Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name BRK1P1
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Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr3). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:9179382-9180502  UCSC
Coordinates (T2T) chrX:8746417-8747537  UCSC
Coordinates (hg19) chrX:9147423-9148543  UCSC
Strand +
Parental Sequence NM_018462.5
Parental seq. overlap 946 bp
Parental seq. overlap (%) 81.7%
Genomic Region Intergenic
Retrocopy Summary BRK1P1, located on chrX:9179382-9180502, is a retrocopy of the parental gene BRK1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name BRK1
Full Name BRICK1 subunit of SCAR/WAVE actin nucleating complex
Also known as C3orf10|HSPC300|MDS027|hHBrk1
Coordinate chr3:10115675-10127190
Strand +
Gene summary Enables identical protein binding activity. Contributes to small GTPase binding activity. Involved in Rac protein signal transduction and positive regulation of cellular component organization. Located in extracellular exosome. Part of SCAR complex. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes BRK1P2
Bonobo Pan paniscus BRK1P2
Gorilla Gorilla gorilla BRK1P2
Orangutan Pongo abelii BRK1P2
Gibbon Nomascus leucogenys BRK1P2
Green monkey Chlorocebus sabaeus BRK1P3
Rhesus Macaca mulatta BRK1P3
Baboon Papio anubis BRK1P3
Golden snub-nosed monkey Rhinopithecus roxellana BRK1P1
Marmoset Callithrix jacchus BRK1P3
Crab-eating macaque Macaca fascicularis Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Related Sequence

>BRK1P1
ACCATGGCAGGACAAGAGGATCTGGTGCAGCAGGAGATTCAGTAGGACTGGGCGAACTGGGAGTACATTGAGATAATCACCAGCAGCATCAAGAAAACTGCAGACTTTCTCAACTCGTTCAATATGTCTTATTCAAGATTTGCAACACTAAGGGAGAAATTGACAGCCCTTGAACAGAGAATAGAGTACATTGAAGCATGGGTGACAAAAGGTGAGATGCTTACCTAGAACAGTGCCATGCTGCTGCTGGGAAGTTGCTTTACAGAACACAGGCCACGTGAGAAAGGCCCCAGCAGCCTTCTGTTCCTTCCTTTCTCCTTAAAGAGCAACAGGGCTTATTCTTGTTTTTCCTTTTCAAAAGTGTGGCCTTTGGGTTCTTCCATGTACATCTGAGGGTGTGATGTGGTATATGAGGAAAAGTCTAGAGGAACTCTTGGAAACAACATTAGGTATTTTACCTTTCCAGTAACATTTTGTAGAATTACTTGTCAATGTATTTGAGACATTCACAGCCAAAAGCCTGGGATTCTTTGTGAAGGTCCTCCCCACCCCTATCCTTCTTTCTCTCTCAGACTTTCCTTAAAGTTCTCATTGCCTCTGCACTGCTTCTGTGAACAGTCTTTGTCTCCTCCCCACCTTTGGTGGGAAGTGTGAGGCAGTCCTGGCCAAGACACTCATGCTCTGGCAATGTGGCTACCAGAGAATGCTGTTGCTAATCCGCCGGTTTCCTGTTGATTTGGGGAGGTCGAGGCCAGGCTCCCACTTGGCTTAAAGGGACATTTTCAGACATTTCTTTCTGTCACTTGGGGTGTCTATGCCTCTCAAATTTCCCTAATAAACTCCTCAACTTGATCTGACTGCTGTGATTATGGTAGGGACAGGACCTAGAGATGGGTTCACTTATTCCACAGTAATGTAATGTATGGGATTATTATTCCAACAAAACTTTCAGATGTAGCTGTTTGATTCAAAGCCTAAGTGGCTTACCAGCCCAAGCCCCCATGTTTGGACTTTCAGCTGATTAGTTTATCCTAGGAATC
>NM_018462.5
GCAGTCGCTCTTCCTCAGGCGGCGGCCATGGCGGGACAGGAGGATCCGGTGCAGCGGGAGATTCACCAGGACTGGGCTAACCGGGAGTACATTGAGATAATCACCAGCAGCATCAAGAAAATCGCAGACTTTCTCAACTCGTTCGATATGTCTTGTCGTTCAAGACTTGCAACACTAAACGAGAAATTGACAGCCCTTGAACGGAGAATAGAGTACATTGAAGCTCGGGTGACAAAAGGTGAGACACTCACCTAGAACAGTGCCGTGCTGCTGCTGGGAAGTTGCTTTACACAACACAGGCCACATGGGAAAGGCCCCAGCAGCCTTCAGCTCCTTCCTTTCTCCTTAAAGAGCAACAGGGCTTATTCTTGTTTTTCTTTTTTCAAAAGTGTGGCCTTTGGGCTCTGCCATCTGGGGTGTGGTGTGGTATGTGGGAAGAAGTTCAGAGGAACCGTTGGAAACGACGTTAGGCATTTTACCTTTTCAGTAACATTTTATACATCTACTTGTCAATGTATTTGAGACATTCACAGCCAAAAGCCTGGGACTCTTTGTGAAGGTCctcctcacctctatctttctttctctctctctcAAACTTTCCTTAAAGTTCTCATTGCCTTTGCACTGCTTCTGTGAACAGTCTTTGTCTCCTCCCCACCTTTGGTGGGAAGTGCGGGGCAGTCCTGGTCAAGACACTCATGCCCTGGCAATGTGGCTGCCAGAGAATGTTGTTGCTAACCCACCAGTTTCTTGTTGATTTGGAGAGGTCAAGGCCAGGCCCCCACTTGGCTTGAAGGGACATTTTCAGACTTTTCTTTCTGTCACTTGGAGTGTCTATGCCTCTCATATTTCCCTAATAAACTCCTCAACTTTTTATCTGACTGCTGTGATTATGGTGGGGAGAGGAGCTAGAGATGGGTTCACTTATTGCACAGAAATGTAATACATGGCGTTATTATTCTAACATAAAACTTTCAGATGTAGCTGTTTGATTCAAAGCCTAGGTGGCTTACCAGCCCAAGTCCCCATGTTTGGACTTTCAGCTGACTAGCTCATCTTGGGAATCatttggtcattcagcacatttaccaagtatttactatgtaggcatgttaaactccaataaaacatacagcattgaatcaga

Publications

PMID - Link Title
No publications available for this retrocopy