Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name XRCC6P5
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Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr22). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:99719129-99721190  UCSC
Coordinates (T2T) chrX:98161387-98163448  UCSC
Coordinates (hg19) chrX:98974127-98976188  UCSC
Strand -
Parental Sequence NM_001469.5
Parental seq. overlap 1803 bp
Parental seq. overlap (%) 81.8%
Genomic Region Intergenic
Retrocopy Summary XRCC6P5, located on chrX:99719129-99721190, is a retrocopy of the parental gene XRCC6. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name XRCC6
Full Name X-ray repair cross complementing 6
Also known as CTC75|CTCBF|G22P1|KU70|ML8|TLAA
Coordinate chr22:41621295-41664041
Strand +
Gene summary The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes XRCC6P5
Bonobo Pan paniscus XRCC6P5
Gorilla Gorilla gorilla XRCC6P5
Orangutan Pongo abelii XRCC6P6
Gibbon Nomascus leucogenys XRCC6P5
Green monkey Chlorocebus sabaeus LOC103216276P2
Crab-eating macaque Macaca fascicularis XRCC6P3
Rhesus Macaca mulatta XRCC6P4
Baboon Papio anubis XRCC6P5
Golden snub-nosed monkey Rhinopithecus roxellana XRCC6P2
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Adipose SubcutaneousMuscle SkeletalArtery TibialArtery CoronaryHeart Atrial AppendageAdipose VisceralUterusVaginaBreast Mammary TissueSkin Not Sun ExposedMinor Salivary GlandBrain CortexAdrenal GlandThyroidLungSpleenPancreasEsophagus MuscularisEsophagus MucosaEsophagus Gastroesophageal JunctionStomachColon SigmoidSmall Intestine Terminal IleumColon TransverseProstateTestisNerve TibialSkin Sun ExposedHeart Left VentricleBrain CerebellumWhole BloodArtery AortaPituitaryBrain Frontal CortexBrain CaudateBrain Nucleus AccumbensBrain PutamenBrain HypothalamusBrain Spinal CordBrain HippocampusBrain Anterior Cingulate CortexOvaryBrain Cerebellar HemisphereLiverBrain Substantia NigraKidney CortexBrain AmygdalaCervix EctocervixFallopian TubeCervix EndocervixBladderKidney Medulla00.050.1
log10(TPM+1)

Related Sequence

>XRCC6P5
CCTTGAAGCAAGTGAATACTAGAAATATTCAGGAAGTGATAGTTTAATTTTTTTTGGTTGATGCCTCCAGGGCTATGTTTGAATCTCAGAGCGAAGGTGAGTTGACTCCTTTTGACATGAGCATCCAGTGTATCCAAAGTGTGTACATGAGTAAGATCATAAGCAGTGATCGAGATCTTTATGATACTGAGAAAGACAAAAATTCAGTGAATTTTAAAAATATTTACGTCTTACAGGAGTTGGAAAATCCAGGTGCAAAACAAATTCTAAAGCTTGACCAGTTTAAGGGGCAGCAGGGACAAAAATGTTTCGAAGACCTGATGGGCCATGGATCTGACTACTCATTCAGTGAAGTTCTGTGGGTCTGTGCCAAACTGTTTAGTGATATCCAGTTCAAGATGAGTCATAGAAAATCATGCTGCTCACCAATGAAGACAACCCTCATGGCAATGACAGTGTTAAGGCCTGCCAGGCCAGGACCAAAGCCGGTGATCTACGAGATATAGGCATCTTCCTTGACTTGATGCCCCTGAAGAAACCTGGGGGCTTTGACATATCCTTGTTCTACAGAGATATCATCAGCATGGCAAAGGATGAGGACCTCATCCTTTGAGGAATCCAGTTCACTTTGAGGAATCCAGCAATCTAGAAGACCTGTTGCAGAAGGTTCGTGCCAAGGAGACCAGGAAATGGGCACTCAGCAGGTTAAAGCTGAAGCTCAACAAAGACATAGTGATCTCTGTGGGCATTTACAGTCTCGTCCAGAAGGCTCTCAAGCCTCCTTCAATAAAACTCTATCGGAAAACAAATGAACCAGTGAAAACCAAGTCCCGGAAATTTAATATTAATACCGGCAGTTTGCTTCTGCCTAGCGATACCAAGCGGTCTCAGATCTATGGGAGTCATCAGATTATACTGGAGAAAGAGGAAACAGAAGAGCTAAAATGGTTTGATGAACCAGCTTTGATGCTCATGGTTTTCAAGCCCTTGGTAATGCTGAAGGAGCACCATTACCCGAGGCCCTCCTTGTTCACGTACCCTGAGGAGTCGCCGGTGAATGGGAGTTCAACCCTGTTCAGTGCTCTGCTCATTAAGTGTCTGGAGAAGGTGGTCATAGCATTGTGCAGATACACACCCCGCAGGAACATCCCCCCTTATTTGGTGGCTTTGGTGTCACAGGAAGAGGAGTTGGATGACCAGAAAATTCAGGTGACTACTCCAGGTTTCCAGCTGGTCTTTTTACCCTTTGCTGATGATAAAAGGAAGGTGCCCTTTACTGAAAAAGTCATGGCAACTCCAGAGCAGGTGGACAACATGAAGGCTATCATTCAGAAGCTCTGCTTCACATACAGAAGTGACAGCTTTGAGAACCCCGTGCTGCAGCAGCACTTCGGGAACCTGGAGCCCTTGATCTTGTATTTGATGGAGGAACAAGCAGTGGACCTTATATTACCCAAGGTTGAAGAAATGAATAAAAGACTGGGCTCCATGGTGAATGAGTTTAAGGAACTTGTCTACTCACCAGATTATAATCCTGAAGGGAAAATTACCAAGAGAAAATGCAATAATGAAGGTTCCAGAAGCAAAAGGCCCAAGCGGAGTATTCAGAAGAGGAGCTGAAGACCCACATCAGCAAGGGCACATTGGGAAAGTTCACTGTGCCAATGATGAAAGAGGCCTGCCTGGAGTACTGGCTGAAGAAGCAGGAGCTGCTAGAAGCCCTCACCAAGCACTTCCAGGACTGACCAGAGGCCGCGCCTCTGGCTGCCCTTCCACACTGTGGCCAGGCTGCCTGGCCTTGTTCTCAGCCAGTTAAAACATGTTTCTCCTGAGCTAGGAAGAGTCTGCCCAACAGAAGTCGAGGGACTTTACGTTTATGAGGCTTTCTGTTGTCATGGTGATGGTGTAGCCCTCCCACTTTGCTGTTCCTTACTCTATCGTCTGAATAAAGAGCCCCAACTTTGTACTATTTCCCTGTGCCAAAGTGAGCAGTAGCCAACACATCAGGGTGTGAGTCTTATTATAAAACCGAGGGTg
>NM_001469.5
ATGCGTGGATTGTCGTCTTCTGTCCAAGTTGGTCGCTTCCCTGCGCCAAAGTGAGCAGTAGCCAACATGTCAGGGTGGGAGTCATATTACAAAACCGAGGGCgatgaagaagcagaggaagaacaagaagagaaCCTTGAAGCAAGTGGAGACTATAAATATTCAGGAAGAGATAGTTTGATTTTTTTGGTTGATGCCTCCAAGGCTATGTTTGAATCTCAGAGTGAAGATGAGTTGACACCTTTTGACATGAGCATCCAGTGTATCCAAAGTGTGTACATCAGTAAGATCATAAGCAGTGATCGAGATCTCTTGGCTGTGGTGTTCTATGGTACCGAGAAAGACAAAAATTCAGTGAATTTTAAAAATATTTACGTCTTACAGGAGCTGGATAATCCAGGTGCAAAACGAATTCTAGAGCTTGACCAGTTTAAGGGGCAGCAGGGACAAAAACGTTTCCAAGACATGATGGGCCACGGATCTGACTACTCACTCAGTGAAGTGCTGTGGGTCTGTGCCAACCTCTTTAGTGATGTCCAATTCAAGATGAGTCATAAGAGGATCATGCTGTTCACCAATGAAGACAACCCCCATGGCAATGACAGTGCCAAAGCCAGCCGGGCCAGGACCAAAGCCGGTGATCTCCGAGATACAGGCATCTTCCTTGACTTGATGCACCTGAAGAAACCTGGGGGCTTTGACATATCCTTGTTCTACAGAGATATCATCAGCATAGCAGAGGATGAGGACCTCAGGGTTCACTTTGAGGAATCCAGCAAGCTAGAAGACCTGTTGCGGAAGGTTCGCGCCAAGGAGACCAGGAAGCGAGCACTCAGCAGGTTAAAGCTGAAGCTCAACAAAGATATAGTGATCTCTGTGGGCATTTATAATCTGGTCCAGAAGGCTCTCAAGCCTCCTCCAATAAAGCTCTATCGGGAAACAAATGAACCAGTGAAAACCAAGACCCGGACCTTTAATACAAGTACAGGCGGTTTGCTTCTGCCTAGCGATACCAAGAGGTCTCAGATCTATGGGAGTCGTCAGATTATACTGGAGAAAGAGGAAACAGAAGAGCTAAAACGGTTTGATGATCCAGGTTTGATGCTCATGGGTTTCAAGCCGTTGGTACTGCTGAAGAAACACCATTACCTGAGGCCCTCCCTGTTCGTGTACCCAGAGGAGTCGCTGGTGATTGGGAGCTCAACCCTGTTCAGTGCTCTGCTCATCAAGTGTCTGGAGAAGGAGGTTGCAGCATTGTGCAGATACACACCCCGCAGGAACATCCCTCCTTATTTTGTGGCTTTGGTGCCACAGGAAGAAGAGTTGGATGACCAGAAAATTCAGGTGACTCCTCCAGGCTTCCAGCTGGTCTTTTTACCCTTTGCTGATGATAAAAGGAAGATGCCCTTTACTGAAAAAATCATGGCAACTCCAGAGCAGGTGGGCAAGATGAAGGCTATCGTTGAGAAGCTTCGCTTCACATACAGAAGTGACAGCTTTGAGAACCCCGTGCTGCAGCAGCACTTCAGGAACCTGGAGGCCTTGGCCTTGGATTTGATGGAGCCGGAACAAGCAGTGGACCTGACATTGCCCAAGGTTGAAGCAATGAATAAAAGACTGGGCTCCTTGGTGGATGAGTTTAAGGAGCTTGTTTACCCACCAGATTACAATCCTGAAGGGAAAGTTACCAAGAGAAAACACGATAATGAAGGTTCTGGAAGCAAAAGGCCCAAGGTGGAGTATTCAGAAGAGGAGCTGAAGACCCACATCAGCAAGGGTACGCTGGGCAAGTTCACTGTGCCCATGCTGAAAGAGGCCTGCCGGGCTTACGGGCTGAAGAGTGGGCTGAAGAAGCAGGAGCTGCTGGAAGCCCTCACCAAGCACTTCCAGGACTGACCAGAGGCCGCGCGTCCAGCTGCCCTTCCGCAGTGTGGCCAGGCTGCCTGGCCTTGTCCTCAGCCAGTTAAAATGTGTTTCTCCTGAGCTAGGAAGAGTCTACCCGACATAAGTCGAGGGACTTTATGTTTTTGAGGCTTTCTGTTGCCATGGTGATGGTGTAGCCCTCCCACTTTGCTGTTCCTTACTTTACTGCCTGAATAAAGAGCCCTAAGTTTGTACTATA

Publications

PMID - Link Title
17712032The association of DNA repair gene polymorphisms with the development and progression of renal cell carcinoma.