Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Summary

Retrocopy Name NLRP2B
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr19_GL949746v1_alt). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:57676909-57680276  UCSC
Coordinates (T2T) chrX:56975694-56979061  UCSC
Coordinates (hg19) chrX:57703342-57706709  UCSC
Strand -
Parental Sequence NM_017852.5_3
Parental seq. overlap 1643 bp
Parental seq. overlap (%) 32.7%
Genomic Region Intergenic
Retrocopy Summary NLRP2B, located on chrX:57676909-57680276, is a retrocopy of the parental gene NLRP2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name NLRP2
Full Name NLR family pyrin domain containing 2
Also known as CLR19.9|NALP2|NBS1|PAN1|PYPAF2
Coordinate chr19_GL949746v1_alt:868682-904536
Strand +
Gene summary This gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). Members of this gene family are thought to be important regulators of immune responses. This gene product interacts with components of the IkB kinase (IKK) complex, and can regulate both caspase-1 and NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity. The pyrin domain is necessary and sufficient for suppression of NF-kB activity. An allelic variant (rs147585490) has been found that is incapable of blocking the transcriptional activity of NF-kB. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes NLRP2P1
Bonobo Pan paniscus NLRP2P1
Gorilla Gorilla gorilla NLRP2P1
Orangutan Pongo abelii NLRP2P1
Gibbon Nomascus leucogenys NLRP2P1
Crab-eating macaque Macaca fascicularis NLRP2P1
Rhesus Macaca mulatta NLRP2P1
Green monkey Chlorocebus sabaeus Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>NLRP2B
CAAGGACGGCCACGCCTGGGACAATGGAGACGTGCAGAAGCTGTTTTCTAGAGAAGAAAGACTCAAGAACCCCGACCTGATCCAAGCAAGACACTTCTTATTCGGCTTCGCCAACGAGAAGAAAGCCAAGGAGTTGGAGACCACTTTGGGCTGCCTGATGTCACCGGAGATCAAAAAGGAATTACTGTGATGAGAGATAAATTGTGAAAAGGTTGGACACTCAACAATGATGAACCCGAAGGAGCTCTTGTGCTGTCTGTACGAGTCTCAGGAGGAGGAGCTGGTGAAGGGAGTGATGGCTCCGTTCAAAGAAATATCCCTGCACTTAAATGCAGTAGACATTATGCTGTTTTCAATCTGCCTCAAGCATTGTCGAAACTTGCAGAAAATGCCACTGCAGGCAGCAAAGGCAAAGCTCCCAGAGAATGTCACTGTGTCTGAATCAGATGCTGAAGTTGAGAGATCCCAGGATGATCAACACATGCTTCCTTTCTGGACCGACCTTTGTTCCATATTTGGCTCAAATAAGGATCTGATCATTCTAGAAATCAATAATAGCTTTCTTGGTGCCACATTAGTAAGGATCCTGTGTGAACAAATAGCTTCTGACACCTGTCGTCTCCAGAGAGTGATGTTCAAAAACATTTCACCAGCTGATGCTTATCGGAACCTCTGCCTAGCTCTTTGAGGTCACAAGACTGTAAGATATCTGACCCTTCAAGGCAATGACCAGAATGATATGCTTCCTGCATTGTGTAAGGTCTTGAGACACTCAAAATGTAACCTGCAATATCTCGGGTTGGTGTCTTTTTCCACCACCACTTAGCAATGGGCTGATCTCTCCTTGGCCCTTGAAGTCAACCAGTCCCTGACATGTGTAAACCTCTCTCACAATGAGCTCTTGGATGAGGGTGCCAAGTTGCTGTACACAACTTTGAGACACCCAAAATGCTTCCTGCCGAGGTTGTTGTTGGAAAACTGTCACTTTATAGAAGGCAATTGCAAGAACTTTGCTGCTGTTTTGGTTGTCAGCGGGGAGCTGACACACCTGTGCTTGGCCAAGAACCCCCCACTCGGGGATACATGGGTGATGTTTCTGTGTAAGGGTTTGAGTTACCCCCATTGTAAACTACAGACCCTGGTGCTGTGGGACTGCGACATAACTAGCAATGGCTGCTGTTATCTCGCAGAGCTTCTCCAAGAAAAATCAAGCCTAATGTGCTTGGATCTGGGACTGAATCACATAGGAGTTACTGGAGTGAAGCTCCTATGTGAGGCTTTGAAGAAACCACTGTGTAACTTGAGATGTCTGTGGTTGTGGGGGTGTTCCATCCCTCTGTTCAGTTGTGAGGACCTCTGCTCTGTGCTCAGCTGCAACCACAGCCTCGTCGTTCTGGACCTGAGCCAGAATCCCTTGGGGTCTAGTGGAGTAAAGATGCTGTTTGAAACCTTGACACATCCAAATTGCACCCTCCAGACACTCAGGTTGAAAATAGATGACTTTAATGTTGAACTCGATAAGCTGCTGGAAGAAATAGAAGAAAACAACCCACAACTGCCTGCTGATAACTGAGAAACATGATCCTTTGGGGGGGAAAAAAGGCTTTCTTTTCATTACTTCATTATCTGAATCCCCCCAGAGTCATTCATTCTCAATGAAGTCATGGATTTTCCAGGTGTTGGTGAACAGCCTGTGACTCTTCCCCTCCCCTATCCCCACTTCTCAGGGATAATGAGTTGATTGCTGGGCTAGGTGTTTTAGCCATGGTTCTGCCTCTGTTTTACTCCCACGTCAGACGAGATGGTGTCTTCTGCACAGCTGGACTTCAACCTGCAGGCTCTTCTGGGACAGCTCAGCCAGGATGACTTGTGCAAGTTCAAGTCTCTGATCAGGACCGTCTCCCTGGGAAATGAGCTGCAAAAGATCCCCCAGACATAGGTAGACAAGGCTGATGGGAAGCAACTGGCAGAAATCATCACCAGCCATTGCCACAGCTACTGGATGAAGATAGAGACCATCCAGGTCTTTGAAAAGATGCACCGAGCGGATCTGTCTGAGAAAGTAAAGGATGAACTCAGAGAAGACACTTTGAAATCAAGCCTGTATCATTAGGGAAAACAGGGAAAGAAGAGCCAAAACCTATAGACCTGAAACAAATGCTGGGGCGTTTCGAAGCAGAAGCACTAGAGTTTATAGAAACGGAGGAAGATGTCACCAGCCTAAGAGAAGCTAAAGAAGTCTTGAAAGGAGAAAAGCCAGGTAAAGAGGATAGGTACAGGAGTATATTGAAGACGAAGTTCTGGCAAATGTGGAAAACCTGGCCTGGAGACCTCAAAGTGGTCCATATTATGGCTCAGAGATACAAGATGCTGATCCCGTTCAGCAACCCCAGGGTGCTTCCCGGGCCCTGCCCACACACGGTGGTGCTGCATGGTCCTGCGGGCCTTGGGAAAACCACGCTGGCCAAGAAATTAATGCTGGACTGGGCAGAGGACAACCTCAGCCAGAAATTTAGATAGGCTTTCTACCTCACCTGCAAGGAGCTCATCTGCCTGGGCCCGTGCAGTTTTGCAGAGCTGGTCTTCAGGAACTGGCCTGAATTGCAGGATGACATTCCAAACATCCTAGCCCAAGCACAGAAAATCCTGTTCGTGGTCGACGGCTTTGATGAGCTGGGAGCCCCACCTGGGGCACTGATCTAGGACATCTGTGGGGACTGGGAGAAGCAGAAGCCGGTGCCGGTCTTCTTGGGGAGGTTACTGAAGAGGAAGATTTTACCCAGGGCCGCCGTGCTGGTCACCACGTGGCCTGCGGGCCCTGAGAGACCTCCGGCTGTTGGTGGAGCGGCCGATCTATGTAAGGGTGGAGGAGTTCCTGGAGAAGGACAGGAGGGCATATTTCCTGAGACACTTTGGAGACGAGGACCAAGCCATGTGTGCCTTTGAGCTGATGAGAAGAAACGCGGCCCTGTTCCAGCCTGTCTCGGCACCCATGGTGTGCTGGATCATGTGCATGAGTCTGAAGCTGCAGAGGTTAGAAGGGGAAGGACCCGCCCCACCCGCACGGGGCTGTTCCTGCGCTTCCTTTGCGGCCGGTTCCCGCAGGGCGCACAGCTCTGGGGCGTGCTGCGGGCGCTGAGCCTCCTGGCGGCACAGGGCCTGTGGGCGCAGATGTCAGTGTTCCGTGGAGAGGACTTGGCGAGGCTCGGGGTGCAGGAGTTCAACATCCGCCCGTCCCTGGACAGAGACATCCTCCGCCAGGACATAGTCTCTAAAGGCTGCTATTCCTACATCCACCTCAGCTTCCAGCAGTTTTTCACTGTGCTGTTCCACGCCCTg
>NM_017852.5_3
AATCACAGGGCTGCGGCCGAGAGAGAAGCCTTATTAGAGCTTTCTCAACCTGCAGCCCTCATCTCCGCCGGCGAGTAGGGCCAGGTGTTGGGAGCTCCCACGTGGGACAAGATGGTGTCTTCGGCACAGATGGGCTTCAACCTGCAGGCTCTCCTGGAGCAGCTCAGCCAGGATGAGTTGAGCAAGTTCAAGTATCTGATCACGACCTTCTCCCTGGCACACGAGCTCCAGAAGATCCCCCACAAGGAGGTAGACAAGGCTGATGGGAAGCAACTGGTAGAAATCCTCACCACCCATTGTGACAGCTACTGGGTGGAGATGGCGAGCCTCCAGGTCTTTGAAAAGATGCACCGAATGGATCTGTCTGAGAGAGCAAAGGATGAAGTCAGAGAAGCAGCTTTGAAATCCTTTAATAAAAGGAAGCCTCTATCATTAGGGATAACACGGAAAGAACGACCACCTCTAGACGTGGACGAAATGCTGGAGCGCTTCAAAACAGAAGCACAAGCGTTTACAGAAACGAAAGGAAATGTCATCTGCCTGGGTAAAGAAGTCTTTAAAGGAAAAAAGCCAGACAAAGACAATAGGTGCAGGTATATATTGAAGACGAAGTTCCGGGAGATGTGGAAGAGCTGGCCTGGAGATAGCAAAGAGGTCCAGGTTATGGCTGAGAGATACAAGATGCTGATCCCATTCAGCAACCCCAGGGTGCTTCCCGGGCCCTTCTCATACACGGTGGTGCTGTATGGTCCTGCAGGCCTTGGGAAAACCACGCTGGCCCAGAAACTAATGCTAGACTGGGCAGAGGACAACCTCATCCACAAATTCAAATATGCGTTCTACCTCAGCTGCAGGGAGCTCAGCCGCCTGGGCCCGTGCAGTTTTGCAGAGCTGGTCTTCAGGGACTGGCCTGAATTGCAGGATGACATTCCACACATCCTAGCCCAAGCACGGAAAATCTTGTTCGTGATTGACGGCTTTGATGAGCTGGGAGCCGCACCTGGGGCGCTGATCGAGGACATCTGCGGGGACTGGGAGAAGAAGAAGCCGGTGCCCGTCCTCCTGGGGAGTTTGCTGAACAGGGTGATGTTACCCAAGGCCGCCCTGCTGGTCACCACGCGGCCCAGGGCCCTGAGGGACCTCCGGATCCTGGCGGAGGAGCCGATCTACATAAGGGTGGAGGGCTTCCTGGAGGAGGACAGGAGGGCCTATTTCCTGAGACACTTTGGAGATGAGGACCAAGCCATGCGTGCCTTTGAGCTAATGAGGAGCAACGCGGCCCTGTTCCAGCTGGGCTCGGCCCCCGCGGTGTGCTGGATCGTGTGCACGACTCTGAAGCTGCAGATGGAGAAGGGGGAGGACCCGGTCCCCACCTGCCTCACCCGCACGGGGCTGTTCCTGCGTTTCCTCTGCAGCCGGTTCCCGCAGGGCGCACAGCTGCGGGGCGCGCTGCGGACGCTGAGCCTCCTGGCCGCGCAGGGCCTGTGGGCGCAGACGTCCGTGCTTCACCGAGAGGATCTGGAAAGGCTCGGGGTGCAGGAGTCCGACCTCCGTCTGTTCCTGGACGGAGACATCCTCCGCCAGGACAGAGTCTCCAAAGGCTGCTACTCCTTCATCCACCTCAGCTTCCAGCAGTTTCTCACTGCCCTGTTCTACACCCTGGAGAAGGAGGAGGAAGAGGATAGGGACGGCCACGCCTGGGACATTGGGGACGTACAGAAGCTGCTTTCCGGAGTAGAAAGACTCAGGAACCCCGACCTGATCCAAGCAGGCTACTACTCCTTCGGCCTCGCTAACGAGAAGAGAGCCAAGGAGTTGGAGGCCACTTTTGGCTGCCGGATGTCACCGGACATCAAACAGGAATTGCTGCGATGCGACATAAGTTGTAAGGGTGGACATTCAACGGTGACAGACCTGCAGGAGCTGCTCGGCTGTCTGTACGAGTCTCAGGAGGAGGAGCTGGTGAAGGAGGTGATGGCTCAGTTCAAAGAAATATCCCTGCACTTAAATGCAGTAGACGTTGTGCCATCTTCATTCTGCGTCAAGCACTGTCGAAACCTGCAGAAAATGTCACTGCAGGTAATAAAGGAGAATCTCCCGGAGAATGTCACTGCGTCTGAATCAGACGCCGAGGTTGAGAGATCCCAGGATGATCAGCACATGCTTCCTTTCTGGACGGACCTTTGTTCCATATTTGGATCAAATAAGGATCTGATGGGTCTAGCAATCAATGATAGCTTTCTCAGTGCCTCCCTAGTAAGGATCCTGTGTGAACAAATAGCCTCTGACACCTGTCATCTCCAGAGAGTGGTGTTCAAAAACATTTCCCCAGCTGATGCTCATCGGAACCTCTGCCTAGCTCTTCGAGGTCACAAGACTGTAACGTATCTGACCCTTCAAGGCAATGACCAGGATGATATGTTTCCCGCATTGTGTGAGGTCTTGAGACATCCAGAATGTAACCTGCGATATCTCGGGTTGGTGTCTTGTTCCGCTACCACTCAGCAGTGGGCTGATCTCTCCTTGGCCCTTGAAGTCAACCAGTCCCTGACGTGCGTAAACCTCTCCGACAATGAGCTTCTGGATGAGGGTGCTAAGTTGCTGTACACAACTTTGAGACACCCCAAGTGCTTTCTGCAGAGGTTGTCGTTGGAAAACTGTCACCTTACAGAAGCCAATTGCAAGGACCTTGCTGCTGTGTTGGTTGTCAGCCGGGAGCTGACACACCTGTGCTTGGCCAAGAACCCCATTGGGAATACAGGGGTGAAGTTTCTGTGTGAGGGCTTGAGGTACCCCGAGTGTAAACTGCAGACCTTGGTGCTTTGGAACTGCGACATAACTAGCGATGGCTGCTGCGATCTCACAAAGCTTCTCCAAGAAAAATCAAGCCTGTTGTGTTTGGATCTGGGGCTGAATCACATAGGAGTTAAGGGAATGAAGTTCCTGTGTGAGGCTTTGAGGAAACCACTGTGCAACTTGAGATGTCTGTGGTTGTGGGGATGTTCCATCCCTCCGTTCAGTTGTGAAGACCTCTGCTCTGCCCTCAGCTGCAACCAGAGCCTCGTCACTCTGGACCTGGGTCAGAATCCCTTGGGGTCTAGTGGAGTGAAGATGCTGTTTGAAACCTTGACATGTTCCAGTGGCACCCTCCGGACACTCAGGTTGAAAATCGATGACTTTAATGATGAACTCAATAAGCTGCTGGAAGAAATAGAAGAAAAAAACCCACAACTGATTATTGATACTGAGAAACATCATCCCTGGGCAGAAAGGCCTTCTTCTCATGACTTCATGATCTGAATCCCCCCGAGTCATTCATTCTCCATGAAGTCATCGATTTTCCAGGTGTTGGTGAACTGCCTGTGACTCCTCTCCTCCCCGGCCCCTACCCCTCAGGGATAATGAGTTCATTGCTGGGCTAGATGTTTTAGCCATGATTCTGCCTCTGTTTTATACCTGCACACATCCTTATCTTTGTTACATATGAAATATCTGTATCACGGGTATATTGAGAGAAATAAAGGTGAGAGCATTCACAAA

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