Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name STIP1P3
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:86084303-86086398  UCSC
Coordinates (T2T) chrX:84515517-84517612  UCSC
Coordinates (hg19) chrX:85339307-85341402  UCSC
Strand -
Parental Sequence NM_006819.3
Parental seq. overlap 1965 bp
Parental seq. overlap (%) 91.7%
Genomic Region Intergenic
Retrocopy Summary STIP1P3, located on chrX:86084303-86086398, is a retrocopy of the parental gene STIP1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name STIP1
Full Name stress induced phosphoprotein 1
Also known as HEL-S-94n|HOP|IEF-SSP-3521|P60|STI1|STI1L
Coordinate chr11:64185272-64204543
Strand +
Gene summary STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes STIP1P1
Bonobo Pan paniscus STIP1P1
Gorilla Gorilla gorilla STIP1P1
Gibbon Nomascus leucogenys STIP1P1
Green monkey Chlorocebus sabaeus STIP1P1
Crab-eating macaque Macaca fascicularis STIP1P1
Rhesus Macaca mulatta STIP1P1
Baboon Papio anubis STIP1P1
Golden snub-nosed monkey Rhinopithecus roxellana STIP1P1
Orangutan Pongo abelii Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>STIP1P3
TGGGAACGCAGAGCGGACAGATTCGATTCAGCGGGGTTCCGGGCCGCGCTGTGCTATGAAGCAGGTCAATGAGCTGAAAGAGAAGGGCAACAAGGCCCTGGGCGTGGAAAACATCGACAATGCCTTACAGTGCTACTCTGAAGCCATTAAGCTGGATCCCCACAACCACGTGCTCTACAGCAACTGTTCTGCCACCTATGCCAAGAAAGGAGACTACCAGAAGGCTTACAAGGACGGCTGCAAGACCGTCGACCTAAAAGTTTGACTGGGGCAAGGGATATTCACGAAAAGCAGCAGCTCTAGAGTTCTTAAACCGATTTGAAGAAGCCAAGTGAACCTACGAGGAGAGCTTAAAACACGAGGCAGATAACCCTCAACTGAAAGAGGGTTTACAGAATATGGAGGCCAGGTTGGCAGAGAGAAAATGTATGAATGCTTTCAACATGCCCAATCTGTAACAGAAGTTGGAGAGTGATCCCAGGACAAGGACACTGCTCAGTGATCCTACCTACCGGGAGCTGATAGAGCAACTATAAAACAAGCCTTCTGATCTGGGCACAAAACTACGAGATCCCCGGATCCTGACCACTCTCAGTGTCCTCCTTGAGGTCGATCGGGGCAGTATGGATGAGGAGGAACAGGTTGCAACACCTTCACCACCACCCCTTCCCAAAAAGGAGACCAAGCCAGAGCCAGTGGAAGAAGATCTTCCAGAGAATAAGAAGCAGGCACTGAAAGAAAAAGAGCTGAGGAACGATGCCTACAAGAAGAAAGACTGACAGCCTTGAAGCATTACGACAAAGCCAAGGAGCTGGACCCCAGCAACATGACTTACATTACCAATCAAGCAGCGGTATACTTTGAAAAGGGCGACTACAATAAGTGTTGGGAGCTTTGTGAGAAGTCCATTGAAGTGGGGAGAGAAAACAGAGAAGACTATCTACAGATTGCCAAAGTGTGTGCTCGAATTGGCAACTCCTACTTCAAAGAAGAAAAGTACAAGGATGCCATCCATTTCTATAACAAGTCTCTGGCAGAGCACCGAACTCCAGATGTGCTCAAGAAATGCCAGCAGGCAGAGAAAATCCTGAAGGAGCAAGAACGGCTGGCCTACATAAACCCCGACCTGGCTTTAGAAGAGAAGAACAAAGGCAACGAGTGTTTTCAGAAAGGGGACTATCCCCACGCCATGAAGCATTATACGGAAGCCATCAAAAGGAACCCGAAAGATGCCAAATTATACAGCAATCGAGCTGCCTGTTACACCAAACTCCTGGATTCCAGCTGGCACTCAAGGACTGTGAAGAATGTATCCAGCTAGAACCGACCTTCATCAAGGGTTATACACGGAAAGCCGTTGCCCTGGAAGCGATGAAGGACTACACCAAAGTCATGGATGTGTACCGGAAGGCGCTAGACCCGGACTCCAGCTGTAAGGAGGCGGCAGACGGCTACCAGCGCTGTATGATGGCGCAGTACAACCGGCACCACAGCCCCGAAGATGTGAAGCGACGAGCCATGGCCGACCCCGAGGTGCAGCAGATCATGAGTGACATAGCCATGCACCTTATCCTGGAGCAGATGCAGAAGGACCCCCCAGGCACTCAGCGAACACTTAAAGAATCCTGTAATCGCAAAGAAGATCCAGAAGCTGATGGATGTGGGTCTGATTGCAATTCGACAATGACTTGTCCATCCCCGCTTCCCTTCGCCCTCATGCGGAAAGAGGAGCGGGGACCGCGGCAAGCAGCACGGAGCGGAAGGGAGAGCAGGGGGAGAGAAGGCCTCACCTCTCTGTATTTATACGTAAGCCCAGGGAAAACACGGAGATTTGTACCTGCGCTGTTCGTGCTGCCGCTGCCTCTGGGCCCTCTCAGCACATACATGGTCTCTTCACAGCTGCCCTTGAGTTCAGTGTCTCCTTTCCCTGCCCCCAGTGGCTGTCTCAGTTGCTCTCCCATAGTTGGTTATTTTTTATTTGGGGCAGTGGGCATGTATAGGGAGGGGAGGGGGTTCTTCCCAGCCTCAGGTCCCAGCTGTCTCACGTTGTTTATTCCGCGTCCCCTTCTCCAATAAAACAAGCCAGTTGGGCA
>NM_006819.3
AGCTTCTAGTAGGTTCCAGAAGGCGGCGCGTGCGGTTGGGAACGCGGAGCGGACGGATTCGATTCAACGGGGTTCCGGACCGCGCTGCGCTATGGAGCAGGTCAATGAGCTGAAGGAGAAAGGCAACAAGGCCCTGAGCGTGGGTAACATCGATGATGCCTTACAGTGCTACTCCGAAGCTATTAAGCTGGATCCCCACAACCACGTGCTGTACAGCAACCGTTCTGCTGCCTATGCCAAGAAAGGAGACTACCAGAAGGCTTATGAGGATGGCTGCAAGACTGTCGACCTAAAGCCTGACTGGGGCAAGGGCTATTCACGAAAAGCAGCAGCTCTAGAGTTCTTAAACCGCTTTGAAGAAGCCAAGCGAACCTATGAGGAGGGCTTAAAACACGAGGCAAATAACCCTCAACTGAAAGAGGGTTTACAGAATATGGAGGCCAGGTTGGCAGAGAGAAAATTCATGAACCCTTTCAACATGCCTAATCTGTATCAGAAGTTGGAGAGTGATCCCAGGACAAGGACACTACTCAGTGATCCTACCTACCGGGAGCTGATAGAGCAGCTACGAAACAAGCCTTCTGACCTGGGCACGAAACTACAAGATCCCCGGATCATGACCACTCTCAGCGTCCTCCTTGGGGTCGATCTGGGCAGTATGGATGAGGAGGAAGAGATTGCAACACCTCCACCACCACCCCCTCCCAAAAAGGAGACCAAGCCAGAGCCAATGGAAGAAGATCTTCCAGAGAATAAGAAGCAGGCACTGAAAGAAAAAGAGCTGGGGAACGATGCCTACAAGAAGAAAGACTTTGACACAGCCTTGAAGCATTACGACAAAGCCAAGGAGCTGGACCCCACTAACATGACTTACATTACCAATCAAGCAGCGGTATACTTTGAAAAGGGCGACTACAATAAGTGCCGGGAGCTTTGTGAGAAGGCCATTGAAGTGGGGAGAGAAAACCGAGAAGACTATCGACAGATTGCCAAAGCATATGCTCGAATTGGCAACTCCTACTTCAAAGAAGAAAAGTACAAGGATGCCATCCATTTCTATAACAAGTCTCTGGCAGAGCACCGAACCCCAGATGTGCTCAAGAAATGCCAGCAGGCAGAGAAAATCCTGAAGGAGCAAGAGCGGCTGGCCTACATAAACCCCGACCTGGCTTTGGAGGAGAAGAACAAAGGCAACGAGTGTTTTCAGAAAGGGGACTATCCCCAGGCCATGAAGCATTATACAGAAGCCATCAAAAGGAACCCGAAAGATGCCAAATTATACAGCAATCGAGCTGCCTGCTACACCAAACTCCTGGAGTTCCAGCTGGCACTCAAGGACTGTGAGGAATGTATCCAGCTGGAGCCGACCTTCATCAAGGGTTATACACGGAAAGCCGCTGCGCTGGAAGCGATGAAGGACTACACCAAAGCCATGGATGTGTACCAGAAGGCGCTAGACCTGGACTCCAGCTGTAAGGAGGCGGCAGACGGCTACCAGCGCTGTATGATGGCGCAGTACAACCGGCACGACAGCCCCGAAGATGTGAAGCGACGAGCCATGGCCGACCCTGAGGTGCAGCAGATCATGAGTGACCCAGCCATGCGCCTTATCCTGGAACAGATGCAGAAGGACCCCCAGGCACTCAGCGAACACTTAAAGAATCCTGTAATAGCACAGAAGATCCAGAAGCTGATGGATGTGGGTCTGATTGCAATTCGGTGATGACTTGTTCATCCCCCCTTCCCTTCGCCCTCATGTGGAAAGAGGAGCTGGGACCGCGGCGAGCAGCACGGAGCGGAAGGGAGAGCAGGGGAGAGAAGGCCTCATCTCTCTATATTTATACATAACCCCGGGGAAGACACAGAGACTCGTACCTGCGCTGTTTGTGCCGCCGCTGCCTCTGGGCCCTCCCAGCACACGCATGGTCTCTTCACCGCTGCCCTCGAGTTCCATGTCTCTTTCCCCTGCCCCTAGTTGCTGTCTCGGCTGCTCTCCCATAGTTGGTTTTTTTTTTATTTGGGGCAGTGGGCATGTTATGGGGAGGGGAGGGGGTTCTTCCAGCCTCAGGTCCCAGCTGTCTCACGTTGTTTATTCTGCGTCCCCTTCTCCAATAAAACAAGCCAGTTGGGCGTGGTTATA

Publications

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