCGAAGGAGTGTTTGAGGGATTTTATGTACGTGTCTCACAATCTGAAAGATCAACTATTATTCAGACCAACATATGCGACTCCAAAAATTCTAGAAAAGGCAGGATTAACCATGAGTGATATTGATGCTTTTGAATTTCACAAAGCTTTCTCAGGTAAGATTTTAGCTAATTTTAAAGCCATGGATTCTGATTAGTTTGCACAAAATTACATGGGTAGAAAAAGCAAGGTTACATTGCTTCCTTCGGAGAAGTTTAATAACTGGGGTGGATCTCTGTCCCTGGAACACCCATTTGGAGCTACTGGCTGCAGGTTGGTCGTGGCAGCTGCCAACAGATTACGGAAGGAAGGAGGCCAGTATGCCTTAGCGGCTGCCTGTGCAGCTGGAGGGCAGGGCCATGGTATGATAGTGGAAGCTTACCCAAAATAATAGATCCAGAAGAAATGACCAGGAGTTTCTGTGCAACACTAACACTAGGCAACGGCATTTCAGTGCATTCCTAAATGACATTTATAGTTCCTAGCTCCTGTTAGGAAAACGATTCTTGTGGCCTTCTGTTAAATGCTTTGCACTTAAGCCTTGCCAGTGTTCTGAGCTTTTCAATAATCACAGTTTACTGCTCTTTCAGGGATTTCTAAGCCACCAGAATCTCACACAGACGTGTGTAGGTGGTTGTTTTTGTTCTCTCTTGTCACTAAAGACTAAATGAGTGCTTGCAATTGGGAAAGAGGTCAGCTGAGATTCGGAAATCATCTTTGTAATATTTGCAAATTATACATGTTCCTATCTGTATCCTAAAGAAAATTGTTCTCTATAAAATACAAACAAATTTCCCTAAATTAACTTAATTCTGGAAAAATAATTCAGAATCTAAACATCACTGAAAACTTATAAAAAATGTTTAGATACATAAATATCATGGTGGTCAACCTTAATAAAGTGGGGAAATATTGGAA
>NM_000183.3
ACTTGGACCTGAACCTTGCTCCGAGAGGGAGTCCTCGCGGACGTCAGCCAAGATTCCAGAATGACTATCTTGACTTACCCCTTTAAAAATCTTCCCACTGCATCAAAATGGGCCCTCAGATTTTCCATAAGACCTCTGAGCTGTTCCTCCCAGCTACGAGCTGCCCCAGCTGTCCAGACCAAAACGAAGAAGACGTTAGCCAAACCCAATATAAGGAATGTTGTGGTGGTGGATGGTGTTCGCACTCCATTTTTGCTGTCTGGCACTTCATATAAAGACCTGATGCCACATGATTTGGCTAGAGCAGCGCTTACGGGTTTGTTGCATCGGACCAGTGTCCCTAAGGAAGTAGTTGATTATATCATCTTTGGTACAGTTATTCAGGAAGTGAAAACAAGCAATGTGGCTAGAGAGGCTGCCCTTGGAGCTGGCTTCTCTGACAAGACTCCTGCTCACACTGTCACCATGGCTTGTATCTCTGCCAACCAAGCCATGACCACAGGTGTTGGCTTGATTGCTTCTGGCCAGTGTGATGTGATCGTGGCAGGTGGTGTTGAGTTGATGTCCGATGTCCCTATTCGTCACTCAAGGAAAATGAGAAAACTGATGCTTGATCTCAATAAGGCCAAATCTATGGGCCAGCGACTGTCTTTAATCTCTAAATTCCGATTTAATTTCCTAGCACCTGAGCTCCCTGCGGTTTCTGAGTTCTCCACCAGTGAGACCATGGGCCACTCTGCAGACCGACTGGCCGCTGCCTTTGCTGTTTCTCGGCTGGAACAGGATGAATATGCACTGCGCTCTCACAGTCTAGCCAAGAAGGCACAGGATGAAGGACTCCTTTCTGATGTGGTACCCTTCAAAGTACCAGGAAAAGATACAGTTACCAAAGATAATGGCATCCGTCCTTCCTCACTGGAGCAGATGGCCAAACTAAAACCTGCATTCATCAAGCCCTACGGCACAGTGACAGCTGCAAATTCTTCTTTCTTGACTGATGGTGCATCTGCAATGTTAATCATGGCGGAGGAAAAGGCTCTGGCCATGGGTTATAAGCCGAAGGCATATTTGAGGGATTTTATGTATGTGTCTCAGGATCCAAAAGATCAACTATTACTTGGACCAACATATGCTACTCCAAAAGTTCTAGAAAAGGCAGGATTGACCATGAATGATATTGATGCTTTTGAATTTCATGAAGCTTTCTCGGGTCAGATTTTGGCAAATTTTAAAGCCATGGATTCTGATTGGTTTGCAGAAAACTACATGGGTAGAAAAACCAAGGTTGGATTGCCTCCTTTGGAGAAGTTTAATAACTGGGGTGGATCTCTGTCCCTGGGACACCCATTTGGAGCCACTGGCTGCAGGTTGGTCATGGCTGCTGCCAACAGATTACGGAAAGAAGGAGGCCAGTATGGCTTAGTGGCTGCGTGTGCAGCTGGAGGGCAGGGCCATGCTATGATAGTGGAAGCTTATCCAAAATAATAGATCCAGAAGAAGTGACCTGAAGTTTCTGTGCAACACTCACACTAGGCAATGCCATTTCAATGCATTACTAAATGACATTTGTAGTTCCTAGCTCCTCTTAGGAAAACAGTTCTTGTGGCCTTCTATTAAATAGTTTGCACTTAAGCCTTGCCAGTGTTCTGAGCTTTTCAATAATCAGTTTACTGCTCTTTCAGGGATTTCTAAGCCACCAGAATCTCACATGAGATGTGTGGGTGGTTGTTTTTGGTCTCTGTTGTCACTAAAGACTAAATGAGGGTTTGCAGTTGGGAAAGAGGTCAACTGAGATTTGGAAATCATCTTTGTAATATTTGCAAATTATACTTGTTCTTATCTGTGTCCTAAAGATGTGTTCTCTATAAAATACAAACCAACGTGCCTAATTAATTATGGAAAAATAATTCAGAATCTAAACACCACTGAAAACTTATAAAAAATGTTTAGATACATAAATATGGTGGTCAGCGTTAATAAAGTGGAGAAATATTGGA

Publications

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