Retrocopy Name | NLRP2B |
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Species | Homo sapiens | |
Coordinates (hg38) | chrX:57676909-57680276 UCSC | |
Coordinates (T2T) | chrX:56975694-56979061 UCSC | |
Coordinates (hg19) | chrX:57703342-57706709 UCSC | |
Strand | - | |
Parental Sequence | NM_017852.5_3 | |
Parental seq. overlap | 1643 bp | |
Parental seq. overlap (%) | 32.7% | |
Genomic Region |
Intergenic |
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Retrocopy Summary | NLRP2B, located on chrX:57676909-57680276, is a retrocopy of the parental gene NLRP2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes. |
Gene Name | NLRP2 |
Full Name | NLR family pyrin domain containing 2 |
Also known as | CLR19.9|NALP2|NBS1|PAN1|PYPAF2 |
Coordinate | chr19_GL949746v1_alt:868682-904536 |
Strand | + |
Gene summary | This gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). Members of this gene family are thought to be important regulators of immune responses. This gene product interacts with components of the IkB kinase (IKK) complex, and can regulate both caspase-1 and NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity. The pyrin domain is necessary and sufficient for suppression of NF-kB activity. An allelic variant (rs147585490) has been found that is incapable of blocking the transcriptional activity of NF-kB. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016] |
Species | Scientific Name | Retrocopy | |
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Chimpanzee | Pan troglodytes | NLRP2P1 |
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Bonobo | Pan paniscus | NLRP2P1 |
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Gorilla | Gorilla gorilla | NLRP2P1 |
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Orangutan | Pongo abelii | NLRP2P1 |
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Gibbon | Nomascus leucogenys | NLRP2P1 |
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Crab-eating macaque | Macaca fascicularis | NLRP2P1 |
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Rhesus | Macaca mulatta | NLRP2P1 |
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Green monkey | Chlorocebus sabaeus | Without Homology |
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Baboon | Papio anubis | Without Homology |
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Golden snub-nosed monkey | Rhinopithecus roxellana | Without Homology |
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Marmoset | Callithrix jacchus | Without Homology |
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Mouse lemur | Microcebus murinus | Without Homology |
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Mouse | Mus musculus | Without Homology |
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Rat | Rattus norvegicus | Without Homology |
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Chinese hamster | Cricetulus griseus | Without Homology |
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Rabbit | Oryctolagus cuniculus | Without Homology |
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Pig | Sus scrofa | Without Homology |
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Cow | Bos taurus | Without Homology |
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Sheep | Ovis aries | Without Homology |
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Dolphin | Tursiops truncatus | Without Homology |
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Horse | Equus caballus | Without Homology |
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Dog | Canis familiaris | Without Homology |
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Panda | Ailuropoda melanoleuca | Without Homology |
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Cat | Felis catus | Without Homology |
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Pale spear-nosed bat | Phyllostomus discolor | Without Homology |
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Velvety free-tailed bat | Molossus molossus | Without Homology |
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Greater mouse-eared bat | Myotis myotis | Without Homology |
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Kuhl's pipistrelle | Pipistrellus kuhlii | Without Homology |
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Greater horseshoe bat | Rhinolophus ferrumequinum | Without Homology |
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Egyptian rousette | Rousettus aegyptiacus | Without Homology |
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Sloth | Choloepus didactylus | Without Homology |
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Tasmanian Devil | Sarcophilus harrisii | Without Homology |
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Opossum | Monodelphis domestica | Without Homology |
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Platypus | Ornithorhynchus anatinus | Without Homology |
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Chicken | Gallus gallus | Without Homology |
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Turkey | Meleagris gallopavo | Without Homology |
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Zebra Finch | Taeniopygia guttata | Without Homology |
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Budgerigar | Melopsittacus undulatus | Without Homology |
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Painted Turtle | Chrysemys picta | Without Homology |
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Lizard | Anolis Carolinensis | Without Homology |
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Frog | Xenopus tropicalis | Without Homology |
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Zebrafish | Danio rerio | Without Homology |
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Drosophila | Drosophila melanogaster | Without Homology |
>NLRP2B |
CAAGGACGGCCACGCCTGGGACAATGGAGACGTGCAGAAGCTGTTTTCTAGAGAAGAAAGACTCAAGAACCCCGACCTGATCCAAGCAAGACACTTCTTATTCGGCTTCGCCAACGAGAAGAAAGCCAAGGAGTTGGAGACCACTTTGGGCTGCCTGATGTCACCGGAGATCAAAAAGGAATTACTGTGATGAGAGATAAATTGTGAAAAGGTTGGACACTCAACAATGATGAACCCGAAGGAGCTCTTGTGCTGTCTGTACGAGTCTCAGGAGGAGGAGCTGGTGAAGGGAGTGATGGCTCCGTTCAAAGAAATATCCCTGCACTTAAATGCAGTAGACATTATGCTGTTTTCAATCTGCCTCAAGCATTGTCGAAACTTGCAGAAAATGCCACTGCAGGCAGCAAAGGCAAAGCTCCCAGAGAATGTCACTGTGTCTGAATCAGATGCTGAAGTTGAGAGATCCCAGGATGATCAACACATGCTTCCTTTCTGGACCGACCTTTGTTCCATATTTGGCTCAAATAAGGATCTGATCATTCTAGAAATCAATAATAGCTTTCTTGGTGCCACATTAGTAAGGATCCTGTGTGAACAAATAGCTTCTGACACCTGTCGTCTCCAGAGAGTGATGTTCAAAAACATTTCACCAGCTGATGCTTATCGGAACCTCTGCCTAGCTCTTTGAGGTCACAAGACTGTAAGATATCTGACCCTTCAAGGCAATGACCAGAATGATATGCTTCCTGCATTGTGTAAGGTCTTGAGACACTCAAAATGTAACCTGCAATATCTCGGGTTGGTGTCTTTTTCCACCACCACTTAGCAATGGGCTGATCTCTCCTTGGCCCTTGAAGTCAACCAGTCCCTGACATGTGTAAACCTCTCTCACAATGAGCTCTTGGATGAGGGTGCCAAGTTGCTGTACACAACTTTGAGACACCCAAAATGCTTCCTGCCGAGGTTGTTGTTGGAAAACTGTCACTTTATAGAAGGCAATTGCAAGAACTTTGCTGCTGTTTTGGTTGTCAGCGGGGAGCTGACACACCTGTGCTTGGCCAAGAACCCCCCACTCGGGGATACATGGGTGATGTTTCTGTGTAAGGGTTTGAGTTACCCCCATTGTAAACTACAGACCCTGGTGCTGTGGGACTGCGACATAACTAGCAATGGCTGCTGTTATCTCGCAGAGCTTCTCCAAGAAAAATCAAGCCTAATGTGCTTGGATCTGGGACTGAATCACATAGGAGTTACTGGAGTGAAGCTCCTATGTGAGGCTTTGAAGAAACCACTGTGTAACTTGAGATGTCTGTGGTTGTGGGGGTGTTCCATCCCTCTGTTCAGTTGTGAGGACCTCTGCTCTGTGCTCAGCTGCAACCACAGCCTCGTCGTTCTGGACCTGAGCCAGAATCCCTTGGGGTCTAGTGGAGTAAAGATGCTGTTTGAAACCTTGACACATCCAAATTGCACCCTCCAGACACTCAGGTTGAAAATAGATGACTTTAATGTTGAACTCGATAAGCTGCTGGAAGAAATAGAAGAAAACAACCCACAACTGCCTGCTGATAACTGAGAAACATGATCCTTTGGGGGGGAAAAAAGGCTTTCTTTTCATTACTTCATTATCTGAATCCCCCCAGAGTCATTCATTCTCAATGAAGTCATGGATTTTCCAGGTGTTGGTGAACAGCCTGTGACTCTTCCCCTCCCCTATCCCCACTTCTCAGGGATAATGAGTTGATTGCTGGGCTAGGTGTTTTAGCCATGGTTCTGCCTCTGTTTTACTCCCACGTCAGACGAGATGGTGTCTTCTGCACAGCTGGACTTCAACCTGCAGGCTCTTCTGGGACAGCTCAGCCAGGATGACTTGTGCAAGTTCAAGTCTCTGATCAGGACCGTCTCCCTGGGAAATGAGCTGCAAAAGATCCCCCAGACATAGGTAGACAAGGCTGATGGGAAGCAACTGGCAGAAATCATCACCAGCCATTGCCACAGCTACTGGATGAAGATAGAGACCATCCAGGTCTTTGAAAAGATGCACCGAGCGGATCTGTCTGAGAAAGTAAAGGATGAACTCAGAGAAGACACTTTGAAATCAAGCCTGTATCATTAGGGAAAACAGGGAAAGAAGAGCCAAAACCTATAGACCTGAAACAAATGCTGGGGCGTTTCGAAGCAGAAGCACTAGAGTTTATAGAAACGGAGGAAGATGTCACCAGCCTAAGAGAAGCTAAAGAAGTCTTGAAAGGAGAAAAGCCAGGTAAAGAGGATAGGTACAGGAGTATATTGAAGACGAAGTTCTGGCAAATGTGGAAAACCTGGCCTGGAGACCTCAAAGTGGTCCATATTATGGCTCAGAGATACAAGATGCTGATCCCGTTCAGCAACCCCAGGGTGCTTCCCGGGCCCTGCCCACACACGGTGGTGCTGCATGGTCCTGCGGGCCTTGGGAAAACCACGCTGGCCAAGAAATTAATGCTGGACTGGGCAGAGGACAACCTCAGCCAGAAATTTAGATAGGCTTTCTACCTCACCTGCAAGGAGCTCATCTGCCTGGGCCCGTGCAGTTTTGCAGAGCTGGTCTTCAGGAACTGGCCTGAATTGCAGGATGACATTCCAAACATCCTAGCCCAAGCACAGAAAATCCTGTTCGTGGTCGACGGCTTTGATGAGCTGGGAGCCCCACCTGGGGCACTGATCTAGGACATCTGTGGGGACTGGGAGAAGCAGAAGCCGGTGCCGGTCTTCTTGGGGAGGTTACTGAAGAGGAAGATTTTACCCAGGGCCGCCGTGCTGGTCACCACGTGGCCTGCGGGCCCTGAGAGACCTCCGGCTGTTGGTGGAGCGGCCGATCTATGTAAGGGTGGAGGAGTTCCTGGAGAAGGACAGGAGGGCATATTTCCTGAGACACTTTGGAGACGAGGACCAAGCCATGTGTGCCTTTGAGCTGATGAGAAGAAACGCGGCCCTGTTCCAGCCTGTCTCGGCACCCATGGTGTGCTGGATCATGTGCATGAGTCTGAAGCTGCAGAGGTTAGAAGGGGAAGGACCCGCCCCACCCGCACGGGGCTGTTCCTGCGCTTCCTTTGCGGCCGGTTCCCGCAGGGCGCACAGCTCTGGGGCGTGCTGCGGGCGCTGAGCCTCCTGGCGGCACAGGGCCTGTGGGCGCAGATGTCAGTGTTCCGTGGAGAGGACTTGGCGAGGCTCGGGGTGCAGGAGTTCAACATCCGCCCGTCCCTGGACAGAGACATCCTCCGCCAGGACATAGTCTCTAAAGGCTGCTATTCCTACATCCACCTCAGCTTCCAGCAGTTTTTCACTGTGCTGTTCCACGCCCTg |
>NM_017852.5_3 |
AATCACAGGGCTGCGGCCGAGAGAGAAGCCTTATTAGAGCTTTCTCAACCTGCAGCCCTCATCTCCGCCGGCGAGTAGGGCCAGGTGTTGGGAGCTCCCACGTGGGACAAGATGGTGTCTTCGGCACAGATGGGCTTCAACCTGCAGGCTCTCCTGGAGCAGCTCAGCCAGGATGAGTTGAGCAAGTTCAAGTATCTGATCACGACCTTCTCCCTGGCACACGAGCTCCAGAAGATCCCCCACAAGGAGGTAGACAAGGCTGATGGGAAGCAACTGGTAGAAATCCTCACCACCCATTGTGACAGCTACTGGGTGGAGATGGCGAGCCTCCAGGTCTTTGAAAAGATGCACCGAATGGATCTGTCTGAGAGAGCAAAGGATGAAGTCAGAGAAGCAGCTTTGAAATCCTTTAATAAAAGGAAGCCTCTATCATTAGGGATAACACGGAAAGAACGACCACCTCTAGACGTGGACGAAATGCTGGAGCGCTTCAAAACAGAAGCACAAGCGTTTACAGAAACGAAAGGAAATGTCATCTGCCTGGGTAAAGAAGTCTTTAAAGGAAAAAAGCCAGACAAAGACAATAGGTGCAGGTATATATTGAAGACGAAGTTCCGGGAGATGTGGAAGAGCTGGCCTGGAGATAGCAAAGAGGTCCAGGTTATGGCTGAGAGATACAAGATGCTGATCCCATTCAGCAACCCCAGGGTGCTTCCCGGGCCCTTCTCATACACGGTGGTGCTGTATGGTCCTGCAGGCCTTGGGAAAACCACGCTGGCCCAGAAACTAATGCTAGACTGGGCAGAGGACAACCTCATCCACAAATTCAAATATGCGTTCTACCTCAGCTGCAGGGAGCTCAGCCGCCTGGGCCCGTGCAGTTTTGCAGAGCTGGTCTTCAGGGACTGGCCTGAATTGCAGGATGACATTCCACACATCCTAGCCCAAGCACGGAAAATCTTGTTCGTGATTGACGGCTTTGATGAGCTGGGAGCCGCACCTGGGGCGCTGATCGAGGACATCTGCGGGGACTGGGAGAAGAAGAAGCCGGTGCCCGTCCTCCTGGGGAGTTTGCTGAACAGGGTGATGTTACCCAAGGCCGCCCTGCTGGTCACCACGCGGCCCAGGGCCCTGAGGGACCTCCGGATCCTGGCGGAGGAGCCGATCTACATAAGGGTGGAGGGCTTCCTGGAGGAGGACAGGAGGGCCTATTTCCTGAGACACTTTGGAGATGAGGACCAAGCCATGCGTGCCTTTGAGCTAATGAGGAGCAACGCGGCCCTGTTCCAGCTGGGCTCGGCCCCCGCGGTGTGCTGGATCGTGTGCACGACTCTGAAGCTGCAGATGGAGAAGGGGGAGGACCCGGTCCCCACCTGCCTCACCCGCACGGGGCTGTTCCTGCGTTTCCTCTGCAGCCGGTTCCCGCAGGGCGCACAGCTGCGGGGCGCGCTGCGGACGCTGAGCCTCCTGGCCGCGCAGGGCCTGTGGGCGCAGACGTCCGTGCTTCACCGAGAGGATCTGGAAAGGCTCGGGGTGCAGGAGTCCGACCTCCGTCTGTTCCTGGACGGAGACATCCTCCGCCAGGACAGAGTCTCCAAAGGCTGCTACTCCTTCATCCACCTCAGCTTCCAGCAGTTTCTCACTGCCCTGTTCTACACCCTGGAGAAGGAGGAGGAAGAGGATAGGGACGGCCACGCCTGGGACATTGGGGACGTACAGAAGCTGCTTTCCGGAGTAGAAAGACTCAGGAACCCCGACCTGATCCAAGCAGGCTACTACTCCTTCGGCCTCGCTAACGAGAAGAGAGCCAAGGAGTTGGAGGCCACTTTTGGCTGCCGGATGTCACCGGACATCAAACAGGAATTGCTGCGATGCGACATAAGTTGTAAGGGTGGACATTCAACGGTGACAGACCTGCAGGAGCTGCTCGGCTGTCTGTACGAGTCTCAGGAGGAGGAGCTGGTGAAGGAGGTGATGGCTCAGTTCAAAGAAATATCCCTGCACTTAAATGCAGTAGACGTTGTGCCATCTTCATTCTGCGTCAAGCACTGTCGAAACCTGCAGAAAATGTCACTGCAGGTAATAAAGGAGAATCTCCCGGAGAATGTCACTGCGTCTGAATCAGACGCCGAGGTTGAGAGATCCCAGGATGATCAGCACATGCTTCCTTTCTGGACGGACCTTTGTTCCATATTTGGATCAAATAAGGATCTGATGGGTCTAGCAATCAATGATAGCTTTCTCAGTGCCTCCCTAGTAAGGATCCTGTGTGAACAAATAGCCTCTGACACCTGTCATCTCCAGAGAGTGGTGTTCAAAAACATTTCCCCAGCTGATGCTCATCGGAACCTCTGCCTAGCTCTTCGAGGTCACAAGACTGTAACGTATCTGACCCTTCAAGGCAATGACCAGGATGATATGTTTCCCGCATTGTGTGAGGTCTTGAGACATCCAGAATGTAACCTGCGATATCTCGGGTTGGTGTCTTGTTCCGCTACCACTCAGCAGTGGGCTGATCTCTCCTTGGCCCTTGAAGTCAACCAGTCCCTGACGTGCGTAAACCTCTCCGACAATGAGCTTCTGGATGAGGGTGCTAAGTTGCTGTACACAACTTTGAGACACCCCAAGTGCTTTCTGCAGAGGTTGTCGTTGGAAAACTGTCACCTTACAGAAGCCAATTGCAAGGACCTTGCTGCTGTGTTGGTTGTCAGCCGGGAGCTGACACACCTGTGCTTGGCCAAGAACCCCATTGGGAATACAGGGGTGAAGTTTCTGTGTGAGGGCTTGAGGTACCCCGAGTGTAAACTGCAGACCTTGGTGCTTTGGAACTGCGACATAACTAGCGATGGCTGCTGCGATCTCACAAAGCTTCTCCAAGAAAAATCAAGCCTGTTGTGTTTGGATCTGGGGCTGAATCACATAGGAGTTAAGGGAATGAAGTTCCTGTGTGAGGCTTTGAGGAAACCACTGTGCAACTTGAGATGTCTGTGGTTGTGGGGATGTTCCATCCCTCCGTTCAGTTGTGAAGACCTCTGCTCTGCCCTCAGCTGCAACCAGAGCCTCGTCACTCTGGACCTGGGTCAGAATCCCTTGGGGTCTAGTGGAGTGAAGATGCTGTTTGAAACCTTGACATGTTCCAGTGGCACCCTCCGGACACTCAGGTTGAAAATCGATGACTTTAATGATGAACTCAATAAGCTGCTGGAAGAAATAGAAGAAAAAAACCCACAACTGATTATTGATACTGAGAAACATCATCCCTGGGCAGAAAGGCCTTCTTCTCATGACTTCATGATCTGAATCCCCCCGAGTCATTCATTCTCCATGAAGTCATCGATTTTCCAGGTGTTGGTGAACTGCCTGTGACTCCTCTCCTCCCCGGCCCCTACCCCTCAGGGATAATGAGTTCATTGCTGGGCTAGATGTTTTAGCCATGATTCTGCCTCTGTTTTATACCTGCACACATCCTTATCTTTGTTACATATGAAATATCTGTATCACGGGTATATTGAGAGAAATAAAGGTGAGAGCATTCACAAA |
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