Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SHISA5P2
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr3). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:74065738-74067455  UCSC
Coordinates (T2T) chrX:72499283-72501000  UCSC
Coordinates (hg19) chrX:73285573-73287290  UCSC
Strand +
Parental Sequence NM_001272082.4
Parental seq. overlap 1344 bp
Parental seq. overlap (%) 74.5%
Genomic Region Intergenic
Retrocopy Summary SHISA5P2, located on chrX:74065738-74067455, is a retrocopy of the parental gene SHISA5. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SHISA5
Full Name shisa family member 5
Also known as SCOTIN
Coordinate chr3:48467876-48504810
Strand -
Gene summary This gene encodes a member of the shisa family. The encoded protein is localized to the endoplasmic reticulum, and together with p53 induces apoptosis in a caspase-dependent manner. Alternative splicing results in multiple transcript variants. Related pseudogenes of this gene are found on chromosome X. [provided by RefSeq, Apr 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes SHISA5P3
Bonobo Pan paniscus SHISA5P3
Gorilla Gorilla gorilla SHISA5P2
Orangutan Pongo abelii SHISA5P3
Gibbon Nomascus leucogenys SHISA5P2
Green monkey Chlorocebus sabaeus APOOLP4
Crab-eating macaque Macaca fascicularis SHISA5P5
Rhesus Macaca mulatta SHISA5P5
Baboon Papio anubis APOOLP3
Golden snub-nosed monkey Rhinopithecus roxellana SHISA5P1
Marmoset Callithrix jacchus SHISA5P3
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SHISA5P2
GGGAGATTTCCTTTCCTTTTCTCCGAAAGGGGAAGAAATTGAAACTGAGTGGCCCATGATGGAAAGAGGGGAAGTCCAGGGGTGCAGAAGGCCCCTGGGTGAAGGCAGAGGCTAACATGGGGTTCGTAGCTATGGGTGGCCATCAGCCTGACCAACTTTGTGCTGTCTGTCATCACTATCATCATCTGCTTCACCTGCTCCTGCTGCTGCCTGTACAAGATGTGCCGCCGAACACGTCCGGTTGTCACCAGCATCACGTTCACCACTGTGGTGCACGCCCCTTACACTCAGCCTCCAAGTGTGCCGCCCAGCTACCCTGGATCGAGCTACCAGGGCTACTACCCCATGCTCCCCCAGCCAGGGATGACAGCAGCACCCTACCCAACACAGTACCCACCACCTTACTCGGCCCAGCCCATGGGCCCGCCGGCCTACCAGGAGACGCTGGCTGGAGGAGCAACCGCGCCATACCCCACGAGCCAGCCTCCTTACAACCCGGCCTACATATATGCCCCGAAGGCGGCTCCCGGAGCGTGCCCCGGCCTCTCCGGCTGCCACTAGATTACAAGCACGGTTCCTTACGCCCCGTGCGTGCTGTGTGTGTCCTGCCTGTATATGTGGCTTCCTTTGATGCTGACGAGGTGGGGAACGTTCCTTGCCAGAGTGGGCTGGGACCAGACTTTCTTCTCTTCCTCACCTGAAATTATGCTTCCTAAAATCTCAAGCCAAACTCAAAGAATGGGGTGGGGAGCACCCTGTGAGGTGGCCCCTGAGAGGTGGGGGGCTCTCCATGGCACATCTGGAGTTCTTTTCCAGCTTACCCTAGGGTGACCAAGTGTGGCCTGTCACACCAGGATGGTGCAGCTTTCTGTGAGTATGATACAGATGTGTCCTGGTTTTGGCAACGTAGCCAGCTGCTGCTCAGGGGCATGGTTTGTCCCCAGAGTTGGGGGTACCCTTTGCAGAGCCAGCCTGCTTACCTGATAGCTGTCTACCTGGACTGTTCCTGTCCCTACATCCTCCCTAGGACCACCTGGAGGGCCACACACACAGCCTAGCTACCCACAGGGAGCTCTCCTGCCCTTGCTGGCCCTGCCCTTCCCACAGGTGAACAGGGCGCTCTGTCCACCAGCACACTCAGGTCTCTTCCCTGCAGTGTTTTCATTTTATTTTAACCAAACATTTTGCCTGTTTTCTGTTTTAAAATGTGATAGTTGATGTGAGACTGAAACCCCaCACCAGCCTCATGGAATATGCAACTCCTGTACCCCAGTCCAGTGTGTTCTGGCAGCAGGGACACCTGGGCCAAGGGGCCATCTGGACCAAAGGTGGGGTGTGGGGTCCTGGATGGCAGACATGAATACCTCGGTATTCCCTGTCTCTCAGTTATTGTTTCACCAGAGCTGTCTCAGCTTCGTATCTGTTGTGTTTCTGAGAGTCTAGAGTCTGCACCCTTGTTTATAATAAATGCAATAGTTTGGA
>NM_001272082.4
GTGCTTCCTGTGGCTGACGTCATCTGGAGGAGATTTGCTTTCTTTTTCTCCAAAAGGGGAGGAAATTGAAACTGAGTGGCCCACGATGGGAAGAGGGGAAAGCCCAGGGGTACAGGAGGCCTCTGGGTGAAGGCAGAGGCTAACATGGGGTTCGGAGCGACCTTGGCCGTTGGCCTGACCATCTTTGTGCTGTCTGTCGTCACTATCATCATCTGCTTCACCTGCTCCTGCTGCTGCCTTTACAAGACGTGCCGCCGACCACGTCCGGTTGTCACCACCACCACATCCACCACTGTGGTGCATGCCCCTTATCCTCAGCCTCCAAGTGTGCCGCCCAGCTACCCTGGACCAAGCTACCAGGGCTACCACACCATGCCGCCTCAGCCAGGGATGCCAGCAGCACCCTACCCAATGCAGTACCCACCACCTTACCCAGCCCAGCCCATGGGCCCACCGGCCTACCACGAGACCCTGGCTGGAGGAGCAGCCGCGCCCTACCCCGCCAGCCAGCCTCCTTACAACCCGGCCTACATGGATGCCCCGAAGGCGGCCCTCTGAGCATTCCCTGGCCTCTCTGGCTGCCACTTGGTTATGTTGTGTGTGTGCGTGAGTGGTGTGCAGGCGCGGTTCCTTACGCCCCATGTGTGCTGTGTGTGTCCAGGCACGGTTCCTTACGCCCCATGTGTGCTGTGTGTGTCCTGCCTGTATATGTGGCTTCCTCTGATGCTGACAAGGTGGGGAACAATCCTTGCCAGAGTGGGCTGGGACCAGACTTTGTTCTCTTCCTCACCTGAAATTATGCTTCCTAAAATCTCAAGCCAAACTCAAAGAATGGGGTGGTGGGGGGCACCCTGTGAGGTGGCCCCTGAGAGGTGGGGGCCTCTCCAGGGCACATCTGGAGTTCTTCTCCAGCTTACCCTAGGGTGACCAAGTAGGGCCTGTCACACCAGGGTGGCGCAGCTTTCTGTGTGATGCAGATGTGTCCTGGTTTCGGCAGCGTAGCCAGCTGCTGCTTGAGGCCATGGCTCGTCCCCGGAGTTGGGGGTACCCGTTGCAGAGCCAGGGACATGATGCAGGCGAAGCTTGGGATCTGGCCAAGTTGGACTTTGATCCTTTGGGCAGATGTCCCATTGCTCCCTGGAGCCTGTCATGCCTGTTGGGGATCAGGCAGCCTCCTGATGCCAGAACACCTCAGGCAGAGCCCTACTCAGCTGTACCTGTCTGCCTGGACTGTCCCCTGTCCCCGCATCTCCCCTGGGACCAGCTGGAGGGCCACATGCACACACAGCCTAGCTGCCCCCAGGGAGCTCTGCTGCCCTTGCTGGCCCTGCCCTTCCCACAGGTGAGCAGGGCTCCTGTCCACCAGCACACTCAGTTCTCTTCCCTGCAGTGTTTTCATTTTATTTTAGCCAAACATTTTGCCTGTTTTCTGTTTCAAACATGATAGTTGATATGAGACTGAAACCCCTGGGTTGTGGAGGGAAATTGGCTCAGAGATGGACAACCTGGCAACTGTGAGTCCCTGCTTCCCGACACCAGCCTCATGGAATATGCAACAACTCCTGTACCCCAGTCCACGGTGTTCTGGCAGCAGGGACACCTGGGCCAATGGGCCATCTGGACCAAAGGTGGGGTGTGGGGCCCTGGATGGCAGCTCTGGCCCAGACATGAATACCTCGTGTTCCTCCTCCCTCTATTACTGTTTCACCAGAGCTGTCTTAGCTCAAATCTGTTGTGTTTCTGAGTCTAGGGTCTGTACACTTGTTTATAATAAATGCAATCGTTTGGA

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