Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name MTHFD1P1
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr14). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:57392403-57395452  UCSC
Coordinates (T2T) chrX:56691210-56694259  UCSC
Coordinates (hg19) chrX:57418836-57421885  UCSC
Strand -
Parental Sequence NM_005956.4
Parental seq. overlap 2879 bp
Parental seq. overlap (%) 91.2%
Genomic Region Intergenic
Retrocopy Summary MTHFD1P1, located on chrX:57392403-57395452, is a retrocopy of the parental gene MTHFD1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MTHFD1
Full Name methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
Also known as CIMAH|MTHFC|MTHFD
Coordinate chr14:64388353-64460025
Strand +
Gene summary This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes MTHFD1P1
Bonobo Pan paniscus MTHFD1P1
Gorilla Gorilla gorilla MTHFD1P1
Orangutan Pongo abelii MTHFD1P1
Gibbon Nomascus leucogenys MTHFD1P1
Crab-eating macaque Macaca fascicularis MTHFD1P1
Rhesus Macaca mulatta MTHFD1P1
Baboon Papio anubis LOC101014176P1
Golden snub-nosed monkey Rhinopithecus roxellana MTHFD1P1
Green monkey Chlorocebus sabaeus Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>MTHFD1P1
TTGGTGGTGTCCATCGTGGGCAGCAGACTAATAAAGGCCATGGCACCAGCAGAAATCCTGAACAGGAAGGAGATCTCCGCACAAATAAGGGCGAGACTGAAGAATCAAGTCACTCAGTTGAAGGACAAGTACCTGGTTTCACACCAGGCCTGGCAATATTACAGGTTGGCAACAGAGATGATTCCAATCTTTATATAATGTGAAGCTGAAGGCTGCTGAAGAGATTGGGATGAAAGCCACTGACATTAAGTTACCAAGAACAACCACAGAATCTGAGGTGATCAAGTACATCATATCTTTGAATGAAGACTCTACTGTACACGGGTTCGTAGTGCAGCTATCTCTAGACTCAGACAATACACTGAAGGAGTGATCAATGCTATTGCACCTGAAAAGGATGTGGATGGATTGACTAGCATCAGTGCTGGGAAACTTGCTAGAGGTGACCTAAATGACTGTTTCATTCCTTGTATGCCTAAAGGATGCTTGGAACTCATGAAAGAGACAGGGGTGCAGATTGCCAGAAGGCATGCTGTGGTGGTTGGGTGCAGTAAAATAGTCAGGGCCCTGATGCGTGACTTGCTTCTGTGGAACAATGCCACAGTGACCACCTGCCACTCCAAGACTGCCAATCTGGATGAGGAGGTAAATAAAGGCGACATCCTGGTGGTTGCAACTGGTCGGCCTGAAATGGTTAAAGGGGAATGGATCAAACCTAGCAATAGTCATCAACTGTGGAATCAATTATGTCCCAGATGATAAAAAAAACAAATGGGAGAAAAGTTGTGGGTGATGTGGCATACGACGAGGCCCGTTCCTGGTGGCTTAGGGCTCATGACGGTTGCAATGCTCATGCAGAGCACTGTAGAGAGTGCCAAGCGTTTCCTGGAGAAATTTAAGCCAGGAAAGTGGATGATTCAGTATAACAACCTTAACCTCAAGACACCTGTTCCAAGTGACATTGATATATCACGATCTTGTAAACCGAAGCCCATTGGTAAGCTGGCTTGAGTAATTGGTCTGCTGTCTGAAGAGGTAGAATTATATGGTGAAACAAAGGCCAAAGTTCTGCTGTCAGCACTAGAACGCCTGAAGCACCAGCCTGTTGGGAAATATCAGGTGGTGACTGGAATAACTCCAACACCCCTGGGAGAAGGGAAAAGCACGACTACAATCGGGCTGGTGCAAGCCCTTCTTGCCCATCTTTACCAGAACTTTTTTATGTGTGTGCGACAGCCTTCTCAGGGCCCCACCTTTGGAATAAAAGGTGGTGTTGCAGGAGGCGGCTACTCCCAGGTCATTCCTATGGAAGAGTTTAATCTTCACCTCACAGGTGACATCCATGCCATCACTGTATCTAATAACCTTGTTGCTGCGGCTATTGATGCTCAGATATTTCATGAACTGACCCAGACAGACAAGGCTACCTTTACTCATTTGGTGCCATCAGTAAATGGAGTGAGAAAGTTCTCTGATATCCACATACAAAGGTTAAACAGACTAGGCATTGACAAGACTGACTCTACCACACTGACAGATGAAGAGATAAACAGATTTGCAAGATTGGACATTGATCCAGAAACCATAGCTTGGCAAAGAGTGTTGAATACCAATGATAGATTCCTGAGGAAGATCACGATTGGACAGGCTCCAACGAAGAAAAGTCACACACAGACGGTCCACTTTGATATCTCTGTGGCCAGTGAAATTATGGCTGTCCTGGCTCTCACCACTTCTCTAGAAGACAGGAGAGAGAGACTGGGCAAAATGGTGGTGGCATCCAGTAAGAAAGGAGACCCCGTCAGTGCTGAAGATCTGGGGGTGAGTGGTGCATTGATAGTGCTTATGAAGGACACAATCAAGCCCAATCTCATGCAGAGATTGGAGGGCACTCCAGTGTTTGTCCATGCAGGCCCATTTGCCATCATCGCACACGGCAATTCCTCTATCATTGCAGACCGGATCACACTCTAGCTTGTTGGCCCAGAAGGGTTTGTAGTGACGGAGGCGGGATTTGGAGCAGACATTGGAATAGAAAAGTTTCTTAACATCAAATCCCAGTATTCCGGTCTCCACCCTCACGTGGTGGTGCTTGTTGCCACTGTCAGCGCTCTAAAGATGCACAGGGGTGGCCCTATGGTCACTGCTGGAATGCCTCTTCCCAAGGCTTACATAGAGGAGAACCTGGAGCTGGTTGAAAAAGGCTTCAGTAACTTGAAGAAACAAACTGAAAATGCCAGAATGTTTGGAATTCCAGTAGTAGTGGCCGTGAATGCATTCAAGACAGATACAGAGACTGAGCTGGACCTCATCGGCTGCCTTTCCAGAGAACAGAGGGCTTTTGATGCCGTGAAGTGCACTCACTGGCAGAAGGGGGCAAGGGTACCTTAGCCCTGGCTCAGGCTGTCCAGAGAGCAGGACAAGCACCCAGCAGCTTCCAACTCCTTTATGACCTCAAGCTCCCAGTTGAGGATAAAATCAGGATCATTGCACAGAAGATCTATGGAGCAGACAACATTGAATTACTCCTCAAAGCTCAACACAAAGCTGAAGTCTACACAAAGCAGGGCTTTGGGAATCTCCCCATCTGCATGGCCAAAACACACTTGTCCTTGTCTCACAACCCAGAGCGAAAAGGTGTCCCTACAGGATTCATTCTGCCCATTCGCAACATCCATGCCAGCATCGGGGCTGGTTTTCTGTACCCTTTAGTAGGAACGATGAGCACAATGGACTCCCCACCCAGCCCTGTTTTTATGATACTGATTTGGACCCTGAAACAGAACAGGTGAATGGATCATTCTAAACAGATCATCATCCATCTTCAAGAAGCTACTTTGAAAATCTGGCCAGTGTCTATTCAGGCCCACTGGGAGTTAGGAAGTATAAGGCAGCCAAGAGTCAGCCCCTGCCCAGAAGATCTGAAACTAATAGTAGGAGTTTTCCCGGATGTCATTTTCAGCCTTAATTCTCATCGTGTATAAATTAACATAAATCATGCACATGTCTATTTACGTTAGTGACGTTCCACAGAATAAAAGGAAAT
>NM_005956.4
GTCCTGCTTGGCTGCGGAGGGAGTGGAACCTCGATATTGGTGGTGTCCATCGTGGGCAGCGGACTAATAAAGGCCATGGCGCCAGCAGAAATCCTGAACGGGAAGGAGATCTCCGCGCAAATAAGGGCGAGACTGAAAAATCAAGTCACTCAGTTGAAGGAGCAAGTACCTGGTTTCACACCACGCCTGGCAATATTACAGGTTGGCAACAGAGATGATTCCAATCTTTATATAAATGTGAAGCTGAAGGCTGCTGAAGAGATTGGGATCAAAGCCACTCACATTAAGTTACCAAGAACAACCACAGAATCTGAGGTGATGAAGTACATTACATCTTTGAATGAAGACTCTACTGTACATGGGTTCTTAGTGCAGCTACCTTTAGATTCAGAGAATTCCATTAACACTGAAGAAGTGATCAATGCTATTGCACCCGAGAAGGATGTGGATGGattgactagcatcaatgctgggaaacttgctagaggtgacctcaatgactGTTTCATTCCTTGTACGCCTAAGGGATGCTTGGAACTCATCAAAGAGACAGGGGTGCCGATTGCCGGAAGGCATGCTGTGGTGGTTGGGCGCAGTAAAATAGTTGGGGCCCCGATGCATGACTTGCTTCTGTGGAACAATGCCACAGTGACCACCTGCCACTCCAAGACTGCCCATCTGGATGAGGAGGTAAATAAAGGTGACATCCTGGTGGTTGCAACTGGTCAGCCTGAAATGGTTAAAGGGGAGTGGATCAAACCTGGGGCAATAGTCATCGACTGTGGAATCAATTATGTCCCAGATGATAAAAAACCAAATGGGAGAAAAGTTGTGGGTGATGTGGCATACGACGAGGCCAAAGAGAGGGCGAGCTTCATCACTCCTGTTCCTGGCGGCGTAGGGCCCATGACAGTTGCAATGCTCATGCAGAGCACAGTAGAGAGTGCCAAGCGTTTCCTGGAGAAATTTAAGCCAGGAAAGTGGATGATTCAGTATAACAACCTTAACCTCAAGACACCTGTTCCAAGTGACATTGATATATCACGATCTTGTAAACCGAAGCCCATTGGTAAGCTGGCTCGAGAAATTGGTCTGCTGTCTGAAGAGGTAGAATTATATGGTGAAACAAAGGCCAAAGTTCTGCTGTCAGCACTAGAACGCCTGAAGCACCGGCCTGATGGGAAATACGTGGTGGTGACTGGAATAACTCCAACACCCCTGGGAGAAGGGAAAAGCACAACTACAATCGGGCTAGTGCAAGCCCTTGGTGCCCATCTCTACCAGAATGTCTTTGCGTGTGTGCGACAGCCTTCTCAGGGCCCCACCTTTGGAATAAAAGGTGGCGCTGCAGGAGGCGGCTACTCCCAGGTCATTCCTATGGAAGAGTTTAATCTCCACCTCACAGGTGACATCCATGCCATCACTGCAGCTAATAACCTCGTTGCTGCGGCCATTGATGCTCGGATATTTCATGAACTGACCCAGACAGACAAGGCTCTCTTTAATCGTTTGGTGCCATCAGTAAATGGAGTGAGAAGGTTCTCTGACATCCAAATCCGAAGGTTAAAGAGACTAGGCATTGAAAAGACTGACCCTACCACACTGACAGATGAAGAGATAAACAGATTTGCAAGATTGGACATTGATCCAGAAACCATAACTTGGCAAAGAGTGTTGGATACCAATGATAGATTCCTGAGGAAGATCACGATTGGACAGGCTCCAACGGAGAAGGGTCACACACGGACGGCCCAGTTTGATATCTCTGTGGCCAGTGAAATTATGGCTGTCCTGGCTCTCACCACTTCTCTAGAAGACATGAGAGAGAGACTGGGCAAAATGGTGGTGGCATCCAGTAAGAAAGGAGAGCCCGTCAGTGCCGAAGATCTGGGGGTGAGTGGTGCACTGACAGTGCTTATGAAGGACGCAATCAAGCCCAATCTCATGCAGACACTGGAGGGCACTCCAGTGTTTGTCCATGCTGGCCCGTTTGCCAACATCGCACATGGCAATTCCTCCATCATTGCAGACCGGATCGCACTCAAGCTTGTTGGCCCAGAAGGGTTTGTAGTGACGGAAGCAGGATTTGGAGCAGACATTGGAATGGAAAAGTTTTTTAACATCAAATGCCGGTATTCCGGCCTCTGCCCCCACGTGGTGGTGCTTGTTGCCACTGTCAGGGCTCTCAAGATGCACGGGGGCGGCCCCACGGTCACTGCTGGACTGCCTCTTCCCAAGGCTTACATACAGGAGAACCTGGAGCTGGTTGAAAAAGGCTTCAGTAACTTGAAGAAACAAATTGAAAATGCCAGAATGTTTGGAATTCCAGTAGTAGTGGCCGTGAATGCATTCAAGACGGATACAGAGTCTGAGCTGGACCTCATCAGCCGCCTTTCCAGAGAACATGGGGCTTTTGATGCCGTGAAGTGCACTCACTGGGCAGAAGGGGGCAAGGGTGCCTTAGCCCTGGCTCAGGCCGTCCAGAGAGCAGCACAAGCACCCAGCAGCTTCCAGCTCCTTTATGACCTCAAGCTCCCAGTTGAGGATAAAATCAGGATCATTGCACAGAAGATCTATGGAGCAGATGACATTGAATTACTTCCCGAAGCTCAACACAAAGCTGAAGTCTACACGAAGCAGGGCTTTGGGAATCTCCCCATCTGCATGGCTAAAACACACTTGTCTTTGTCTCACAACCCAGAGCAAAAAGGTGTCCCTACAGGCTTCATTCTGCCCATTCGCGACATCCGCGCCAGCGTTGGGGCTGGTTTTCTGTACCCCTTAGTAGGAACGATGAGCACAATGCCTGGACTCCCCACCCGGCCCTGTTTTTATGATATTGATTTGGACCCTGAAACAGAACAGGTGAATGGATTATTCTAAACAGATCACCATCCATCTTCAAGAAGCTACTTTGAAAGTCTGGCCAGTGTCTATTCAGGCCCACTGGGAGTTAGGAAGTATAAGTAAGCCAAGAGAAGTCAGCCCCTGCCCAGAAGATCTGAAACTAATAGTAGGAGTTTCCCCAGAAGTCATTTTCAGCCTTAATTCTCATCATGTATAAATTAACATAAATCATGCATGTCTGTTTACTTTAGTGACGTTCCACAGAATAAAAGGAAACAAGTTTGCCATCTTGGTGTTGCAATATGAA

Publications

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