Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Casp3P1
Plot displaying the genomic locations of a retrocopy (in chr5) and its respective parental gene (in chr16). Each line represents a retrocopy.
Species Rattus norvegicus
Coordinates chr5:35062561-35065446  UCSC
Strand +
Parental Sequence XM_006253130.3
Parental seq. overlap 2060 bp
Parental seq. overlap (%) 80.4%
Genomic Region Intergenic
Retrocopy Summary Casp3P1, located on chr5:35062561-35065446, is a retrocopy of the parental gene Casp3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Casp3
Full Name caspase 3
Also known as CPP32-beta|Lice|Yama
Coordinate chr16:48845011-48863249
Strand -
Gene summary Enables several functions, including death receptor binding activity; phospholipase A2 activator activity; and protease binding activity. Involved in several processes, including luteolysis; nervous system development; and positive regulation of amyloid-beta formation. Located in cytosol; membrane raft; and neuronal cell body. Part of death-inducing signaling complex. Used to study artery disease (multiple); brain disease (multiple); and pre-malignant neoplasm. Biomarker of several diseases, including artery disease (multiple); brain disease (multiple); diabetes mellitus (multiple); heart disease (multiple); and pancreatitis (multiple). Human ortholog(s) of this gene implicated in Parkinson's disease; colon cancer; lung non-small cell carcinoma; and stomach cancer. Orthologous to human CASP3 (caspase 3). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Casp3P1
TGAGCTTGGAATGGTACACTAAGAAATGTGACCATGGAGAACAACAAAACCTTGGTGGATTCAAAATCCATTAATTATTTTGAAGTAAAGACTACATAGAAGCAAGCCAATGGACTCTGGAGTAGATCTGAACAGTAGTTACAAAATGGGTTATTCTAAAATGGGATTATGTATAATAATTAATAATAAGAACTTGCTTAAAACACTGAAATGACATCTCGCTCTGGTACTGATGTTGCTGCAGCTAACCTTATGAATTAAGGCATGTCTGAGACATTCATGGTCCTGAAATATAAAGTCAGGAATAAAAATGATCTTACCCATGAAGAAATTATGGAATTGATGGATAATGTTTCTAAGGAAGATCACAGCGAAAGGAGCAGTTTTGTGTGTGTGATTCCAAGACATGGTGACAAAGGATTAATTTTTGGAACCAATAGACCTGTTGACCTGGAAAAACTAACTAGTTTCTTCAGAGACGACTACTGCCAGAGTCTGACTGGAAAGAAGAAACTCTTCATTACTCAGGACTGCCAGGGTACAGAGCTGGACTGTGGCATTGAGACAGACAGTGGAACTGAGGATGGTATGTCATGCCAGAAGATACCAGTAGAGGCCAACTTCCTCTATGTTTACTCTACAAAACCCAATTACTATTCCTGAGAAATTAAAAGTCTTGGTTCATCCACTCACTTTGTACCATGCTGCAACTGTGTACCCACAAGCTGGAATTCATGCACATCCTCACTCATGCTAACAGGAAGGTGGCCACGGAATTTAAGTCCTTCTCTCTGGGCGGCACTTTCCACAAAAAGAAACAGATCCCATGTATATTGTCAATGCTCCCAAAAGAATTGTACTTTTATCACTAAAGAAATGATTGGGGGTGAGGTGGGGACATGTTTCTGTTTTGGTTTTTTGTTGGTTTGAATGCCACATCAGAAAACTGTCAGGGAAACTTCATTTCCCTCTCATATAAATCAAATCTGATGTACCAGGTGTTCTTTAAACAATATCACTGCCTAGCAATGCAGCCACAATGCAGCTACCTCAATTTTGATATCAGGTACTTGAAATGAAATTTAATTAGGAACAAATAAATGGCAATAATGGTACTATCATCATAGGAGAAATTACAAAGTTACAGTTTTGTAATTAGCAAGATTTGGTGATACTATGAATTTGAAAGTAAATTATGAAGCAGTGATGATTTTATACTCCCTCCTCATGTTAAGAATGACATTTTAGTTTTCCTTAAATGTAGAAATGATAATGGCAAATGATATGTCTTAGAACTTGAATCCACGAGCAGAGTCAAAGGCTCGAACCGTTGATTTGTAACTGATCTATGGAAATGAAGTTAGAGTACCATAACATACATTATAGCTACTGGTTTTGTGACAATTGTCCAGGGCATGTATTTCTTATTTAAAAATAATCATGTTTTATTATTGGAACAAAACTAACTTGAGTATTTATGTGAGAGGAAACCATGTGCGAACTTGGTTGACTTCTTGAAGGCTGCCATCCTTCAGTGGTGGACATGATGACAGGGTGCTAAAATCCACCAGCATTTGTTCCTTAATTAACCTTATACAAATCAGCTTAGTTTTACAGACCAGCAAAATATCTAAAGAGTGTTTATGCAACAGCCTCAAATTGTTGACTATTAAAATGCAATAAAGGAATTCTACAGGAATATACCATAATATCAATTGTTAAACAGAGCATAAGGAAAAGAGAGAGGACATCTACTGTAATTGGAGAGAAGATGGTTTAAGCCAGAGCAGAGCCATGGCAGAACCATGGGAACATCTTCAGAAAAAGTCTGCTAGTTGGACCCACCCTATGAGTACTGGTCTATGTGGATAATGTCCAAGTTATCACAAGAGAGTGAGCCAGGTTAGAAGCTTCTGCAAAAGGGCTTTCCCAGAATACTAAGAGCCTCAAGAAAGTTTACTGGACTCCATGTACAAAGTCTGTAGCATGTTGACTTTTCTGTTGAAGTTTACAATTCAAGGAAAATAATGGTGGTATTTGTATTGTTGCTAGAAATGAAAGGGCCATGGCACATAGGACTTGGAAAGCATCAGCAATAGGTCCTGCAGCCCACATGGAGGAGTTGCGGACTGGAGTCGATCCCCAACAGGGAGGCTATACTCCAGGCTTCCGTATTCATGGAGGAGCAGAGTCTTGCTGGCTCTCCTAATGGGTCCAGCATTTCCCATAAGCTTCTTTTTTGCAAAAAGAAAGGAAGGAACTCACATTATAATTGATAGTAGGTTCTTGTTTAGACTGAATTTATTGTTAACTCTTTCTAAGTAAGTACAGCATGTGATGGCATTTTAGTGTGTTCCCATGTGACAACTTTATAAAAGTTTGTTATTTTGCAATTTT
>XM_006253130.3
tgggcgggaccggcggTAGGCTGCTGATGCAGTGTTGGTGTTGGTGGGATCAAAGCTTAGTGTCCTGAGGTGCGGAGCTTGGAACGGTACGCGAAGAAAAGTGACCATGGACAACAACGAAACCTCCGTGGATTCAAAATCCATTAATAATTTTGAAACAAAGACTATCCATGGAAGCAAGTCGATGGACTCTGGAATATATCTGGACAGCAGTTACAAAATGGATTACCCTGAAATGGGCTTGTGTATAATAATTAATAATAAGAACTTCCATAAAAGCACTGGAATGTCAGCTCGCAATGGTACCGATGTCGATGCAGCTAACCTCAGAGAGACATTCATGGCCCTGAAATACGAAGTCAGGAATAAAAATGACCTTACTCGTGAAGAAATTATGGAATTGATGGATAGTGTTTCTAAGGAAGATCACAGCAAAAGGAGCAGTTTTGTGTGTGTGATTCTAAGTCATGGAGATGAAGGAGTAATTTTTGGAACGAACGGACCTGTGGACCTGAAAAAACTAACTAGTTTCTTCAGAGGCGACTACTGCCGGAGTCTGACTGGAAAGCCGAAACTCTTCATCATTCAGGCCTGCCGAGGTACAGAGCTGGACTGCGGTATTGAGACAGACAGTGGAACTGACGATGATATGGCATGCCAGAAGATACCAGTGGAGGCCGACTTCCTGTATGCTTACTCTACCGCACCCGGTTACTATTCCTGGAGAAATTCAAGGGACGGGTCATGGTTCATCCAGTCACTTTGCGCCATGCTGAAACTGTACGCGCACAAGCTGGAATTCATGCACATCCTCACTCGTGTTAACCGGAAGGTGGCCACGGAATTTGAGTCCTTCTCCCTGGACGCCACTTTCCATGCAAAGAAACAGATCCCGTGTATTGTGTCAATGCTCACAAAAGAACTGTACTTTTATCACTAAAGGAATGACTGGGAGTGGGGTAGGGGCATGtttctgttttggtttttttttttggtttttgttttttgtttttttttttttatttGAATGCCAAATGAGAAAACTGTCAGGGAGACTTTTTTTTTCCCCTCTCATTTAAATCAAATCCGATGTTCCAGGTCGTCATTGAACAATACCACTGCCTGCAATGCAGCCACAATACAATACCTCAGCTTTGATATCAGGTAGTTGAAATGAAATTTAATTAGGAACAAATAAATGTCAATAATGGTACAACCATCATAGAAGAAATTGGAAAGTCACACTTTGGTAATTAGAGAGATTTGGTGCCACTATGAATTTGAAATTACGAAGCAGTGATGATCTTATACCCCCTCCTCACATCTAGAATGTCACTTTAGTTTTCGTTAAGCATAGGAACGATAATGTCAAGTGGTATGTCTTAGAACTTGAATCCACGAGCAGAGTCAAAGGCTGGTTTTGGAACTGATCTGTGGAAATGAAGAGTTGGAGCACTGTAGCACACATTATAGCTACTGGTTTTGTGACAGTTGACCAGGTCACATATTTATTATTTAAGACAAAAGTCGTGTTTTATTATTGGAACAAAAATAACTTTATATGAGAGGAAAACCATGTGTGAACTTGGTTGGCTTGTTGAAGGCTACCATCCTTCAGTGGTGGACATGACGACAGGGTGCTACGATCCACCAGCATTTGTTTCTTACTTATTCTTATGCAAATCAGCCTAATTTTACAGACCAGCAAAATATCTAAAGAGCGATTATGCAGCAGCCTCAAATTGTTGACTATTAGAATGGAATAAAGGAATTCTACAGGAACAGACCATAATACCAGCTGTCAGTCAGAGCGTAAGGAAAGGAGAGGTGGCATCTCCTGTGATTGGAGAGAAGATGGTTTGAGCCGGAGCAGAGCCATGGGCACGTCTTCAGAAAAGGCCTGCTAGTTGGACCCACCTTGTGAGCACTGGTCTGTGTGGATGATGTCCAAGTTACCACATGAGACTGAACCAGATCAGAAGCTCCTGCAAAAAGGCTTTCCCAGAGTGCTGAGCATCTCAAGAAAGTTCACTGGACTCCATGTACAGAGTCTGTAGCATGCTGACTTTTCTGTTGAAGTTTACAATGAAAGGAAAATGATGGTGATATTTGTACCGTCACTAGAAATGAAGGGCCCTGGCACACGGGACTTGGAAAGCATCCAGCAATAGGCCCTGCAGCCCATGTGGAGGAGCTGCAGACTGGAGTCCACCCCTCCTCCCCATCAGGGCGTCTGTGCTCCAGGCTTCCTTAATCATGGAGGTGCTGAGTCATCGCTGGCTCTCCCTGTGGGTCCAGCATTTCCCATAAGCCTCCTTATTGCACAAAGAAAGGAAGGAACTCACATTATAACTGATAGTAGGTTCTTGTTTAGACTGGATTTACTGTTAACTCTTTTCTAAGTAAATACAGCATGTGGTGGTATTTTAAAATGTGTTCCCATGTGACAATTTTATAAAAGTCAGATATCTTGCATTTTTATTTCAAAACATAAATTCAGATTTAAAATTA

Publications

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