Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name USP22P2
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr17). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:55486821-55487008  UCSC
Coordinates (T2T) chrX:54779358-54779545  UCSC
Coordinates (hg19) chrX:55513254-55513441  UCSC
Strand -
Parental Sequence NM_015276.2
Parental seq. overlap 156 bp
Parental seq. overlap (%) 3%
Genomic Region Intergenic
Retrocopy Summary USP22P2, located on chrX:55486821-55487008, is a retrocopy of the parental gene USP22. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name USP22
Full Name ubiquitin specific peptidase 22
Also known as USP3L
Coordinate chr17:20999596-21043409
Strand -
Gene summary Enables enzyme binding activity; nuclear receptor coactivator activity; and thiol-dependent deubiquitinase. Contributes to H4 histone acetyltransferase activity. Involved in positive regulation of mitotic cell cycle; positive regulation of transcription, DNA-templated; and protein modification by small protein conjugation or removal. Part of SAGA complex. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Bonobo Pan paniscus USP22P2
Gorilla Gorilla gorilla USP22P2
Orangutan Pongo abelii USP22P2
Gibbon Nomascus leucogenys USP22P1
Green monkey Chlorocebus sabaeus USP22P2
Rhesus Macaca mulatta USP22P2
Golden snub-nosed monkey Rhinopithecus roxellana USP22P2
Marmoset Callithrix jacchus USP22P2
Mouse lemur Microcebus murinus USP22P2
Dog Canis familiaris USP22P2
Cat Felis catus USP22P2
Greater mouse-eared bat Myotis myotis USP22P1
Greater horseshoe bat Rhinolophus ferrumequinum USP22P1
Egyptian rousette Rousettus aegyptiacus USP22P2
Chimpanzee Pan troglodytes Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Baboon Papio anubis Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Panda Ailuropoda melanoleuca Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>USP22P2
CAATGAGAATAAGTATTCCTTGTTTGCAGTGATTAATCACCATGGAACTTTGGAAAGTGGCCACTATACCAGCTTCATCCGGCAACAAAAGGACCAGTGGTTCAGCTGTGATGATGCCATCATCACCAAGGCTACCATTGAGGACTTACTCTACAGTGAAGGGTATTTACTGTTCTATCACAAACAGG
>NM_015276.2
CTTGCAGCCTCCCCTCGGCGATCGCGCAGCCCCATCTTTGTCCGGCCTCCGCGCTTTGTTCTCGGCGCCCGGGCCTTGGCCAGCCTGgccagccgccgagcagcccccacgccgcgctggcgtcgtcctcgcctccctcgccgccgccccccgcgcgcggccgggccttgccCCCCATGGTGTCCCGGCCAGAGCCCGAGGGCGAGGCCATGGACGCCGAGCTGGCGGTAGCGCCGCCGGGCTGCTCGCACCTGGGCAGCTTCAAGGTGGACAACTGGAAGCAGAACCTGCGGGCCATCTACCAGTGCTTCGTGTGGAGCGGCACGGCTGAGGCCCGCAAGCGCAAGGCCAAGTCCTGTATCTGCCATGTCTGTGGCGTCCACCTCAACAGGCTGCATTCCTGCCTCTACTGTGTCTTCTTCGGCTGTTTCACAAAGAAGCATATTCACGAGCATGCGAAGGCGAAGCGGCACAACCTGGCCATTGATCTGATGTACGGAGGCATCTACTGTTTTCTGTGCCAGGACTACATCTATGACAAAGACATGGAAATAATCGCCAAGGAGGAGCAGCGAAAAGCTTGGAAAATGCAAGGCGTTGGAGAGAAGTTTTCAACTTGGGAACCAACCAAACGGGAGCTTGAACTGCTGAAGCACAACCCGAAAAGGAGAAAGATCACCTCGAACTGCACCATAGGTCTGCGTGGGCTGATCAACCTTGGGAACACATGCTTCATGAACTGCATCGTGCAGGCCCTGACCCACACGCCACTTCTGCGGGACTTCTTCCTGTCTGACAGGCACCGCTGTGAGATGCAGAGCCCCAGCTCCTGTCTGGTCTGTGAGATGTCCTCACTGTTTCAGGAGTTTTACTCTGGACACCGGTCCCCTCACATCCCGTATAAGTTGCTGCACCTGGTGTGGACCCACGCGAGGCACCTAGCAGGCTACGAGCAGCAGGACGCCCACGAGTTCCTCATCGCGGCCCTGGACGTGCTCCACCGACACTGCAAAGGTGATGACAATGGGAAGAAGGCCAACAACCCCAACCACTGCAACTGCATCATAGACCAGATCTTCACAGGCGGGTTGCAGTCAGACGTCACCTGCCAAGTCTGCCATGGAGTCTCCACCACCATCGACCCCTTCTGGGACATCAGCTTGGATCTCCCCGGCTCTTCCACCCCATTCTGGCCCCTGAGCCCAGGGAGCGAGGGCAACGTGGTAAACGGGGAAAGCCACGTGTCGGGAACCACCACGCTCACGGACTGCCTGCGACGATTCACCAGACCAGAGCACTTGGGCAGCAGCGCCAAGATCAAGTGCAGCGGTTGCCATAGCTACCAGGAGTCCACAAAGCAGCTCACTATGAAGAAACTGCCCATCGTAGCCTGTTTTCATCTCAAACGATTTGAACACTCAGCCAAGCTGCGGCGGAAGATCACCACGTATGTGTCCTTCCCCCTGGAGCTGGACATGACCCCTTTCATGGCCTCCAGCAAAGAGAGCAGGATGAATGGACAGTACCAGCAGCCCACGGACAGTCTCAACAATGACAACAAGTATTCCCTGTTTGCTGTTGTTAACCATCAAGGGACCTTGGAGAGTGGCCACTACACCAGCTTTATCCGGCAGCACAAAGACCAGTGGTTCAAGTGTGACGATGCCATCATCACCAAGGCCAGCATCAAGGACGTCCTGGACAGCGAAGGGTACTTGCTGTTCTATCACAAACAGTTCCTGGAATACGAGTAGCCTTATCTGCAGCTGGTCAGAAAAACAAAGGCAATGCATTGGCAAGCCTCACAAAGTGATCCTCCCTGGCCCCCCCCTCCCCCAAGTCTCCCGCCGCCTCCCCGGCCTGGTGACACCACCTCCCATGCAGATGTGGCCCCTCTGCACCTGGGACCCATCGGGTCGGGATGGACCACACGGACGGGGAGGCTCCTGGAGCTGCTTTGAAGATGGATGAGATGAGGGGTGTGCTCTGGGTGGGAGGAGCAGCGTACACCCGTCACCAGAACATCTCTTGTGTCATGACATGGGGGTGCAACGGGGGCCTCACAGCACAGAGTGACCGCTGCCTGGCGTTCCCCAGCACTCGGTGTGGAAAGGCCCCTACCTGCTGTAAGATTATGGGTCCATGAAAGCAGTAAGCTGGACACAGAGGTGTAGTGTGCGGGACAGAGGGCCTTGCAGATGCCTTTCTGTTGGTGTTTTAGTGTTAAAATACGGAGAGTATGGAACTCTTCACCTCCATTTTCTCAGCGGCTGTGAAGCAGCCTCCTAGCTTCGGAAGTACGGACACTACGTCGCGTTTTCAAGCGTGTCTGTTCTGCAGGTAACAGCATCAAGCTGCACGTGGAAGCATCTCGCGGTTTTCTAGAAACAGGCATTTTCTTATCCCTCTCCCGCTCCTTTTTCCACAAAGGTGAATTTCATAAATGTAATACTAGTAAAGTGAATGAATTACTGAGTTTATACAGAAATTTAGGTAACTTCTCCTTTAGTCTCAAGAGCGAGTCTTGCTTTTTAATGGGTGCCGTTTATGTTGCTGCCCGCCCTGTGTGCCTGGCTCCTCTGGGTGCCTTGGTGTCTGCTGGTGGCTGGCAGTGGGCGCAGCGGAGGAGAGTTGTGCTGCAGCTCATACGGTGTGTCTGTCATCTCAGTCTGGAGTAAATGCAGTGTCTGCCGGTGTCTGATGGGTTCTGTCCCTCGTATTTTCTTTGCCTTCTATCCCATTGCCTGGCTACCGCTGCCTGGCAGCCAAGGGTGTTGGTCGCGAAGCTGGAGTGGCCTCTGGTGGAGCCTGCATCTTGTCTCGTCTGCCTCTGCTTTACATTTGGTGTACTTTCGGGCGTGGTGGCAGTAAAATGACACCGTGATTGAGCTTGTCAGCAGAGCTGAAAGAGAAAGTAGAAGGATGTGCATTGTTTCTTGTAAGATATCTTGCATGTATCTGTGTATTCAAATTCAAACAGAGATGGTTTGTCCATTTGTCCACTGAGAAATTAGAAACTAGGGACAAGGGGGAGGAAAAGTACTGAAATACAGTTTATGAAGCAAGTGTGTCTCGGGCTGTGCTTGTCCCAGGAGCCCCAGCAGCATCTGAACTGAGGCTTCTTCAGTCCTGCAGGAACAGGATCATCTGTCTcagcggtgggcagatgttttcatagacagccagggagtaaacactgttggctctgtgggctgtatggtctctgccataaatagtacagagatgtggctgtgtctagtacaacttttagacacagaaatctgaatgacatatattgttctgtgtcaagaaacttagattttttttttaactatttaaaaacgtgaaacctattcttagctcacaggccatggagaagctggtggggaccagaCCCAGCTCCTTAGCTGGCTGGGCTGGGGAGGGGGTAGTGACAGTGGCAGCTGCTACTCACTGCTCAGTGTGGAAAACACAGGACTTGGCAATCACAGCCCGCAGAACCATCATGTGTGGCAGAAGCCTGAGGGATGCGGTTTCTTGCCCACGTGCTCTGTTCATTTTCTGTTGTTTTTCTGCACTTAAAGAATTCACATGGAAGCATGTTTTATAAAATGAATTACCAGAGAAACAGAGATGGGCCGAGATTTTCAGAAATGGTCCCATGTGACCAAGTTCTGCTGTTTGGGTGACAGTGCTTTGAAGATCTCCTTTGAGGATGTGCAGTCtttttttttttttttttgagatggagtttgttgcccaggctggagtgagtggcacagtctcggctcactgcaacctccacctcctgggttcaagcagttctcgtgccgcagcctcccaagtagctgggactacaggcatgcaccaccacgccaggctaatttttgtatttttagtagagatggggtttcaccatgtctcaaactcctgacctcaggcgatccacccacctcagcgtcccaaagtgctgggattataggcgtgagccaccgcacctggccTATGAGTGGTCTTTTAATTAGGAACAAATCTAATGGAAAGGAGAGTTGACTGAAGTTGGCCCACAGGATTGTGAGCTGGGCAGTGCCTTCATGAAGGCTTGCCACCTTGGGACGCCCCAGTTTACTGGGGTGTCTTGCGGAGTGCAGAAGGCTTTCTGGCAGCTGCCTGGGTTTGGCCAGACCCTGCCTCCCCTCCCGCCGGCCAACCCCTAGTCCCCTTCCTGTCTCCACTTGCATTCAGGGGTGGCTGCTGTTCTGAGAACATTAGAACTGGGAAGAGAGATGGAGTCACATGGATTTTTGGTGGGCATTATTCTAAACTTTCGTATCCAAGTTAGTCCCCCTTATTCCACTGTGGCATTGCCGTTCTAAGCAGTTACCTGATGCCTGCTGCTGAAGAGCTGCTCACAGGAGGCGGCGGCGGCCCTGGCACTGCCCCTTGCATTAGGTCTTGTGTTTGATGTGTTCTTGTGAATTTACTTTGTCAGAACAAAATATTTACGCGTTGGGTTCAGGAATTTCTTTTAGCTCCCCATCTGGCTGTGAAATTCAGGAAACCTCCCGTTGCCTAGTAATCACCCCATGTAGGTGTACATTGTGACAAAGTGCATCTGACCACTAAGGGGCCCCCTTGGTGACCCCAGCACATTCACAGCAGTGTTAAAATGGCCTGCATTTTGGAGATGCTGGCTGGCCTTTCAGTGCCTCCCAGGAAGACACATGGCCTTTCCCTCTTCAGATGCCTGAAGGGAGTGCTTTGAGGCAGGTGATGTGCTGGGAGTGTGGGCGGCCTCCCTCTGGCCCCGGGGCCCTCTGTGGACCTTGGCTCCCTCCGTGGACCTGGGCTTCGTGGTGAGCACTGCAGCCTCCCTGGGCATTCCCTCCAGCGCCAGCACCACTGCAACATATAGACCTGAGTGCTATTGTATTTTGGCTTGGTGTGTATGCTCTTCATTGTGTAAAATTGCTGTTCTTTTGACAATTTAAGTGATTGTTTTGTTTACTGTAAGTTTGAAAATAAAAATGAAGAAAAAAATTCCAATGACTGTGCTGTGGTTGGAGACTTTATTTACCAAGATGTTTACTCTTCCTTTCCCCTTCCATTTTGAGGAGCTGTGTCACTCCTCCTCCCCCCCAGTGCTTTGTAGTCTCTCCTATGTCATAATAAAGCTACATTTTCTCTGA

Publications

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