Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Summary

Retrocopy Name CCT4P2
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Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:65270990-65272832  UCSC
Coordinates (T2T) chrX:63696513-63698355  UCSC
Coordinates (hg19) chrX:64490870-64492712  UCSC
Strand +
Parental Sequence NM_006430.4
Parental seq. overlap 1075 bp
Parental seq. overlap (%) 41%
Genomic Region Intragenic (ZC3H12B)
Retrocopy Summary CCT4P2, located on chrX:65270990-65272832, is a retrocopy of the parental gene CCT4. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CCT4
Full Name chaperonin containing TCP1 subunit 4
Also known as CCT-DELTA|Cctd|SRB
Coordinate chr2:61868085-61888671
Strand -
Gene summary The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 [PubMed 9819444]).[supplied by OMIM, Mar 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes CCT4P2
Bonobo Pan paniscus CCT4P2
Gorilla Gorilla gorilla CCT4P2
Orangutan Pongo abelii CCT4P2
Green monkey Chlorocebus sabaeus CCT4P1
Crab-eating macaque Macaca fascicularis CCT4P1
Rhesus Macaca mulatta CCT4P1
Baboon Papio anubis CCT4P1
Gibbon Nomascus leucogenys Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

This retrocopy transcript is not present in the GTEx database for expression quantification.

Related Sequence

>CCT4P2
AAAAGAGGTTGCTAATGCTCTTAGAACAAGCTTGCAACCAAAAGGAAAGGATAAAAAAGTAAAAATAGAAAAGGTGATATGACCATTACATATGATGCTGTTACCATTGTGAAACAAATGTAAGGGTTACATCCAGCAGCCAGAATCCTAGCGGTGCTGTCTAAGGCTCCAAGATATAGAAGCCGGAGATGACCACATCAGTGGTCATTATTGCTGGATCTCTCTTATATTCTTATAATAAGCTTCTTCAGAAAAGAATTCATCTAGCCATCATCTCTGAGTCATTCTAGAAGGCTTTGGGAAATGGTATTAAAATTATAACTGACATGTCTTAACATATGGAAGTAAATGACAAAGAAACATTTTAAAATAGTACAACCAATTTATTGAACTCAATGCTTATTATTCAGCATTCCAGTTTAATTTCTCCAATGAGTGTAAATACAGTGATTAAAAAGGGTGGCATTCTTCACATTTTAGAAGAAATTATTGCCCAACCTCTGTTGGTTTCAATTGTTGATCTGACTTTGGCAGCTGAAAGTCTCTCAGGCATTCTGAAACTGGATGATATGGTAAACATTTAACATTCTGGATAACACTGGCTGACTGTTCTGTTGTGGCCACTAACAGTGTGACTTCAGTGGAAGAAGAGTATCTTGGTTATCCTTGATTTTGACTTTACAGATGATATGGATCTAGCCACAGCTACCACTGTGGATCTTAGGGATATTAAAATAGTTAAGTAACTTGGCAGGACAATTGATTGCAGTGAGTTAGTGAAAGGGATTATCACCCAAAAGGTGGAAAATTCTGGGATAGCCAGAGTTGAAAAGGCTAAAATTGGGCTTATTCAGTTTTGCTTCTCTGCTCCCAGAAGAGATGGATAATCAAATAGTTTCAGACTTACCCACGTGGAACAAGTGCTGTGAAAAGAAAGAGCCTAaGAAAGAGCCTAATACTAAATTTAGTAAAAAAAAAAAAAAACTGGAGATAACATCCTGCTCACACAGAAGTCTCTTCTAATTGGTGCTCTTAGTGATCTTGAATTACACTTTCTAAACAAAATGAAGATTATGGTGATTAAGGATATTGAAAAAGAAGGCATTGAATTTATTTGTAAAACAATTGGAAACAAGCCAGTTGCTTATATTGACTAATTCACTACTAACATGCTGGGAGCTGCTCCTTTAGCCAAAGGGGTCAATTTAAATAGTTCTGGCAAATTGCTTAAGACTGCAGGCTGTGCAGGCCCTGGAAAAGCAGTTATAGTTGTTGTTCATGATTCTAATAAACTGATGATTGGAAAGCTAAATGCTCCATTTATGATGCCCTCTGTTTTATTTCCTATTTAGTGAAGAATAGAGCTCTTATTATAAGATATGGTGCTCCAGAAATCAGAGTAGCTCTAAAATTACCTGAATATTCCTGAATATTGAGAGGTATAGAATCCTACTGCATTTATGACTTTACAGATGATATGGAGGTAACTTCATTTACACTAGCTAAAAACACTGGCCTGAATCACATTTCT
>NM_006430.4
CTTCTCCGCCTCCGCCTCCTCCCGACGCCGGCGCCGCTTTCTGGAAGGTTCGTGAAGGCAGTGAGGGCTTACCGTTATTACACTGCGGCCGGCCAGAATCCGGGTCCATCCGTCCTTCCCGAGCCAACCCAGACACAGCGGAGTTTGCCATGCCCGAGAATGTGGCACCCCGGAGCGGGGCGACTGCCGGGGCTGCCGGCGGCCGCGGGAAAGGCGCCTATCAGGACCGCGACAAGCCAGCCCAGATCCGCTTCAGCAACATTTCCGCCGCCAAAGCGGTTGCTGATGCTATTAGAACAAGCCTTGGACCAAAAGGAATGGATAAAATGATTCAAGATGGAAAAGGTGATGTAACCATTACAAATGATGGTGCTACCATTCTGAAACAAATGCAAGTATTACATCCAGCAGCCAGAATGCTGGTGGAGCTGTCTAAGGCTCAAGATATAGAAGCAGGAGATGGCACCACATCAGTAGTCATCATTGCTGGCTCCCTCTTAGATTCTTGTACCAAGCTTCTTCAGAAAGGGATTCATCCAACCATCATTTCTGAGTCATTCCAGAAGGCCCTGGAAAAGGGCATTGAAATCTTGACTGACATGTCTCGACCTGTGGAACTGAGTGACAGAGAAACTTTGTTAAATAGTGCAACCACTTCACTGAACTCAAAGGTGGTTTCTCAGTATTCAAGTCTGCTTTCTCCAATGAGTGTAAATGCAGTGATGAAAGTGATTGACCCAGCCACAGCCACCAGTGTAGATCTTAGAGATATTAAAATAGTTAAGAAGCTTGGTGGGACAATTGATGACTGTGAGTTGGTGGAAGGGCTGGTTCTCACCCAAAAAGTGTCAAATTCTGGCATAACCAGAGTTGAAAAGGCCAAGATTGGGCTTATTCAGTTTTGCTTATCTGCTCCCAAAACAGACATGGATAATCAAATAGTGGTTTCTGACTATGCCCAGATGGACCGAGTGCTGCGAGAAGAGAGAGCCTATATTTTAAATTTAGTGAAGCAAATTAAAAAAACAGGATGTAATGTCCTTCTCATACAGAAATCTATTCTAAGAGATGCTCTTAGTGATCTTGCATTACACTTTCTGAATAAAATGAAGATCATGGTGATTAAGGATATTGAAAGAGAAGACATTGAATTCATTTGTAAGACAATTGGAACCAAGCCAGTTGCTCATATTGACCAATTTACTGCTGACATGCTGGGTTCTGCTGAGTTAGCTGAGGAGGTCAATTTAAATGGTTCTGGCAAACTGCTCAAGATTACAGGCTGTGCCAGCCCTGGAAAAACAGTTACAATTGTTGTTCGTGGTTCTAACAAACTGGTGATTGAAGAAGCTGAGCGCTCCATTCATGATGCCCTATGTGTTATTCGTTGTTTAGTGAAGAAGAGGGCTCTTATTGCAGGAGGTGGTGCTCCAGAAATAGAGTTGGCCCTACGATTAACTGAATATTCACGAACACTGAGTGGTATGGAATCCTACTGCGTTCGTGCTTTTGCAGATGCTATGGAGGTCATTCCATCTACACTAGCTGAAAATGCCGGCCTGAATCCCATTTCTACAGTAACAGAACTAAGAAACCGGCATGCCCAGGGAGAAAAAACTGCAGGCATTAATGTCCGAAAGGGTGGTATTTCCAACATTTTGGAGGAACTGGTTGTCCAGCCTCTGTTGGTATCAGTCAGTGCTCTGACTCTTGCAACTGAAACTGTTCGGAGCATTCTGAAAATAGATGATGTGGTAAACACTCGATAATCTGGATAACTGACTAGCACCATTATGATCACCAGTATTGTGGCTGGAATGGAAGAAGATCACCTTGGTGTTCCTTGTTTGGAAGATTATTTCCTCTGAATTTCTGGGCTTGGTCTTCCAGTTGGCATTTGCCTGAAGTTGTATTGAAACAATTTAATGAAAATATTAAATATTTGGTTTCAAAAGGCAGATTTATCTTCTCCCAACATTCTGTTATTTCTGATACTTTTGAAAAACTAATAAAAACTAATAAAAGAAGCGTAAAAAGTGAGTTTACATGTTGAGGAAAAAAATGGCCCAATATGCTCATCACTGATAAATGCTCCCTGGCCTTAAAAACTACCAACATATAATATATATGCTGTCTTAAAAGTTAATGATCCAAGTGGCACCtctctgaacctactttggcttgggaggctgcccagttAAAACAAAAATAAGTTAATGGTACAGAAAGAGAATGAAAAATGAAAGCCTCCTTTTATCCTATCATCCTAATTCCTTTTCCCAGTAATAATGACTGCTGTGTTGGATTCCTTCTGCAAATAAAAGTGTATACATATATGTAGCAAATCTTACTTAAACAAAAGGGTTTCTTAACTAA

Publications

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