Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Advanced Search

Summary

Retrocopy Name MAP2K4P1
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr17). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:73522483-73526165  UCSC
Coordinates (T2T) chrX:71955846-71959528  UCSC
Coordinates (hg19) chrX:72742319-72746001  UCSC
Strand -
Parental Sequence NM_003010.4
Parental seq. overlap 3465 bp
Parental seq. overlap (%) 91.4%
Genomic Region Intergenic
Retrocopy Summary MAP2K4P1, located on chrX:73522483-73526165, is a retrocopy of the parental gene MAP2K4. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MAP2K4
Full Name mitogen-activated protein kinase kinase 4
Also known as JNKK|JNKK1|MAPKK4|MEK4|MKK4|PRKMK4|SAPKK-1|SAPKK1|SEK1|SERK1|SKK1
Coordinate chr17:12020822-12143828
Strand +
Gene summary This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes MAP2K4P1
Bonobo Pan paniscus MAP2K4P1
Gorilla Gorilla gorilla MAP2K4P2
Orangutan Pongo abelii MAP2K4P1
Gibbon Nomascus leucogenys MAP2K4P1
Green monkey Chlorocebus sabaeus MAP2K4P1
Crab-eating macaque Macaca fascicularis MAP2K4P1
Rhesus Macaca mulatta MAP2K4P1
Baboon Papio anubis MAP2K4P1
Golden snub-nosed monkey Rhinopithecus roxellana MAP2K4P1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>MAP2K4P1
CTCACCCCGGGACCTGTAGGATCCCTGAAGCCAGGCCACCCAGCCATCAGCAGCATGCAGGGTAAACGCAAAGCACTGAAGTTGAATTTTGCAAATCCACCTTTCAAATCTACAGCAAGGTTTACTCTGAATCCCAATCCTACAGGAGTTCAAAACCCACACATAGAGAGACTGAGATCACACAGCATTGAGTCATCAGGAAAACTGAAGATCTCCCCTGAACAACACTGGGATTTCACTGCAGAGGACTTGAAAGACCTTGGAGAAATTGGATGAGGAGTTTATGGTTCTGCCAACAAAATGGTCCACAAACCAAGTGGGCAAATAATGGCAGTTAAAAGAATTCGGTCAACAGTGAATGAAAAAGAACAAAAACAACCTCTTACGGATTTGGATGAAGTAATGCAGAGTAGTGATTGCCCTTACATTGTTCAGTTTTATGATGCACTCTACAGACAGGGTGACTGTTGGACCTGTATGGAACTCATGTCTATCTCGTTTGATAAGTTTTACAAATATGTGTATAGTGTATTAGATGATGTTATTCCAGAAGAAATTTTAGGCAGAATCACTTTAGCATCTGTGAAAGCATTAAATCACTTAAAAGAAAACTTGAAAATTATTCACAGAGATATCAAACCTTCCAATATTCTTCTGGACAGAAGTGAAAATATTAAACTCTGTGACTTTGGCATCAGTGGGCAGCTTGTGGACTCTATTGCCAAGACAGAAGATGCTGGCTGTAGGCCATACATGGCACCTGAAAGAATAGACCCAAGTGCATCATGACAAGCATATGATGTCTGCTCTGATGTCTGGAGTTTGGGGATCACATTGTGTGAGTTGGCCACGGGCTGATTTCCTTATCCAAAGTGGAATAGTGTATTTGATCAACTAACACAAGTCGTGAAAGGAGATCCTCCGCAGCTGAGTAATTCTGAGGAAAACGAATTCTCCCCAAGTTTCATCAACTTTGTCAACTTGTGCCTTACGAAGGATGAATCCAAAAGACCACAGCATAAAGAGCTTCTGAAACATCTTTTTATTTTGATTTATGAAGAACGTACCATTGAAGTCGCATGCTATGTTTTGTCAAATCCTGGATCAAATGCCAGCTACTCCCAGCTTTCCCATGTATGTTGTTTGATATCGCTGCTACATCAGACTAAAAAAAAGGGCTGAGAGGAAGCAAAAGGTAAAGAATTTTCATCCCTATCACAGTGTTTTTATTGCTCACCCAGACACCATGTGCAATGACATTGGTGTTCATTTCCATCATGTCTACATATTCCTGTCACCTAGAACGTGCATCCTGGTAATACCTGATTGATCACACAGTGTTAGTGCTGGTCAGAGAGACCTCATCCTGCTCTTTTGTGATGAACATATTCATGAAATGTAGAAGTCAGTATGATCAAGTTGTTGACTGTGATTAGATCACATCTTATATTCATTTATAGACTCCAAACCTGGAGATGCAGCTACTGGAATGGTGTTTTATCAGACTTCCAAATCCTGGAAGGACACGGTGATGGATGTACTATGTCTGAACATAGAGACTCAGGCTTGAGTGAGAAGAGCTTGCACAGCCAACGAGACACATTGCCTTCTGGAGCTAGGAGACAAAGGAGGAATTTACTTTCTTCACCAAGTGCAATAGATTTACTGATGTGATATTCTGTTGCTTTACAGTTACAGTTGATGTTTGGGGATTGATGTGCTCAGCCAAATTTCCTGTTTGACATATCATGTTAAATTAGAATGAATTTATCTTTACCAAAAACCATGTTGCGTTCAAAGAGGTGAACATTAAAATATTGAGACAGGACCAGATGTGTTCTTTTCTCCTTTACCAGTCCTACTTTGCATTGGGAAGACTCAGGAGTCTGCCACTTGTCAAAGAAGGAGCTGATCCTAATAATTTTTCATTCTCAGAATTCGGTGTGCTGCCAACTTGATGTTCCACCTGCCACAAACCACCAGGACTGAAAGAAGAAAACAGTACAGAAGGCAAAGTTTACAGATGTTTTTAATTCTACTATTTTATCTGGAACAACTTGTAGCAGTTATATATTTCCCTTTGGTCTTAAGCCTGATACTTTAGCCATCCTAACTCACTAACAGGGAGAAGTAGCTAGTAGCAATGTGCCTTGATTGATTAGATAAAGATTTCTGGTAGGCAGCAAAAGACCAAATCTCAGTTGTTTCCTTCTTGCCATCACTGGTCCAGGTCTTCAGTTTCCGAATCTCTTTCCCTTCCCCTGTGGTCTGTTGTCGCTATGTGACTTTTGCTTAATCCAATATTTTGCCTTTTTTTATATCAAAAAACCTTTATAATTACCAGGGATGTTTCTTACCAAGGATTTTTAGCCCCAAATCTCTCATATGCGCTAGTGTTTAAAAGGCTAAGAATAGTGGGGCCCAGCCGATGTGGTAAGTGATAAAGAGGCATCTTTTCTAGAGACACATTGGACCAGATGAGGATCTGAAATGGCAGCCTTTATGTTCATCACCAGCTAGAACCTCCTGTAGTACAACACCATTTCTTGGCATTGGAAGCCTACTGGAAAAAATATAAAAAGCAAAACAAAACCCTCAGCACTGTTACAAGAGACCATTTAAGTATCTTGCGCTTCTTAACTTACTCATTAGCCAGGTTCTCATTAGATTTTGCTCGGGCCTCCCTGGCACTGAACCTTAAGGCTTTGTATGACAGTGAAGCAGCACCGTGAATGGTTCAAGCACACTGGAATATAAAACAGCCATGGTCTGATATGCAGGTGATGCCATTACAGAACCAAATCATGGCAGGTATTGCTGTGTCTCCTCTTAGAGTGACAGTCATAAATACTATCAAACAATAAAGGAAGAATGGTGCTGTTTAAAATCACATCCCTGTAAATTGCAGAATTCAAAAGTGATTATCTCTTTGATCTACTTGCCTTATTTCCTTATCTTCTCCCCCATGGCATCCTAAACTTTAGACTTCCCACTGTTCTGAAAGGAGACATTGCTTTATGTCTCCCTTTGACCACAGCAAGCTGTCATCCTCCATTGTTCCCGGGGACTCAAGAGGAATCTGTTTCTCTGCTGTCAGCTTCCCATCTGGCTCAGCATAGGGTCACTTTGCCATTATGCAAATGGAGATAAAAGCAATTCTGACTGTCCAGGAGCGAATCTGACCATTCTATTGTGTGGATGACCACATAAAAAGGAAATTTTCATGTATTAATCATAGATTATTATAAACTATAAACTTAAGGGCAAGGAGTTTATTGCAATATATCTTTATTAAAACAAAAGTGTGAATAGTGTTCACAAACTGTGAAAATAGTGTAAGAACTGTACATTGTTAGCTCTGGTTATTTTTCTCTTGTACCAGAGAAAAATGTATAAAAATTATCAAAAAGATAATGTGCAGGGATATTGCCTTATTTGTCTGTAAAAAATGGAGCTCAGTAACATAACTGCTTCTTGGAGCTTTGGAATATTTTATCCTGTATTCTTGTTTGAATTCCTCCTCTATTTAAGTTGTATACATGGAATCAAAGTGTTTATGTAGTAGTTCTGTCCTTTTGCCTGCAGGTCAGTTGTAATAAATCTAGGATGTGATGATGAAACTCCCAACAATGGCAGCTCCGAGACTGAg
>NM_003010.4
ACTCCCAACAATGGCGGCTCCGAGCCCGAgcggcggcggcggctccgggggcggcagcggcagcggcACCCCCGGCCCCGTAGGGTCCCCGGCGCCAGGCCACCCGGCCGTCAGCAGCATGCAGGGTAAACGCAAAGCACTGAAGTTGAATTTTGCAAATCCACCTTTCAAATCTACAGCAAGGTTTACTCTGAATCCCAATCCTACAGGAGTTCAAAACCCACACATAGAGAGACTGAGAACACACAGCATTGAGTCATCAGGAAAACTGAAGATCTCCCCTGAACAACACTGGGATTTCACTGCAGAGGACTTGAAAGACCTTGGAGAAATTGGACGAGGAGCTTATGGTTCTGTCAACAAAATGGTCCACAAACCAAGTGGGCAAATAATGGCAGTTAAAAGAATTCGGTCAACAGTGGATGAAAAAGAACAAAAACAACTTCTTATGGATTTGGATGTAGTAATGCGGAGTAGTGATTGCCCATACATTGTTCAGTTTTATGGTGCACTCTTCAGAGAGGGTGACTGTTGGATCTGTATGGAACTCATGTCTACCTCGTTTGATAAGTTTTACAAATATGTATATAGTGTATTAGATGATGTTATTCCAGAAGAAATTTTAGGCAAAATCACTTTAGCAACTGTGAAAGCACTAAACCACTTAAAAGAAAACTTGAAAATTATTCACAGAGATATCAAACCTTCCAATATTCTTCTGGACAGAAGTGGAAATATTAAGCTCTGTGACTTCGGCATCAGTGGACAGCTTGTGGACTCTATTGCCAAGACAAGAGATGCTGGCTGTAGGCCATACATGGCACCTGAAAGAATAGACCCAAGCGCATCACGACAAGGATATGATGTCCGCTCTGATGTCTGGAGTTTGGGGATCACATTGTATGAGTTGGCCACAGGCCGATTTCCTTATCCAAAGTGGAATAGTGTATTTGATCAACTAACACAAGTCGTGAAAGGAGATCCTCCGCAGCTGAGTAATTCTGAGGAAAGGGAATTCTCCCCGAGTTTCATCAACTTTGTCAACTTGTGCCTTACGAAGGATGAATCCAAAAGGCCAAAGTATAAAGAGCTTCTGAAACATCCCTTTATTTTGATGTATGAAGAACGTGCCGTTGAGGTCGCATGCTATGTTTGTAAAATCCTGGATCAAATGCCAGCTACTCCCAGCTCTCCCATGTATGTCGATTGATATCGCTGCTACATCAGACTCTAGAAAAAAGGGCTGAGAGGAAGCAAGACGTAAAGAATTTTCATCCCGTATCACAGTGTTTTTATTGCTCGCCCAGACACCATGTGCAATAAGATTGGTGTTCGTTTCCATCATGTCTGTATACTCCTGTCACCTAGAACGTGCATCCTTGTAATACCTGATTGATCACACAGTGTTAGTGCTGGTCAGAGAGACCTCATCCTGCTCTTTTGTGATGAACATATTCATGAAATGTGGAAGTCAGTACGATCAAGTTGTTGACTGTGATTAGATCACATCTTAAATTCATTTCTAGACTCAAAACCTGGAGATGCAGCTACTGGAATGGTGTTTTGTCAGACTTCCAAATCCTGGAAGGACACAGTGATGAATGTACTATGTCTGAACATAGAAACTCGGGCTTGAGTGAGAAGAGCTTGCACAGCCAACGAGACACATTGCCTTCTGGAGCTGGGAGACAAAGGAGGAATTTACTTTCTTCACCAAGTGCAATAGATTACTGATGTGATATTCTGTTGCTTTACAGTTACAGTTGATGTTTGGGGATCGATGTGCTCAGCCAAATTTCCTGTTTGAAATATCATGTTAAATTAGAATGAATTTATCTTTACCAAAAACCATGTTGCGTTCAAAGAGGTGAACATTAAAATATAGAGACAGGACAGAATGTGTTCTTTTCTCCTTTACCAGTCCTATTTTTCAATGGGAAGACTCAGGAGTCTGCCACTTGTCAAAGAAGGTGCTGATCCTAAGAATTTTTCATTCTCAGAATTCGGTGTGCTGCCAACTTGATGTTCCACCTGCCACAAACCACCAGGACTGAAAGAAGAAAACAGTACAGAAGGCAAAGTTTACAGATGTTTTTAATTCTAGTATTTTATCTGGAACAACTTGTAGCAGCTATATATTTCCCCTTGGTCCCAAGCCTGATACTTTAGCCATCATAACTCACTAACAGGGAGAAGTAGCTAGTAGCAATGTGCCTTGATTGATTAGATAAAGATTTCTAGTAGGCAGCAAAAGACCAAATCTCAGTTGTTTGCTTCTTGCCATCACTGGTCCAGGTCTTCAGTTTCCGAATCTCTTTCCCTTCCCCTGTGGTCTATTGTCGCTATGTGACTTGCGCTTAATCCAATATTTTGCCTTTTTTCTATATCAAAAAACCTTTACAGTTAGCAGGGATGTTCCTTACCAAGGATTTTTAGCCCCAAATCTCTCATATTCGCTAGTGTTTAAAAGGCTAAGAATAGTGGGGCCCAGCCGATGTGGTAGGTGATAAAGAGGCATCTTTTCTAGAGACACATTGGACCAGATGAGGATCCGAAACGGCAGCCTTTACGTTCATCACCTGCTAGAACCTCTCGTAGTCCATCACCATTTCTTGGCATTGGAATTCTACTGGAAAAAAATACAAAAAGCAAAACAAAACCCTCAGCACTGTTACAAGAGGCCATTTAAGTATCTTGTGCTTCTTCACTTACCCATTAGCCAGGTTCTCATTAGGTTTTGCTTGGGCCTCCCTGGCACTGAACCTTAGGCTTTGTATGACAGTGAAGCAGCACTGTGAGTGGTTCAAGCACACTGGAATATAAAACAGTCATGGCCTGAGATGCAGGTGATGCCATTACAGAACCAAATCGTGGCACGTATTGCTGTGTCTCCTCTCAGAGTGACAGTCATAAATACTGTCAAACAATAAAGGGAGAATGGTGCTGTTTAAAGTCACATCCCTGTAAATTGCAGAATTCAAAAGTGATTATCTCTTTGATCTACTTGCCTCATTTCCCTATCTTCTCCCCCACGGTATCCTAAACTTTAGACTTCCCACTGTTCTGAAAGGAGACATTGCTCTATGTCTGCCTTCGACCACAGCAAGCCATCATCCTCCATTGCTCCCGGGGACTCAAGAGGAATCTGTTTCTCTGCTGTCAACTTCCCATCTGGCTCAGCATAGGGTCACTTTGCCATTATGCAAATGGAGATAAAAGCAATTCTGACTGTCCAGGAGCTAATCTGACCGTTCTATTGTGTGGATGACCACATAAGAAGGCAATTTTAGTGTATTAATCATAGATTATTATAAACTATAAACTTAAGGGCAAGGAGTTTATTACAATGTATCTTTATTAAAACAAAAGGGTGTATAGTGTTCACAAACTGTGAAAATAGTGTAAGAACTGTACATTGTGAGCTCTGGTTATTTTTCTCTTGTACCATAGAAAAATGTATAAAAATTATCAAAAAGCTAATGTGCAGGGATATTGCCTTATTTGTCTGTAAAAAATGGAGCTCAGTAACATAACTGCTTCTTGGAGCTTTGGAATATTTTATCCTGTATTCTTGTTTGAATTCCTCCTCTATTTAAGATATATACATGGAATCGAAGTGTTTATGTAATAGTTCTATCCTTTTGCCTGCAGGTCAGTTGTAATAAATCTAGGATGTGATGATGACTTTGTAATTTGATTTTCTGAAATCAGACCCTGAGAGGGGAAAATCTTAAAGTAAATTACATTAAATTATCTGTGCATTTCACACCAGGGAAAA

Publications

PMID - Link Title