RCPedia: Rtcs

Summary

Retrocopy Name	TSC22D3P1	Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chrX). Each line represents a retrocopy.
Species	Homo sapiens
Coordinates (hg38)	chrX:91422189-91422543 UCSC
Coordinates (T2T)	chrX:89874306-89874660 UCSC
Coordinates (hg19)	chrX:90677188-90677542 UCSC
Strand	+
Parental Sequence	NM_001015881.2
Parental seq. overlap	302 bp
Parental seq. overlap (%)	16.9%
Genomic Region	Intergenic
Retrocopy Summary	TSC22D3P1, located on chrX:91422189-91422543, is a retrocopy of the parental gene TSC22D3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name	TSC22D3
Full Name	TSC22 domain family member 3
Also known as	DIP\|DSIPI\|GILZ\|TSC-22R
Coordinate	chrX:107713221-107777329
Strand	-
Gene summary	This gene encodes the anti-inflammatory protein glucocorticoid (GC)-induced leucine zipper. Expression of this gene stimulated by glucocorticoids and interleukin 10 and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid. This protein has also been shown to inhibit pro-inflammatory molecules including nuclear factor κB. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Homology

Species	Scientific Name	Retrocopy
Chimpanzee	Pan troglodytes	TSC22D3P1
Bonobo	Pan paniscus	TSC22D3P1
Gorilla	Gorilla gorilla	TSC22D3P1
Orangutan	Pongo abelii	TSC22D3P1
Gibbon	Nomascus leucogenys	TSC22D3P1
Green monkey	Chlorocebus sabaeus	TSC22D3P1
Crab-eating macaque	Macaca fascicularis	TSC22D3P1
Rhesus	Macaca mulatta	TSC22D3P1
Baboon	Papio anubis	TSC22D3P1
Golden snub-nosed monkey	Rhinopithecus roxellana	Without Homology
Marmoset	Callithrix jacchus	Without Homology
Mouse lemur	Microcebus murinus	Without Homology
Mouse	Mus musculus	Without Homology
Rat	Rattus norvegicus	Without Homology
Chinese hamster	Cricetulus griseus	Without Homology
Rabbit	Oryctolagus cuniculus	Without Homology
Pig	Sus scrofa	Without Homology
Cow	Bos taurus	Without Homology
Sheep	Ovis aries	Without Homology
Dolphin	Tursiops truncatus	Without Homology
Horse	Equus caballus	Without Homology
Dog	Canis familiaris	Without Homology
Panda	Ailuropoda melanoleuca	Without Homology
Cat	Felis catus	Without Homology
Pale spear-nosed bat	Phyllostomus discolor	Without Homology
Velvety free-tailed bat	Molossus molossus	Without Homology
Greater mouse-eared bat	Myotis myotis	Without Homology
Kuhl's pipistrelle	Pipistrellus kuhlii	Without Homology
Greater horseshoe bat	Rhinolophus ferrumequinum	Without Homology
Egyptian rousette	Rousettus aegyptiacus	Without Homology
Sloth	Choloepus didactylus	Without Homology
Tasmanian Devil	Sarcophilus harrisii	Without Homology
Opossum	Monodelphis domestica	Without Homology
Platypus	Ornithorhynchus anatinus	Without Homology
Chicken	Gallus gallus	Without Homology
Turkey	Meleagris gallopavo	Without Homology
Zebra Finch	Taeniopygia guttata	Without Homology
Budgerigar	Melopsittacus undulatus	Without Homology
Painted Turtle	Chrysemys picta	Without Homology
Lizard	Anolis Carolinensis	Without Homology
Frog	Xenopus tropicalis	Without Homology
Zebrafish	Danio rerio	Without Homology
Drosophila	Drosophila melanogaster	Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Related Sequence

>TSC22D3P1
TGCTTTGGAGAAGGCTGCAAGCTTCCCAGCCCAGAAGGACTTCCTAGCTAGCTTTAAAGTCAGTGCCTCCAGAGCCAGCACGGTGGCCGTAGACAACAAGATAGAGCAAGCCACGGATCCCTGGATGTGATGAAGAATCATCTGATGCATGCTGTGAGAGAAGAGGTGGAGATTCTGAAGGAGCAGATACTAGAGCTGATGGAGATGAACTCCTAGCTGGAGTGCAACAACACCCTCTTGAAAACCCTGGCGAGCCCAGAGCAGCTGGAGAAGTTCCAGTCTGGTCTGAGCCCTAAAGAGGAAGCTCCAGAATCCCAAGTGCCTGAGGCCCTTGGTGGTTCTGCAGTGTAAGTGG

>NM_001015881.2
GTCATCGAAGCGTCCCTGCGGCCGCTGCGCCGTGAAAACCAGCTGCTGCAGCCgcagaggcagccggaggcagaggggcggcgggcaggaccagacagggctgggcagggGGCTGGCCGAGCGCCGTGCGCCGCTTGGGAGAAGGCCGGAAGCTTACCAGCCGAGAAGGAATTCCTAGCTAGCTTCAGAGCCGGTGCCTCCGGAGCCAGCGTGGTGGCCATAGACAACAAGATCGAACAGGCCATGGATCTGGTGAAGAATCATCTGATGTATGCTGTGAGAGAGGAGGTGGAGATCCTGAAGGAGCAGATCCGAGAGCTGGTGGAGAAGAACTCCCAGCTAGAGCGTGAGAACACCCTGTTGAAGACCCTGGCAAGCCCAGAGCAGCTGGAGAAGTTCCAGTCCTGTCTGAGCCCTGAAGAGCCAGCTCCCGAATCCCCACAAGTGCCCGAGGCCCCTGGTGGTTCTGCGGTGTAAGTGGCTCTGTCCTCAGGGTGGGCAGAGCCACTAAACTTGTTTTACCTAGTTCTTTCCAGTTTGTTTTTGGCTCCCCAAGCATCATCTCACGAGGAGAACTTTACACCTAGCACAGCTGGTGCCAAGAGATGTCCTAAGGACATGGCCACCTGGGTCCACTCCAGCGACAGACCCCTGACAAGAGCAGGTCTCTGGAGGCTGAGTTGCATGGGGCCTAGTAACACCAAGCCAGTGAGCCTCTAATGCTACTGCGCCCTGGGGGCTCCCAGGGCCTGGGCAACTTAGCTGCAACTGGCAAAGGAGAAGGGTAGTTTGAGGTGTGACACCAGTTTGCTCCAGAAAGTTTAAGGGGTCTGTTTCTCATCTCCATGGACATCTTCAACAGCTTCACCTGACAACGACTGTTCCTATGAAGAAGCCACTTGTGTTTTAAGCAGAGGCAACCTCTCTCTTCTCCTCTGTTTCGTGAAGGCAGGGGACACAGATGGGAGAGATTGAGCCAAGTCAGCCTTCTGTTGGTTAATATGGTATAATGCATGGCTTTGTGCACAGCCCAGTGTGGGATTACAGCTTTGGGATGACCGCTTACAAAGTTCTGTTTGGTTAGTATTGGCATAGTTTTTCTATATAGCCATAAATGCGTATATATACCCATAGGGCTAGATCTGTATCTTAGTGTAGCGATGTATACATATACACATCCACCTACATGTTGAAGGGCCTAACCAGCCTTGGGAGTATTGACTGGTCCCTTACCTCTTATGGCTAAGTCTTTGACTGTGTTCATTTACCAAGTTGACCCAGTTTGTCTTTTAGGTTAAGTAAGACTCGAGAGTAAAGGCAAGGAGGGGGGCCAGCCTCTGAATGCGGCCACGGATGCCTTGCTGCTGCAACCCTTTCCCCAGCTGTCCACTGAAACGTGAAGTCCTGTTTTGAATGCCAAACCCACCATTCACTGGTGCTGACTACATAGAATGGGGTTGAGAGAAGATCAGTTTGGGCTTCACAGTGTCATTTGAAAACGTTTTTTGTTTTGTTTTGTAATTATTGTGGAAAACTTTCAAGTGAACAGAAGGATGGTGTCCTACTGTGGATGAGGGATGAACAAGGGGATGGCTTTGATCCAATGGAGCCTGGGAGGTGTGCCCAGAAAGCTTGTCTGTAGCGGGTTTTGTGAGAGTGAACACTTTCCACTTTTTGACACCTTATCCTGATGTATGGTTCCAGGATTTGGATTTTGATTTTCCAAATGTAGCTTGAAATTTCAATAAACTTTGCTCTGTTTTTCTAAAAATAAA

>NM_001015881.2 

GTCATCGAAGCGTCCCTGCGGCCGCTGCGCCGTGAAAACCAGCTGCTGCAGCCgcagaggcagccggaggcagaggggcggcgggcaggaccagacagggctgggcagggGGCTGGCCGAGCGCCGTGCGCCGCTTGGGAGAAGGCCGGAAGCTTACCAGCCGAGAAGGAATTCCTAGCTAGCTTCAGAGCCGGTGCCTCCGGAGCCAGCGTGGTGGCCATAGACAACAAGATCGAACAGGCCATGGATCTGGTGAAGAATCATCTGATGTATGCTGTGAGAGAGGAGGTGGAGATCCTGAAGGAGCAGATCCGAGAGCTGGTGGAGAAGAACTCCCAGCTAGAGCGTGAGAACACCCTGTTGAAGACCCTGGCAAGCCCAGAGCAGCTGGAGAAGTTCCAGTCCTGTCTGAGCCCTGAAGAGCCAGCTCCCGAATCCCCACAAGTGCCCGAGGCCCCTGGTGGTTCTGCGGTGTAAGTGGCTCTGTCCTCAGGGTGGGCAGAGCCACTAAACTTGTTTTACCTAGTTCTTTCCAGTTTGTTTTTGGCTCCCCAAGCATCATCTCACGAGGAGAACTTTACACCTAGCACAGCTGGTGCCAAGAGATGTCCTAAGGACATGGCCACCTGGGTCCACTCCAGCGACAGACCCCTGACAAGAGCAGGTCTCTGGAGGCTGAGTTGCATGGGGCCTAGTAACACCAAGCCAGTGAGCCTCTAATGCTACTGCGCCCTGGGGGCTCCCAGGGCCTGGGCAACTTAGCTGCAACTGGCAAAGGAGAAGGGTAGTTTGAGGTGTGACACCAGTTTGCTCCAGAAAGTTTAAGGGGTCTGTTTCTCATCTCCATGGACATCTTCAACAGCTTCACCTGACAACGACTGTTCCTATGAAGAAGCCACTTGTGTTTTAAGCAGAGGCAACCTCTCTCTTCTCCTCTGTTTCGTGAAGGCAGGGGACACAGATGGGAGAGATTGAGCCAAGTCAGCCTTCTGTTGGTTAATATGGTATAATGCATGGCTTTGTGCACAGCCCAGTGTGGGATTACAGCTTTGGGATGACCGCTTACAAAGTTCTGTTTGGTTAGTATTGGCATAGTTTTTCTATATAGCCATAAATGCGTATATATACCCATAGGGCTAGATCTGTATCTTAGTGTAGCGATGTATACATATACACATCCACCTACATGTTGAAGGGCCTAACCAGCCTTGGGAGTATTGACTGGTCCCTTACCTCTTATGGCTAAGTCTTTGACTGTGTTCATTTACCAAGTTGACCCAGTTTGTCTTTTAGGTTAAGTAAGACTCGAGAGTAAAGGCAAGGAGGGGGGCCAGCCTCTGAATGCGGCCACGGATGCCTTGCTGCTGCAACCCTTTCCCCAGCTGTCCACTGAAACGTGAAGTCCTGTTTTGAATGCCAAACCCACCATTCACTGGTGCTGACTACATAGAATGGGGTTGAGAGAAGATCAGTTTGGGCTTCACAGTGTCATTTGAAAACGTTTTTTGTTTTGTTTTGTAATTATTGTGGAAAACTTTCAAGTGAACAGAAGGATGGTGTCCTACTGTGGATGAGGGATGAACAAGGGGATGGCTTTGATCCAATGGAGCCTGGGAGGTGTGCCCAGAAAGCTTGTCTGTAGCGGGTTTTGTGAGAGTGAACACTTTCCACTTTTTGACACCTTATCCTGATGTATGGTTCCAGGATTTGGATTTTGATTTTCCAAATGTAGCTTGAAATTTCAATAAACTTTGCTCTGTTTTTCTAAAAATAAA

Publications

PMID - Link	Title
No publications available for this retrocopy